A novel finding by teams from the National Cancer Institute, The University of Texas (UT) Health Science Center at San Antonio, and the University of Toronto, offers a clue as to how genes can have what you might call multiple personalities.
Genes are long strings of DNA letters, but they can be cut and spliced to make different proteins, something like the word "Saskatchewan" can have its middle cut out to leave the word "Swan," its front, middle and end deleted to leave the word "skate," or its front and back chopped off to make the word "chew."
The discovery reveals that the protein MRG15, which previously had been known to affect cell growth and aging, also directs the gene-splicing machinery. Olivia Pereira-Smith, Ph.D. (pictured), a professor in the Department of Cellular and Structural Biology and the Sam and Ann Barshop Institute for Longevity and Aging Studies at the UT Health Science Center San Antonio, has studied the function of MRG15 for more than 10 years.
As people or animals age, this gene-splicing machinery can go awry, producing nonsense proteins ("Sskt" instead of "Swan," for instance) rather than the proper ones. These aberrant proteins can damage cells, possibly leading to cancer or other diseases of aging. Today's finding thus has potential implications for therapies to treat both cancer and aging, a Texas researcher said.
Illustration: University of Texas Health Science Center at San Antonio.
University of Texas Health Science Center at San Antonio News Release (02/04/10)
Science Daily (02/05/10)
Abstract (Science; Vol. 327, No. 5968, 996-1000 (02/19/10))