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A pilot study of consolidative immunotherapy in patients with high-risk pediatric sarcomas

Authors: Crystal L. Mackall, Eunice H. Rhee, Elizabeth J. Read, Hanh M. Khuu, Susan F. Leitman, Donna Bernstein, Merertu Tesso, Lauren M. Long, David Grindler, Margret Merino, William Kopp, Maria Tsokos, Jay A. Berzofsky, and Lee J. Helman

Summary:

Purpose - Patients with metastatic or recurrent Ewing’s sarcoma family of tumors and alveolar rhabdomyosarcoma have <25% 5-year survival in most studies. This study administered a novel immunotherapy regimen aimed at consolidating remission in these patients.

Experimental Design - Fifty-two patients with translocation positive, recurrent, or metastatic Ewing’s sarcoma family of tumors or alveolar rhabdomyosarcoma underwent prechemotherapy cell harvest via apheresis for potential receipt of immunotherapy. Following completion of standard multimodal therapy, 30 patients ultimately initiated immunotherapy and were sequentially assigned to three cohorts. All cohorts received autologous T cells, influenza vaccinations, and dendritic cells pulsed with peptides derived from tumor-specific translocation breakpoints and E7, a peptide known to bind HLA-A2. Cohort 1 received moderate-dose recombinant human interleukin-2 (rhIL-2), cohort 2 received low-dose rhIL-2, and cohort 3 did not receive rhIL-2.

Results - All immunotherapy recipients generated influenza-specific immune responses, whereas immune responses to the translocation breakpoint peptides occurred in 39%, and only 25% of HLA-A2+ patients developed E7-specific responses. Toxicity was minimal. Intention-to-treat analysis revealed a 31% 5-year overall survival for all patients apheresed (median potential follow-up 7.3 years) with a 43% 5-year overall survival for patients initiating immunotherapy.

Conclusions - Consolidative immunotherapy is a scientifically based and clinically practical approach for integrating immunotherapy into a multimodal regimen for chemoresponsive cancer. Patients receiving immunotherapy experienced minimal toxicity and favorable survival. The robust influenza immune responses observed suggest that postchemotherapy immune incompetence will not fundamentally limit this approach. Future studies will seek to increase efficacy by using more immunogenic antigens and more potent dendritic cells.

Source: Clinical Cancer Research; 14, 4850-4858 (08/01/08)

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Part 1: relevance for autism Activation of multiple signaling pathways during the differentiation of mesenchymal stem cells cultured in a silicon nanowire microenvironment Imaging dynamic molecular signaling by the Cdc42 GTPase within the developing CNS Mechanism suppressing glycogen synthesis in neurons and its demise in progressive myoclonus epilepsy Glycogen accumulation underlies neurodegeneration and autophagy impairment in Lafora disease Neurons have an active glycogen metabolism that contributes to tolerance to hypoxia Transgenerational transmission of hyperactivity in a mouse model of ADHD Promoter-bound trinucleotide repeat mRNA drives epigenetic silencing in Fragile X Syndrome MicroRNAs located in the hox gene clusters are implicated in Huntington's disease pathogenesis Hypercaloric enteral nutrition in patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled phase 2 trial Hsp90-tau complex reveals molecular basis for specificity in 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injury HIV-1 persistence in CD4+ T cells with stem cell–like properties Clot contraction: compression of erythrocytes into tightly packed polyhedra and redistribution of platelets and fibrin Transcriptome in vivo analysis (TIVA) of spatially defined single cells in live tissue Characterization and molecular profiling of PSEN1 familial Alzheimer's disease iPSC-derived neural progenitors Generation of iPSC lines from archived non-cryoprotected biobanked dura mater Long-term stability and safety of transgenic cultured epidermal stem cells in gene therapy of junctional epidermolysis bullosa Identification of novel human leukocyte antigen-A*0201-restricted, cytotoxic T lymphocyte epitopes on CD133 for cancer stem cell immunotherapy Retinal detachment after open globe injury Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial Cellular resolution maps of X chromosome inactivation: implications for neural development, function, and disease Patients’ attitudes toward the donation of biological materials for the derivation of induced pluripotent stem cells Engineering cells with intracellular agent–loaded microparticles to control cell phenotype Synergy between multiple microtubule-generating pathways confers robustness to centrosome-driven mitotic spindle formation Accurate prediction of drug-induced liver injury using stem cell-derived populations Collaborative care outcomes for pediatric behavioral health problems: a cluster randomized trial Early intervention to preempt major depression among older black and white adults Testing Turing’s theory of morphogenesis in chemical cells Novel processing of iron-manganese alloy-based biomaterials by inkjet 3-D printing Human placental trophoblasts confer viral resistance to recipient cells A randomized trial of protocol-based care for early septic shock Human muscle-derived stem/progenitor cells promote functional murine peripheral nerve regeneration Validation of cell-cycle arrest biomarkers for acute kidney injury using clinical adjudication Sialylneolacto-N-tetraose c (LSTc)-bearing liposomal decoys capture influenza A virus Autophagy variation within a cell population determines cell fate through selective degradation of Fap-1 Combinatorial effects of multiple enhancer variants in linkage disequilibrium dictate levels of gene expression to confer susceptibility to common traits Optogenetic stimulation of VTA dopamine neurons reveals that tonic but not phasic patterns of dopamine transmission reduce ethanol self-administration Human RPE stem cells grown into polarized RPE monolayers on a polyester matrix are maintained after grafting into rabbit subretinal space Autologous mesenchymal stromal cell infusion as adjunct treatment in patients with multidrug and extensively drug-resistant tuberculosis: an open-label phase 1 safety trial Feasibility of repairing glomerular basement membrane defects in Alport Syndrome Stem cell quiescence acts as a tumour suppressor in squamous tumours Glycolytic ATP fuels the plasma membrane calcium pump critical for pancreatic cancer cell survival Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging Human natural killer cells prevent infectious mononucleosis features by targeting lytic Epstein-Barr virus infection Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library Transcriptional targeting of primary and metastatic tumor neovasculature by an adenoviral type 5 roundabout4 vector in mice Smad1 and 5 but not Smad8 establish stem cell quiescence which is critical to transform the premature hair follicle during morphogenesis toward the postnatal state Competitive balance of intrabulge BMP/Wnt signaling reveals a robust gene network ruling stem cell homeostasis and cyclic activation Wnt7b is an important intrinsic regulator of hair follicle stem cell homeostasis and hair follicle cycling Adult rat retinal ganglion cells and glia can be printed by piezoelectric inkjet printing A UV-induced genetic network links the RSC complex to nucleotide excision repair and shows dose-dependent rewiring Mesothelin-specific chimeric antigen receptor mRNA-engineered T cells induce antitumor activity in solid malignancies Handheld ultrahigh speed swept source optical coherence tomography instrument using a MEMS scanning mirror Epithelial-to-mesenchymal transition enhances the cardioprotective capacity of human amniotic epithelial cells Targeting β-secretase with RNAi in neural stem cells for Alzheimer's disease therapy Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers Copper-transporting P-type ATPases use a unique ion-release pathway Genome-wide transcriptional analysis of differentially expressed genes in diabetic, healing corneal epithelial cells: hyperglycemia-suppressed TGFβ3 expression contributes to the delay of epithelial wound healing in diabetic corneas Human developmental chondrogenesis as a basis for engineering chondrocytes from pluripotent stem cells Silencing of RB1 and RB2/P130 during adipogenesis of bone marrow stromal cells results in dysregulated differentiation Giant Vesicle Arrays: A Simple and Versatile Method for the Formation of Arrays of Giant Vesicles with Controlled Size and Composition Sterilization of granulomas is common in active and latent tuberculosis despite within-host variability in bacterial killing Long-term efficient gene delivery using polyethylenimine with modified Tat peptide Prevention of inflammation-mediated bone loss in murine and canine periodontal disease via recruitment of regulatory lymphocytes Abortive HIV infection mediates CD4 T cell depletion and inflammation in human lymphoid tissue IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection Epithelial bridges maintain tissue integrity during collective cell migration In vivo reprogramming of adult somatic cells to pluripotency by overexpression of Yamanaka factors Co-culture with mesenchymal stem cells results in improved viability and function of human hepatocytes Distinct fibroblast lineages determine dermal architecture in skin development and repair Adding spatial control to click chemistry: phototriggered diels–alder surface (bio)functionalization at ambient temperature (Bio)molecular surface patterning by phototriggered oxime ligation Spatially controlled surface immobilization of nonmodified peptides Spatially controlled surface immobilization of nucleophiles via trapping of photo-generated thioaldehydes Three-dimensional microscaffolds exhibiting spatially resolved surface chemistry Controlled cell adhesion on poly(dopamine) interfaces photopatterned with non-fouling brushes Cell-cycle control of developmentally regulated transcription factors accounts for heterogeneity in human pluripotent cells Salmonella Typhimurium impedes innate immunity with a mast-cell-suppressing protein tyrosine phosphatase, SptP Pre- and postnatal transplantation of fetal mesenchymal stem cells in osteogenesis imperfecta: a two-center experience Sustained complete responses in patients with lymphoma receiving autologous cytotoxic T lymphocytes targeting Epstein-Barr Virus latent membrane proteins Stem cell transplantation in traumatic spinal cord injury: a systematic review and meta-analysis of animal studies Targeted therapy resistance mediated by dynamic regulation of extrachromosomal mutant EGFR DNA It’s time to bring dendritic cell therapy to type 1 diabetes Fluphenazine reduces proteotoxicity in C. elegans and mammalian models of Alpha-1-antitrypsin deficiency Electrically controlled drug delivery from graphene oxide nanocomposite films Decellularized allogeneic and xenogeneic tissue as a bioscaffold for regenerative medicine: factors that influence the host response Frequent mutation of receptor protein tyrosine phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer Biologically derived melanin electrodes in aqueous sodium-ion energy storage devices Reaction-based fluorescent sensor for investigating mobile Zn2+ in mitochondria of healthy versus cancerous prostate cells Marker-free phenotyping of tumor cells by fractal analysis of reflection interference contrast microscopy images Quantifying cell-generated mechanical forces within living embryonic tissues Unmasking the roles of N- and C-terminal flanking sequences from exon 1 of huntingtin as modulators of polyglutamine aggregation Platelet-targeted gene therapy with human factor VIII establishes haemostasis in dogs with haemophilia A PKM2 regulates chromosome segregation and mitosis progression of tumor cells Antiviral treatment for hepatitis C virus infection is associated with improved renal and cardiovascular outcomes in diabetic patients Transcranial amelioration of inflammation and cell death after brain injury Mapping eQTLs in the Norfolk Island genetic isolate identifies candidate genes for CVD risk traits Restoration of testis function in hypogonadotropic hypogonadal mice harboring a misfolded GnRHR mutant by pharmacoperone drug therapy Motor excitability during movement preparation in Tourette syndrome In vivo performance of a drug-eluting contact lens to treat glaucoma for a month A special population of regulatory T cells potentiates muscle repair Distinct functions for Wnt/β-catenin in hair follicle stem cell proliferation and survival and interfollicular epidermal