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NAIL-MS reveals the repair of 2-methylthiocytidine by AlkB in E. coli

Authors: Valentin F. Reichle, Dimitar P. Petrov, Verena Weber, Kirsten Jung, Stefanie Kellner

Summary:

RNAs contain post-transcriptional modifications, which fulfill a variety of functions in translation, secondary structure stabilization and cellular stress survival. Here, 2-methylthiocytidine (ms2C) is identified in tRNA of E. coli and P. aeruginosa using NAIL-MS (nucleic acid isotope labeling coupled mass spectrometry) in combination with genetic screening experiments. ms2C is only found in 2-thiocytidine (s2C) containing tRNAs, namely tRNAArgCCG, tRNAArgICG, tRNAArgUCU and tRNASerGCU at low abundances. ms2C is not formed by commonly known tRNA methyltransferases. Instead, we observe its formation in vitro and in vivo during exposure to methylating agents. More than half of the s2C containing tRNA can be methylated to carry ms2C. With a pulse-chase NAIL-MS experiment, the repair mechanism by AlkB dependent sulfur demethylation is demonstrated in vivo. Overall, we describe ms2C as a bacterial tRNA modification and damage product. Its repair by AlkB and other pathways is demonstrated in vivo by our powerful NAIL-MS approach.

Source: Nature Communications, 2019; 10 (1)

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External beam accelerated partial breast irradiation versus whole breast irradiation after breast conserving surgery in women with ductal carcinoma in situ and node-negative breast cancer (RAPID): a randomized controlled trial Nongenic cancer-risk SNPs affect oncogenes, tumor-suppressor genes, and immune function Molecular profiling of single neurons of known identity in two ganglia from the crab Cancer borealis Engineered E. coli Nissle 1917 for the delivery of matrix-tethered therapeutic domains to the gut Carboxylated branched poly(β-amino ester) nanoparticles enable robust cytosolic protein delivery and CRISPR-Cas9 gene editing NAIL-MS reveals the repair of 2-methylthiocytidine by AlkB in E. coli Unified mechanism of local drivers in a percolation model of atrial fibrillation Structure of the human metapneumovirus polymerase phosphoprotein complex CSB promoter downregulation via histone H3 hypoacetylation is an early determinant of replicative senescence Distinct tumor microenvironments of lytic and blastic bone metastases in prostate cancer patients Multi-layered core-sheath fiber membranes for controlled drug release in the local treatment of brain tumor Achieving spin-triplet exciton transfer between silicon and molecular acceptors for photon upconversion Functional organization of motor networks in the lumbosacral spinal cord of non-human primates Group A streptococcal S protein utilizes red blood cells as immune camouflage and is a critical determinant for immune evasion Molecular determinants of chaperone interactions on MHC-I for folding and antigen repertoire selection Proliferating transitory T Cells with an effector-like transcriptional signature emerge from PD-1 stem-like CD8 T cells during chronic infection MOWChIP-seq for low-input and multiplexed profiling of genome-wide histone modifications Eomes and Brachyury control pluripotency exit and germ-layer segregation by changing the chromatin state Specific inhibition of the NLRP3 inflammasome as an anti-inflammatory strategy in Cystic Fibrosis Effects of total sleep deprivation on procedural placekeeping: More than just lapses of attention Peritumoral activation of the Hippo pathway effectors Yap and Taz suppresses liver cancer in mice CRISPR/Cas13a‐powered electrochemical microfluidic biosensor for nucleic acid amplification‐free miRNA diagnostics Oral ionic liquid for the treatment of diet-induced obesity PTK2/FAK regulates UPS impairment via SQSTM1/p62 phosphorylation in TARDBP/TDP-43 proteinopathies Fructose-1,6-bisphosphatase 2 inhibits sarcoma progression by restraining mitochondrial biogenesis How many rare diseases are there? A Tppp3 Pdgfra tendon stem cell population contributes to regeneration and reveals a shared role for PDGF signalling in regeneration and fibrosis Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis Nucleolar dynamics and interactions with nucleoplasm in living cells Protective immunity against severe malaria in children is associated with a limited repertoire of antibodies to conserved PfEMP1 variants Rab5-mediated endosome formation is regulated at the trans-Golgi network P. aeruginosa lectin LecB impairs keratinocyte fitness by abrogating growth factor signalling Transcriptional regulatory model of fibrosis progression in the human lung Topology, geometry, and mechanics of strongly stretched and twisted filaments: solenoids, plectonemes, and artificial muscle fibers Positive and negative chemotaxis of enzyme-coated liposome motors Colorectal cancer-associated microbiota contributes to oncogenic epigenetic signatures A functional link between nuclear RNA decay and transcriptional control mediated by the polycomb repressive complex 2 Metabolic modifier screen reveals secondary targets of protein kinase inhibitors within nucleotide metabolism Generation of complex human organoid models including vascular networks by incorporation of mesodermal progenitor cells Dopamine D2 receptor modulates Wnt expression and control of cell proliferation Bioscaffold-induced brain tissue regeneration Lipid signaling drives proteolytic rewiring of mitochondria by YME1L Incorporation of biomarkers into risk assessment for allocation of antihypertensive medication according to the 2017 ACC/AHA high blood pressure guideline: a pooled cohort analysis Metabolic effects of JAK1/2 inhibition in patients with myeloproliferative neoplasms The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35 Integrative transcriptomics reveals sexually dimorphic control of the cholinergic/neurokine interface in schizophrenia and bipolar disorder CD9 identifies pancreatic cancer stem cells and modulates glutamine metabolism to fuel tumor growth Late developing cardiac lymphatic vasculature supports adult zebrafish heart function and regeneration Combined electrostatic and air driven electrospinning for biomedical applications Is running associated with a lower risk of all-cause, cardiovascular and cancer mortality, and is the more the better? A systematic review and meta-analysis Memory retrieval modulates spatial tuning of single neurons in the human entorhinal cortex Transcriptional signature derived from murine tumor-associated macrophages correlates with poor outcome in breast cancer patients Wearable sensors for estimation of Parkinsonian tremor severity during free body movements Loading dependent structural model of polymeric micelles encapsulating curcumin by solid-state NMR spectroscopy Dynorphin‐based “release on demand” gene therapy for drug‐resistant temporal lobe epilepsy Dental epithelial stem cells as a source for mammary gland regeneration and milk producing cells in vivo Non-enzymatic roles of human RAD51 at stalled replication forks A mechanism for increased sensitivity of acute myeloid leukemia to mitotoxic drugs Structure of the RSC complex bound to the nucleosome RhoA controls axon extension independent of specification in the developing brain Broadly protective human antibodies that target the active site of influenza virus neuraminidase PilT and PilU are homohexameric ATPases that coordinate to retract type IVa pili Search-and-replace genome editing without double-strand breaks or donor DNA Association between cardiovascular health and cognitive performance: a twins study Individualized recovery of gut microbial strains post antibiotics Haptoglobin administration into the subarachnoid space prevents hemoglobin-induced cerebral vasospasm Overall mortality after diagnosis of breast cancer in men vs women Peptoid nanotubes: bioinspired peptoid nanotubes for targeted tumor cell imaging and chemo‐photodynamic therapy (small 43/2019) Association of acquired and heritable factors with intergenerational differences in age at symptomatic onset of Alzheimer disease between offspring and parents with dementia Mucin glycans attenuate the virulence of Pseudomonas aeruginosa in infection Regulation of lifespan by neural excitation and REST Fusing randomized trials with big data: the key to self-learning health care systems? Habitual tea drinking modulates brain efficiency: evidence from brain connectivity evaluation Phenolic compounds from coffee by-products modulate adipogenesis-related inflammation, mitochondrial dysfunction, and insulin resistance in adipocytes, via insulin/PI3K/AKT signaling pathways Patient-tailored, connectivity-based forecasts of spreading brain atrophy Multiplexed activation of endogenous genes by CRISPRa elicits potent antitumor immunity TCF-1-centered transcriptional network drives an effector versus exhausted CD8 T cell-fate decision Peripheral blood DNA methylation differences in twin pairs discordant for Alzheimer’s disease Robust prediction of HLA class II epitopes by deep motif deconvolution of immunopeptidomes 1-Deoxydihydroceramide causes anoxic death by impairing chaperonin-mediated protein folding Global impact of somatic structural variation on the DNA methylome of human cancers Analysis of “old” proteins unmasks dynamic gradient of cartilage turnover in human limbs Whole-genome sequencing of triple-negative breast cancers in a population-based clinical study Cardiovascular risk scoring and magnetic resonance imaging detected subclinical cerebrovascular disease Cannabidiol counteracts the psychotropic side-effects of δ-9-tetrahydrocannabinol in the ventral hippocampus through bi-directional control of ERK1-2 phosphorylation Amyloid-beta impairs TOM1-mediated IL-1R1 signaling The use of biologics for the elbow: a critical analysis review The role of biologic agents in the management of common shoulder pathologies: current state and future directions Dietary sugars alter hepatic fatty acid oxidation via transcriptional and post-translational modifications of mitochondrial proteins Global trends in antimicrobial resistance in animals in low- and middle-income countries Structures of the rhodopsin-transducin complex: insights into G-protein activation Ultralow-threshold, continuous-wave upconverting lasing from subwavelength plasmons A triple drug combination targeting components of the nutrient-sensing network maximizes longevity Preclinical performance of a pediatric mechanical circulatory support device: The PediaFlow ventricular assist device Impact of the 2016 revision of US pediatric heart allocation policy on waitlist characteristics and outcomes Control of cytokinesis by β-adrenergic receptors indicates an approach for regulating cardiomyocyte endowment American Society for Bone and Mineral Research‐Orthopaedic Research Society Joint Task Force report on cell‐based therapies Effects of high glucose–induced lysyl oxidase propeptide on retinal endothelial cell survival Fatty liver disease caused by high-alcohol-producing Klebsiella pneumoniae Targeted delivery of CRISPR interference system against Fabp4 to white adipocytes ameliorates obesity, inflammation, hepatic steatosis, and insulin resistance Structural insight into eukaryotic sterol transport through Niemann-Pick type C proteins Ultra-long-acting tunable biodegradable and removable controlled release implants for drug delivery Nilotinib, an approved leukemia drug, inhibits smoothened signaling in Hedgehog-dependent medulloblastoma Impact of the 2016 revision of US pediatric heart allocation policy on waitlist characteristics and outcomes Fungal biofilm morphology impacts hypoxia fitness and disease progression N822K- or V560G-mutated KIT activation preferentially occurs in lipid rafts of the Golgi apparatus in leukemia cells Monitoring the formation of amyloid oligomers using photoluminescence anisotropy A neuroD1 AAV-based gene therapy for functional brain repair after ischemic injury through in vivo astrocyte-to-neuron conversion A cell fitness selection model for neuronal survival during development Machine learning analysis of DNA methylation profiles distinguishes primary lung squamous cell carcinomas from head and neck metastases Discovery and preclinical evaluation of anti-miR-17 oligonucleotide RGLS4326 for the treatment of polycystic kidney disease Distinct initiating events underpin the immune and metabolic heterogeneity of KRAS-mutant lung adenocarcinoma B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma Microvesicle-mediated delivery of minicircle DNA results in effective gene-directed enzyme prodrug cancer therapy Inhibition of IL-2 responsiveness by IL-6 is required for the generation of GC-Tfh cells Induction of immunological tolerance to myelinogenic glial-restricted progenitor allografts PSEN1ΔE9, APPswe, and APOE4 confer disparate phenotypes in human iPSC-derived microglia Interrogating Parkinson's disease associated redox targets: potential application of CRISPR editing Complex oscillatory waves emerging from cortical organoids model early human brain network development Electronic skin to feel “pain”: detecting “prick” and “hot” pain sensations Comparable rates of integrated myofibrillar protein synthesis between endurance-trained master athletes and untrained older individuals Notch coordinates periodontal ligament maturation through regulating Lamin A. Transplantation of kidneys from hepatitis C–infected donors to hepatitis C–negative recipients: Single center experience Position B57 of I-A controls early anti-insulin responses in NOD mice, linking an MHC susceptibility allele to type 1 diabetes onset Single-cell transcriptomics reveals multi-step adaptations to endocrine therapy OmpK36-mediated Carbapenem resistance attenuates ST258 Klebsiella pneumoniae in vivo A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research A cell-penetrating scorpion toxin enables mode-specific modulation of TRPA1 and pain MDSC targeting with Gemtuzumab ozogamicin restores T cell immunity and immunotherapy against cancers MiR322 mediates cardioprotection against ischemia/reperfusion injury via FBXW7/notch pathway Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis Mechanical stabilization of the glandular acinus by linker of nucleoskeleton and cytoskeleton complex Chemoptogenetic damage to mitochondria causes rapid telomere dysfunction A mechanism for statin-induced susceptibility to myopathy Nab-paclitaxel: a new standard of care in neoadjuvant therapy of high-risk early breast cancer? Gold nanoshell-localized photothermal ablation of prostate tumors in a clinical pilot device study Structure, function, and ion-binding properties of a K+ channel stabilized in the 2,4-ion–bound configuration Organ-on-e-chip: Three-dimensional self-rolled biosensor array for electrical interrogations of human electrogenic spheroids Optimization of silicone 3d printing with hierarchical machine learning Longitudinal neurometabolic changes in the hippocampus of a rat model of chronic hepatic encephalopathy Pro-survival lipid sphingosine-1-phosphate metabolically programs T cells to limit anti-tumor activity Abemaciclib is effective against pancreatic cancer cells and synergizes with HuR and YAP1 inhibition MEK inhibition modulates cytokine response to mediate therapeutic efficacy in lung cancer Remote post-ischemic conditioning promotes stroke recovery by shifting circulating monocytes to CCR2+ pro-inflammatory subset Energy‐mediated machinery drives cellular mechanical allostasis Genetic liability to insomnia and cardiovascular disease risk Interaction of α carboxyl terminus 1 peptide