Authors:
Ryan M. Stayshich, Ryan M. Weiss, Jian Li, & Tara Y. Meyer
Summary:
A series of repeating sequence poly(lactic-co-glycolic acid) copolymers (RSC PLGAs) has been prepared with the precise incorporation of a pendant benzyl-ether substituted monomer derived from serine. Copolymers were synthesized from the assembly of sequence-specific, stereopure dimeric, and trimeric segmers of lactic, glycolic, and (S)-3-benzyloxy-2-hydroxypropionic acids with controlled and varied tacticities. Deprotection of the hydroxyl groups was accomplished by catalytic hydrogenolysis to yield highly functionialized, hydrophilic polyesters. The 1H and 13C NMR spectra for all of the copolymers were consistent with sequence and stereochemical retention and lacked the signal broadening that is inherent with more random copolymers.
Source:
Macromolecular Rapid Communications, Special Issue: Precision Macromolecular Chemistry, Volume 32, Issue 2, pages 220–225, (January 17, 2011)