University of Adelaide researchers have uncovered a new pathway which regulates the spread of prostate cancer around the body.
The discovery has potential to lead to the development of a blood test that could predict whether cancer will spread from the prostate tumor to other parts of the body. The research also reveals potential new targets for drugs that may inhibit the spread of cancer.
"Prostate cancers only kill men after they have spread or 'metastasized' from the prostate," says project leader Dr. Luke Selth, Senior Research Fellow at the University of Adelaide's Dame Roma Mitchell Cancer Research Laboratories and a member of the Freemasons Foundation Centre for Men's Health.
"The identification of markers that accurately predict, at an early stage, prostate tumors that are likely to metastasize could guide the urgency and aggressiveness of treatment -- and this could save lives."
The international research team -- led by the University of Adelaide and including members from the University of Michigan, Vancouver Prostate Centre, the Mayo Clinic, and Johns Hopkins University -- showed that a specific microRNA (a type of molecule involved in regulating the level and activity of genes) called miR-194 promotes cancer metastasis by inhibiting a key protein called SOCS2. SOCS2 can suppress the spread of cancer cells.
"In previous work, we had found that a high level of miR-194 in a patient's blood was associated with rapid relapse of prostate cancer following surgical removal of the tumor," says Dr. Selth. "This new work explains why miR-194 is associated with a poor outcome, and in the process reveals a completely novel pathway regulating prostate cancer metastasis.
"Importantly, measuring miR-194 in a patient's blood at the time of diagnosis could become a test for the likelihood of metastasis. Patients with high levels of miR-194 in their blood could receive more aggressive treatment to reduce the chance of the cancer spreading to other parts of the body." Dr. Selth's team is currently testing this idea using larger patient groups to validate their findings.
Dr. Selth says miR-194 also represents a potential therapeutic target. "There are currently no drugs that effectively inhibit the spread of prostate cancer," he says. "We propose that inhibiting miR-194 could reduce rates of metastasis in patients with aggressive disease, but the development of a drug to achieve this goal is still a long way off."
Illustration: MiR-194 decreases SOCS2 mRNA expression in prostate cancer cells compared to a negative control (NC). Data is normalized to the GAPDH reference gene. P value was determined using an unpaired two-sided t test (*, P < 0.05). Error bars are SEM. Cancer Research.
University of Adelaide News Release (01/25/17)
Science Daily (01/25/17)
Abstract (Cancer Research; 2016, canres.2529.2016.)