Authors:
Shawn J. Tan, Pichamon Kiatwuthinon, Young Hoon Roh, Jason S. Kahn, & Dan Luo
Summary:
The discovery of RNA interference has revitalized the long ongoing pursuit of gene therapy for the treatment of diseases. Nevertheless, despite promising results from experimental studies, there remains a pressing need for the development of nanocarriers that are clinically-relevant, biocompatible, efficient, and that can be tailored to specific disease targets. This review surveys the broad spectrum of nanomaterials and their functional add-ons, and aims to provide a guide towards engineering nanocarriers for effective siRNA delivery.
Source:
Small; Vol. 7, Issue 7, 841-856 (04/04/11)