with the connexin 43 carboxyl terminus preserves left ventricular function after ischemia‐reperfusion injury Spatially selective activation of the visual cortex via intraneural stimulation of the optic nerve Downgrading of regulation in regenerative medicine Adenosine kinase inhibition augments conducted vasodilation and prevents left ventricle diastolic dysfunction in heart failure with preserved ejection fraction Mutations in RABL3 alter KRAS prenylation and are associated with hereditary pancreatic cancer A robotic neck brace to characterize head‐neck motion and muscle electromyography in subjects with amyotrophic lateral sclerosis Molecular structure of an N-terminal phosphorylated β-amyloid fibril A glomerulus-on-a-chip to recapitulate the human glomerular filtration barrier Neuronal BC RNA transport impairments caused by systemic lupus erythematosus autoantibodies In vivo restoration of myocardial conduction with carbon nanotube fibers A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea Wireless optofluidic brain probes for chronic neuropharmacology and photostimulation Spontaneous isomerization of long-lived proteins provides a molecular mechanism for the lysosomal failure observed in Alzheimer’s disease Development of a clinically relevant chemoresistant mantle cell lymphoma cell culture model Long-term host immune response trajectories among hospitalized patients with sepsis Generation of human fatty livers using custom-engineered induced pluripotent stem cells with modifiable SIRT1 metabolism High-dose spironolactone when patients with acute decompensated heart failure are resistant to loop diuretics: a pilot study Metal oxide semiconductor nanomembrane–based soft unnoticeable multifunctional electronics for wearable human-machine interfaces Modeling steatohepatitis in humans with pluripotent stem cell-derived organoids Meta-weighted gaussian process experts for personalized forecasting of AD cognitive changes An artificial intelligence-enabled ECG algorithm for the identification of patients with atrial fibrillation during sinus rhythm: a retrospective analysis of outcome prediction Structural redundancy in supracellular actomyosin networks enables robust tissue folding Repressive gene regulation synchronizes development with cellular metabolism Exosomes containing HIV protein Nef reorganize lipid rafts potentiating inflammatory response in bystander cells Inhibition of nucleotide synthesis promotes replicative senescence of human mammary epithelial cells Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors 3D bioprinting of collagen to rebuild components of the human heart The AMPK-related kinases SIK1 and SIK3 mediate key tumor suppressive effects of LKB1 in NSCLC RPS25 is required for efficient RAN translation of C9orf72 and other neurodegenerative disease-associated nucleotide repeats Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis Biomimetic sensory feedback through peripheral nerve stimulation improves dexterous use of a bionic hand Modular and tunable biological feedback control using a de novo protein switch De novo design of bioactive protein switches AEBP1 expression increases with severity of fibrosis in NASH and is regulated by glucose, palmitate, and miR-372-3p Canine osteosarcoma genome sequencing identifies recurrent mutations in DMD and the histone methyltransferase gene SETD2 Adenylyl cyclase 5–generated cAMP controls cerebral vascular reactivity during diabetic hyperglycemia Predicting bacterial infection outcomes using single cell RNA-sequencing analysis of human immune cells Noncoding CGG repeat expansions in neuronal intranuclear inclusion disease, oculopharyngodistal myopathy and an overlapping disease A case report of clonal EBV-like memory CD4 T cell activation in fatal checkpoint inhibitor-induced encephalitis Targeting seizure-induced neurogenesis in a clinically relevant time-period leads to transient but not persistent seizure reduction Potential roles of gut microbiome and metabolites in modulating ALS in mice Optogenomic interfaces: bridging biological networks with the electronic digital world Persistent gamma spiking in SI nonsensory fast spiking cells predicts perceptual success Damage sensor role of UV-DDB during base excision repair Association between state-mandated protocolized sepsis care and in-hospital mortality among adults with sepsis Adult living donor versus deceased donor liver transplant (LDLT Versus DDLT) at a single center. Time to change our paradigm for liver transplant Using a continuum model to decipher the mechanics of embryonic tissue spreading from time-lapse image sequences: An approximate Bayesian computation approach Enhanced CAR–T cell activity against solid tumors by vaccine boosting through the chimeric receptor Targeting IDH1 as a prosenescent therapy in high-grade serous ovarian cancer Forward genetic screen for Caenorhabditis elegans mutants with a shortened locomotor healthspan Biocide resistance and transmission of Clostridium difficile spores spiked onto clinical surfaces from an American healthcare facility Electrocardiomatrix facilitates accurate detection of atrial fibrillation in stroke patients Protein interaction networks revealed by proteome coevolution Sheath-run artificial muscles Structure and mechanism of pyrimidine–pyrimidone (6-4) photoproduct recognition by the Rad4/XPC nucleotide excision repair complex DNA translocation mechanism of the MCM complex and implications for replication initiation Nerve injury drives a heightened state of vigilance and neuropathic sensitization in Drosophila Targeting a ceramide double bond improves insulin resistance and hepatic steatosis Single-cell analysis reveals T cell infiltration in old neurogenic niches Designer artificial membrane binding proteins to direct stem cells to the myocardium Inhibition of HER2-positive breast cancer growth by blocking the HER2 signaling pathway with HER2-glycan-imprinted nanoparticles Crystal structure of the mitochondrial protein mitoNEET bound to a benze-sulfonide ligand An ultrafast system for signaling mechanical pain in human skin Myelinating Schwann cells ensheath multiple axons in the absence of E3 ligase component Fbxw7 National and state estimates of lost earnings from cancer deaths in the United States Self-organized synchronous calcium transients in a cultured human neural network derived from cerebral organoids Sequential LASER ART and CRISPR treatments eliminate HIV-1 in a subset of infected humanized mice Targeting a ceramide double bond improves insulin resistance and hepatic steatosis Single-cell analysis reveals T cell infiltration in old neurogenic niches Designer artificial membrane binding proteins to direct stem cells to the myocardium Inhibition of HER2-positive breast cancer growth by blocking the HER2 signaling pathway with HER2-glycan-imprinted nanoparticles Crystal structure of the mitochondrial protein mitoNEET bound to a benze-sulfonide ligand An ultrafast system for signaling mechanical pain in human skin Myelinating Schwann cells ensheath multiple axons in the absence of E3 ligase component Fbxw7 National and state estimates of lost earnings from cancer deaths in the United States Self-organized synchronous calcium transients in a cultured human neural network derived from cerebral organoids Sequential LASER ART and CRISPR treatments eliminate HIV-1 in a subset of infected humanized mice Nrf2 activation promotes lung cancer metastasis by inhibiting the degradation of Bach1 BACH1 stabilization by antioxidants stimulates lung cancer metastasis Human intestinal enteroids with inducible neurogenin-3 expression as a novel model of gut hormone secretion Structure of the Cdc48 segregase in the act of unfolding an authentic substrate LC3-associated endocytosis facilitates β-amyloid clearance and mitigates neurodegeneration in murine Alzheimer’s disease The x-linked DDX3X RNA helicase dictates translation reprogramming and metastasis in melanoma Infection as a stroke trigger SGEF forms a complex with Scribble and Dlg1 and regulates epithelial junctions and contractility Engineered signaling centers for the spatially controlled patterning of human pluripotent stem cells Noninvasive neuroimaging enhances continuous neural tracking for robotic device control Microbiota therapy acts via a regulatory T cell MyD88/RORγt pathway to suppress food allergy De novo lung biofabrication: clinical need, construction methods, and design strategy Patterns of opioid administration among opioid-naive inpatients and associations with postdischarge opioid use: a cohort study Vitamin K status and mobility limitation and disability in older adults: the health, aging, and body composition study Comparative “virtual biopsies” of normal skin and skin lesions using vibrational optical coherence tomography Cartilage binding antibodies induce pain through immune complex mediated activation of neurons Improved outcomes after autologous hematopoietic cell transplantation for light chain amyloidosis: a Center for International Blood and Marrow Transplant Research study Viral capsid trafficking along treadmilling tubulin filaments in bacteria Sporadic Creutzfeldt-Jakob disease prion infection of human cerebral organoids Long-duration hippocampal sharp wave ripples improve memory Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism Identifying brain tumors by differential mobility spectrometry analysis of diathermy smoke Stabilization of the cardiac sarcolemma by sarcospan rescues DMD-associated cardiomyopathy Preimplant phosphodiesterase-5 inhibitor use is associated with higher rates of severe early right heart failure after left ventricular assist device implantation: an INTERMACS analysis. Spatiotemporal structure of cell fate decisions in murine neural crest Mitochondrial dysfunction causes Ca2 overload and ECM degradation–mediated muscle damage in C. elegans Single-cell transcriptomics unveils gene regulatory network plasticity Pre-existing commensal dysbiosis is a host-intrinsic regulator of tissue inflammation and tumor cell dissemination in hormone receptor-positive breast cancer Cooperation between constitutive and inducible chemokines enables T cell engraftment and immune attack in solid tumors Tau binding protein CAPON induces tau aggregation and neurodegeneration Age mosaicism across multiple scales in adult tissues Cell-based therapy restores olfactory function in an inducible model of hyposmia Tissue-engineering the intestine: the trials before the trials Establishment of porcine and human expanded potential stem cells New neural activity patterns emerge with long-term learning Fatty acid transport protein 2 reprograms neutrophils in cancer Association of net ultrafiltration rate with mortality among critically ill adults with AKI receiving continuous venovenous hemodiafiltration… Propagation and selectivity of axonal loss in Leber hereditary optic neuropathy Differentiation of mild cognitive impairment using an entorhinal cortex-based test of virtual reality navigation Membralin deficiency dysregulates astrocytic glutamate homeostasis leading to ALS-like impairment The cell-wide web coordinates cellular processes by directing site-specific Ca2 flux across cytoplasmic nanocourses Translation affects mRNA stability in a codon-dependent manner in human cells A randomized trial evaluating bioimpedance spectroscopy versus tape measurement for the prevention of lymphedema following treatment for breast cancer: interim analysis Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment Targeted homology-directed repair in blood stem and progenitor cells with CRISPR nanoformulations The viral protein corona directs viral pathogenesis and amyloid aggregation Artificially enhancing and suppressing hippocampus-mediated memories Solution processable liquid metal nanodroplets by surface-initiated atom transfer radical polymerization Reward-driven changes in striatal pathway competition shape evidence evaluation in decision-making Electric field based dressing disrupts mixed-species bacterial biofilm infection and restores functional wound healing Egg consumption, cholesterol intake, and risk of incident stroke in men: the Kuopio Ischaemic Heart Disease Risk Factor Study BRD4 regulates metastatic potential of castration-resistant prostate cancer through AHNAK Epigenetic dysregulation of enhancers in neurons is associated with Alzheimer’s disease pathology and cognitive symptoms Light entrains diurnal changes in insulin sensitivity of skeletal muscle via ventromedial hypothalamic neurons Bioactive site-specifically modified proteins for 4D patterning of gel biomaterials Charting cellular identity during human in vitro β-cell differentiation Insufficient sleep is associated with a pro‐atherogenic circulating microRNA signature Coordinated conformational processing of the tumor suppressor protein p53 by the Hsp70 and Hsp90 chaperone machineries Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway Treatment of volumetric muscle loss in mice using nanofibrillar scaffolds enhances vascular organization and integration Early neuromuscular blockade in the acute respiratory distress syndrome Derivation, validation, and potential treatment implications of novel clinical phenotypes for sepsis Targeted and persistent 8-oxoguanine base damage at telomeres promotes telomere loss and crisis Expression of endogenous retroviruses reflects increased usage of atypical enhancers in T cells Autocrine LTA signaling drives NF-κB and JAK-STAT activity and myeloid gene expression in Hodgkin lymphoma Dual inhibition of glutaminase and carnitine palmitoyltransferase decreases growth and migration of glutaminase inhibition–resistant triple-negative breast cancer cells Prospective comprehensive genomic profiling of primary and metastatic prostate tumors ‘Non-self’ Mutation: Double-stranded RNA elicits antiviral pathogenic response in a Drosophila model of expanded CAG repeat neurodegenerative diseases Aβ oligomer elimination restores cognition in transgenic Alzheimer’s mice with full-blown pathology Osteoblasts are “educated” by crosstalk with metastatic breast cancer cells in the bone tumor microenvironment Rare protein-truncating variants in APOB, lower LDL-C, and protection against coronary heart disease A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip Rapid invariant encoding of scene layout in human OPA A prospective, single-arm, multicenter trial of catheter-directed mechanical thrombectomy for intermediate-risk acute pulmonary embolism--the FLARE study A high-throughput platform to identify small-molecule inhibitors of CRISPR-Cas9 Balance of mechanical forces drives endothelial gap formation and may facilitate cancer and immune-cell extravasation Neural population control via deep image synthesis Human salivary amylase gene copy number impacts oral and gut microbiomes Optogenetic control shows that kinetic proofreading regulates the activity of the T cell receptor Deficient endoplasmic reticulum-mitochondrial phosphatidylserine transfer causes liver disease Inhibition of MYC by the SMARCB1 tumor suppressor Chromatin three-dimensional interactions mediate genetic effects on gene expression Direct induction of the three pre-implantation blastocyst cell types from fibroblasts A compact synthetic pathway rewires cancer signaling to therapeutic effector release Pericyte transplantation improves skeletal muscle recovery following hindlimb immobilization Neural control of body-plan axis in regenerating planaria A niche-dependent myeloid transcriptome signature defines dormant myeloma cells Lung cancer in never-smokers: a hidden disease TET