Through a detailed study of leukemia cells from more than 200 children, a research group at Lund University in Sweden has discovered two new types of childhood leukemia. Using next-generation sequencing technology (NGS), the researchers were able to study the genome of cancer cells, which is how they discovered the new types of cancer.
Acute lymphoblastic leukemia is a rare disease, but the most common form of cancer in children. Today the treatment is very successful, but requires heavy interventions at the risk of causing many side effects. There is therefore a need to distinguish between different types of acute lymphoblastic leukemia, in order to adapt the treatment according to the severity of each case, and to detect possible relapse.
"Like all types of cancer, childhood leukemia is caused by genetic mutations in normal cells, which are then transformed into cancer cells. Finding the critical mutations in the diseased cells is an important condition for understanding the mechanisms of the disease and ultimately discovering new therapies," explains Thoas Fioretos, professor and senior consultant at the Division of Clinical Genetics, and principal investigator of the project
Through the relatively new next-generation sequencing method, the researchers were able to examine the changes that occur in cancer cells in greater detail, which is how they discovered the two new types of childhood leukemia.
"One type occurs when a gene called DUX4, which is normally inactive in blood cells, becomes activated when the gene is relocated in the genome. The second type resembles a previously known type of childhood leukemia, but is caused by other genetic mutations," says Henrik Lilljebjörn, researcher and project manager of the study.
Previous studies of childhood acute lymphoblastic leukemia have shown that there are six major groups of acute lymphoblastic leukemia in children. The discovered two new types, together representing about 10 per cent of all childhood leukemia, can now be added to these groups.
"Over the last few years, our research group has worked extremely intensely on this study, which would not have been possible without collaboration with several other researchers at Lund University, Skåne University Hospital, and research groups in Germany," concludes Thoas Fioretos.
The hope is that the findings will lead to improved diagnosis and monitoring of childhood leukemia, and ultimately new forms of treatment.
The two new types of leukemia are called "DUX4-rearranged" and "ETV6/RUNX1-like."
Illustration: This is a picture of DNA and RNA molecules. Credit: MostPhotos.
Science Daily (06/07/16)
Abstract (Nature Communications; 2016, 7: 11790.)