Human embryonic stem cells could help people with learning and memory deficits after radiation treatment for brain tumors, suggests a new University of California Irvine (UCI) study.
Research with rats found that transplanted stem cells restored learning and memory to normal levels 4 months after radiotherapy. In contrast, irradiated rats that didn't receive stem cells experienced a more than 50 percent drop in cognitive function.
"Our findings provide the first evidence that such cells can be used to ameliorate radiation-induced damage of healthy tissue in the brain," said Charles Limoli (pictured), UCI radiation oncology associate professor and senior author of the study.
Radiotherapy for brain tumors is limited by how well the surrounding tissue tolerates the treatment. In receiving radiation at levels needed to treat tumors, patients suffer varying degrees of learning and memory impairment that can affect their quality of life.
"It's a progressive, debilitating side effect of cranial irradiation," Limoli said. "Any treatments showing promise at reversing this are worthy of pursuit."
In the UCI study, stem cells were transplanted into the heads of rats that had undergone radiation treatment. They migrated to a brain region known to support the growth of neurons, scientists observed, and developed into new brain cells.
Work is under way to determine how the transplanted stem cells improved cognition: Did they integrate into healthy tissue or did they help repair and support existing brain cells?
Said Limoli, "With further research, stem cells may one day be used to manage a variety of adverse conditions associated with radiotherapy."
Illustration: University of California, Irvine/Steve Zylius, University Communications.
University of California, Irvine News Release (11/09/09)
Science Daily (11/10/09)
Proceedings of the National Academy of Sciences of the United States of America; Vol. 106, No. 45, 19150-19155 (11/10/09))