enzymes augment AID expression via 5hmC modifications 1 at the Aicda superenhancer Cross-sectional study of HPV testing in self-sampled urine and comparison with matched vaginal and cervical samples in women attending colposcopy for the management of abnormal cervical screening A nanoelectronics-blood-based diagnostic biomarker for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) Why does Clostridium difficile infection recur? Catalytic antimicrobial robots for biofilm eradication An integrated microfluidic flow-focusing platform for on-chip fabrication and filtration of cell-laden microgels Collaboration and competition between active sheets for self-propelled particles Cost-effectiveness of the US Food and Drug Administration added sugar labeling policy for improving diet and health TRIM9-mediated resolution of neuroinflammation confers neuroprotection upon ischemic stroke in mice Defining UHRF1 domains that support maintenance of human colon cancer DNA methylation and oncogenic properties A single-cell atlas of the tumor and immune ecosystem of human breast cancer CRISPR-suppressor scanning reveals a nonenzymatic role of LSD1 in AML A novel, widespread qacA allele results in reduced chlorhexidine susceptibility in Staphylococcus epidermidis Clinical credence — SGLT2 inhibitors, diabetes, and chronic kidney disease Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM Working memory revived in older adults by synchronizing rhythmic brain circuits 3D printing of personalized thick and perfusable cardiac patches and hearts Association of closed-loop brain stimulation neurophysiological features with seizure control among patients with focal epilepsy Quiescence modulates stem cell maintenance and regenerative capacity in the aging brain Systemic clinical tumor regressions and potentiation of PD1 blockade with in situ vaccination Biomarkers for closed-loop deep brain stimulation in Parkinson disease and beyond Diagnostic and prognostic potential of AKR1B10 in human hepatocellular carcinoma The antiangiogenic activity of naturally occurring and synthetic homoisoflavonoids from the Hyacinthaceae (sensu APGII) Immunization with components of the viral fusion apparatus elicits antibodies that neutralize Epstein-Barr virus in B cells and epithelial cells Single-cell transcriptomics of human and mouse lung cancers reveals conserved myeloid populations across individuals and species Outcomes after proton therapy for treatment of pediatric high-risk neuroblastoma Genetic testing and results in a population-based cohort of breast cancer patients and ovarian cancer patients cisTopic: cis-regulatory topic modeling on single-cell ATAC-seq data Patient behaviors and characteristics related to weight regain after Roux-en-Y gastric bypass: a multicenter prospective cohort study The emerging relationship between regenerative medicine and physical therapeutics GRASP55 and UPR control interleukin-1β aggregation and secretion MYC recruits SPT5 to RNA polymerase II to promote processive transcription elongation Association of in vitro fertilization with childhood cancer in the United States Skin-inspired, open mesh electrochemical sensors for lactate and oxygen monitoring Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5−/− mice Ultrasensitive hyperspectral imaging and biodetection enabled by dielectric metasurfaces Tendinosis develops from age‐ and oxygen tension‐dependent modulation of Rac1 activity Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer Prediction of premature all-cause mortality: A prospective general population cohort study comparing machine-learning and standard epidemiological approaches A common embryonic origin of stem cells drives developmental and adult neurogenesis Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion p190RhoGAP filters competing signals to resolve axon guidance conflicts Ptpn21 controls hematopoietic stem cell homeostasis and biomechanics The TNF-derived TIP peptide activates the epithelial sodium channel and ameliorates experimental nephrotoxic serum nephritis Stimuli-responsive injectable cellulose thixogel for cell encapsulation Cell-free gene-regulatory network engineering with synthetic transcription factors Proposed percutaneous aortic valve prosthesis made of cryogel L-sepiapterin restores SLE serum-induced markers of endothelial function in endothelial cells Genome-wide association meta-analysis of functional outcome after ischemic stroke Targeting senescent cells alleviates obesity‐induced metabolic dysfunction High-fructose corn syrup enhances intestinal tumor growth in mice Total pancreatectomy with islet autologous transplantation: the cure for chronic pancreatitis? Total pancreatectomy and islet autotransplantation in chronic pancreatitis: recommendations from PancreasFest Novel insights from uncultivated genomes of the global human gut microbiome Oscillations of MyoD and Hes1 proteins regulate the maintenance of activated muscle stem cells Effects of icosapent ethyl on total ischemic events: from REDUCE-IT A nuclear phosphoinositide kinase complex regulates p53 Role of human ventromedial prefrontal cortex in learning and recall of enhanced extinction GARP dampens cancer immunity by sustaining function and accumulation of regulatory T cells in the colon Biomaterials-aided mandibular reconstruction using in vivo bioreactors Infection drives long-term meningeal engraftment by inflammatory monocytes that impair central nervous system immunity Using a deep learning algorithm and integrated gradients explanation to assist grading for diabetic retinopathy Restoration of high-sensitivity and adapting vision with a cone opsin Intrahepatic fibrin(ogen) deposition drives liver regeneration after partial hepatectomy in mice and humans HLA-A*32:01 is strongly associated with vancomycin-induced drug reaction with eosinophilia and systemic symptoms PARP inhibition enhances tumor cell–intrinsic immunity in ERCC1-deficient non–small cell lung cancer Associations between vascular risk factors and brain MRI indices in UK Biobank Retinal microvascular and neurodegenerative changes in Alzheimer’s disease and mild cognitive impairment compared with control participants 68Ga-FAPI PET/CT: Biodistribution and Preliminary Dosimetry Estimate of 2 DOTA-Containing FAP-Targeting Agents in Patients with Various Cancers Pan-cancer association of a centrosome amplification gene expression signature with genomic alterations and clinical outcome Successful genetic transfection of the colonic protistan parasite blastocystis for reliable expression of ectopic genes Interactions between a pathogenic Blastocystis subtype and gut microbiota: in vitro and in vivo studies Label-free Raman spectroscopy reveals signatures of radiation resistance in the tumor microenvironment Association of muscular strength and incidence of type 2 diabetes Fabrication of 3D-nanofibrous fibrinogen scaffolds using salt-induced self-assembly ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis Foxg1 antagonizes neocortical stem cell progression to astrogenesis Impact of sarcopenia in patients with advanced non–small cell lung cancer treated with PD-1 inhibitors: A preliminary retrospective study Tapered InP nanowire arrays for efficient broadband high-speed single-photon detection Fibroblasts activation and abnormal extracellular matrix remodelling as common hallmarks in three cancer-prone genodermatoses Identification of PKD1L1 gene variants in children with the biliary atresia splenic malformation syndrome Tubuloids derived from human adult kidney and urine for personalized disease modeling Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers RNA binding antagonizes neurotoxic phase transitions of TDP-43 Real-time targeted genome profile analysis of pancreatic ductal adenocarcinomas identifies genetic alterations that might be targeted with existing drugs or used as biomarkers The Society of Thoracic Surgeons Intermacs database annual report: Evolving indications, outcomes, and scientific partnerships Transplanting hepatitis C virus‐infected hearts into uninfected recipients: A single‐arm trial The ATP-binding cassette gene ABCF1 functions as an E2 ubiquitin-conjugating enzyme controlling macrophage polarization to dampen lethal septic shock Structure of Calcarisporiella thermophila Hsp104 disaggregase that antagonizes diverse proteotoxic misfolding events H4K20me0 recognition by BRCA1–BARD1 directs homologous recombination to sister chromatids Bisulfite-free direct detection of 5-methylcytosine and 5-hydroxymethylcytosine at base resolution Intracellular bacteria engage a STING–TBK1–MVB12b pathway to enable paracrine cGAS–STING signalling Isolation of circulating tumor cells in non-small-cell-lung-cancer patients using a multi-flow microfluidic channel Osteoporosis and skeletal dysplasia caused by pathogenic variants in SGMS2 Cognitive and physical activity and dementia A neuron-optimized CRISPR/dCas9 activation system for robust and specific gene regulation Young bone marrow transplantation preserves learning and memory in old mice Concentric organization of A- and B-type lamins predicts their distinct roles in the spatial organization and stability of the nuclear lamina The role of astrocytes in seizure generation: insights from a novel in vitro seizure model based on mitochondrial dysfunction Neurons with complex karyotypes are rare in aged human neocortex Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle Avelumab plus Axitinib versus Sunitinib for advanced renal-cell carcinoma Integrated analysis of population genomics, transcriptomics and virulence provides novel insights into Streptococcus pyogenes pathogenesis Long-term evaluation of AAV-CRISPR genome editing for Duchenne muscular dystrophy Fibroblasts and alectinib switch the evolutionary games played by non-small cell lung cancer Gene-by-sex interactions in mitochondrial functions and cardio-metabolic traits A novel combinatorial technique for simultaneous quantification of oxygen radicals and aggregation reveals unexpected redox patterns in the activation of platelets by different physiopathological stimuli Diabetes relief in mice by glucose-sensing insulin-secreting human alpha-cells Intracortical neural stimulation with untethered, ultrasmall carbon fiber electrodes mediated by the photoelectric effect Obstructive sleep apnea and inflammation: proof of concept based on two illustrative cytokines eIF5A inhibition influences T cell dynamics in the pancreatic microenvironment of the humanized mouse model of Type 1 Diabetes Measles vector as a multiple genes delivery platform facilitating iPSC reprogramming Hearing impairment and cognitive decline in older, community-dwelling adults Inflammation, necrosis, and the kinase RIP3 are key mediators of AAG-dependent alkylation-induced retinal degeneration Species-specific maturation profiles of human, chimpanzee and bonobo neural cells Dynamically stiffened matrix promotes malignant transformation of mammary epithelial cells via collective mechanical signaling Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation Estrogen improves insulin sensitivity and suppresses gluconeogenesis via the transcription factor Foxo1 CEBPA-mutated leukemia is sensitive to genetic and pharmacological targeting of the MLL1 complex A human gut bacterial genome and culture collection for improved metagenomic analyses SMARCA4 loss is synthetic lethal with CDK4/6 inhibition in non-small cell lung cancer CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary Predictors of symptomatic kidney stone recurrence after the first and subsequent episodes Codon stabilization coefficient as a metric to gain insights into mRNA stability and codon bias and their relationships with translation HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited antiviral immune responses Physical activity of UK adults with chronic disease: cross-sectional analysis of accelerometer-measured physical activity in 96,706 UK Biobank participants Patterned human microvascular grafts enable rapid vascularization and increase perfusion in infarcted rat hearts Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation Wild-type p53 promotes cancer metabolic switch by inducing PUMA-dependent suppression of oxidative phosphorylation Energy harvesting: flexible porous piezoelectric cantilever on a pacemaker lead for compact energy harvesting Inhibiting glutamine-dependent mTORC1 activation ameliorates liver cancers driven by β-catenin mutations Safety, tolerability, pharmacokinetics, and immunogenicity of the therapeutic monoclonal antibody mAb114 targeting Ebola virus glycoprotein (VRC 608): an open-label phase 1 study NFIL3 mutations alter immune homeostasis and sensitise for arthritis pathology Astrocytes regulate the development and maturation of retinal ganglion cells derived from human pluripotent stem cells Skeletal muscles do not undergo apoptosis during either atrophy or programmed cell death-revisiting the myonuclear domain hypothesis The endoplasmic reticulum chaperone glucose-regulated protein 94 is essential for proinsulin handling Targeting Sirt-1 controls GVHD by inhibiting T-cell allo-response and promoting Treg stability in mice Spectral contrast optical coherence tomography angiography enables single-scan vessel imaging Allogeneic ex vivo expanded corneal epithelial stem cell transplantation: a randomized controlled clinical trial EZH2 oncogenic mutations drive epigenetic, transcriptional, and structural changes within chromatin domains Cholecystokinin and Alzheimer’s disease: a biomarker of metabolic function, neural integrity, and cognitive performance Timed GDNF gene therapy using an immune-evasive gene switch promotes long distance axon regeneration COL6A3-derived endotrophin links reciprocal interactions among hepatic cells in the pathology of chronic liver disease Functional synaptic architecture of callosal inputs in mouse primary visual cortex Microvascular endothelial cells engulf myelin debris and promote macrophage recruitment and fibrosis after neural injury Structural elements of a pH-sensitive inhibitor binding site in NMDA receptors Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data Metabolic rewiring of macrophages by CpG potentiates clearance of cancer cells and overcomes tumor-expressed CD47−mediated ‘don’t-eat-me’ signal Basophil-derived tumor necrosis factor can enhance survival in a sepsis model in mice Endosomolytic polymersomes increase the activity of cyclic dinucleotide STING agonists to enhance cancer immunotherapy Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer's Disease Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones High Rac1 activity is functionally translated into cytosolic structures with unique nanoscale cytoskeletal architecture Comparison of immune infiltrates in melanoma and pancreatic cancer highlights VISTA as a potential target in pancreatic cancer Cell number in mesenchymal stem cell aggregates dictates cell stiffness and chondrogenesis Disruption of coronin 1 signaling in T Cells promotes allograft tolerance while maintaining anti-pathogen immunity Intergenerational inheritance of high fat diet-induced cardiac lipotoxicity in Drosophila 3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice An interferon-driven oxysterol-based defense against tumor-derived extracellular vesicles Genetic liver-specific AMPK activation protects against diet-induced obesity and NAFLD Synapse-selective control of cortical maturation and plasticity by Parvalbumin-autonomous action of SynCAM 1 Pancreatic islet-autonomous insulin and smoothened-mediated signalling modulate identity