Authors:
Dianren Xia, Dingzhi Wang, Sun-Hee Kim, Hiroshi Katoh, & Raymond N DuBois
Summary:
Although aberrant DNA methylation is considered to be one of the key ways by which tumor-suppressor and DNA-repair genes are silenced during tumor initiation and progression, the mechanisms underlying DNA methylation alterations in cancer remain unclear. Here we show that prostaglandin E2 (PGE2) silences certain tumor-suppressor and DNA-repair genes through DNA methylation to promote tumor growth. These findings uncover a previously unrecognized role for PGE2 in the promotion of tumor progression.
Source:
Nature Medicine; (01/22/12)