Authors:
Halil Tekin, Jefferson G. Sanchez, Christian Landeros, Karen Dubbin, Robert Langer, & Ali Khademhosseini
Summary:
A simple method to control spatial organizations of multiple cell types in predefined geometries by using poly(N-isopropylacrylamide)-based dynamic microwells is described. Dynamic microwells are used to pattern two different cell types in a spatially controlled manner by exploiting their shape changing properties at two different temperatures. Both spatial organization of two different cell types and control of pattern geometry are achieved with circular and square dynamic microwells.
Source:
Advanced Materials; Vol. 24, Issue 41, 5543-5547 (11/02/12)