changes of glucagon α-cells WISP-1 drives bone formation at the expense of fat formation in human perivascular stem cells Senolytics in idiopathic pulmonary fibrosis: results from a first-in-human, open-label, pilot study Lactosylceramide synthase β-1,4-GalT-V: A novel target for the diagnosis and therapy of human colorectal cancer Maternal choline supplementation ameliorates Alzheimer’s disease pathology by reducing brain homocysteine levels across multiple generations Antigen-specific TCR signatures of cytomegalovirus infection Arginine citrullination at the C-terminal domain controls RNA polymerase II transcription A collicular visual cortex: Neocortical space for an ancient midbrain visual structure Inhaled nanoformulated mRNA polyplexes for protein production in lung epithelium Biologically inspired, cell‐selective release of aptamer‐trapped growth factors by traction forces Calcium activation of cortical neurons by continuous electrical stimulation: Frequency dependence, temporal fidelity, and activation density Designing self-propelled, chemically active sheets: Wrappers, flappers, and creepers Identification of genes required for eye development by high-throughput screening of mouse knockouts Disruption of the interaction of RAS with PI 3-kinase induces regression of EGFR-mutant-driven lung cancer Harnessing genetic complexity to enhance translatability of Alzheimer’s disease mouse models: a path toward precision medicine A novel alkaliphilic streptomyces inhibits ESKAPE pathogens Identifying cis elements for spatiotemporal control of mammalian DNA replication Targeted muscle reinnervation technique in below-knee amputation A novel form of JARID2 is required for differentiation in lineage‐committed cells Parity and risk of maternal cardiovascular disease: A dose–response meta-analysis of cohort studies Effects of a hydrophilic/hydrophobic interface on amyloid-β peptides studied by molecular dynamics simulations and NMR experiments Effective wound healing enabled by discrete alternative electric fields from wearable nanogenerators Mitochondria modulate programmed neuritic retraction Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice Integrative functional genomic analysis of human brain development and neuropsychiatric risks Geographic disparities in lung transplant rates A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology Portraits of communication in neuronal networks Tryptophan 32 mediates SOD1 toxicity in a in vivo motor neuron model of ALS and is a promising target for small molecule therapeutics TAC-seq: targeted DNA and RNA sequencing for precise biomarker molecule counting Commensals suppress intestinal epithelial cell retinoic acid synthesis to regulate interleukin-22 activity and prevent microbial dysbiosis A host-produced quorum-sensing autoinducer controls a phage lysis-lysogeny decision Identifying the pathways required for coping behaviours associated with sustained pain HIPPO signaling resolves embryonic cell fate conflicts during establishment of pluripotency in vivo Integrating chemical and mechanical signals through dynamic coupling between cellular protrusions and pulsed ERK activation Quantifying single-cell secretion in real time using resonant hyperspectral imaging Importin α5 regulates anxiety through MeCP2 and Sphingosine Kinase 1 Jamming of deformable polygons Relationships between indicators of cardiovascular disease and intensity of oil and natural gas activity in northeastern Colorado Multivariate computational analysis of gamma delta T cell inhibitory receptor signatures reveals the divergence of healthy and ART-suppressed HIV aging Tau monomer encodes strains Dual inhibition of the lactate transporters MCT1 and MCT4 is synthetic lethal with metformin due to NAD depletion in cancer cells Livebirth after uterus transplantation from a deceased donor in a recipient with uterine infertility Ingestion of subthreshold doses of environmental toxins induces ascending Parkinsonism in the rat Mycoplasma promotes malignant transformation in vivo, and its DnaK, a bacterial chaperon protein, has broad oncogenic properties Cartilage-penetrating nanocarriers improve delivery and efficacy of growth factor treatment of osteoarthritis Active wrinkles to drive self-cleaning: A strategy for anti-thrombotic surfaces for vascular grafts Topography-driven surface renewal Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration Tamoxifen prolongs survival and alleviates symptoms in mice with fatal X-linked myotubular myopathy Assembly of a pan-genome from deep sequencing of 910 humans of African descent Prion seeds distribute throughout the eyes of sporadic Creutzfeldt-Jakob disease patients Injectable macroporous hydrogel formed by enzymatic cross-linking of gelatin microgels Self-implantable double-layered micro-drug-reservoirs for efficient and controlled ocular drug delivery Large-scale preparation of extracellular vesicles enriched with specific microRNA Alginate-graphene oxide hydrogels with enhanced ionic tunability and chemomechanical stability for light-directed 3D printing Strain-triggered mechanical feedback in self-organizing optic-cup morphogenesis The fibrinolytic factor tPA drives LRP1-mediated melanoma growth and metastasis Convective forces increase CXCR4-dependent glioblastoma cell invasion in GL261 murine model Genetic analysis reveals AMPK is required to support tumor growth in murine kras-dependent lung cancer models DNA origami nanostructures can exhibit preferential renal uptake and alleviate acute kidney injury Dissociation between urate and blood pressure in mice and in people with early Parkinson's disease Oestrogen receptor α AF-1 and AF-2 domains have cell population-specific functions in the mammary epithelium LncRNA HOTAIR regulates lipopolysaccharide-induced cytokine expression and inflammatory response in macrophages Spatiotemporal regulation of the GPCR activity of BAI3 by C1qL4 and Stabilin-2 controls myoblast fusion Pneumolysin binds to the mannose receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival Inhibition of amino acid metabolism selectively targets human leukemia stem cells Shape selective bifacial recognition of double helical DNA Organophosphate exposures during pregnancy and child neurodevelopment: Recommendations for essential policy reforms Association of obesity subtypes in the longitudinal assessment of bariatric surgery study and 3‐year postoperative weight change Statins attenuate outgrowth of breast cancer metastases Magnetocardiography on an isolated animal heart with a room-temperature optically pumped magnetometer Mutational landscape of secondary glioblastoma guides MET-targeted trial in brain tumor Variation in TMEM106B in chronic traumatic encephalopathy A biodegradable hybrid inorganic nanoscaffold for advanced stem cell therapy Antifibrotic synergy between phosphodiesterase type 5 inhibitors and selective oestrogen receptor modulators in Peyronie's Disease models Partial loss of psychiatric risk gene Mir137 in mice causes repetitive behavior and impairs sociability and learning via increased Pde10a Evaluating the evidence on sitting, smoking, and health: is sitting really 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A chemoselective strategy for late-stage functionalization of complex small molecules with polypeptides and proteins Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice Detailed visual cortical responses generated by retinal sheet transplants in rats with severe retinal degeneration The Artificial Intelligence Clinician learns optimal treatment strategies for sepsis in intensive care Wireless resonant circuits for the minimally invasive sensing of biophysical processes in magnetic resonance imaging A histone acetylome-wide association study of Alzheimer’s disease identifies disease-associated H3K27ac differences in the entorhinal cortex Pancreatic islet-autonomous insulin and smoothened-mediated signalling modulate identity changes of glucagon α-cells MUC5B promoter variant and rheumatoid arthritis with interstitial lung disease Antiphospholipid antibodies in patients with myocardial infarction Gut microbiota in the first 2 years of life and the association with body mass index at age 12 in a Norwegian birth cohort BacCapSeq: a platform for diagnosis and characterization of bacterial infections A microfabricated nerve-on-a-chip platform for rapid assessment of neural conduction in explanted peripheral nerve fibers Reticular adhesions are a distinct class of cell-matrix adhesions that mediate attachment during mitosis Programmed assembly of synthetic protocells into thermoresponsive prototissues Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration Colonic epithelial miR-31 associates with the development of Crohn’s phenotypes NR2F1 stratifies dormant disseminated tumor cells in breast cancer patients The lineage-defining transcription factors SOX2 and NKX2-1 determine lung cancer cell fate and shape the tumor immune microenvironment Reservoir computing with a single delay-coupled non-linear mechanical oscillator Small-molecule-based regulation of RNA-delivered circuits in mammalian cells Dynamic intercellular transport modulates the spatial patterning of differentiation during early neural commitment Mammographic breast density assessment using deep learning: clinical implementation ERBB2 signaling drives supporting cell proliferation in vitro and apparent supernumerary hair cell formation in vivo in the neonatal mouse cochlea Comparison of the performance of common measures of weight regain after bariatric surgery for association with clinical outcomes Engineered nanoparticles bind elapid snake venom toxins and inhibit venom-induced dermonecrosis Modeling and prediction of clinical symptom trajectories in Alzheimer’s disease using longitudinal data Reprogramming normal human epithelial tissues to a common, lethal neuroendocrine cancer lineage Complement component C3 is highly expressed in human pancreatic islets and prevents β cell death via ATG16L1 interaction and autophagy regulation Conformational dynamics of the ABC transporter McjD seen by single‐molecule FRET Genome-wide identification of structure-forming repeats as principal sites of fork collapse upon ATR inhibition Electric field–induced release and measurement liquid biopsy for noninvasive early lung cancer assessment ERβ-mediated induction of cystatins results in suppression of TGFβ signaling and inhibition of triple-negative breast cancer metastasis Nondestructive, base-resolution sequencing of 5-hydroxymethylcytosine using a DNA deaminase Multi-axial self-organization properties of mouse embryonic stem cells into gastruloids Incorporation of macrophages into engineered skeletal muscle enables enhanced muscle regeneration Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program Lifetime risk of common neurological diseases in the elderly population The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20 Consumption of red and processed meat and breast cancer incidence: a systematic review and meta-analysis of prospective studies Restoration of vision after de novo genesis of rod photoreceptors in mammalian retinas Adult spinal motoneurons change their neurotransmitter phenotype to control locomotion NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease Combination therapy with anti-HIV-1 antibodies maintains viral suppression Fisetin is a senotherapeutic that extends health and lifespan Biofabrication of autologous human hepatocytes for transplantation: how do we get there? Preclinical performance of a pediatric mechanical circulatory support device: The PediaFlow ventricular assist device Overexpression of the VRK1 kinase, which is associated with breast cancer, induces a mesenchymal to epithelial transition in mammary epithelial cells An inhibitor of GSK3B and HDACs kills pancreatic cancer cells and slows pancreatic tumor growth and metastasis in mice Brain endothelial erythrophagocytosis and hemoglobin transmigration across brain endothelium: implications for pathogenesis of cerebral microbleeds MAVS deficiency induces gut dysbiotic microbiota conferring a proallergic phenotype Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons Active wetting of epithelial tissues Aging suppresses skin-derived circulating SDF1 to promote full-thickness tissue regeneration Structure of the human epithelial sodium channel by cryo-electron microscopy Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells Changing dynamics of the drug overdose epidemic in the United States from 1979 through 2016 Functional classification of long non-coding RNAs by k-mer content Serum biomarker signature-based liquid biopsy for diagnosis of early-stage pancreatic cancer Genome-edited skin epidermal stem cells protect mice from cocaine-seeking behaviour and cocaine overdose Membrane-induced hydroelastic migration of a particle surfing its own wave CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature MicroRNA-141-3p negatively modulates SDF-1 expression in age dependent pathophysiology of human and murine bone marrow stromal cells A high throughput screen for next-generation leads targeting malaria parasite transmission Treatment of human glioblastoma with a live attenuated Zika virus vaccine candidate Disease-associated short tandem repeats co-localize with chromatin domain boundaries Experimental evaluation of the importance of colonization history in early-life gut microbiota assembly Biodegradation of ECM hydrogel promotes endogenous brain tissue restoration in a rat model of stroke Tissue-adhesive wirelessly powered optoelectronic device for metronomic photodynamic cancer therapy Large-scale plasma lipidomic profiling identifies lipids that predict cardiovascular events in secondary prevention Staufen1 links RNA stress granules and autophagy in a model of neurodegeneration Susceptible period for cardiovascular complications in patients recovering from sepsis COMRADES determines in vivo RNA structures and interactions Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology Mood variations decoded from multi-site intracranial human brain activity A fluid-to-solid jamming transition underlies vertebrate body axis elongation In vivo reprogramming of wound-resident cells generates skin epithelial tissue Direct generation of human cortical organoids from primary cells Cancer mutations and targeted drugs can disrupt dynamic signal encoding by the Ras-Erk pathway RandomiSed clinical trial assessing Use of an anti-inflammatoRy aGent in attenUating peri-operatiVe inflAmmatioN in non-meTastatic colon cancer – the S.U.R.G.U.V.A.N.T. trial SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix Epistatic control of intrinsic resistance by virulence genes in Listeria Neutrophil membrane-coated nanoparticles inhibit synovial inflammation and alleviate joint damage in inflammatory arthritis Junction-based lamellipodia drive endothelial cell rearrangements in vivo via a VE-cadherin-F-actin based oscillatory cell-cell interaction Visual rehabilitation training alters attentional networks in hemianopia: An fMRI study Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy Time-restricted feeding prevents obesity and metabolic syndrome in mice lacking a circadian clock Minimizing context dependency of gene networks using artificial cells Discovery of novel cell surface markers for purification of embryonic dopamine progenitors for transplantation in Parkinson’s disease animal models Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes SIRT6 haploinsufficiency induces BRAFV600E melanoma cell resistance to MAPK inhibitors via IGF