Authors:
Botond Z. Igyártó, Krystal Haley, Daniela Ortner, Aleh Bobr, Maryam Gerami-Nejad, Brian T. Edelson, Sandra M. Zurawski, Bernard Malissen, Gerard Zurawski, Judith Berman, & Daniel H. Kaplan
Summary:
Skin-resident dendritic cells (DCs) are well positioned to encounter cutaneous pathogens and are required for the initiation of adaptive immune responses. There are at least three subsets of skin DC— Langerhans cells (LC), Langerin+ dermal DCs (dDCs), and classic dDCs. Whether these subsets have distinct or redundant function in vivo is poorly understood. Using a Candida albicans skin infection model, we have shown that direct presentation of antigen by LC is necessary and sufficient for the generation of antigen-specific T helper-17 (Th17) cells but not for the generation of cytotoxic lymphocytes (CTLs). In contrast, Langerin+ dDCs are required for the generation of antigen specific CTL and Th1 cells. Langerin+ dDCs also inhibited the ability of LCs and classic DCs to promote Th17 cell responses. This work demonstrates that skin-resident DC subsets promote distinct and opposing antigen-specific responses.
Source:
Immunity; Vol. 35, Issue 2, 260-272 (08/26/11)