homeostasis Histology of CorMatrix bioscaffold 5 Years after pericardial closure APP processing in human pluripotent stem cell-derived neurons is resistant to NSAID-based γ-secretase modulation Gata2 cis-element is required for hematopoietic stem cell generation in the mammalian embryo Strategies for expanding the operational range of channelrhodopsin in optogenetic vision Structural basis for Ca2+ selectivity of a voltage-gated calcium channel Nanowell-trapped charged ligand-bearing nanoparticle surfaces: a novel method of enhancing flow-resistant cell adhesion c-Met-dependent multipotent labyrinth trophoblast progenitors establish placental exchange interface Contractile forces sustain and polarize hematopoiesis from stem and progenitor cells High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny Sca1-derived cells are a source of myocardial renewal in the murine adult heart Lysosomal NEU1 deficiency affects amyloid precursor protein levels and amyloid-β secretion via deregulated lysosomal exocytosis The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment Efficient generation of lung and airway epithelial cells from human pluripotent stem cells Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation Analysis of serum inflammatory mediators identifies unique dynamic networks associated with death and spontaneous survival in pediatric acute liver failure Characterization of a biodegradable coralline hydroxyapatite/calcium carbonate composite and its clinical implementation Microbial colonization influences early B-lineage development in the gut lamina propria Auto-attraction of neural precursors and their neuronal progeny impairs neuronal migration EMRE is an essential component of the mitochondrial calcium uniporter complex Deficits in adult neurogenesis, contextual fear conditioning, and spatial learning in a Gfap mutant mouse model of Alexander disease Metabolically active human brown adipose tissue derived stem cells Mitochondrial retrograde signaling induces epithelial–mesenchymal transition and generates breast cancer stem cells Human Treg responses allow sustained recombinant adeno-associated virus–mediated transgene expression Design and formulation of functional pluripotent stem cell-derived cardiac microtissues HiRIEF LC-MS enables deep proteome coverage and unbiased proteogenomics The presenilin-1 ΔE9 mutation results in reduced -γsecretase activity, but not total loss of PS1 function, in isogenic human stem cells Chromosomal contact permits transcription between coregulated genes Directed differentiation of human pluripotent cells to ureteric bud kidney progenitor-like cells Ammonia triggers neuronal disinhibition and seizures by impairing astrocyte potassium buffering Ultrasound-triggered regulation of blood glucose levels using injectable nano-network CD137 accurately identifies and enriches for naturally-occurring tumor-reactive T cells in tumor Beta cell dysfunction due to increased ER stress in a stem cell model of Wolfram syndrome Activated ClpP kills persisters and eradicates a chronic biofilm infection The BET family of proteins targets moloney murine leukemia virus integration near transcription start sites Parvalbumin interneurons mediate neuronal circuitry–neurogenesis coupling in the adult hippocampus Tension-oriented cell divisions limit anisotropic tissue tension in epithelial spreading during zebrafish epiboly SERCA2a controls the mode of agonist-induced intracellular Ca2+ signal, transcription factor NFAT and proliferation in human vascular smooth muscle cells SUMO1-dependent modulation of SERCA2a in heart failure SUMO-1 gene transfer improves cardiac function in a large-animal model of heart failure The cytotoxic necrotizing factor of Yersinia pseudotuberculosis (CNFY) enhances inflammation and Yop delivery during infection by activation of Rho GTPases Psychobiotics: a novel class of psychotropic Two-wave nanotherapy to target the stroma and optimize gemcitabine delivery to a human pancreatic cancer model in mice JUNB/AP-1 controls IFN-γ during inflammatory liver disease Human induced pluripotent stem cell-derived cortical neurons integrate in stroke-injured cortex and improve functional recovery Spherical nucleic acid nanoparticle conjugates as an RNAi-based therapy for glioblastoma Sorafenib/regorafenib and phosphatidyl inositol 3 kinase/thymoma viral proto-oncogene inhibition interact to kill tumor cells Intravenous multipotent adult progenitor cell therapy attenuates activated microglial/macrophage response and improves spatial learning after traumatic brain injury Computed tomography-guided tissue engineering of equine upper airway cartilage Nanotechnology in the regulation of stem cell behavior Exome sequencing identifies distinct mutational patterns in liver fluke–related and non-infection-related bile duct cancers Enrichment of human prostate cancer cells with tumor initiating properties in mouse and zebrafish xenografts by differential adhesion Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis Social stress up-regulates inflammatory gene expression in the leukocyte transcriptome via β-adrenergic induction of myelopoiesis Autologous transplantation as consolidation for aggressive non-hodgkin's lymphoma Differentiated kidney epithelial cells repair injured proximal tubule Plasmapheresis eliminates the negative impact of AAV antibodies on micro-dystrophin gene expression following vascular delivery A genetic and developmental pathway from STAT3 to the OCT4–NANOG circuit is essential for maintenance of ICM lineages in vivo Fiber-optic two-photon optogenetic stimulation Identification and rescue of α-synuclein toxicity in Parkinson patient–derived neurons Yeast reveal a “druggable” Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons Protein phosphatase 4 and Smek complex negatively regulate Par3 and promote neuronal differentiation of neural stem/progenitor cells Elongation of the C-terminal domain of an anti-amyloid β single-chain variable fragment increases its thermodynamic stability and decreases its aggregation tendency Early intervention in the 3xTg-AD mice with an amyloid β-antibody fragment ameliorates first hallmarks of Alzheimer disease Loss of deep cerebellar nuclei neurons in the 3xTg-AD mice and protection by an anti-amyloid β antibody fragment High-throughput fingerprinting of human pluripotent stem cell fate responses and lineage bias Targeted deletion of Vegfa in adult mice induces vision loss Ras pathway inhibition prevents neovascularization by repressing endothelial cell sprouting Quantitative transcriptomics using designed primer-based amplification Harnessing interfacially-active nanorods to regenerate severed polymer gels Genome-wide association study of obsessive-compulsive disorder Genome-wide association study of Tourette's syndrome Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture Failure of stem cell therapy to improve visual acuity in children with optic nerve hypoplasia Thymic stromal lymphopoietin induces corticosteroid resistance in natural helper cells during airway inflammation Positional information is reprogrammed in blastema cells of the regenerating limb of the Axolotl (Ambystoma mexicanum) Molecular mechanisms of cellular mechanosensing Magneto-electric nanoparticles to enable field-controlled high-specificity drug delivery to eradicate ovarian cancer cells Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion Transplantation of expanded fetal intestinal progenitors contributes to colon regeneration after injury Biophysical regulation of epigenetic state and cell reprogramming A nanopore machine promotes the vectorial transport of DNA across membranes SCRIB and PUF60 are primary drivers of the multisystemic phenotypes of the 8q24.3 copy-number variant Transplantation of expanded fetal intestinal progenitors contributes to colon regeneration after injury Pulse wave velocity is associated with β-amyloid deposition in the brains of very elderly adults Recombinant AAV-mediated BEST1 transfer to the retinal pigment epithelium: analysis of serotype-dependent retinal effects Relationship between 17-alpha hydroxyprogesterone caproate concentration and spontaneous preterm birth Weight change and health outcomes at 3 years after bariatric surgery among individuals with severe obesity Smurf2 regulates the senescence response and suppresses tumorigenesis in mice Smurf2 suppresses B-cell proliferation and lymphomagenesis by mediating ubiquitination and degradation of YY1 Multifunctional nanomedicine platform for concurrent delivery of chemotherapeutic drugs and mild hyperthermia to ovarian cancer cells Lower HIV provirus levels are associated with more APOBEC3G protein in blood resting memory CD4+ T lymphocytes Dielectrophoresis-based discrimination of bacteria at the strain level based on their surface properties Early outgrowth cells release soluble endocrine anti-fibrotic factors that reduce progressive organ fibrosis Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity DGIdb: mining the druggable genome Genome-wide sequencing of cellular microRNAs identifies a combinatorial expression signature diagnostic of sepsis RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention SLIT3–ROBO4 activation promotes vascular network formation in human engineered tissue and angiogenesis in vivo Cytoplasmic genetic variation and extensive cytonuclear interactions influence natural variation in the metabolome Automatic diagnosis of pathological myopia from heterogeneous biomedical data Identification of neural connectivity signatures of autism using machine learning Spatial organization within a niche as a determinant of stem-cell fate Differentiated troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium Sustained release of bone morphogenetic protein 2 via coacervate improves the osteogenic potential of muscle-derived stem cells Prevention of inflammation-mediated bone loss in murine and canine periodontal disease via recruitment of regulatory lymphocytes Sox2+ stem/progenitor cells in the adult mouse pituitary support organ homeostasis and have tumor-inducing potential Induction and suppression of RNA silencing by an animal virus Antiviral RNA interference in mammalian cells RNA interference functions as an antiviral immunity mechanism in mammals Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome DNMT1-interacting RNAs block gene-specific DNA methylation Spontaneous lytic replication and epitheliotropism define an Epstein-Barr virus strain found in carcinomas Retinal proteome alterations in a mouse model of type 2 diabetes Klotho regulates retinal pigment epithelial functions and protects against oxidative stress Mammalian cells preferentially internalize hydrogel nanodiscs over nanorods and use shape-specific uptake mechanisms An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level Aberrant dolichol chain lengths as biomarkers for retinitis pigmentosa caused by impaired dolichol biosynthesis The housekeeping gene hypoxanthine guanine phosphoribosyltransferase (HPRT) regulates multiple developmental and metabolic pathways of murine embryonic stem cell neuronal differentiation Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors 5-HT2 receptors facilitate JC polyomavirus entry Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via respecification of lineage-restricted precursors Cross talk between Wnt/β-catenin and Irf8 in leukemia progression and drug resistance Integrative annotation of variants from 1092 humans: application to cancer genomics Addiction of t(8;21) and inv(16) acute myeloid leukemia to native RUNX1 Dendritic epidermal T cells regulate skin antimicrobial barrier function Defining cell-type specificity at the transcriptional level in human disease How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function Simple, inexpensive technique for high-quality Smartphone fundus photography in human and animal eyes Identifying division symmetry of mouse embryonic stem cells: negative impact of DNA methyltransferases on symmetric self-renewal Directional tissue migration through a self-generated chemokine gradient Direct comparison of autologous and allogeneic transplantation of iPSC-derived neural cells in the brain of a nonhuman primate CMX001 to prevent cytomegalovirus disease in hematopoietic-cell transplantation Pan-cancer patterns of somatic copy number alteration Paneth cells as a site of origin for intestinal inflammation mRNA-engineered mesenchymal stem cells for targeted delivery of interleukin-10 to sites of inflammation With an eye to low vision: optic flow enables perception despite image blur The epithelial cell-derived atopic dermatitis cytokine TSLP activates neurons to induce itch Mitochondrial genetic background modulates