In a landmark study, researchers at the BC Cancer Agency, British Columbia, have discovered that all blood stem cells are not created equal. The discovery adds another layer of understanding about the basic biology of blood stem cells, which may lead to improved treatments for leukemia patients.
Published in the August edition of the new scientific journal Cell Stem Cell, the study by Dr. Connie Eaves and her team at the BC Cancer Agency’s Terry Fox Laboratory identified distinct subtypes of blood stem cells in the adult mouse. Each stem cell subtype behaves uniquely and produces different types of mature blood cells in a transplant setting.
“For the first time, we have been able to show that in mice there are different types of blood stem cells that can perpetuate themselves for a lifetime,” says Dr. Brad Dykstra, first author of the paper. “This could have important implications for understanding human leukemia since many leukemias are thought to arise from a single blood stem cell.”
If this discovery holds true in humans, it could explain why certain leukemias are harder to treat. Transplanting specific stem cell subtypes that produce different amounts of mature blood cells might also make bone marrow transplants more effective and improve outcomes for patients.
Blood stem cells are highly versatile, self-sustaining cells that can generate multiple types of other specialized cells that make up our blood, including immune cells, platelet-producing cells, red blood cells and other infection-fighting white cells.
“This discovery has really turned the field on its head,” explains Dr. Eaves, Director of the BC Cancer Agency’s Terry Fox Laboratory. “For many years, it has been assumed that all blood stem cells are identical and that the differences in their behavior are determined by the stimuli they receive from their environment and a differential partitioning of limited internal components.”
“Our evidence that individual blood stem cells have intrinsic differences will now force a major change in how we will have to investigate normal blood cell development and leukemogenesis at a molecular level,” adds Dr. Eaves.
Illustration: MicroSoft clipart.
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Cell Stem Cell Abstract (Cell Stem Cell, Vol 1, 218-229, 16 August 2007)