Authors:
Summary:
Background - ΔNp63α is an isoform of p63 that is predominantly expressed in normal epidermis.
Results - Retroviral transduction of ΔNp63α into rapidly proliferating primary human epidermal keratinocytes led to epithelial-mesenchymal transition (EMT) and acquisition of stemlike properties.
Conclusion - ΔNp63α regulates EMT in primary human keratinocytes in a TGF-β-dependent manner.
Significance - Altering p63 level in NHEK may be a novel method to generate “induced mesenchymal stem cells” with multipotent capacity.
Source:
The Journal of Biological Chemistry; 286, 38757-38767 (11/04/11)