bioenergetics and susceptibility to acute cardiac volume overload Early human prostate adenocarcinomas harbor androgen-independent cancer cells Deterministic direct reprogramming of somatic cells to pluripotency Helicobacter pylori infection in a pig model is dominated by Th1 and cytotoxic CD8+ T cell responses Epigenetic control of natural killer cell maturation by histone H2A deubiquitinase, MYSM1 Scalable spray deposition process for high-performance carbon nanotube gas sensors Flexible carbon nanotube based gas sensors fabricated by large-scale spray deposition Fabrication of carbon nanotube thin films on flexible substrates by spray deposition and transfer printing Glassy dynamics in three-dimensional embryonic tissues Targeting sonic hedgehog-associated medulloblastoma through inhibition of aurora and polo-like kinases Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis Generation of effector memory T cell–based mucosal and systemic immunity with pulmonary nanoparticle vaccination Genetically dictated change in host mucus carbohydrate landscape exerts a diet-dependent effect on the gut microbiota Whole genome sequencing in patients with retinitis pigmentosa reveals pathogenic DNA structural changes and NEK2 as a new disease gene Smart-seq2 for sensitive full-length transcriptome profiling in single cells Biochemical and physical signal gradients in hydrogels to control stem cell behavior Single-cell Hi-C reveals cell-to-cell variability in chromosome structure Multifocal pupillography identifies retinal dysfunction in early age-related macular degeneration Macrophage phenotype in the mammary gland fluctuates over the course of the estrous cycle and is regulated by ovarian steroid hormones Hippocampal interneuron transplants reverse aberrant dopamine system function and behavior in a rodent model of schizophrenia Reprogramming in vivo produces teratomas and iPS cells with totipotency features Targeted delivery of proapoptotic peptides to tumor-associated macrophages improves survival CDK8-mediated STAT1-S727 phosphorylation restrains NK cell cytotoxicity and tumor surveillance Usp16 contributes to somatic stem-cell defects in Down’s syndrome Initiation of GalNAc-type O-glycosylation in the endoplasmic reticulum promotes cancer cell invasiveness Network-based stratification of tumor mutations Activated EGFR stimulates MUC1 expression in human uterine and pancreatic cancer cell lines An experimental test on the probability of extinction of new genetic variants Retinal angiogenesis suppression through small molecule activation of p53 Identification of a rare coding variant in complement 3 associated with age-related macular degeneration A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity SON connects the splicing-regulatory network with pluripotency in human embryonic stem cells Human circulating PD-1+CXCR3CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses Physical clustering of FLC alleles during Polycomb-mediated epigenetic silencing in vernalization Early role for IL-6 signalling during generation of induced pluripotent stem cells revealed by heterokaryon RNA-Seq Superpixel classification based optic disc and optic cup segmentation for glaucoma screening Age of the donor reduces the ability of human adipose-derived stem cells to alleviate symptoms in the experimental autoimmune encephalomyelitis mouse model Defining the disease liability of variants in the cystic fibrosis transmembrane conductance regulator gene Genome engineering of drosophila with the CRISPR RNA-guided Cas9 nuclease Effects of sleep and wake on oligodendrocytes and their precursors Mechanism-based epigenetic chemosensitization therapy of diffuse large B-cell lymphoma Cellular and synaptic architecture of multisensory integration in the mouse neocortex Functional consequences of platelet binding to T lymphocytes in inflammation Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells Enrichment of autologous fat grafts with ex-vivo expanded adipose tissue-derived stem cells for graft survival: a randomised placebo-controlled trial Adipose stem cell therapy for soft tissue reconstruction Technology, trends, and the future for people with spinal cord injury The p130 isoform of angiomotin is required for Yap-mediated hepatic epithelial cell proliferation and tumorigenesis Probing red blood cell morphology using high-frequency photoacoustics In vitro study of α-synuclein protofibrils by cryo-EM suggests a Cu2+-dependent aggregation pathway Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiation Increasing the complexity of chromatin: functionally distinct roles for replication-dependent histone H2A isoforms in cell proliferation and carcinogenesis Stomach cancer risk after treatment for Hodgkin lymphoma Immunotherapy of chronic hepatitis C virus infection with antibodies against programmed cell death-1 (PD-1) Tunable and multifunctional eukaryotic transcription factors based on CRISPR/Cas Eukaryotic stress granules are cleared by autophagy and Cdc48/VCP function Induced pluripotent stem cell intervention rescues ventricular wall motion disparity, achieving biological cardiac resynchronization post-infarction In situ regulation of DC subsets and T cells mediates tumor regression in mice The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism Purification of cardiomyocytes from differentiating pluripotent stem cells using molecular beacons targeting cardiomyocyte-specific mRNA Migraine and structural changes in the brain: A systematic review and meta-analysis Genetic basis for in vivo daptomycin resistance in enterococci Daptomycin-resistant Enterococcus faecalis diverts the antibiotic molecule from the division septum and remodels cell membrane phospholipids Chemoprevention of prostate cancer by D,L-sulforaphane is augmented by pharmacological inhibition of autophagy Blocking macrophage leukotriene B4 prevents endothelial injury and reverses pulmonary hypertension What can information-asymmetric games tell us about the context of Crick's ‘frozen accident’? Topoisomerases facilitate transcription of long genes linked to autism Self-assembled carbon nanotube honeycomb networks using a butterfly wing template as a multifunctional nanobiohybrid GATA-3 regulates the self-renewal of long-term hematopoietic stem cells Low-dose food contaminants trigger sex-specific, hepatic metabolic changes in the progeny of obese mice Two cells are better than one: Optimizing stem cell survival by co-grafting “helper” cells that offer regulated trophic support Neural progenitor cell survival in mouse brain can be improved by co-transplantation of helper cells expressing bFGF under doxycycline control Notch1 is required for Kras-induced lung adenocarcinoma and controls tumor cell survival via p53 Generation and characterization of spiking and non-spiking oligodendroglial progenitor cells from embryonic stem cells Molecular mechanism for age-related memory loss: the histone-binding protein RbAp48 PET/MRI: applications in clinical imaging Richness of human gut microbiome correlates with metabolic markers Ether lipid generating enzyme AGPS alters the balance of structural and signaling lipids to fuel cancer pathogenicity A new role for histone deacetylase 5 in the maintenance of long telomeres Potential protective effect of biphasic electrical stimulation against growth factor-deprived apoptosis on olfactory bulb neural progenitor cells through the brain-derived neurotrophic factor–phosphatidylinositol 3′-kinase/Akt pathway Cerebral organoids model human brain development and microcephaly IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses A nanobody-based system using fluorescent proteins as scaffolds for cell-specific gene manipulation Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds Global comparisons of lectin-glycan interactions using a database of analyzed glycan array data Specific glycoforms of MUC5AC and endorepellin accurately distinguish mucinous from non-mucinous pancreatic cysts Marine omega-3 polyunsaturated fatty acids induce sex-specific changes in reinforcer-controlled behaviour and neurotransmitter metabolism in a spontaneously hypertensive rat model of ADHD Exome sequencing identifies recurring FLT3 N676K mutations in core-binding factor leukemia Long-term suppression of ocular neovascularization by intraocular injection of biodegradable polymeric particles containing a serpin-derived peptide Transplantation of human fetal-derived neural stem cells improves cognitive function following cranial irradiation Deacetylase inhibition promotes the generation and function of regulatory T cells Inhibition of p300 impairs Foxp3+ T regulatory cell function and promotes antitumor immunity Patterned prevascularised tissue constructs by assembly of polyelectrolyte hydrogel fibres Functional vascular endothelium derived from human induced pluripotent stem cells Fruit and vegetable intakes are associated with lower risk of bladder cancer among women in the multiethnic cohort study A multi-stakeholder perspective on the use of alternative test strategies for nanomaterial safety assessment Molecular crowding shapes gene expression in synthetic cellular nanosystems Mortality among patients admitted to strained intensive care units In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes Direct reprogramming of human fibroblasts toward a cardiomyocyte-like state Autophagy activation clears ELAVL1/HuR-mediated accumulation of SQSTM1/p62 during proteasomal inhibition in human retinal pigment epithelial cells Mesenchymal stem cells enhance the engraftment and myelinating ability of allogeneic oligodendrocyte progenitors in dysmyelinated mice Clinical and pathological effects of intrathecal injection of mesenchymal stem cell-derived neural progenitors in an experimental model of multiple sclerosis Characterization of autologous mesenchymal stem cell-derived neural progenitors as a feasible source of stem cells for central nervous system applications in multiple sclerosis Cerebrospinal fluid derived from progressive multiple sclerosis patients promotes neuronal and oligodendroglial differentiation of human neural precursor cells in vitro Plasma lipids, genetic variants near APOA1, and the risk of infantile hypertrophic pyloric stenosis MC1R is a potent regulator of PTEN after UV exposure in melanocytes Population-based prognostic factors for survival in patients with Burkitt lymphoma: An analysis from the Surveillance, Epidemiology, and End Results database Bacteria activate sensory neurons that modulate pain and inflammation Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitides Muscle cells provide instructions for planarian regeneration T follicular helper cell dynamics in germinal centers Signatures of mutational processes in human cancer Pediatric intestinal failure–associated liver disease is reversed with 6 months of intravenous fish oil The Mll2 branch of the COMPASS family regulates bivalent promoters in mouse embryonic stem cells Polymalic acid nanobioconjugate for simultaneous immunostimulation and inhibition of tumor growth in HER2/neu-positive breast cancer SCHEMA computational design of virus capsid chimeras: calibrating how genome packaging, protection, and transduction correlate with calculated structural disruption Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy Induction of intestinal stem cells by R-spondin 1 and Slit2 augments chemoradioprotection Adult c-kitpos cardiac stem cells are necessary and sufficient for functional cardiac regeneration and repair ST2 as a marker for risk of therapy-resistant graft-versus-host disease and death Inactivation of hepatitis B virus replication in cultured cells and in vivo with engineered transcription activator-like effector nucleases Mouse genetics and proteomic analyses demonstrate a critical role for complement in a model of DHRD/ML, an inherited macular degeneration De novo mutations in epileptic encephalopathies Molecular profiling supports the role of epithelial-to-mesenchymal transition (EMT) in ovarian cancer metastasis Paternally expressed genes predominate in the placenta The epidermis comprises autonomous compartments maintained by distinct stem cell populations Onecut1 is essential for horizontal cell genesis and retinal integrity Low CSF concentration of mitochondrial DNA in preclinical Alzheimer's disease Specific elimination of mutant mitochondrial genomes in patient-derived cells by mitoTALENs Teplizumab (anti-CD3 mAb) treatment preserves C-peptide responses in patients with new-onset type 1 diabetes in a randomized controlled trial: Metabolic and immunologic features at baseline identify a subgroup of responders Nano-imprinting lithography of P(VDF–TrFE–CFE) for flexible freestanding MEMS devices