signalling Small molecules co-targeting CKIα and the transcriptional kinases CDK7/9 control AML in preclinical models Digitally tunable microfluidic bioprinting of multilayered cannular tissues County-level air quality and the prevalence of diagnosed chronic kidney disease in the US Medicare population The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and space Multimorbidity and survival for patients with acute myocardial infarction in England and Wales: Latent class analysis of a nationwide population-based cohort Intestinal metabolism and bioaccumulation of sucralose in adipose tissue in the rat Telomere shortening is a hallmark of genetic cardiomyopathies Association of variants in BAG3 with cardiomyopathy outcomes in African American individuals Lack of Sprouty 1 and 2 enhances survival of effector CD8 T cells and yields more protective memory cells Circulating tumor DNA measurements as early outcome predictors in diffuse large B-cell lymphoma A framework to rank genomic alterations as targets for cancer precision medicine: the ESMO Scale for Clinical Actionability of molecular Targets (ESCAT) Correlation between polar surface area and bioferroelectricity in DNA and RNA nucleobases Electrostatic lock in the transport cycle of the multidrug resistance transporter EmrE Mutation-independent rhodopsin gene therapy by knockdown and replacement with a single AAV vector Progressive massive fibrosis resurgence identified in U.S. coal miners filing for black lung benefits, 1970–2016 Integrated phosphorescence-based photonic biosensor (iPOB) for monitoring oxygen levels in 3D cell culture systems Huntingtin aggregation impairs autophagy, leading to Argonaute-2 accumulation and global microRNA dysregulation A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells KIM-1 as a blood-based marker for early detection of kidney cancer: a prospective nested case-control study Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors Dysregulation in actin cytoskeletal organization drives increased stiffness and migratory persistence in polyploidal giant cancer cells Intestinal P-glycoprotein exports endocannabinoids to prevent inflammation and maintain homeostasis Cortisol facilitates the immune escape of human acute myeloid leukemia cells by inducing latrophilin 1 expression Photochemical 'in-air' combinatorial discovery of antimicrobial copolymers Wireless control of cellular function by activation of a novel protein responsive to electromagnetic fields Dysregulation of neuronal iron homeostasis as an alternative unifying effect of mutations causing familial Alzheimer’s disease Multisensory bionic limb to achieve prosthesis embodiment and reduce distorted phantom limb perceptions The environmental sensor AHR protects from inflammatory damage by maintaining intestinal stem cell homeostasis and barrier integrity Differences in neural stem cell identity and differentiation capacity drive divergent regenerative outcomes in lizards and salamanders Effect of platelet-rich plasma on chondrogenic differentiation of adipose- and bone marrow-derived mesenchymal stem cells Stretchable, implantable, nanostructured flow-diverter system for quantification of intra-aneurysmal hemodynamics Impact of edible cricket consumption on gut microbiota in healthy adults, a double-blind, randomized crossover trial Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion Optical imaging of metabolic dynamics in animals Evaluation of a novel rule-out myocardial infarction protocol incorporating high-sensitivity troponin T in a US hospital Orthogonal self-assembly of an organoplatinum(II) metallacycle and cucurbit[8]uril that delivers curcumin to cancer cells 18F-fluoroestradiol tumor uptake is heterogeneous and influenced by site of metastasis in breast cancer patients Hematopoietic cell-derived RELMα regulates hookworm immunity through effects on macrophages Prioritizing the needs of children in a changing climate Kinetic basis for DNA target specificity of CRISPR-Cas12a Remission of human type 2 diabetes requires decrease in liver and pancreas fat content but is dependent upon capacity for β cell recovery Transcriptional synergy as an emergent property defining cell subpopulation identity enables population shift Combining H-FABP and GFAP increases the capacity to differentiate between CT-positive and CT-negative patients with mild traumatic brain injury Kidney-targeted inhibition of protein kinase C-α ameliorates nephrotoxic nephritis with restoration of mitochondrial dysfunction A reliable murine model of bone metastasis by injecting cancer cells through caudal arteries Diffusible, highly bioactive oligomers represent a critical minority of soluble Aβ in Alzheimer’s disease brain An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer’s disease Magnetic drug targeting: a novel treatment for intramedullary spinal cord tumors Glial acetate metabolism is increased following a 72-h fast in metabolically healthy men and correlates with susceptibility to hypoglycemia Microfluidic chemotaxis platform for differentiating the roles of soluble and bound amyloid-β on microglial accumulation A three-dimensional human neural cell culture model of Alzheimer's disease A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer’s disease Repeated exposure to heat stress induces mitochondrial adaptation in human skeletal muscle Wnt/PCP controls spreading of Wnt/β-catenin signals by cytonemes in vertebrates Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures Gene exchange drives the ecological success of a multi-host bacterial pathogen Hippocampal projections to the anterior olfactory nucleus differentially convey spatiotemporal information during episodic odour memory Topical curcumin nanocarriers are neuroprotective in eye disease Visual impairment and progressive phthisis bulbi caused by recessive pathogenic variant in MARK3 Ex vivo biomechanical characterization of syringe-needle ejections for intracerebral cell delivery Compressed collagen enhances stem cell therapy for corneal scarring Human limbal biopsy-derived stromal stem cells prevent corneal scarring Concise review: stem cells in the corneal stroma Association between the New York sepsis care mandate and in-hospital mortality for pediatric sepsis Smart surgical catheter for c-reactive protein sensing based on an imperceptible organic transistor Human pluripotent reprogramming with CRISPR activators Smart bandage for monitoring and treatment of chronic wounds Fibronectin rescues estrogen receptor α from lysosomal degradation in breast cancer cells ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma Anti-tumour necrosis factor therapy for Dupuytren's disease: a randomised dose response proof of concept phase 2a clinical trial Thermal proteome profiling in bacteria: probing protein state in vivo Ras and rap signal bidirectional synaptic plasticity via distinct subcellular microdomains DNA-induced liquid phase condensation of cGAS activates innate immune signaling Unique Francisella phosphatidylethanolamine acts as a potent anti-inflammatory lipid Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein Discovery of UDP-glycosyltransferases and BAHD-acyltransferases involved in the biosynthesis of the anti-diabetic plant metabolite montbretin Changes in pain intensity following discontinuation of long-term opioid therapy for chronic non-cancer pain Sampling molecular conformations and dynamics in a multiuser virtual reality framework Integrated time course omics analysis distinguishes immediate therapeutic response from acquired resistance Direct pericyte-to-neuron reprogramming via unfolding of a neural stem cell-like program Continuous biomarker monitoring by particle mobility sensing with single molecule resolution Control of spreading depression with electrical fields Human embryonic stem cell–derived cardiomyocytes restore function in infarcted hearts of non-human primates Costs and benefits of provocation in bacterial warfare Sympathetic neuronal activation triggers myeloid progenitor proliferation and differentiation A Ca2 -stimulated exosome release pathway in cancer cells is regulated by Munc13-4 Multiscale analysis of independent Alzheimer’s cohorts finds disruption of molecular, genetic, and clinical networks by human herpesvirus Locally coordinated synaptic plasticity of visual cortex neurons in vivo Resistance to enediyne antitumor antibiotics by sequestration Newfound effect of N -acetylaspartate in preventing and reversing aggregation of amyloid-beta in vitro How diverse retinal functions arise from feedback at the first visual synapse Precision therapeutic targeting of human cancer cell motility A naturally occurring antiviral ribonucleotide encoded by the human genome Multiple membrane extrusion sites drive megakaryocyte migration into bone marrow blood vessels The Drosophila immune deficiency pathway modulates enteroendocrine function and host metabolism Therapeutic luminal coating of the intestine Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure Sustained release of targeted cardiac therapy with a replenishable implanted epicardial reservoir Potent laminin-inspired antioxidant regenerative dressing accelerates wound healing in diabetes BAFF neutralization aggravates atherosclerosis Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis Hippocampal calcifications: risk factors and association with cognitive function α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease Human plasma and serum extracellular small RNA reference profiles and their clinical utility Association between systolic blood pressure and dementia in the Whitehall II cohort study: role of age, duration, and threshold used to define hypertension Cost-effectiveness analysis of biopsy strategies for endometrial cancer diagnosis in women with postmenopausal bleeding: Pipelle sampling curette versus dilatation & curettage Gestational changes in buprenorphine exposure: a physiologically based pharmacokinetic analysis Low-dose NSAIDs reduce pain via macrophage targeted nanoemulsion delivery to neuroinflammation of the sciatic nerve in rat PAX3-FOXO1 transgenic zebrafish models identify HES3 as a mediator of rhabdomyosarcoma tumorigenesis Clinical trials in a dish: a perspective on the coming revolution in drug development Ultra-protective mechanical ventilation without extra-corporeal carbon dioxide removal for acute respiratory distress syndrome Testosterone is an endogenous regulator of BAFF and splenic B cell number Local immunomodulation with Fas ligand-engineered biomaterials achieves allogeneic islet graft acceptance TMS-induced neuronal plasticity enables targeted remodeling of visual cortical maps BigSCale: an analytical framework for big-scale single-cell data Computationally identified novel agonists for GPRC6A Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1 Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer Extracellular matrix-based materials for regenerative medicine Assessment of follow-up care after emergency department presentation for mild traumatic brain injury and concussion: results from the TRACK-TBI study A randomized trial of a family-support intervention in intensive care units Restoring vision Expanded autologous regulatory T-lymphocyte infusions in ALS A causal mechanism for childhood acute lymphoblastic leukaemia Stabilized single-injection inactivated polio vaccine elicits a strong neutralizing immune response Xenoprotein engineering via synthetic libraries Genomes of all known members of a Plasmodium subgenus reveal paths to virulent human malaria 3′ UTR shortening represses tumor-suppressor genes in trans by disrupting ceRNA crosstalk Analysis of red blood cell partitioning at bifurcations in simulated microvascular networks Associations of egg consumption with cardiovascular disease in a cohort study of 0.5 million Chinese adults Microfluidics-enabled multimaterial maskless stereolithographic bioprinting Dual-function injectable angiogenic biomaterial for the repair of brain tissue following stroke The RNA-binding protein Celf1 post-transcriptionally regulates p27Kip1 and Dnase2b to control fiber cell nuclear degradation in lens development Procalcitonin-guided use of antibiotics for lower respiratory tract infection Cross-specificity of protective human antibodies against Klebsiella pneumoniae LPS O-antigen S-nitrosylation of β-arrestins biases receptor signaling and confers ligand independence Spatial mutation patterns as markers of early colorectal tumor cell mobility Staphylococcus aureus utilizes host-derived lipoprotein particles as sources of fatty acids Sheathless inertial cell focusing and sorting with serial reverse wavy channel structures Benefits and safety of dietary protein for bone health—an expert consensus paper endorsed by the European Society for Clinical and Economical Aspects of Osteopororosis, Osteoarthritis, and Musculoskeletal Diseases and by the International Osteoporos Dual-wavelength 3D photoacoustic imaging of mammalian cells using a photoswitchable phytochrome reporter protein Platelets expressing IgG receptor FcγRIIA/CD32A determine the severity of experimental anaphylaxis Have we made progress with educational services for students with TBI NDF, a nucleosome destabilizing factor that facilitates transcription through nucleosomes Sharpening of hierarchical visual feature representations of blurred images Human gut microbiota predicts susceptibility to Vibrio cholera infection Negative feedback phosphorylation of Gγ subunit Ste18 and the Ste5 scaffold synergistically regulates MAPK activation in yeast Broadly neutralizing antibodies from human survivors target a conserved site in the Ebola virus glycoprotein HR2–MPER region Bone marrow is a major parasite reservoir in Plasmodium vivax infection Centrosome amplification arises before neoplasia and increases upon p53 loss in tumorigenesis TAR DNA-binding protein 43 and disrupted in schizophrenia 1 coaggregation disrupts dendritic local translation and mental function in frontotemporal lobar degeneration Coarse particulate matter (PM2.5–10) in Los Angeles Basin air induces expression of inflammation and cancer biomarkers in rat brains Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning Validating the concept of mutational signatures with isogenic cell models Overexpression of Cx43 in cells of the myocardial scar: Correction of post-infarct arrhythmias through heterotypic cell-cell coupling Impact of healthy lifestyle factors on life expectancies in the US population Enzymatic or in vivo installation of propargyl groups in combination with click chemistry for the enrichment and detection of methyltransferase target sites in RNA Oral administration and detection of a near-infrared molecular imaging agent in an orthotopic mouse model for breast cancer screening Memory deficiency, cerebral amyloid angiopathy, and amyloid-β plaques in APP PS1 double transgenic rat model of Alzheimer’s disease DNA methylation and regulatory elements during chicken germline stem cell differentiation Spatial heterogeneity and evolutionary dynamics modulate time to recurrence in continuous and adaptive cancer therapies Multifunctional biophotonic nanostructures inspired by the longtail glasswing butterfly for medical devices Precise multimodal optical control of neural ensemble activity Shared strategies for β-lactam catabolism in the soil microbiome Radiomic features on MRI enable risk categorization of prostate cancer patients on active surveillance: preliminary findings Training a cell-level classifier for detecting basal-cell carcinoma by combining human visual attention maps