A University of Melbourne study has revealed that certain breast cancer genetic variants increase mammographic density, confirming the link between mammographic breast density and breast cancer.
Professor John Hopper (pictured) of the University’s School of Population Health says women vary greatly in their underlying risk of breast cancer. “These findings provide an insight into possible new pathways into the development of breast cancer.”
“We hope our research on mammographic density will eventually help identify women at higher risk of getting breast cancer. That is still a way off, but for now women should follow national guidelines for screening,” he says.
The findings have come from contributions from researchers in the University’s School of Population Health and Department of Pathology along with key national and international collaborators.
“Previous twin studies have suggested there is a genetic link between mammographic density and breast cancer. For the first time, we have been able to identify some of the breast cancer genetic variants involved.”
The amount of light areas on a mammogram reveals the mammographic density of a woman’s breast. Women who have high mammographic density for their age are at an increased risk of breast cancer.
Using mammograms and blood samples from a study of 830 twin pairs and 600 of their sisters aged between 30 and 80 years recruited via the Australian Twin Registry, researchers investigated 12 genetic variants which are known to be associated with breast cancer.
Dr. Jennifer Stone, who led the measurement of mammographic density, says, “We aimed to determine if these genetic variants associated with breast cancer risk also influenced mammographic density. We found at least two variants were linked.”
“To date, three other studies had examined this question but have not provided a convincing answer.”
“Finding that several genetic variants associated with breast cancer genes are also associated with mammographic density could help explain some of the biological reasons why women of the same age differ so much in mammographic density,” Professor Hopper says.
“In doing so, it could also help unravel how these genetic variants are associated with breast cancer risk. This is the beginning of a new research focus on how cancers begin and the role mammographic density plays.”
Illustration: University of Melbourne.
University of Melbourne News Release (02/16/10)
Medical News Today (02/17/10)
Science Daily (02/17/10)
Abstract (Cancer Research; 70(4), 1449-1458 (02/15/10))