Authors:
Dr. Shuang Hou, Dr. Libo Zhao, Qinglin Shen, Dr. Juehua Yu, Charles Ng, Xiangju Kong, Dr. Dongxia Wu, Dr. Min Song, Dr. Xiaohong Shi, Xiaochun Xu, Wei-Han OuYang, Rongxian He, Prof. Xing-Zhong Zhao, Tom Lee, Prof. F. Charles Brunicardi, Dr. Mitch André Garcia, Prof. Antoni Ribas, Prof. Roger S. Lo, & Prof. Hsian-Rong Tseng
Summary:
Confined to one cell: A method to detect and isolate single circulating melanoma cells (CMCs; see figure) has been produced by integrating a polymer-nanofiber-embedded nanovelcro cell-affinity assay with a laser microdissection (LMD) technique. This method is able to separate CMCs from normal white blood cells (WBCs) and sequence individual cells for a specific mutation related to cancer progression, allowing for more personalized cancer therapy.
Source:
Angewandte Chemie International Edition; (02/21/13)