Obstructive sleep apnea and increased risk of glaucoma: a population-based matched-cohort study Single-cell optoporation and transfection using femtosecond laser and optical tweezers Rheumatoid arthritis increases the risk of deep vein thrombosis and pulmonary thromboembolism: a nationwide cohort study Low-frequency (<100 kHz), low-intensity (<100 mW/cm2) ultrasound to treat venous ulcers: A human study and in vitro experiments Spatial dynamics of chromosome translocations in living cells Connectomic reconstruction of the inner plexiform layer in the mouse retina Relationship between dry eye symptoms and pain sensitivity Gingivae contain neural-crest- and mesoderm-derived mesenchymal stem cells Epoxyeicosanoids promote organ and tissue regeneration Efficient generation of human iPSCs by a synthetic self-replicative RNA Transforming fusions of FGFR and TACC genes in human glioblastoma The integrated landscape of driver genomic alterations in glioblastoma Localization of magnetic pills Can bioadhesive nanoparticles allow for more effective particle uptake from the small intestine? Oral delivery of proteins by biodegradable nanoparticles Unique insights into the intestinal absorption, transit, and subsequent biodistribution of polymer-derived microspheres Regional localization within the bone marrow influences the functional capacity of human HSCs SIGIRR, a negative regulator of TLR/IL-1R signalling promotes microbiota dependent resistance to colonization by enteric bacterial pathogens Creating a false memory in the hippocampus AID stabilizes stem-cell phenotype by removing epigenetic memory of pluripotency gene Increased sphingosine-1-phosphate improves muscle regeneration in acutely injured mdx mice Combined alloreactive CTL cellular therapy with prodrug activator gene therapy in a model of breast cancer metastatic to the brain A cyclic peptide inhibitor of C-terminal binding protein dimerization links metabolism with mitotic fidelity in breast cancer cells Therapeutic efficacy of AAV1.SERCA2a in monocrotaline-induced pulmonary arterial hypertension 14-step synthesis of (+)-Ingenol from (+)-3-Carene Purged versus non-purged peripheral blood stem-cell transplantation for high-risk neuroblastoma (COG A3973): a randomised phase 3 trial Adolescent behavior and dopamine availability are uniquely sensitive to dietary omega-3 fatty acid deficiency The DREAM complex mediates GIST cell quiescence and is a novel therapeutic target to enhance Imatinib-induced apoptosis Motile axonal mitochondria contribute to the variability of presynaptic strength Green biosynthesis of gold nanometre scale plates using the leaf extracts from an indigenous Australian plant Eucalyptus macrocarpa The conditional nature of genetic interactions: the consequences of wild-type backgrounds on mutational interactions in a genome-wide modifier screen Acute myeloid leukemia does not deplete normal hematopoietic stem cells but induces cytopenias by impeding their differentiation Repopulation of decellularized mouse heart with human induced pluripotent stem cell-derived cardiovascular progenitor cells Extended practice of a motor skill is associated with reduced metabolic activity in M1 Modeling the photoinduced reconfiguration and directed motion of polymer gels hESC-derived Olig2+ progenitors generate a subtype of astroglia with protective effects against ischaemic brain injury Alzheimer’s disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production Temporomandibular joint pain: A critical role for Trpv4 in the trigeminal ganglion Patient-derived induced pluripotent stem cells recapitulate hematopoietic abnormalities of juvenile myelomonocytic leukemia Ribosomal and hematopoietic defects in induced pluripotent stem cells derived from Diamond Blackfan anemia patients Single molecular hyperbranched nanoprobes for fluorescence and magnetic resonance dual modal imaging Correction of diabetic hyperglycemia and amelioration of metabolic anomalies by minicircle DNA mediated glucose-dependent hepatic insulin production Interkinetic nuclear migration is a broadly conserved feature of cell division in pseudostratified epithelia Epithelial junctions maintain tissue architecture by directing planar spindle orientation Activated carbon cloth as support for mesenchymal stem cell growth and differentiation to osteocytes Human umbilical cord stromal stem cell express CD10 and exert contractile properties The importance of bystander effects in radiation therapy in melanoma skin-cancer cells and umbilical-cord stromal stem cells Growth and spontaneous differentiation of umbilical-cord stromal stem cells on activated carbon cloth Self-organized vascular networks from human pluripotent stem cells in a synthetic matrix Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis Label-free detection of single protein using a nanoplasmonic-photonic hybrid microcavity Optical control of mammalian endogenous transcription and epigenetic states Dravet syndrome patient-derived neurons suggest a novel epilepsy mechanism Premature cell senescence and T cell receptor–independent activation of CD8+ T cells in juvenile idiopathic arthritis Reactivating head regrowth in a regeneration-deficient planarian species Transcription factor EBF1 is essential for the maintenance of B cell identity and prevention of alternative fates in committed cells Myeloid/microglial driven autologous hematopoietic stem cell gene therapy corrects a neuronopathic lysosomal disease TGFβ receptor mutations impose a strong predisposition for human allergic disease Gingivae contain neural-crest- and mesoderm-derived mesenchymal stem cells Generation of functionally competent and durable engineered blood vessels from human induced pluripotent stem cells Zeb1 regulates E-cadherin and Epcam (epithelial cell adhesion molecule) expression to control cell behavior in early zebrafish development Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina Integrative genomics identifies APOE ε4 effectors in Alzheimer's disease Overcoming preexisting humoral immunity to AAV using capsid decoys The antagonistic modulation of Arp2/3 activity by N-WASP/WAVE2 and PICK1 defines dynamic changes in astrocyte morphology Special section guest editorial: optical methods of imaging in the skin Translating dosage compensation to trisomy 21 Wnt/β-catenin signaling triggers neuron reprogramming and regeneration in the mouse retina LRG1 promotes angiogenesis by modulating endothelial TGF-β signaling Molecular crowding shapes gene expression in synthetic cellular nanosystems Prospective randomized clinical evaluation of conventional single-bundle, anatomic single-bundle, and anatomic double-bundle anterior cruciate ligament reconstruction: 281 cases with 3- to 5-year follow-up Transient B cell depletion combined with apoptotic donor splenocytes induces xeno-specific T and B cell tolerance to islet xenografts Nanoengineering gold particle composite fibers for cardiac tissue engineering TCR-ligand koff rate correlates with the protective capacity of antigen-specific CD8+ T cells for adoptive transfer Noncanonical autophagy promotes the visual cycle Disturbed sleep and inflammatory cytokines in depressed and nondepressed pregnant women: an exploratory analysis of pregnancy outcomes Systemic delivery of SapC-DOPS has antiangiogenic and antitumor effects against glioblastoma Lentiviral hematopoietic stem cell gene therapy benefits Metachromatic Leukodystrophy Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich Syndrome Passive joint forces are tuned to limb use in insects and drive movements without motor activity SLC26A4 targeted to the endolymphatic sac rescues hearing and balance in Slc26a4 mutant mice Heart grafts tolerized through third-party multipotent adult progenitor cells can be retransplanted to secondary hosts with no immunosuppression Magnetic targeting of human mesenchymal stem cells with internalized superparamagnetic iron oxide nanoparticles Positive feedback between PU.1 and the cell cycle controls myeloid differentiation Loss of function of the melanocortin 2 receptor accessory protein 2 is associated with mammalian obesity Insulin and IGF1 modulate turnover of polysialylated neuronal cell adhesion molecule (PSA-NCAM) in a process involving specific extracellular matrix components Reprogramming to pluripotency using designer TALE transcription factors targeting enhancers Iron administration before stem cell harvest enables MR imaging tracking after transplantation DNA computation in mammalian cells: microRNA logic operations In vivo cardiac reprogramming contributes to zebrafish heart regeneration Tunable touch sensor and combined sensing platform: toward nanoparticle-based electronic skin A microparticle approach to morphogen delivery within pluripotent stem cell aggregates Cell-based therapy for ischemic stroke Engineered neural tissue for peripheral nerve repair Translation-dependent displacement of UPF1 from coding sequences causes its enrichment in 3′ UTRs eIF4E-bound mRNPs are substrates for nonsense-mediated mRNA decay in mammalian cells Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich Syndrome Reversal of succinylcholine induced apnea with an organophosphate scavenging recombinant butyrylcholinesterase Chemical communication of antibiotic resistance by a highly resistant subpopulation of bacterial cells MBNL proteins repress ES-cell-specific alternative splicing and reprogramming Global epigenomic reconfiguration during mammalian brain development Lipidomic profiling of influenza infection identifies mediators that induce and resolve inflammation Human placental trophoblasts confer viral resistance to recipient cells Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay Aspirin exposure reveals novel genes associated with platelet function and cardiovascular events 5S ribosomal RNA is an essential component of a nascent ribosomal precursor complex that regulates the Hdm2-p53 checkpoint Reduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children Switchable telescopic contact lens β-globin gene transfer to human bone marrow for sickle cell disease Whole body correction of mucopolysaccharidosis IIIA by intracerebrospinal fluid gene therapy Transplantation of autologous olfactory ensheathing cells in complete human spinal cord injury A comprehensive assessment of gait accelerometry signals in time, frequency and time-frequency domains In vitro integration of ribosomal RNA synthesis, ribosome assembly, and translation Influence of surface features on the adhesion of Staphyloccocus epidermidis to Ag–TiCN thin films Neurons within the same network independently achieve conserved output by differentially balancing variable conductance magnitudes The relationship between diabetic retinopathy and cognitive impairment Efficacy and safety of autologous bone marrow derived stem cell transplantation in patients with type 2 diabetes mellitus: a randomized placebo-controlled study Rapid detection of bacterial resistance to antibiotics using AFM cantilevers as nanomechanical sensors Regulatory dendritic cell infusion prolongs kidney allograft survival in nonhuman primates Wnt activation in nail epithelium couples nail growth to digit regeneration Gold nanorod vaccine for respiratory syncytial virus Dapper antagonist of Catenin-1 cooperates with Dishevelled-1 during postsynaptic development in mouse forebrain Sustained mobilization of endogenous neural progenitors delays disease progression in a transgenic model of Huntingtons Disease Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes An iPSC line from human pancreatic ductal adenocarcinoma undergoes early to invasive stages of pancreatic cancer progression Identification of Drosophila type II neuroblast lineages containing transit amplifying ganglion mother cells Combinatorial temporal patterning in progenitors expands neural diversity A largely random AAV integration profile after LPLD gene therapy Scalable nano-bioprobes with sub-cellular resolution for cell detection MEK inhibitors selectively suppress alloreactivity and graft-versus-host disease in a memory stage-dependent manner iPSC-derived β cells model diabetes due to glucokinase deficiency Hydrogels that mimic developmentally relevant matrix and N-cadherin interactions enhance MSC chondrogenesis Role of reduced-intensity conditioning allogeneic hematopoietic stem-cell transplantation in older patients with de novo myelodysplastic syndromes: an international collaborative decision analysis Self-organization of bacterial biofilms is facilitated by extracellular DNA Intravital FLIM-FRET imaging reveals dasatinibinduced spatial control of Src in pancreatic cancer Awakened by cellular stress: isolation and characterization of a novel population