Authors:
Dr. Zeyu Xiao, Dr. Changwei Ji, Dr. Jinjun Shi, Eric M. Pridgen, Jillian Frieder, Dr. Jun Wu, & Prof. Omid C. Farokhzad
Summary:
Targeted cancer therapy: Inspired by the ability of DNA hybridization, a targeted near-infrared (NIR) light-responsive delivery system has been developed through simple DNA self-assembly (see picture; PEG=polyethylene glycol). This DNA-based platform shows the ability of releasing therapeutics upon near-infrared irradiation, and remarkable targeted thermo- and chemotherapeutic efficacy in vitro and in vivo.
Source:
Angewandte Chemie International Edition; Vol. 51, Issue 47, 11853-11857 (11/19/12)