with low-level handcrafted features A deep-learning classifier identifies patients with clinical heart failure using whole-slide images of H&E tissue Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis Long ncRNA A-ROD activates its target gene DKK1 at its release from chromatin Proton-pump inhibitors and long-term risk of community-acquired pneumonia in older adults A new method for the high-precision assessment of tumor changes in response to treatment Cardiac mTORC1 dysregulation impacts stress adaptation and survival in Huntington's disease Drought-sensitivity of fine dust in the U.S. Southwest: Implications for air quality and public health under future climate change Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases Neuropsychological predictors of long-term (10 years) mild cognitive impairment stability Age is relative—impact of donor age on induced pluripotent stem cell-derived cell functionality An exome-wide sequencing study of lipid response to high-fat meal and fenofibrate in Caucasians from the GOLDN cohort In silico optimization of a guava antimicrobial peptide enables combinatorial exploration for peptide design Neoadjuvant PD-1 blockade in resectable lung cancer High-speed live-cell interferometry: a new method for quantifying tumor drug resistance and heterogeneity The long non‐coding RNA Paupar promotes KAP1‐dependent chromatin changes and regulates olfactory bulb neurogenesis An in vivo model of functional and vascularized human brain organoids A single injection of crystallizable fragment domain–modified antibodies elicits durable protection from SHIV infection Potent antitumor efficacy of anti-GD2 CAR T cells in H3-K27M diffuse midline gliomas Risk and prognosis of cancer after lower limb arterial thrombosis The dynamics of concussion: mapping pathophysiology, persistence, and recovery with causal-loop diagramming Artificial intelligence estimation of carotid-femoral pulse wave velocity using carotid waveform Use of antiepileptic drugs and dementia risk-an analysis of Finnish health register and German health insurance data Highly scalable generation of DNA methylation profiles in singles cells Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector Hemodynamic forces tune the arrest, adhesion, and extravasation of circulating tumor cells Adipocyte p62/SQSTM1 suppresses tumorigenesis through opposite regulations of metabolism in adipose tissue and tumor Simultaneous lineage tracing and cell-type identification using CRISPR-Cas9-induced genetic scars Machine learning detects pan-cancer ras pathway activation in The Cancer Genome Atlas State estimation for a penicillin fed-batch process combining particle filtering methods with online and time delayed offline measurements Mitochondrial DNA and TLR9 drive muscle inflammation upon Opa1 deficiency Proprioceptive and cutaneous sensations in humans elicited by intracortical microstimulation Natural regulatory mutations elevate the fetal globin gene via disruption of BCL11A or ZBTB7A binding APC inhibits ligand-independent Wnt signaling by the clathrin endocytic pathway Evaluation of 1C-Me-NB1 as a potential PET radioligand for measuring GluN2B-containing NMDA receptors, drug occupancy, and receptor cross talk A global transcriptional network connecting noncoding mutations to changes in tumor gene expression Nanoengineered injectable hydrogels for wound healing application MicroRNA-17-92 is required for T-cell and B-cell pathogenicity in chronic graft-versus-host disease in mice Ablation of insulin receptor substrates 1 and 2 suppresses Kras-driven lung tumorigenesis Transcatheter laceration of aortic leaflets to prevent coronary obstruction during transcatheter aortic valve replacement Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD in healthy middle-aged and older adults Complete biosynthesis of noscapine and halogenated alkaloids in yeast Low-dose NSAIDs reduce pain via macrophage targeted nanoemulsion delivery to neuroinflammation of the sciatic nerve in rat Large volume syringe pump extruder for desktop 3D printers Referral regions for time-sensitive acute care conditions in the United States Genome-wide somatic variant calling using localized colored de Bruijn graphs Lymph node blood vessels provide exit routes for metastatic tumor cell dissemination in mice SpdC, a novel virulence factor, controls histidine kinase activity in Staphylococcus aureus Mutations in PMPCB encoding the catalytic subunit of the mitochondrial presequence protease cause neurodegeneration in early childhood Cancer-secreted hsa-miR-940 induces an osteoblastic phenotype in the bone metastatic microenvironment via targeting ARHGAP1 and FAM134A Design and syntheses of highly potent teixobactin analogues against Staphylococcus aureus, Methicillin-Resistant Staphylococcus aureus (MRSA), and Vancomycin-Resistant Enterococci (VRE) in vitro and in vivo Cell-free protein synthesis from genomically recoded bacteria enables multisite incorporation of noncanonical amino acids Suppression of diabetes by accumulation of non-islet-specific CD8 effector T cells in pancreatic islets Thyroid disrupting chemicals and brain development: an update Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction Reconfigurable paramagnetic microswimmers: Brownian motion affects non-reciprocal actuation A bit-encoding based new data structure for time and memory efficient handling of spike times in an electrophysiological setup Dynamic protein assembly by programmable DNA strand displacement Phase 1 clinical study of an embryonic stem cell–derived retinal pigment epithelium patch in age-related macular degeneration Intracranial metastasis in fibrolamellar hepatocellular carcinoma Genetically encoded lipid–polypeptide hybrid biomaterials that exhibit temperature-triggered hierarchical self-assembly EFF-1 fusogen promotes phagosome sealing during cell process clearance in Caenorhabditis elegans Linear assembly of a human centromere on the Y chromosome Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis Apixaban in patients at risk of stroke undergoing atrial fibrillation ablation Capture Hi-C identifies putative target genes at 33 breast cancer risk loci Mid-infrared imaging in breast cancer tissue: an objective measure of grading breast cancer biopsies Antibiotic-induced population fluctuations and stochastic clearance of bacteria Nanofibrous peptide hydrogel elicits angiogenesis and neurogenesis without drugs, proteins, or cells A breathing atom-transfer radical polymerization: fully oxygen-tolerant polymerization inspired by aerobic respiration of cells Solid-phase synthesis of protein-polymers on reversible immobilization supports Learning by neural reassociation Balanced crystalloids versus saline in noncritically ill adults 4-1BB costimulation induces T cell mitochondrial function and biogenesis enabling cancer immunotherapeutic responses Skin electronics from scalable fabrication of an intrinsically stretchable transistor array C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction Terahertz microfluidic chips sensitivity-enhanced with a few arrays of meta-atoms Visualization of ligand-induced transmembrane signaling in the full-length human insulin receptor Sexual dimorphism in the behavioral responses and the immuno-endocrine status in D-galactose induced aging Cognitive functioning after hematopoietic cell transplantation for hematologic malignancy: results from a prospective longitudinal study Association of epidural stimulation with cardiovascular function in an individual with spinal cord injury RIPK1-mediated induction of mitophagy compromises the viability of extracellular-matrix-detached cells Very long-chain tear film lipids produced by fatty acid elongase ELOVL1 prevent dry eye disease in mice Differential roles of the Drosophila EMT-inducing transcription factors Snail and Serpent in driving primary tumor growth Rev-erbα dynamically modulates chromatin looping to control circadian gene transcription A vitamin B12 conjugate of Exendin-4 improves glucose tolerance without associated nausea or hypophagia in rodents Daple coordinates organ-wide and cell-intrinsic polarity to pattern inner-ear hair bundles The polyploid state plays a tumor-suppressive role in the liver Rehealable, fully recyclable, and malleable electronic skin enabled by dynamic covalent thermoset nanocomposite Intra-atrial dyssynchrony during sinus rhythm predicts recurrence after the first catheter ablation for atrial fibrillation Positively selected enhancer elements endow osteosarcoma cells with metastatic competence Small interfering RNAs based on huntingtin trinucleotide repeats are highly toxic to cancer cells Multiplex glycan bead array for high throughput and high content analyses of glycan binding proteins Programming of Schwann cells by Lats1/2-TAZ/YAP signaling drives malignant peripheral nerve sheath tumorigenesis Risk factors in Swedish young men for amyotrophic lateral sclerosis in adulthood Aggressive triple negative breast cancers have unique molecular signature on the basis of mitochondrial genetic and functional defects Ribosome incorporation into somatic cells promotes lineage transdifferentiation towards multipotency Ibrutinib inhibition of ERBB4 reduces cell growth in a WNT5A-dependent manner Cataract in patients with diabetes mellitus—incidence rates in the UK and risk factors Bioresorbable optical fiber Bragg gratings Secretion-mediated STAT3 activation promotes self-renewal of glioma stem-like cells during hypoxia Olig2 and Hes regulatory dynamics during motor neuron differentiation revealed by single cell transcriptomics Differential association of microvascular attributions with cardiovascular disease in patients with long duration of type 1 diabetes In vivo wireless photonic photodynamic therapy Relaxin reverses inflammatory and immune signals in aged hearts Mimicking embedded vasculature structure for 3D cancer on a chip approaches through micromilling De novoexpression of human polypeptideN-acetylgalactosaminyltransferase 6 (GalNAc-T6) in colon adenocarcinoma inhibits the differentiation of colonic epithelium Chromosomal instability during neurogenesis in Huntington's disease Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo Specific expression of PD-L1 in RELA-fusion supratentorial ependymoma: Implications for PD-1-targeted therapy Circadian rest-activity pattern changes in aging and preclinical Alzheimer disease Cryo-EM structures of PRC2 simultaneously engaged with two functionally distinct nucleosomes Structures of human PRC2 with its cofactors AEBP2 and JARID2 Male-specific IL-33 expression regulates sex-dimorphic EAE susceptibility Shared genetic effects on chromatin and gene expression indicate a role for enhancer priming in immune response Targeting flavin-containing enzymes eliminates cancer stem cells (CSCs), by inhibiting mitochondrial respiration: Vitamin B2 (Riboflavin) in cancer therapy Sensitization of hypoxic tumors to radiation therapy using ultrasound sensitive oxygen microbubbles Tumor-specific T-Cells engineered to overcome tumor immune evasion induce clinical responses in patients with relapsed Hodgkin lymphoma Safety and efficacy of immunotherapy with the recombinant B-cell epitope–based grass pollen vaccine BM32 Primary cilium-mediated retinal pigment epithelium maturation is disrupted in ciliopathy patient cells Removal of oral biofilm on an implant fixture by a cavitating jet Modeling the ACMG/AMP variant classification guidelines as a Bayesian classification framework Detection and localization of surgically resectable cancers with a multi-analyte blood test Evidence for convergent evolution of SINE-directed Staufen-mediated mRNA decay Loss of an androgen-inactivating and isoform-specific HSD17B4 splice form enables emergence of castration-resistant prostate cancer Co-activation of GR and PPARγ in murine skin prevents worsening of atopic march Structures of β-klotho reveal a ‘zip code’-like mechanism for endocrine FGF signalling Genomic and proteomic resolution of heterochromatin and its restriction of alternate fate genes Ablation of endothelial VEGFR1 improves metabolic dysfunction by inducing adipose tissue browning Polygenic contribution in individuals with early-onset coronary artery disease Multi-day rhythms modulate seizure risk in epilepsy Beta blocker use correlates with better overall survival in metastatic melanoma patients and improves the efficacy of immunotherapies in mice Reprogramming the activatable peptide display function of adeno-associated virus nanoparticles Hedgehog pathway drives fusion-negative rhabdomyosarcoma initiated from non-myogenic endothelial progenitors Whole blood stabilization for the microfluidic isolation and molecular characterization of circulating tumor cells TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD A TFIID-SAGA perturbation that targets MYB and suppresses acute myeloid leukemia Glial responses to implanted electrodes in the brain Enhancing recovery from sepsis, a review Endogenous reprogramming of alpha cells into beta cells, induced by viral gene therapy, reverses autoimmune diabetes Reversible retinal vessel closure from VEGF-induced leukocyte plugging A tunable microfluidic 3D stenosis model to study leukocyte-endothelial interactions in atherosclerosis Amphiphilic nanocarrier-induced modulation of PLK1 and miR-34a leads to improved therapeutic response in pancreatic cancer Programmed platelet derived growth factor‐bb and bone morphogenetic protein‐2 delivery from a hybrid calcium phosphate/alginate scaffold Modern therapeutic approaches for noninfectious ocular diseases involving inflammation TGF-β receptor I/II trafficking and signaling at primary cilia are inhibited by ceramide to attenuate cell migration and tumor metastasis Food-grade cationic antimicrobial ε-polylysine transiently alters the gut microbial community and predicted metagenome function in CD-1 mice Interferon-beta represses cancer stem cell properties in triple-negative breast cancer EGFR feedback-inhibition by Ran-binding protein 6 is disrupted in cancer Substrate-driven chemotactic assembly in an enzyme cascade The Std1 activator of the Snf1/AMPK kinase controls glucose response in yeast by a regulated protein aggregation Direct electrical stimulation of the amygdala enhances declarative memory in humans The oncolytic virus, MG1, targets and eliminates latently HIV-1-infected cells: implications for an HIV cure ERBB3 and NGFR mark a distinct skeletal muscle progenitor cell in human development and hPSCs Sphingosine and dihydrosphingosine as biomarkers for multiple sclerosis identified by metabolomic profiling using coupled UPLC-MS Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer Efficacy of educational video game versus traditional educational apps at improving physician decision making in trauma triage: randomized controlled trial Effect of high-intensity treadmill exercise on motor symptoms in patients with de novo Parkinson disease: a phase 2 randomized clinical trial Injecting instructions into premotor cortex Simple detection of telomere fusions in pancreatic cancer, intraductal papillary mucinous neoplasm, and pancreatic cyst fluid Immunoproteasome inhibition prevents chronic antibody-mediated allograft rejection in renal transplantation Pharmacological inhibition of REV-ERB stimulates differentiation, inhibits turnover and reduces fibrosis in dystrophic muscle Higher blood urea nitrogen is associated with increased risk of incident diabetes mellitus Efficient protein production by yeast requires global tuning of metabolism Clinical implications of Plasmodium resistance