People with diabetes mellitus often suffer from impaired wound healing. Now, scientists in Egypt have developed antibacterial nanofibers of cellulose acetate loaded with silver that could be used in a new type of dressing to promote tissue repair.
Thanaa Ibrahim Shalaby and colleagues, Nivan Mahmoud Fekry, Amal Sobhy El Sodfy, Amel Gaber El Sheredy, and Maisa El Sayed Sayed Ahmed Moustafa, at Alexandria University, prepared nanofibers from cellulose acetate, an inexpensive and easily fabricated, semisynthetic polymer used in everything from photographic film to coatings for eyeglasses and even cigarette filters. It can be spun into fibers and thus used to make an absorbent and safe wound dressing. Shalaby and co-workers used various analytical techniques including scanning electron microscope (SEM) and Fourier-transform infrared (FTIR) spectroscopy to characterize their fibers in which they incorporated silver nanoparticles.
Having characterized the material the team then successfully tested its antibacterial activity against various strains of bacteria that might infect an open wound. They next used the material as a dressing on skin wounds on mice with diabetes and determined how quickly the wound healed with and without the nano dressing. The dressing absorbs fluids exuded by the wound, but also protects the wound from infectious agents while being permeable to air and moisture, the team reports. The use of this dressing also promotes collagen production as the wound heals, which helps to recreate normal skin strength and texture, something that is lacking in unassisted wound healing in diabetes mellitus.
Illustration: Microsoft clipart.
Science Daily (08/10/15)
Abstract (International Journal of Nanoparticles; Vol. 8, No. 1 (2015))