Authors:
Daniel C Kirouac, Gerard J Madlambayan, Mei Yu, Edward A Sykes, Caryn Ito, & Peter W Zandstra
Summary:
- We present a novel mathematical model of blood stem cell development incorporating cell level kinetic parameters as functions of inter-cellular communication networks.
- Negative feedback signalling between differentiated cells and stem and progenitor populations is a dominant factor regulating cell population outputs during in vitro culture of human blood stem cells, producing an antagonistic relationship between mature and primitive cell compartments.
- Stem cell fate can be controlled non-autonomously by the dynamic perturbation of cell-cell signalling networks.
- Dysregulated responsiveness to inter-cellular signals is both necessary and sufficient to induce leukemic transformation in silico.
Source:
Molecular Systems Biology; 5, 293 (07/28/09)