to atovaquone/proguanil: a systematic review and meta-analysis Runx3 programs CD8 T cell residency in non-lymphoid tissues and tumours mTORC2 promotes tumorigenesis via lipid synthesis Do viruses exchange genes across superkingdoms of life? Second-degree burns with six etiologies treated with autologous noncultured cell-spray grafting Nitro-oleic acid (NO2OA) release enhances regional angiogenesis in a rat abdominal wall defect model Heart valve scaffold fabrication: Bioinspired control of macro-scale morphology, mechanics and micro-structure A melanin-mediated cancer immunotherapy patch TDP-43 accelerates age-dependent degeneration of interneurons Hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors Thermostable exoshells fold and stabilize recombinant proteins Nonimmune cells equipped with T-cell-receptorlike signaling for cancer cell ablation Inhibition of TRF1 telomere protein impairs tumor initiation and progression in glioblastoma mouse models and patient-derived xenografts ER-associated degradation regulates Alzheimer’s amyloid pathology and memory function by modulating γ-secretase activity A data-driven modeling approach to identify disease-specific multi-organ networks driving physiological dysregulation Small molecule promotes β-catenin citrullination and inhibits Wnt signaling in cancer Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing Inflammation-induced IgA cells dismantle anti-liver cancer immunity BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer A neoantigen fitness model predicts tumour response to checkpoint blockade immunotherapy Single-cell virology: on-chip investigation of viral infection dynamics Near-infrared remotely triggered drug-release strategies for cancer treatment Regeneration of the entire human epidermis using transgenic stem cells Clinical decision support for in-hospital AKI Understanding tissue-specific gene regulation Fibroblast activation protein augments progression and metastasis of pancreatic ductal adenocarcinoma Common and cell-type specific responses to anti-cancer drugs revealed by high throughput transcript profiling Interleukin33 deficiency causes tau abnormality and neurodegeneration with Alzheimer-like symptoms in aged mice Isoform‐specific localization of DNMT3A regulates DNA methylation fidelity at bivalent CpG islands Virtual reality improves embodiment and neuropathic pain caused by spinal cord injury Long term effect of intensive lifestyle intervention on cerebral blood flow Modulation of inflammation in brain: a matter of fat Synthetic beta cells for fusion-mediated dynamic insulin secretion Safety and efficacy of focused ultrasound thalamotomy for patients with medication-refractory, tremor-dominant Parkinson Disease Aptamer-functionalized neural recording electrodes for the direct measurement of cocaine in vivo Transcription factor ISX mediates the cross talk between diet and immunity PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis Atopic asthmatic immune phenotypes associated with airway microbiota and airway obstruction Synergistic malaria vaccine combinations identified by systematic antigen screening Small GTPase ARF6 controls VEGFR2 trafficking and signaling in diabetic retinopathy Isolation of exosomes from whole blood by integrating acoustics and microfluidics Validation of a metastatic assay using biopsies to improve risk stratification in patients with prostate cancer treated with radical radiation therapy Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets Synthetic hydrogels for human intestinal organoid generation and colonic wound repair Novel nanoparticles with Cr3 substituted ferrite for self-regulating temperature hyperthermia PEBP1 wardens ferroptosis by enabling lipoxygenase generation of lipid death signals Genetic effects on gene expression across human tissues Identification of 76 novel B1 metallo-β-lactamases through large-scale screening of genomic and metagenomic data Sensitivity to BUB1B inhibition defines an alternative classification of glioblastoma CCND2 overexpression enhances the regenerative potency of human induced pluripotent stem cell-derived cardiomyocytes: remuscularization of injured ventricle A novel Fer/FerT targeting compound selectively evokes metabolic stress and necrotic death in malignant cells Bioinspired flexible microfluidic shear force sensor skin Acute myeloid leukaemia disrupts endogenous myelo-erythropoiesis by compromising the adipocyte bone marrow niche Is abdominal hypopressive technique effective in the prevention and treatment of pelvic floor dysfunction? Marketing or evidence from high-quality clinical trials? Molecular analysis of high-grade serous ovarian carcinoma with and without associated serous tubal intra-epithelial carcinoma Determination of the impact of melanoma surgical timing on survival using the National Cancer Database Cbfβ governs osteoblast−adipocyte lineage commitment through enhancing β-catenin signaling and suppressing adipogenesis gene expression Angiopoietin-like 4 induces a β-catenin-mediated upregulation of ID3 in fibroblasts to reduce scar collagen expression A synthetic DNA-binding inhibitor of SOX2 guides human induced pluripotent stem cells to differentiate into mesoderm Induced pluripotent stem cell-derived neural stem cell therapy enhances recovery in an ischemic stroke pig model Tension creates an endoreplication wavefront that leads regeneration of epicardial tissue Effects of autogenous bone marrow aspirate concentrate on radiographic integration of femoral condylar osteochondral allografts Prevention of Alzheimer's Disease: lessons learned and applied Chemical modulation of in vivo macrophage function with subpopulation-specific fluorescent prodrug conjugates Prostaglandin E1 and its analog misoprostol inhibit human CML stem cell self-renewal via EP4 receptor activation and repression of AP-1 A novel neural prediction error found in anterior cingulate cortex ensembles O-Glycosylation modulates the stability of epidermal growth factor-like repeats and thereby regulates Notch trafficking Deletion of interleukin 1 receptor-associated kinase 1 (Irak1) improves glucose tolerance primarily by increasing insulin sensitivity in skeletal muscle Model-based design of RNA hybridization networks implemented in living cells Mechanistic investigation of the specific anticancer property of artemisinin and its combination with aminolevulinic acid for enhanced anticolorectal cancer activity A recombinant human ADAMTS-13: first-in-human study evaluating pharmacokinetics, safety and tolerability in cTTP patients A cargo-sorting DNA robot A predictive model for selective targeting of the Warburg Effect through GAPDH inhibition with a natural product Polymicrobial sepsis impairs bystander recruitment of effector cells to infected skin despite optimal sensing and alarming function of skin resident memory CD8 T cells Locally induced adipose tissue browning by microneedle patch for obesity treatment Neuronal inhibition of the autophagy nucleation complex extends life span in post-reproductive C. elegans Shape-specific nanoceria mitigate oxidative stress-induced calcification in primary human valvular interstitial cell culture In vivo induction of regulatory T cells promotes allergen tolerance and suppresses allergic contact dermatitis Tau exacerbates excitotoxic brain damage in an animal model of stroke Distinct mesenchymal lineages and niches promote epithelial self-renewal and myofibrogenesis in the lung Optical coherence tomography identifies outer retina thinning in frontotemporal degeneration A functional genomics predictive network model identifies regulators of inflammatory bowel disease High resolution 3-Dimensional imaging of the human cardiac conduction system from microanatomy to mathematical modeling The burden and etiology of diarrheal illness in developing countries Taxane-mediated radiosensitization derives from chromosomal missegregation on tripolar mitotic spindles orchestrated by AURKA and TPX2 Human plasma metabolomics study across all stages of age-related macular degeneration identifies potential lipid biomarkers Discovery of a proteolytic flagellin family in diverse bacterial phyla that assembles enzymatically active flagella Glia-specific enhancers and chromatin structure regulate NFIA expression and glioma tumorigenesis A fatal outbreak of ST11 carbapenem-resistant hypervirulent Klebsiella pneumoniae in a Chinese hospital: a molecular epidemiological study β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson’s disease LMO1 synergizes with MYCN to promote neuroblastoma initiation and metastasis Signals from the adipose microenvironment and the obesity–cancer link—a systematic review Pharmacological inhibition of the DNA damage checkpoint prevents radiation-induced oocyte death Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease CNPY2 is a key initiator of the PERK–CHOP pathway of the unfolded protein response Inhibition of autophagy limits vertical transmission of Zika virus in pregnant mice Smac mimetics and oncolytic viruses synergize in driving anticancer T-cell responses through complementary mechanisms The deacetylase HDAC6 mediates endogenous neuritic tau pathology Synthetic quorum sensing in model microcapsule colonies Microbial regulation of microRNA expression in the amygdala and prefrontal cortex Peripherally derived FGF21 promotes remyelination in the central nervous system Interactions between fibroblastic reticular cells and B cells promote mesenteric lymph node lymphangiogenesis Feeding releases endogenous opioids in humans Anti-inflammatory therapy with canakinumab for atherosclerotic disease Stimulation of functional neuronal regeneration from Müller glia in adult mice Microglia turnover with aging and in an Alzheimer´s model via long-term in vivo single-cell imaging Prolonged human neural stem cell maturation supports recovery in injured rodent CNS Proteasome activity regulates CD8 T lymphocyte metabolism and fate specification Secreted protein Del-1 regulates myelopoiesis in the hematopoietic stem cell niche Neuroprotective effects of trigeminal nerve stimulation in severe traumatic brain injury Aurora-B kinase pathway controls the lateral to end-on conversion of kinetochore-microtubule attachments in human cells BACE inhibition-dependent repair of Alzheimer's pathophysiology Mesoscopic adaptive resolution scheme toward understanding of interactions between sickle cell fibers Transcriptomic biomarkers to discriminate bacterial from nonbacterial infection in adults hospitalized with respiratory illness Implications for breast cancer treatment from increased autotaxin production in adipose tissue after radiotherapy Cell segregation and border sharpening by Eph receptor–ephrin-mediated heterotypic repulsion Computational integration of nanoscale physical biomarkers and cognitive assessments for Alzheimer’s disease diagnosis and prognosis The role of retinal carotenoids and age on neuroelectric indices of attentional control among early to middle-aged adults Structural and functional substitution of deleted primary sensory neurons by new growth from intrinsic spinal cord nerve cells: an alternative concept in reconstruction of spinal cord circuits Necroptosis activation in Alzheimer's disease Functional annotation of chemical libraries across diverse biological processes Inverted battery design as ion generator for interfacing with biosystems Genome editing abrogates angiogenesis in vivo Wnt signaling controls pro-regenerative Collagen XII in functional spinal cord regeneration in zebrafish Triggerable tough hydrogels for gastric resident dosage forms Synthetic quorum sensing in model microcapsule colonies Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease Comparison of algorithms for the detection of cancer drivers at subgene resolution Deformation correction for image-guided liver surgery: An intraoperative assessment of fidelity Dll4 and Notch signalling couples sprouting angiogenesis and artery formation Transancestral mapping and genetic load in systemic lupus erythematosus Prosthetic valve endocarditis after surgical aortic valve replacement Dynamic responses of the adrenal steroidogenic regulatory network Infant gut microbiome associated with cognitive development Halogenation of glycopeptide antibiotics occurs at the amino acid level during non-ribosomal peptide synthesis Nonnutritive sweeteners and cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials and prospective cohort studies Acute hemodynamic effects of inhaled sodium nitrite in pulmonary hypertension associated with heart failure with preserved ejection fraction RNA stores tau reversibly in complex coacervates Comparison of the VA and NIDILRR TBI model system cohorts Succinate and its G-protein-coupled receptor stimulates osteoclastogenesis Pretreatment fasting plasma glucose and insulin modify dietary weight loss success: results from 3 randomized clinical trials Tumor-targeted and clearable human protein-based MRI nanoprobes Rv3723/LucA coordinates fatty acid and cholesterol uptake in Mycobacterium tuberculosis Recruitment of Epac2A to insulin granule docking sites regulates priming for exocytosis Surface chemistry for cytosolic gene delivery and photothermal transgene expression by gold nanorods Cellular prion protein (PrPC) in the development of Merlindeficient tumors High-speed and scalable whole-brain imaging in rodents and primates Nanonet force microscopy for measuring forces in single smooth muscle cells of the human aorta Comorbid conditions delay diagnosis of colorectal cancer: a cohort study using electronic primary care records Lutein exerts anti-inflammatory effects in patients with coronary artery disease Whole-body profiling of cancer metastasis with single-cell resolution Microglial inflammatory signaling orchestrates the hypothalamic immune response to dietary excess and mediates obesity susceptibility Inhibition of IKKɛ and TBK1 improves glucose control in a subset of patients with type 2 diabetes Spatiotemporal regulation of autophagy during Caenorhabditis elegans aging Cell-cycle dynamics of chromosomal organization at single-cell resolution Risk of hospitalization with neurodegenerative disease after moderate-to-severe traumatic brain injury in the working-age population: A retrospective cohort study using the Finnish national health registries An immunogenic personal neoantigen vaccine for patients with melanoma Direct imaging of protein stability and folding kinetics in hydrogels Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma Sculpting neurotransmission during synaptic development by 2D nanostructured interfaces A pan-cancer genome-wide analysis reveals tumour dependencies by induction of nonsense-mediated decay Selective optogenetic control of purkinje cells in monkey cerebellum Hydrocortisone, vitamin C, and thiamine for the treatment of severe sepsis and septic shock A calcium- and light-gated switch to induce gene expression in activated neurons Landscape of innovation for cardiovascular pharmaceuticals: from basic science to new molecular entities Adaptive capacity: an evolutionary neuroscience model linking exercise, cognition, and brain health Rat intersubjective decisions are encoded by frequency-specific oscillatory contexts Zolpidem for the treatment of neurologic disorders: a systematic review Donor SIRPα polymorphism modulates the innate immune response to allogeneic grafts Multiscale model predicts increasing focal adhesion size with decreasing stiffness in fibrous matrices Left ventricular dysfunction switches mesenchymal stromal cells toward an inflammatory