RegenerativeMedicine.net

Liver Research Papers Published

Liver cancer and insulin resistance are focus areas.

McGowan Institute for Regenerative Medicine affiliated faculty members who are also members of the Pittsburgh Liver Research Center (PLRC) recently published several articles. The authors include:

Andrew Duncan, PhD, Associate Professor in the Department of Pathology at the University of Pittsburgh with a secondary appointment in the Department of Bioengineering of the Swanson School of Engineering at Pitt

Satdarshan Paul Monga, MD, Endowed Research Chair in Experimental Pathology and Vice-Chair of Experimental Pathology, Department of Pathology at the University of Pittsburgh, Professor of Pathology (Division of Experimental Pathology), Professor of Medicine (Division of Gastroenterology, Hepatology & Nutrition), and Founding Director of the NIH/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)-funded PLRC

Michael Oertel, PhD, Assistant Professor of Pathology, Division of Experimental Pathology, Department of Pathology

The papers include:

Scaffolding protein IQGAP1 is dispensable but its overexpression promotes hepatocellular carcinoma via YAP1 signaling. Delgado ER, Erickson HL, Tao J, Monga SP, Duncan AW, Anakk S.

Nrf2 and β-catenin coactivation in hepatocellular cancer: biological and therapeutic implications. Tao J, Krutsenko Y, Moghe A, Singh S, Poddar M, Bell A, Oertel M, Singhi AD, Geller D, Chen X, Lujambio A, Liu S, Monga SPM.

A Fbxo48 inhibitor prevents pAMPKα degradation and ameliorates insulin resistance. Liu Y, Jurczak MJ, Lear TB, Lin B, Larsen MB, Kennerdell JR, Chen Y, Huckestein BR, Nguyen MK, Tuncer F, Jiang Y, Monga SP, O’Donnell CP, Finkel T, Chen BB, Mallampalli RK.

Illustration: Healthy liver. NIH/NIDDK.

Read more…

Pittsburgh Liver Research Center News Release (02/11/21)

Pittsburgh Liver Research Center News Release (02/12/21)

Pittsburgh Liver Research Center News Release (02/15/21)

Bio: Dr. Andrew Duncan

Bio: Dr. Satdarshan Paul Monga

Bio: Dr. Michael Oertel

Abstract (Molecular and Cellular Biology, 2021 Feb 1;MCB.00596-20.)

Abstract (Hepatology, 2021 Feb 2.)

Abstract (Nature Chemical Biology, 2021 Jan 25.)