of pluripotent stem cells derived from human adipose tissue Pericytes derived from adipose-derived stem cells protect against retinal vasculopathy In vivo–directed evolution of a new adeno-associated virus for therapeutic outer retinal gene delivery from the vitreous Antigen-specific tolerance by autologous myelin peptide–coupled cells: a phase 1 trial in multiple sclerosis Posttranscriptional control of T cell effector function by aerobic glycolysis Astroglial cells regulate the developmental timeline of human neurons differentiated from induced pluripotent stem cells Fgf9 from dermal γδ T cells induces hair follicle neogenesis after wounding KDR identifies a conserved human and murine hepatic progenitor and instructs early liver development InVERT molding for scalable control of tissue microarchitecture Geometric control of vascular networks to enhance engineered tissue integration and function Identification of small molecules for human hepatocyte expansion and iPS differentiation Mediation of protection and recovery from experimental autoimmune encephalomyelitis by macrophages expressing the human voltage-gated sodium channel NaV1.5 Intranasal antibody gene transfer in mice and ferrets elicits broad protection against pandemic influenza Hypothermic storage of human hepatocytes for transplantation Stepwise evolution of essential centromere function in a Drosophila neogene Phase I/II trial of adeno-associated virus–mediated alpha-glucosidase gene therapy to the diaphragm for chronic respiratory failure in pompe disease: initial safety and ventilatory outcomes Targeting of the MNK–eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function The perivascular niche regulates breast tumour dormancy Identification of unsafe human induced pluripotent stem cell lines using a robust surrogate assay for pluripotency WNT3 is a biomarker capable of predicting the definitive endoderm differentiation potential of hESCs 11β-hydroxysteroid dehydrogenase blockade prevents age-induced skin structure and function defects Amelioration of motor/sensory dysfunction and spasticity in a rat model of acute lumbar spinal cord injury by human neural stem cell transplantation A preclinical xenograft model identifies castration-tolerant cancer-repopulating cells in localized prostate tumors Recovery from overt type 1 diabetes ensues when immune tolerance and β cell formation are coupled with regeneration of endothelial cells in the pancreatic islets Synergistic effects of GDNF and VEGF on lifespan and disease progression in a familial ALS rat model Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP High-performance, transparent, and stretchable electrodes using graphene–metal nanowire hybrid structures Significant improvement in survival after allogeneic hematopoietic cell transplantation during a period of significantly increased use, older recipient age, and use of unrelated donors CD4+CD73+ T cells are associated with lower T-cell activation and C reactive protein levels and are depleted in HIV-1 infection regardless of viral suppression Pathogenic plasticity of Kv7.2/3 channel activity is essential for the induction of tinnitus Nanoclays mediate stem cell differentiation and mineralized ECM formation on biopolymer scaffolds Mature HIV-1 capsid structure by cryo-electron microscopy and all-atom molecular dynamics An RNA aptamer provides a novel approach for the induction of apoptosis by targeting the HPV16 E7 oncoprotein The role of gene therapy in regenerative surgery: updated insights Estrogen reduces lipid content in the liver exclusively from membrane receptor signaling Discarded human kidneys as a source of ECM scaffold for kidney regeneration technologies Targeting immunosuppression for cancer therapy Depleting tumor-specific Tregs at a single site eradicates disseminated tumors Risk of cancer among workers exposed to trichloroethylene: analysis of three nordic cohort studies First autologous cell therapy of cerebral palsy caused by hypoxic-ischemic brain damage in a child after cardiac arrest—individual treatment with cord blood Percutaneous tibial nerve stimulation for the long-term treatment of overactive bladder: 3-year results of the STEP study Structural basis of actin filament nucleation by tandem W domains Ectopic activation of germline and placental genes identifies aggressive metastasis-prone lung cancers Adipose tissue-derived multipotent stromal cells have a higher immunomodulatory capacity than their bone marrow-derived counterparts Zwitterionic hydrogels implanted in mice resist the foreign-body reaction Matrix metalloproteinase-8 (collagenase-2) induces the expression of interleukins-6 and -8 in breast cancer cells Bioresorbable airway splint created with a three-dimensional printer Defining single molecular forces required to activate integrin and Notch signaling Identification of candidate genes encoding an LDL-C QTL in baboons Mutations in PDGFRB cause autosomal-dominant infantile myofibromatosis Coordinate transcriptional and translational repression of p53 by TGF-β1 impairs the stress response Do findings on routine examination identify patients at risk for primary open-angle glaucoma? Comment on “ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models” Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells Distinct pathways mediate axon degeneration during apoptosis and axon-specific pruning A molecular roadmap of reprogramming somatic cells into iPS cells Delivery of therapeutic agents by nanoparticles made of grapefruit-derived lipids Generation of engraftable hematopoietic stem cells from induced pluripotent stem cells by way of teratoma formation VEGF induces TGF-β1 expression and myofibroblast transformation after glaucoma surgery SMRT compounds abrogate cellular phenotypes of ataxia telangiectasia in neural derivatives of patient-specific hiPSCs Hybrid equation/agent-based model of ischemia-induced hyperemia and pressure ulcer formation predicts greater propensity to ulcerate in subjects with spinal cord injury Epigenomic analysis of multilineage differentiation of human embryonic stem cells Young at heart Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy Amyloid imaging and CSF biomarkers in predicting cognitive impairment up to 7.5 years later Agent Orange as a risk factor for high-grade prostate cancer Generation of functional thymic epithelium from human embryonic stem cells that supports host T cell development Prefrontal microcircuit underlies contextual learning after hippocampal loss Tissue-engineered cardiac patch for advanced functional maturation of human ESC-derived cardiomyocytes Targeting isoprenylcysteine methylation ameliorates disease in a mouse model of progeria Human embryonic stem cells derived by somatic cell nuclear transfer Novel adenoviral vector induces T-cell responses despite anti-adenoviral neutralizing antibodies in colorectal cancer patients Three-dimensional hydrogel constructs for exposing cells to nanoparticles Transient photoreceptor deconstruction by CNTF enhances rAAV-mediated cone functional rescue in late stage CNGB3-achromatopsia Cognate antigen directs CD8+ T cell migration to vascularized transplants Oligodendrocyte progenitors balance growth with self-repulsion to achieve homeostasis in the adult brain Engineering bone tissue substitutes from human induced pluripotent stem cells Linear mesostructures in DNA–nanorod self-assembly Multicenter study of banked third party virus-specific T-cells to treat severe viral infections after hematopoietic stem cell transplantation Nonmelanoma skin cancer is associated with reduced Alzheimer disease risk Chromosome-specific nonrandom sister chromatid segregation during stem-cell division Prospective evaluation of a molecular marker panel for prediction of recurrence and cancer-specific survival after radical cystectomy SMRT compounds abrogate cellular phenotypes of ataxia telangiectasia in neural derivatives of patient-specific hiPSCs Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan Epigenetic activation of AP1 promotes squamous cell carcinoma metastasis Psl trails guide exploration and microcolony formation in Pseudomonas aeruginosa biofilms Role of pericytes in skeletal muscle regeneration and fat accumulation Long-term effects of vitamins C and E, β-carotene, and zinc on age-related macular degeneration: AREDS report no. 35 Lutein/Zeaxanthin for the treatment of age-related cataract: AREDS2 randomized trial report no. 4 Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial Highly elastic micropatterned hydrogel for engineering functional cardiac tissue Evidence for a common mechanism of SIRT1 regulation by allosteric activators A role for PVRL4-driven cell–cell interactions in tumorigenesis Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development GABA progenitors grafted into the adult epileptic brain control seizures and abnormal behavior Liver preservation with machine perfusion under full oxygenation using a new cell-free oxygen-carrier solution Reduced Oct4 expression directs a robust pluripotent state with distinct signaling activity and increased enhancer occupancy by Oct4 and Nanog Roles of adipocytes and fibroblasts in activation of the alternative pathway of complement in inflammatory arthritis in mice 3D printed bionic ears Chitosan/poly(vinyl alcohol) hydrogel combined with Ad-hTGF-β1 transfected mesenchymal stem cells to repair rabbit articular cartilage defects Generation of integration-free and region-specific neural progenitors from primate fibroblasts Serine proteolytic pathway activation reveals an expanded ensemble of wound response genes in Drosophila The dual role of mesenchymal stem cells in tumor progression The dual effect of mscs on tumour growth and tumour angiogenesis MicroRNA-382 expression is elevated in the olfactory neuroepithelium of schizophrenia patients Symptom severity predicts prolonged recovery after sport-related concussion, but age and amnesia do not Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimers disease Recruitment of mesenchymal stem cells into prostate tumours promotes metastasis Screening of biochemical and molecular mechanisms of secondary injury and repair in the brain after experimental blast-induced traumatic brain injury in rats Bone marrow tinctures for cardiovascular disease: lost in translation Intracoronary injection of bone marrow derived mononuclear cells, early or late after acute myocardial infarction: effects on global left ventricular function four months results of the SWISS-AMI trial Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS–NO–nitrite signaling Late-life depression and risk of vascular dementia and Alzheimer’s disease: systematic review and meta-analysis of community-based cohort studies Generation of oligodendroglial cells by direct lineage conversion Melatonin inhibits the caspase-1/cytochrome c/caspase-3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis Self-assembled, aptamer-tethered DNA nanotrains for targeted transport of molecular drugs in cancer Effect of shock wave–facilitated intracoronary cell therapy on LVEF in patients with chronic heart failure Regulation of stem cell therapies under attack in Europe: for whom the bell tolls A physical sciences network characterization of non-tumorigenic and metastatic cells A systematic genome-wide analysis of zebrafish protein-coding gene function Medial ganglionic eminence–like cells derived from human embryonic stem cells correct learning and memory deficits Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration Transcription factor–mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells Regeneration and experimental orthotopic transplantation of a bioengineered kidney Intranasal delivery of pGDNF nanoparticles provides neuroprotection in the rat 6-hydroxydopamine model of Parkinson’s disease Thrombospondin-1 signaling through CD47 inhibits self-renewal by regulating c-Myc and other stem cell transcription factors Lower baseline prostate-specific antigen is associated with a greater overall survival benefit from sipuleucel-T in the Immunotherapy for Prostate Adenocarcinoma Treatment (IMPACT) trial Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay Transcription factor–mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells Cardiopoietic stem cell therapy in heart failure The C-CURE multicenter randomized trial with lineage-specified biologics Impaired cholesterol efflux in senescent macrophages promotes age-related macular degeneration Implantation of bone marrow-derived mesenchymal stem cells demonstrates improved outcome in horses with overstrain injury of the superficial digital flexor tendon Concentrated bone marrow aspirate improves full-thickness cartilage repair compared