phenotype and impairs their reparative properties via toll-like receptor-4 clinical perspective Ratchet-like polypeptide translocation mechanism of the AAA disaggregase Hsp104 Microbial genetic composition tunes host longevity Antibacterial nucleoside-analog inhibitor of bacterial RNA polymerase A novel genetic technique in Plasmodium berghei allows liver stage analysis of genes required for mosquito stage development and demonstrates that de novo heme synthesis is essential for liver stage development in the malaria parasite Three mutations switch H7N9 influenza to human-type receptor specificity Hypothalamic regulation of distinct adult neural stem cells and neurogenesis Tropism, intracerebral distribution, and transduction efficiency of HIV- and SIV-based lentiviral vectors after injection into the mouse brain: a qualitative and quantitative in vivo study Sequential self-assembly of DNA functionalized droplets Atopic dermatitis and risk of hypertension, type-2 diabetes, myocardial infarction and stroke in a cross-sectional analysis from the Canadian Partnership for Tomorrow Project Pulsed cavitational ultrasound softening Potent inhibitor of drug-resistant HIV-1 strains identified from the medicinal plant Justicia gendarussa A genetic polymorphism repurposes the G-protein coupled and membrane-associated estrogen receptor GPER to a transcription factor-like molecule promoting paracrine signaling between stroma and breast carcinoma cells In situ bone tissue engineering via ultrasound-mediated gene delivery to endogenous progenitor cells in mini-pigs Drag reducing polymers decrease hepatic injury and metastases after liver ischemia-reperfusion Split-BioID a conditional proteomics approach to monitor the composition of spatiotemporally defined protein complexes HDAC1,2 inhibition and doxorubicin impair Mre11-dependent DNA repair and DISC to override BCR-ABL1-driven DSB repair in Philadelphia chromosome-positive B-cell precursor acute lymphoblastic leukemia A novel strategy to engineer pre-vascularized full-length dental pulp-like tissue constructs Polarity of varicosity initiation in central neuron mechanosensation Significant locus and metabolic genetic correlations revealed in genome-wide association study of anorexia nervosa Pyrimethamine significantly lowers cerebrospinal fluid Cu/Zn superoxide dismutase in amyotrophic lateral sclerosis patients with SOD1 mutations Association of amine biomarkers with incident dementia and Alzheimer's disease in the Framingham Study A scalable platform to identify fungal secondary metabolites and their gene clusters Dynamic subunit turnover in ESCRT-III assemblies is regulated by Vps4 to mediate membrane remodelling during cytokinesis ACK1/TNK2 regulates histone H4 Tyr88-phosphorylation and AR gene expression in castration-resistant prostate cancer A systems biology approach identifies FUT8 as a driver of melanoma metastasis Impact of vitamin A and carotenoids on the risk of tuberculosis progression Obesity accelerates Alzheimer-related pathology in APOE4 but not APOE3 mice Tactile defensiveness and impaired adaptation of neuronal activity in the Fmr1 knockout mouse model of autism Vitamin C and Doxycycline: A synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs) Use of prescribed opioids before and after bariatric surgery: prospective evidence from a U.S. multicenter cohort study Adult murine cardiomyocytes exhibit regenerative activity with cell cycle reentry through STAT3 in the healing process of myocarditis Perirhinal firing patterns are sustained across large spatial segments of the task environment Engineered bacteria can function in the mammalian gut long-term as live diagnostics of inflammation JunB is essential for IL-23-dependent pathogenicity of Th17 cells Childhood predictors of cardiovascular disease in adulthood. A systematic review and meta-analysis Aberrant activation of the GIMAP enhancer by oncogenic transcription factors in T-cell acute lymphoblastic leukemia Protein-free formation of bone-like apatite: New insights into the key role of carbonation GLUT 1 receptor expression and circulating levels of fasting glucose in high grade serous ovarian cancer Specification and diversification of pericytes and smooth muscle cells from mesenchymoangioblasts Contralesional brain–computer interface control of a powered exoskeleton for motor recovery in chronic stroke survivors Use of a pedicled omental flap to reduce inflammation and vascularize an abdominal wall patch Endothelial TLR4 and the microbiome drive cerebral cavernous malformations Mutant KRAS promotes malignant pleural effusion formation Light-inducible antimiR-92a as a therapeutic strategy to promote skin repair in healing-impaired diabetic mice SGPL1 (sphingosine phosphate lyase 1) modulates neuronal autophagy via phosphatidylethanolamine production Dynamically and epigenetically coordinated GATA/ETS/SOX transcription factor expression is indispensable for endothelial cell differentiation TIAM1 variants improve clinical outcome in neuroblastoma Quantitative erythrocyte omega-3 EPA plus DHA levels are related to higher regional cerebral blood flow on brain SPECT Targeting latency-associated peptide promotes antitumor immunity Neonatal expression of RNA-binding protein IGF2BP3 regulates the human fetal-adult megakaryocyte transition Maintenance of persistent activity in a frontal thalamocortical loop The complex genetics of hypoplastic left heart syndrome Compositional changes in the gut mucus microbiota precede the onset of colitis-induced inflammation The host ubiquitin-dependent segregase VCP/p97 is required for the onset of human cytomegalovirus replication Outcomes of patients with double-hit lymphoma who achieve first complete remission A novel ALS-associated variant in UBQLN4 regulates motor axon morphogenesis Evaluating the safety of β-interferons in MS Humoral immune reconstitution kinetics following allogeneic hematopoietic stem cell transplantation in children: a maturation block of IgM memory B cells may lead to impaired antibody immune reconstitution Gut microbiome function predicts response to anti-integrin biologic therapy in inflammatory bowel diseases Topical delivery of anti-VEGF drugs to the ocular posterior segment using cell-penetrating peptides The single-parameter, structure-based IsoPSA assay demonstrates improved diagnostic accuracy for detection of any prostate cancer and high-grade prostate cancer compared to a concentration-based assay of total prostate-specific antigen Photosensitization priming of tumor microenvironments improves delivery of nanotherapeutics via neutrophil infiltration Identification of targetable ALK rearrangements in pancreatic ductal adenocarcinoma Impact of genomic profiling on the treatment and outcomes of patients with advanced gastrointestinal malignancies Platelets subvert T cell immunity against cancer via GARP-TGFβ axis Meeting report for NIH 2016 progenitor cell biology consortium cardiovascular tissue engineering 2016 Signalome-wide assessment of host cell response to hepatitis C virus Role of Akt-independent mTORC1 and GSK3β signaling in sublethal NMDA-induced injury and the recovery of neuronal electrophysiology and survival High-throughput, low-loss, low-cost, and label-free cell separation using electrophysiology-activated cell enrichment Identification of cardiac hemo-vascular precursors and their requirement of sphingosine-1-phosphate receptor 1 for heart development County-level cumulative environmental quality associated with cancer incidence CHD4 has oncogenic functions in initiating and maintaining epigenetic suppression of multiple tumor suppressor genes Red blood cells for glucose-responsive insulin delivery Cell-specific pallidal intervention induces long-lasting motor recovery in dopamine-depleted mice Population-based stroke and dementia incidence trends: age and sex variations Interaction of 12/15 lipoxygenase with fatty acids alters the leukocyte kinetics leading to improved post-myocardial infarction healing Birinapant sensitizes platinum-resistant carcinomas with high levels of cIAP to carboplatin therapy Brd4 modulates the innate immune response through Mnk2–eIF4E pathway-dependent translational control of IκBα The future of asthma research and development: a roadmap from the European Asthma Research and Innovation Partnership (EARIP) Decreased microRNA levels lead to deleterious increases in neuronal M2 muscarinic receptors in Spinal Muscular Atrophy models MicroRNA-210 enhances fibrous cap stability in advanced atherosclerotic lesions novelty and significance Evidence of strain structure in Plasmodium falciparum var gene repertoires in children from Gabon, West Africa Bicaudal C mutation causes myc and TOR pathway up-regulation and polycystic kidney disease-like phenotypes in Drosophila Trial of transplantation of HCV-infected kidneys into uninfected recipients MAN2A1–FER fusion gene is expressed by human liver and other tumor types and has oncogenic activity in mice Targeting genomic rearrangements in tumor cells through Cas9-mediated insertion of a suicide gene Data-driven modeling for precision medicine in pediatric acute liver failure Gene and mutation independent therapy via CRISPR-Cas9 mediated cellular reprogramming in rod photoreceptors The transcription factor MAFK induces EMT and malignant progression of triple-negative breast cancer cells through its target GPNMB Phylogenetic analysis of metastatic progression in breast cancer using somatic mutations and copy number aberrations Lyme disease ecology in a changing world: consensus, uncertainty and critical gaps for improving control Differentiation of V2a interneurons from human pluripotent stem cells Biopolymers codelivering engineered T cells and STING agonists can eliminate heterogeneous tumors Raft-based sphingomyelin interactions revealed by new fluorescent sphingomyelin analogs Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells iPSC-derived human microglia-like cells to study neurological diseases Ultrafast laser-probing spectroscopy for studying molecular structure of protein aggregates Tumor-penetrating peptide enhances transcytosis of silicasome-based chemotherapy for pancreatic cancer Access granted: iRGD helps silicasome-encased drugs breach the tumor barrier PD-L1 interacts with CD80 to regulate graft-versus-leukemia activity of donor CD8 T cells Detection of interferon alpha protein reveals differential levels and cellular sources in disease IL-36γ signaling controls the induced regulatory T cell–Th9 cell balance via NFκB activation and STAT transcription factors mTORC1 controls the adaptive transition of quiescent stem cells from G0 to G(Alert) HGFA is an injury-regulated systemic factor that induces the transition of stem cells into GAlert Dynamic range adaptation in primary motor cortical populations In vivo evasion of MxA by avian influenza viruses requires human signature in the viral nucleoprotein Pdgf signalling guides neural crest contribution to the haematopoietic stem cell specification niche Structure of the mycobacterial ESX-5 type VII secretion system membrane complex by single-particle analysis Dectin 1 activation on macrophages by galectin 9 promotes pancreatic carcinoma and peritumoral immune tolerance Biophysical and functional characterization of hippocalcin mutants responsible for human dystonia Report on the National Eye Institute audacious goals initiative: replacement of retinal ganglion cells from endogenous cell sources Increasing efficiency of preclinical research by group sequential designs Technology versus biology: the limits of pre‐implantation genetic screening Early-life antibiotic treatment enhances the pathogenicity of CD4 T cells during intestinal inflammation Melanoma cells undergo aggressive coalescence in a 3D Matrigel model that is repressed by anti-CD44 Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming Flexible and stretchable nanowire-coated fibers for optoelectronic probing of spinal cord circuits The burden of neurological disease in the United States: a summary report and call to action ANGPTL3 deficiency and protection against coronary artery disease CRISPR–Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome Nanomolar concentration of blood-soluble drag-reducing polymer inhibits experimental metastasis of human breast cancer cells In vitro and in vivo evaluation of a novel integrated wearable artificial lung Reducing expression of synapse-restricting protein Ephexin5 ameliorates Alzheimer’s-like impairment in mice Confined space facilitates G-quadruplex formation Myosin-1E interacts with FAK proline-rich region 1 to induce fibronectin-type matrix Reduced DNA methylation and psychopathology following endogenous hypercortisolism – a genome-wide study Hybrid inorganic-organic capsules for efficient intracellular delivery of novel siRNAs against influenza A (H1N1) virus infection Rehabilitation for people living with dementia: A practical framework of positive support Microscopic characterization of the Brazilian giant samba virus Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of reactive oxygen species and AMP-activated protein kinase in muscle Therapy of primary and metastatic liver cancer by human iPS cell-derived myeloid cells producing interferon-β Proteogenomic integration reveals therapeutic targets in breast cancer xenografts Inflammation boosts bacteriophage transfer between Salmonella spp. Classification and adaptive behavior prediction of children with autism spectrum disorder based upon multivariate data analysis of markers of 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of the anti-ageing hormone Klotho in patients with type 1 diabetes and microalbuminuria Perinatal nicotine exposure impairs the maturation of glutamatergic inputs in the auditory brainstem Granulocyte colony-stimulating factor (G-CSF) promotes spermatogenic regeneration from surviving spermatogonia after high-dose alkylating chemotherapy Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2 Synchrotron x-ray fluorescence nanoprobe reveals target sites for organo-osmium complex in human ovarian cancer cells Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington’s disease Arsenic promotes NF-Κb-mediated fibroblast dysfunction and matrix remodeling to impair muscle stem cell function A rapid screening method to evaluate the impact of nanoparticles on macrophages Structure and function of the mycobacterial transcription initiation complex with the essential regulator RbpA Blockade to pathological 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to treatment: a prospective cohort study Health-care-associated infections in neonates, children, and adolescents: an analysis of paediatric data from the European Centre for Disease Prevention and Control point-prevalence survey Deficiency of microRNA miR-34a expands cell fate potential in pluripotent stem cells Prevention of dietary-fat-fueled ketogenesis attenuates BRAF V600E tumor growth The ubiquitin ligase Smurf1 functions in selective autophagy of mycobacterium tuberculosis and anti-tuberculous host defense Flavivirus infection uncouples translation suppression from cellular stress responses A comparison of surrogate endpoints for all cause mortality in men with localized unfavorable-risk prostate cancer Therapeutic targeting of MLL degradation pathways in MLL-rearranged leukemia Evidence for opposing roles of Celsr3 and Vangl2 in glutamatergic synapse formation Insights into the mechanistic basis of plasmid-mediated colistin resistance from crystal structures of the catalytic 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