Authors:
Jennifer Barrila, Andrea L. Radtke, Aurélie Crabbé, Shameema F. Sarker, Melissa M. Herbst-Kralovetz, C. Mark Ott, & Cheryl A. Nickerson
Summary:
Appropriately simulating the three-dimensional (3D) environment in which tissues normally develop and function is crucial for engineering in vitro models that can be used for the meaningful dissection of host–pathogen interactions. This Review highlights how the rotating wall vessel bioreactor has been used to establish 3D hierarchical models that range in complexity from a single cell type to multicellular co-culture models that recapitulate the 3D architecture of tissues observed in vivo. The application of these models to the study of infectious diseases is discussed.
Source:
Nature Reviews Microbiology; 8, 791-801 (11/10)