with microfracture in the equine model Effect of adipose-derived mesenchymal stem and regenerative cells on lameness in dogs with chronic osteoarthritis of the coxofemoral joints: a randomized, double-blinded, multicenter, controlled trial CD24 and CD44 mark human intestinal epithelial cell populations with characteristics of active and facultative stem cells Rigid microenvironments promote cardiac differentiation of mouse and human embryonic stem cells Micromanaging hepatitis C virus Treatment of HCV infection by targeting microRNA Amplifying genetic logic gates Rational design of a ligand-controlled protein conformational switch Optically triggering spatiotemporally confined GPCR activity in a cell and programming neurite initiation and extension Optical control demonstrates switch-like PIP3 dynamics underlying the initiation of immune cell migration Tissue engineering and regenerative medicine: recent innovations and the transition to translation Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice Macrophages support pathological erythropoiesis in polycythemia vera and β-thalassemia A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: a phase 1, randomised, first-in-man study Degradation-mediated cellular traction directs stem cell fate in covalently crosslinked three-dimensional hydrogels Autophagy in stem cells FIP200 is required for maintenance and differentiation of postnatal neural stem cells Mesenchymal stem cells engineered to inhibit complement-mediated damage Stromal cell identity influences the in vivo functionality of engineered capillary networks formed by co-delivery of endothelial cells and stromal cells Cellular and molecular basis of von Willebrand disease: studies on blood outgrowth endothelial cells Klf5 controls bone marrow homing of stem cells and progenitors through Rab5-mediated β1/β2-integrin trafficking Intracellular aggregation of multimodal silica nanoparticles for ultrasound-guided stem cell implantation Improved methods for reprogramming human dermal fibroblasts using fluorescence activated cell sorting The circadian clock gates the intestinal stem cell regenerative state Adhesion strength–based, label-free isolation of human pluripotent stem cells Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease specific patterns of cardiotoxicity Keratocyte fragments and cells utilize competing pathways to move in opposite directions in an electric field Assembly of complex cell microenvironments using geometrically docked hydrogel shapes Chimeric antigen receptor T cells with dissociated signaling domains exhibit focused antitumor activity with reduced potential for toxicity in vivo Laparoscopic pyeloplasty for ureteropelvic junction obstruction in infants Cell-based therapeutics: the next pillar of medicine CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia Regulation of stem cell fate in a three-dimensional micropatterned dual-crosslinked hydrogel system A tissue-like printed material Improved ex vivo expansion of adult hematopoietic stem cells by overcoming CUL4-mediated degradation of HOXB4 Transgenic overexpression of ribonucleotide reductase improves cardiac performance The human placenta methylome Targeting chronic lymphocytic leukemia cells with a humanized monoclonal antibody specific for CD44 Mouse urinary peptides provide a molecular basis for genotype discrimination by nasal sensory neurons Survey of the human pancreatic beta-cell G1/S proteome reveals a potential therapeutic role for cdk-6 and cyclin D1 in enhancing human beta-cell replication and function in vivo A human pancreatic beta cell G1/S molecule cell cycle atlas Cytoplasmic-nuclear trafficking of G1/S cell cycle molecules and adult human beta cell replication: a revised model of human beta cell G1/S control An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state Generation of induced neurons via direct conversion in vivo Self-deployable current sources fabricated from edible materials Inflammatory bowel disease Nonxenogeneic growth and retinal differentiation of human induced pluripotent stem cells A localized Wnt signal orients asymmetric stem cell division in vitro Disparate individual fates compose robust CD8+ T cell immunity A molecular basis for the control of preimmune escape variants by HIV-specific CD8+ T cells Multifunctional T-cell analyses to study response and progression in adoptive cell transfer immunotherapy Four-part leukocyte differential count based on sheathless microflow cytometer and fluorescent dye assay Genes for endosomal NHE6 and NHE9 are misregulated in autism brains Induced pluripotent stem cell-derived neural cells survive and mature in the nonhuman primate brain Temperature sculpting in yoctoliter volumes Mini-chromosome maintenance complexes form a filament to remodel DNA structure and topology Secondary T cell–T cell synaptic interactions drive the differentiation of protective CD8+ T cells Cytolytic nanoparticles attenuate HIV-1 infectivity Targeting the intracellular WT1 oncogene product with a therapeutic human antibody The human gene connectome as a map of short cuts for morbid allele discovery Novel higher-order epigenetic regulation of the Bdnf gene upon seizures EBF2 determines and maintains brown adipocyte identity Synaptic plasticity by antidromic firing during hippocampal network oscillations Hyaluronic acid based self-assembling nanosystems for CD44 target mediated siRNA delivery to solid tumors Rab11 regulates cell–cell communication during collective cell movements Local potentiation of excitatory synapses by serotonin and its alteration in rodent models of depression Tumor VEGF:VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF Mesenchymal stem cells derived from adipose tissue vs bone marrow: in vitro comparison of their tropism towards gliomas Stromal cell-derived factor-1β mediates cell survival through enhancing autophagy in bone marrow-derived mesenchymal stem cells A KRAB/KAP1-miRNA cascade regulates erythropoiesis through stage-specific control of mitophagy Genome-wide study of association and interaction with maternal cytomegalovirus infection suggests new schizophrenia loci Outcomes of transplantation using various hematopoietic cell sources in children with Hurler's syndrome after myeloablative conditioning Mechanism of transport of saquinavir-loaded nanostructured lipid carriers across the intestinal barrier Dextran and protamine-based solid lipid nanoparticles as potential vectors for the treatment of X-linked juvenile retinoschisis Interplay of LRRK2 with chaperone-mediated autophagy Combination treatment of stroke with sub-therapeutic doses of Simvastatin and human umbilical cord blood cells enhances vascular remodeling and improves functional outcome Improvement in poor graft function after allogeneic hematopoietic stem cell transplantation upon administration of mesenchymal stem cells from third-party donors: a pilot prospective study Autologous bone marrow-derived cell therapy combined with physical therapy induces functional improvement in chronic spinal cord injury patients Bench to bedside review: Extracorporeal carbon dioxide removal, past present and future ‘See-saw’ expression of microRNA-198 and FSTL1 from a single transcript in wound healing Topical administration of allogeneic mesenchymal stem cells seeded in a collagen scaffold augments wound healing and increases angiogenesis in the diabetic rabbit ulcer Complement factor H variant increases the risk of age-related macular degeneration Seven new loci associated with age-related macular degeneration Role of ELOVL4 and very long-chain polyunsaturated fatty acids in mouse models of Stargardt type 3 retinal degeneration Relationship of age and body mass index to the expression of obesity and osteoarthritis-related genes in human meniscus Lipid metabolism genes in contralateral unaffected breast and estrogen receptor status of breast cancer Actin depolymerization under force is governed by lysine 113:glutamic acid 195-mediated catch-slip bonds Cell-free protein synthesis and assembly on a biochip Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice Independent category and spatial encoding in parietal cortex Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1 Dynamic regulatory network controlling TH17 cell differentiation An ex vivo gene therapy approach to treat muscular dystrophy using inducible pluripotent stem cells Class II major histocompatibility complex plays an essential role in obesity-induced adipose inflammation MCM proteins are negative regulators of hypoxia-inducible factor 1 Analysis of national and single-center incidence and survival after liver transplantation for hepatoblastoma: New trends and future opportunities Transferred WT1-reactive CD8+ T cells can mediate antileukemic activity and persist in post-transplant patients RNAi–based functional profiling of loci from blood lipid genome-wide association studies identifies genes with cholesterol-regulatory function Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer Jmjd3 inhibits reprogramming by upregulating expression of INK4a/Arf and targeting PHF20 for ubiquitination Seven new loci associated with age-related macular degeneration Biofilm streamers cause catastrophic disruption of flow with consequences for environmental and medical systems Development, characterization, and use of a porcine epiblast-derived liver stem cell line: ARS-PICM-19 Distinct contribution of human cord blood-derived endothelial colony forming cells to liver and gut in a fetal sheep model EphB2 isolates a human marrow stromal cell subpopulation with enhanced ability to contribute to the resident intestinal cellular pool High-fidelity tissue engineering of patient-specific auricles for reconstruction of pediatric microtia and other auricular deformities Virgin birth: engineered heart muscle from parthenogenetic stem cells Parthenogenetic stem cells for tissue-engineered heart repair A nontranscriptional role for HIF-1α as a direct inhibitor of DNA replication Cystoid macular edema in retinitis pigmentosa patients without associated macular thickening Acanthamoeba keratitis associated with tap water use during contact lens cleaning: manufacturer guidelines need to change Three-dimensional spectral-domain optical coherence tomography data analysis for glaucoma detection Immobilization of heparan sulfate on electrospun meshes to support embryonic stem cell culture and differentiation Sequencing of the sea lamprey (Petromyzon marinus) genome provides insights into vertebrate evolution Identification of stem cells in small intestine and colon by marker gene Lgr5 In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration Epigenomic plasticity enables human pancreatic α to β cell reprogramming Safety and efficacy of an injectable extracellular matrix hydrogel for treating myocardial infarction Brain cells for grandmother A pseudogene long-noncoding-RNA network regulates PTEN transcription and translation in human cells Tympanic border cells are Wnt-responsive and can act as progenitors for postnatal mouse cochlear cells An open-label dose escalation study to evaluate the safety of administration of nonviral stromal cell-derived factor-1 plasmid to treat symptomatic ischemic heart failure Polymer nanofiber-embedded microchips for detection, isolation, and molecular analysis of single circulating melanoma cells Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance Discovery and evaluation of a functional ternary polymer blend for bone repair: translation from a microarray to a clinical model Enhancing chemotherapy response with sustained EphA2 silencing using multistage vector delivery NANOG-dependent function of TET1 and TET2 in establishment of pluripotency Treatment of diabetes and long-term survival following insulin and glucokinase gene therapy Neural progenitors derived from human induced pluripotent stem cells survive and differentiate upon transplantation into a rat model of amyotrophic lateral sclerosis C-reactive protein and the incidence of macular degeneration—pooled analysis of 5 cohorts A cis-acting element in retroviral genomic RNA links Gag-Pol ribosomal frameshifting to selective viral RNA encapsidation Identification of genetic susceptibility loci for colorectal tumors in a genome-wide meta-analysis Regenerative biotechnological treatment Nanowire-based electrode for acute in vivo neural recordings in the brain Subretinal electronic chips allow blind patients to read letters and combine them to words Artificial vision with wirelessly powered subretinal electronic implant alpha-IMS FMRP regulates neurotransmitter release and synaptic information transmission by modulating action potential duration via BK channels The epithelial-mesenchymal