Authors:
Thomas Pauloehrl, Dr. Guillaume Delaittre, Dr. Michael Bruns, Maria Meißler, Prof. Dr. Hans G. Börner, Prof. Dr. Martin Bastmeyer, and Prof. Dr. Christopher Barner-Kowollik
Summary:
Making light work of ligation: A novel method utilizes light for oxime ligation chemistry. A quantitative, low-energy photodeprotection generates aldehyde, which subsequently reacts with aminooxy moieties. The spatial control allows patterning on surfaces (see scheme) with a fluoro marker and GRGSGR peptide, and can be imaged by time-of-flight secondary-ion mass spectrometry.
Source:
Angewandte Chemie; Vol. 51, Issue 36, 9181-9184 (09/03/12)