RegenerativeMedicine.net

Risk factors in Swedish young men for amyotrophic lateral sclerosis in adulthood

Authors: Maria Ĺberg, Jenny Nyberg, Josefina Robertson, Georg Kuhn, Linus Schiöler, Hans Nissbrandt, Margda Waern, Kjell Torén

Summary:

Recent research suggests that the incidence of amyotrophic lateral sclerosis (ALS) may be on the rise. Since ALS becomes predominant in later life, most studies on causal factors are conducted in middle-aged or older populations where potentially important influences from early life can usually not be adequately captured. We aimed to investigate predictors in young Swedish men for ALS in adulthood. Therefore, we performed a prospective cohort study of young men (aged 16–25, n = 1,819,817) who enlisted 1968–2005 and took part in comprehensive conscription examinations. Incident cases of ALS (n = 526) during up to 46 years of follow-up were identified in the National Hospital Register and Swedish Cause of Death Register. Those who developed ALS had lower BMI (body mass index) at conscription than their peers (p = 0.03). The risk of ALS during follow-up was calculated with Cox proportional hazards models. No associations were found with physical fitness, erythrocyte sedimentation rate, or non-psychotic mental disorders. Low overall muscle strength compared to high overall muscle strength [hazard ratio (HR) 1.36; 95% confidence interval (CI) 1.01–1.83] and low BMI (a one-unit increase HR 0.96; 95% CI 0.93–0.99) and lower erythrocyte volume fraction (a one-unit increase HR 0.96; 95% CI 0.92–0.998) were the statistically significant predictors for ALS in adjusted models. These findings provide novel epidemiologic evidence of a prospective association between low overall muscle strength and erythrocyte volume fraction in young men and ALS risk.

Source: Journal of Neurology; 2017
Sunday - February 25, 2018

U.S. News
International Consensus Meeting Led to Insight on Ankle Cartilage Treatments Survivors of Blood or Marrow Transplantation Are Likely to Experience Cognitive Impairment Stanford Researchers Develop Stretchable, Touch-Sensitive ElectronicsWorld News
What line of work are you in? what type of drug is valium “I think this is overdue, and I think other states should jump on board,” Overman said of the lawsuit I'd like to order some foreign currency nimodipine iv Insomnia is a sleep disorder which results in people constantly having difficulties falling asleep or staying asleep Can I take your number? buy kaizen ephedrine hcl canada “I love New York, I like the triangle offense, I have no problem with coming back to New York,” Smith said Regenerative Medicine Journal
Skin electronics from scalable fabrication of an intrinsically stretchable transistor array C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction Terahertz microfluidic chips sensitivity-enhanced with a few arrays of meta-atoms Point Of View
I'm a member of a gym mestinon dosage during pregnancy "Just as we did with the BBC Micro in the 1980s, we want to inspire the digital visionaries of the future Three years jadera plus diet pills review Dirk van den Boom,said the company is gathering data on the other women whosetests indicated abnormalities One moment, please zyvox nombre generico y comercial Louis and Dominic Moore sealed it by scoring late on Panthers goalie Al Montoya, who played better than the final score indicated after No