transition generates cells with properties of stem cells FOXC2 expression links epithelial-mesenchymal transition and stem cell properties in breast cancer FOXO3A directs a protective autophagy program in haematopoietic stem cells A heparin-mimicking polymer conjugate stabilizes basic fibroblast growth factor Long noncoding RNAs with enhancer-like function in human cells Activating RNAs associate with Mediator to enhance chromatin architecture and transcription Perivascular mesenchymal progenitors in human fetal and adult liver Fbxl10/Kdm2b recruits polycomb repressive complex 1 to CpG islands and regulates H2A ubiquitylation Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy Expression profiling of mouse subplate reveals a dynamic gene network and disease association with autism and schizophrenia Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia Transferring a synthetic gene circuit from yeast to mammalian cells Synthetic circuits integrating logic and memory in living cells Tcf15 primes pluripotent cells for differentiation Cotransplantation with specific populations of spina bifida bone marrow stem/progenitor cells enhances urinary bladder regeneration Mixed modeling of meta-analysis p-values (MixMAP) suggests multiple novel gene loci for low density lipoprotein cholesterol Cellular complexity captured in durable silica biocomposites Inhibition of JNK mitochondrial localization and signaling is protective against ischemia/reperfusion injury in rats Degradable polymeric nanocapsule for efficient intracellular delivery of a high molecular weight tumor-selective protein complex Extracting intracellular diffusive states and transition rates from single-molecule tracking data Calmodulin mutations associated with recurrent cardiac arrest in infants Long noncoding RNAs regulate adipogenesis Mitochondrial hyperfusion induced by loss of the fission protein Drp1 causes ATM-dependent G2/M arrest and aneuploidy through DNA replication stress Evolutionary rate covariation in meiotic proteins results from fluctuating evolutionary pressure in yeasts and mammals Ras oncoproteins transfer from melanoma cells to T Cells and modulate their effector functions Lgr5-EGFP marks taste bud stem/progenitor cells in posterior tongue Transplanted progenitors generate functional enteric neurons in the postnatal colon Targeting CXCR1/2 significantly reduces breast cancer stem cell activity and increases the efficacy of inhibiting HER2 via HER2-dependent and -independent mechanisms Epidermal growth factor regulates hematopoietic regeneration after radiation injury The effect of the composition of PLA films and lactate release on glial and neuronal maturation and the maintenance of the neuronal progenitor niche Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination Landscape of somatic single-nucleotide and copy-number mutations in uterine serous carcinoma GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression CD271+ bone marrow mesenchymal stem cells may provide a niche for dormant mycobacterium tuberculosis Control of nutrient stress-induced metabolic reprogramming by PKCζ in tumorigenesis Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs Mps1 and Ipl1/Aurora B act sequentially to correctly orient chromosomes on the meiotic spindle of budding yeast An electrocorticographic brain interface in an individual with tetraplegia Comparative analysis of circulating endothelial progenitor cells in age-related macular degeneration patients using automated rare cell analysis (ARCA) and fluorescence activated cell sorting (FACS) LBR and Lamin A/C sequentially tether peripheral heterochromatin and inversely regulate differentiation Acidity generated by the tumor microenvironment drives local invasion A role for Schwann cell–derived neuregulin-1 in remyelination Effects of intravenous administration of allogenic bone marrow- and adipose tissue-derived mesenchymal stem cells on functional recovery and brain repair markers in experimental ischemic stroke Neuregulin-1 enhances depolarization-induced GABA release Erbin interacts with TARP γ-2 for surface expression of AMPA receptors in cortical interneurons Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements The potential of apolipoprotein E4 to act as a substrate for primary cultures of hippocampal neurons Immunogenicity of induced pluripotent stem cells Lack of immune response to differentiated cells derived from syngeneic induced pluripotent stem cells Significance analysis of prognostic signatures Schizophrenia: A neurodevelopmental disorder — Integrative genomic hypothesis and therapeutic implications from a transgenic mouse model Quantitative visualization of DNA G-quadruplex structures in human cells Differential effects of grape seed extract against human colorectal cancer cell lines: The intricate role of death receptors and mitochondria Reprogramming adult schwann cells to stem cell-like cells by leprosy bacilli promotes dissemination of infection BRCA1 loss activates cathepsin L–mediated degradation of 53BP1 in breast cancer cells Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis Population dynamics of normal and leukaemia stem cells in the haematopoietic stem cell niche show distinct regimes where leukaemia will be controlled Uracil DNA glycosylase initiates degradation of HIV-1 cDNA containing misincorporated dUTP and prevents viral integration Braveheart, a long noncoding RNA required for cardiovascular lineage commitment Prenatal cerebral ischemia disrupts MRI-defined cortical microstructure through disturbances in neuronal arborization Human retinal gene therapy for Leber congenital amaurosis shows advancing retinal degeneration despite enduring visual improvement RYBP and Cbx7 define specific biological functions of polycomb complexes in mouse embryonic stem cells Generation of an HIV resistant T-cell line by targeted “stacking” of restriction factors Relationship of aspirin use with age-related macular degeneration: association or causation? The association of aspirin use with age-related macular degeneration The 510(k) ancestry of a metal-on-metal hip implant Interstitial dendritic cell guidance by haptotactic chemokine gradients Cardiomyocyte proliferation contributes to heart growth in young humans A thermoresponsive and chemically defined hydrogel for long-term culture of human embryonic stem cells Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury The 2013 International Society for Heart and Lung Transplantation guidelines for mechanical circulatory support: executive summary Injection of vessel-derived stem cells prevents dilated cardiomyopathy and promotes angiogenesis and endogenous cardiac stem cell proliferation in mdx/utrn−/− but not aged mdx mouse models for Duchenne muscular dystrophy Anticancer activity of rice callus suspension culture Microdystrophin ameliorates muscular dystrophy in the canine model of Duchenne muscular dystrophy Mutation of a NCKX eliminates glial microdomain calcium oscillations and enhances seizure susceptibility Transcriptional reprogramming of mature CD4+ helper T cells generates distinct MHC class II–restricted cytotoxic T lymphocytes Sickle erythrocytes target cytotoxics to hypoxic tumor microvessels and potentiate a tumoricidal response Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus Dynamic chromatin remodeling mediated by polycomb proteins orchestrates pancreatic differentiation of human embryonic stem cells Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy A pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition MHC class I–restricted myelin epitopes are cross-presented by Tip-DCs that promote determinant spreading to CD8+ T cells The impact of Crohn's disease genes on healthy human gut microbiota: a pilot study The cytoplasm of living cells behaves as a poroelastic material Evaluation of the cell viability of human wharton's jelly stem cells for use in cell therapy Abnormal fixation in individuals with age-related macular degeneration when viewing an image of a face Endothelial reconstitution by CD34+ progenitors derived from baboon embryonic stem cells Reversal of end-stage retinal degeneration and restoration of visual function by photoreceptor transplantation MUC1 vaccine for individuals with advanced adenoma of the colon: a cancer immunoprevention feasibility study Retinal vessel caliber is associated with the 10-year incidence of glaucoma In vivo cardiac cellular reprogramming efficacy is enhanced by angiogenic preconditioning of the infarcted myocardium with vascular endothelial growth factor Engineering cell surfaces for orthogonal selectability Sickle erythrocytes target cytotoxics to hypoxic tumor microvessels and potentiate a tumoricidal response Dielectrophoresis based discrimination of human embryonic stem cells from differentiating derivatives CXCR5+ T helper cells mediate protective immunity against tuberculosis Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits A subpopulation of nociceptors specifically linked to itch RNA processing enables predictable programming of gene expression A programmable dual-RNA–guided DNA endonuclease in adaptive bacterial immunity Multiplex genome engineering using CRISPR/Cas systems RNA-guided human genome engineering via Cas9 Notch inhibition induces cochlear hair cell regeneration and recovery of hearing after acoustic trauma Exposure to a cutinase-like serine esterase triggers rapid lysis of multiple mycobacterial species Reconfigurable assemblies of active, autochemotactic gels Comparison of proliferative capacity of genetically-engineered pig and human corneal endothelial cells Klf4 regulates the expression of slurp1, which functions as an immunomodulatory Peptide in the mouse cornea High dynamic range (HDR) imaging concept based signal enhancement method reduced the optical coherence tomography (OCT) measurement variability Detection of glaucoma progression by population and individual derived variability criteria Regeneration of human tumor antigen-specific T cells from iPSCs derived from mature CD8+ T cells Generation of rejuvenated antigen-specific T cells by reprogramming to pluripotency and redifferentiation Maternal serum 25-hydroxyvitamin d and measures of newborn and placental weight in a U.S. multicenter cohort study How insulin engages its primary binding site on the insulin receptor Common variants in psychiatric risk genes predict brain structure at birth Functional characterization of piggyBat from the bat Myotis lucifugus unveils an active mammalian DNA transposon Expression of RORγt marks a pathogenic regulatory T cell subset in human colon cancer Refinement in localization and identification of gene regions associated with Crohn Disease Multimodal actions of neural stem cells in a mouse model of ALS: a meta-analysis PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets Spikes in mammalian bipolar cells support temporal layering of the inner retina Reactivation of neural ensembles during the retrieval of recent and remote memory Capture and stimulated release of circulating tumor cells on polymer-grafted silicon nanostructures Long-term safety and efficacy of human-induced pluripotent stem cell (iPS) grafts in a preclinical model of retinitis pigmentosa Gene therapy provides long-term visual function in a pre-clinical model of retinitis pigmentosa Race and ethnicity in decisions about unrelated hematopoietic stem cell donation Differential susceptibility of inbred mouse strains to chlorine-induced airway fibrosis Comorbidity in patients with branch retinal vein occlusion: case-control study Cord-blood engraftment with ex vivo mesenchymal-cell coculture Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes Cell-extrinsic effects of tumor ER stress imprint myeloid dendritic cells and impair CD8+ T cell priming ATP sequestration by a synthetic ATP-binding protein leads to novel phenotypic changes in Escherichia coli Parkin ubiquitinates Tar-DNA binding protein-43 (TDP-43) and promotes its cytosolic accumulation via interaction with histone deacetylase 6 (HDAC6) Circulatory antigen processing by mucosal dendritic cells controls CD8+ T cell activation Dystroglycan organizes axon guidance cue localization and axonal pathfinding Brown adipose tissue regulates glucose homeostasis and insulin sensitivity The isolation and characterization of renal cancer initiating cells from human Wilms' tumour xenografts unveils new therapeutic targets Competing and noncompeting activities of miR-122 and the 5' exonuclease Xrn1 in regulation of hepatitis C virus replication The RNA Pol II elongation factor Ell3 marks enhancers in ES cells and primes future gene activation Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18 Long-term follow-up assessment of a phase 1 trial