Authors:
Eva Maria Putz, Dagmar Gotthardt, Gregor Hoermann, Agnes Csiszar, Silvia Wirth, Angelika Berger, Elisabeth Straka, Doris Rigler, Barbara Wallner, Amanda M. Jamieson, Winfried F. Pickl, Eva Maria Zebedin-Brandl, Mathias Müller, Thomas Decker, & Veronika Sexl
Summary:
The transcription factor STAT1 is important in natural killer (NK) cells, which provide immediate defense against tumor and virally infected cells. We show that mutation of a single phosphorylation site (Stat1-S727A) enhances NK cell cytotoxicity against a range of tumor cells, accompanied by increased expression of perforin and granzyme B. Stat1-S727A mice display significantly delayed disease onset in NK cell-surveilled tumor models including melanoma, leukemia, and metastasizing breast cancer. Constitutive phosphorylation of S727 depends on cyclin-dependent kinase 8 (CDK8). Inhibition of CDK8-mediated STAT1-S727 phosphorylation may thus represent a therapeutic strategy for stimulating NK cell-mediated tumor surveillance.
Source:
Cell Reports; Vol. 4, Issue 3, 437-444 (08/08/13)