Jackson Laboratory researchers and their collaborators have reported their discovery of a gene implicated in an acute and severe form of glaucoma known as angle-closure glaucoma (ACG). The gene's activity points to previously unsuspected mechanisms involved in both ACG and infant eye development.
Glaucoma is one of the most common eye diseases and a leading cause of blindness. An increase in fluid pressure in the eye (intraocular pressure or IOP) leads to damage to the optic nerve, causing loss of vision. Most people with the more familiar chronic (open-angle) glaucoma don't even know they have the disease until it's detected in an eye exam. The condition develops slowly and can usually be managed with eye drops and laser surgery.
But ACG can be another story: acute attacks of ACG are a medical emergency. Sudden, debilitating symptoms include severe eye pain, headache, blurred vision, nausea, and vomiting, and without prompt intervention to reduce IOP, very rapid loss of vision can occur.
Simon W.M. John, Ph.D. (pictured), the Jackson Laboratory professor and Howard Hughes Medical Investigator who led the glaucoma research team, describes ACG as "a particularly severe and debilitating subtype of glaucoma, which is very poorly understood at the molecular level." ACG, which affects about 16 million people worldwide, accounts for half of all glaucoma blindness.
ACG patients typically have eyes that are slightly smaller than normal, with a lens that is large for the size of the eye, and an abnormally short axial (front-to-back) length of the eye. These features predispose to blockage or closing of the angle of the eye, which contains an important drain for ocular fluid. As a result, the fluid does not drain properly and can quickly build up, sharply raising IOP. However, notes study author Sai Nair, Ph.D., project head and associate research scientist in the John lab, "It's now clear that the mechanisms of IOP elevation are more complicated than simple blockage by the iris, and must include other physiological disturbances."
The research team identified a mouse strain that has anatomical features similar to those seen in patients with ACG, and that develops high IOP. Because this IOP elevation causes the optic nerve to degenerate, these mice represent an important and much needed mouse model for ACG.
Further, studies in the mouse suggest that depending on genetic background, the mutated gene can cause variable reduction in axial length, ranging from modest to severe. In collaboration with Mounira Hmani-Aifa and colleagues at Université de Sfax in Tunisia, they found that mutation in the same gene can result in severe reduction in axial length in people with extreme hyperopia.
In finding a genetic mutation in the mice that produces a previously unknown protein (one that acts as a protease to break down other proteins), the researchers make the first link between the protein's activity and ACG, as well as eye development in infants.
Illustration: Howard Hughes Medical Institute.
The Jackson Laboratory News Release (05/02/11)
e! Science News (05/02/11)
Abstract (Nature Genetics; 43, 579-584 (05/01/11))