Authors:
Thomas Pauloehrl, Dr. Alexander Welle, Dr. Michael Bruns, Katharina Linkert, Prof. Dr. Hans G. Börner, Prof. Dr. Martin Bastmeyer, Dr. Guillaume Delaittre, and Prof. Dr. Christopher Barner-Kowollik
Summary:
A phencyclone derivative is used to achieve light-controlled immobilization of peptides possessing only natural amino acids. The photoactive precursor (blue in picture) is formed in a Diels–Alder reaction and can undergo light-triggered ring-opening reactions with amines. Successful surface patterning with a genuine c(RGDfK) peptide (green) is evidenced by imaging time-of-flight secondary-ion mass spectrometry (ToF-SIMS).
Source:
Angewandte Chemie; Vol. 52, Issue 37, 9714-9718 (09/09/12)