of angiogenic gene therapy using direct intramyocardial administration of an adenoviral vector expressing the VEGF121 cDNA for the treatment of diffuse coronary artery disease Role of km23-1 in RhoA/actin-based cell migration A novel alternative to cryo-preservation for the short term storage of stem cells for use in cell therapy using alginate encapsulation Long-term follow-up after gene therapy for Canavan disease Multiphoton imaging reveals a new leukocyte recruitment paradigm in the glomerulus Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells Derivation and maturation of synthetic and contractile vascular smooth muscle cells from human pluripotent stem cells Nonmuscle myosin IIB links cytoskeleton to IRE1α signaling during ER stress Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues Engineering antigens for in situ erythrocyte binding induces T-cell deletion FMRP targets distinct mRNA sequence elements to regulate protein expression Blockade of myeloid-derived suppressor cells after induction of lymphopenia improves adoptive T cell therapy in a murine model of melanoma Human coronavirus EMC does not require the SARS-coronavirus receptor and maintains broad replicative capability in mammalian cell lines Alkylation sensitivity screens reveal a conserved cross-species functionome Nanoroughened surfaces for efficient capture of circulating tumor cells without using capture antibodies Salmonella transforms follicle-associated epithelial cells into M cells to promote intestinal invasion The structural basis of direct glucocorticoid-mediated transrepression Highly conductive carbon nanotube matrix accelerates developmental chloride extrusion in central nervous system neurons by increased expression of chloride transporter KCC2 Cell-specific multifunctional processing of heterogeneous cell systems in a single laser pulse treatment Influence of water on the structure and properties of PDMS-containing multiblock polyurethanes Simple precision creation of digitally specified, spatially heterogeneous, engineered tissue architectures Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception Large-scale screening using familial dysautonomia induced pluripotent stem cells identifies compounds that rescue IKBKAP expression Sustained effector function of IL-12/15/18–preactivated NK cells against established tumors Use of reprogrammed cells to identify therapy for respiratory papillomatosis Conditionally reprogrammed cells represent a stem-like state of adult epithelial cells Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1 Co-Injection of a targeted, reversibly masked endosomolytic polymer dramatically improves the efficacy of cholesterol-conjugated small interfering RNAs in vivo Biasing amacrine subtypes in the Atoh7 lineage through expression of Barhl2 Autologous mesenchymal stem cell–derived dopaminergic neurons function in parkinsonian macaques Creating a bio-hybrid signal transduction pathway: opening a new channel of communication between cells and machines Prostaglandin e2 increases hematopoietic stem cell survival and accelerates hematopoietic recovery after radiation injury MEF promotes stemness in the pathogenesis of gliomas p27Kip1 directly represses Sox2 during embryonic stem cell differentiation Delayed saccadic eye movements in glaucoma Critical microcarrier properties affecting the expansion of undifferentiated human embryonic stem cells Microcarrier suspension cultures for high-density expansion and differentiation of human pluripotent stem cells to neural progenitor cells Aged human cells rejuvenated by cytokine enhancement of biomaterials for surgical ventricular restoration Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation Longitudinal outcome of isolated mitral repair in older patients: results from 14,604 procedures performed from 1991 to 2007 A versatile synthetic platform for a wide range of functionalized biomaterials Substantial expression of mature elastin in arterial constructs High-performance neuroprosthetic control by an individual with tetraplegia Intermittent fasting: A “new” historical strategy for controlling seizures? Generation of integration-free neural progenitor cells from cells in human urine Sustained effector function of IL-12/15/18–preactivated NK cells against established tumors Autologous mesenchymal stem cell–derived dopaminergic neurons function in parkinsonian macaques Short-term, long-term and paracrine effect of human umbilical cord-derived stem cells in lung injury prevention and repair in experimental bronchopulmonary dysplasia Prolonged strenuous exercise expands the population of developmentally early stem cells in bone marrow & mobilizes them into peripheral blood - evidence...supports a positive effect of physical activity on extension of life span at the level of stem cells No survival advantage after double umbilical cord blood (UCB) compared to single UCB transplant in children with hematological malignancy: results of the blood and marrow transplant clinical trials network (BMT CTN 0501) randomized trial Targeting histone deacetylases as a new strategy for graft versus host disease prevention Injectable polyethylene glycol-fibrinogen hydrogel adjuvant improves survival and differentiation of transplanted mesoangioblasts in acute and chronic skeletal-muscle degeneration Transposable elements reveal a stem cell specific class of long noncoding RNAs Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression Prevalence and predictors of Sjögren's syndrome in a prospective cohort of patients with aqueous-deficient dry eye Topical simvastatin accelerates wound healing in diabetes by enhancing angiogenesis and lymphangiogenesis Motor recovery after spinal cord injury enhanced by strengthening corticospinal synaptic transmission Intramyocardial injections of human mesenchymal stem cells following acute myocardial infarction modulate scar formation and improve left ventricular function Human induced pluripotent stem cell-derived models to investigate human cytomegalovirus infection in neural cells ER stress–mediated autophagy promotes Myc-dependent transformation and tumor growth Hybrid printing of mechanically and biologically improved constructs for cartilage tissue engineering applications Single-cell-resolution imaging of the impact of notch signaling and mitosis on segmentation clock dynamics Robust photoregulation of GABAA receptors by allosteric modulation with a propofol analogue Epigenetic regulation of olfactory receptor gene expression by the Myb–MuvB/dREAM complex De novo derivation of proteomes from transcriptomes for transcript and protein identification Facilitators and impediments of the pluripotency reprogramming factors' initial engagement with the genome A human disease model of drug toxicity–induced pulmonary edema in a lung-on-a-chip microdevice A novel role for lipid droplets in the organismal antibacterial response Long noncoding RNAs with snoRNA ends Critical variables in the alignment of electrospun PLLA nanofibers Combining topographical and genetic cues to promote neuronal fate specification in stem cells A culture system to study oligodendrocyte myelination processes using engineered nanofibers Vitamin D receptor as a master regulator of the c-MYC/MXD1 network MicroRNAs reprogram normal fibroblasts into cancer-associated fibroblasts in ovarian cancer Characterization and therapeutic potential of induced pluripotent stem cell-derived cardiovascular progenitor cells Planar cell polarity controls pancreatic beta cell differentiation and glucose homeostasis Autologous olfactory mucosal cell transplants in clinical spinal cord injury: a randomized double-blinded trial in a canine translational model Printing and prototyping of tissues and scaffolds Systemic TNFα gene therapy synergizes with liposomal doxorubicine in the treatment of metastatic cancer Use of reprogrammed cells to identify therapy for respiratory papillomatosis Conditionally reprogrammed cells represent a stem-like state of adult epithelial cells Adult pancreas side population cells expand after β cell injury and are a source of insulin-secreting cells High-frequency hippocampal oscillations activated by optogenetic stimulation of transplanted human ESC-derived neurons iPS cell modeling of Best disease: insights into the pathophysiology of an inherited macular degeneration Injectable preformed scaffolds with shape-memory properties In vivo directed differentiation of pluripotent stem cells for skeletal regeneration Continued DNA synthesis in replication checkpoint mutants leads to fork collapse Manipulation of PK-M mutually exclusive alternative splicing by antisense oligonucleotides Phenotypic and functional characterization of the luminal cell hierarchy of the mammary gland Fat grafting’s past, present, and future-why adipose tissue is emerging as a critical link to the advancement of regenerative medicine HIRA dependent H3.3 deposition is required for transcriptional reprogramming following nuclear transfer to Xenopus oocytes Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes Lgr5+ve stem/progenitor cells contribute to nephron formation during kidney development Exosomes mediate the cytoprotective action of mesenchymal stromal cells on hypoxia-induced pulmonary hypertension BMP4 sufficiency to induce choroid plexus epithelial fate from embryonic stem cell-derived neuroepithelial progenitors Attenuation of miR-126 activity expands HSC in vivo without exhaustion Stem cell therapy in equine tendon injury Cartilage tissue engineering using differentiated and purified induced pluripotent stem cells Targeting glioma stem cells by functional inhibition of a prosurvival oncomiR-138 in malignant gliomas A bimodular mechanism of calcium control in eukaryotes The genomic landscape and evolutionary resolution of antagonistic pleiotropy in yeast Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis Mitochondrial gene replacement in primate offspring and embryonic stem cells Towards germline gene therapy of inherited mitochondrial diseases ECM microenvironment regulates collective migration and local dissemination in normal and malignant mammary epithelium Regulation of pluripotency and self- renewal of ESCs through epigenetic- threshold modulation and mRNA pruning Improved working memory but no effect on striatal vesicular monoamine transporter type 2 after omega-3 polyunsaturated fatty acid supplementation Patterns of scAAV vector insertion associated with oncogenic events in a mouse model for genotoxicity Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth Generation of functional blood vessels from a single c-kit+ adult vascular endothelial stem cell The ydaO motif is an ATP-sensing riboswitch in Bacillus subtilis Glial progenitor cell–based treatment and modeling of neurological disease N-WASP coordinates the delivery and F-actin–mediated capture of MT1-MMP at invasive pseudopods Efficient direct reprogramming of mature amniotic cells into endothelial cells by ETS factors and TGFβ suppression Circadian Dbp transcription relies on highly dynamic BMAL1-CLOCK interaction with E boxes and requires the proteasome Peripheral-blood stem cells versus bone marrow from unrelated donors Adoptive transfer of cytotoxic T lymphocytes targeting two different antigens limits antigen loss and tumor escape Recognition of glioma stem cells by genetically modified T cells targeting EGFRvIII and development of adoptive cell therapy for glioma Efficacy of adoptive cell transfer of tumor-infiltrating lymphocytes after lymphopenia induction for metastatic melanoma Spermatogonial stem cell transplantation into rhesus testes regenerates spermatogenesis producing functional sperm Synthetic zinc finger repressors reduce mutant huntingtin expression in the brain of R6/2 mice In vivo maturation of functional renal organoids formed from embryonic cell suspensions Ultrasound-induced release of micropallets with cells Grp94 triage of mutant myocilin through ERAD subverts a more efficient autophagic clearance mechanism Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions Induced pluripotent stem cell model recapitulates pathologic hallmarks of Gaucher disease Magnetic nanoparticle–mediated massively parallel mechanical modulation of single-cell behavior DNA self-assembly of targeted near-infrared-responsive gold nanoparticles for cancer thermo-chemotherapy Generation of functional thyroid from embryonic stem cells Imaging neural activity using Thy1-GCaMP transgenic mice Characterization of the inflammatory response to solid cancer metastases in the human brain Histopathological correlates of magnetic resonance imaging–defined chronic perinatal white matter injury Neural stem cell engraftment and myelination in the human brain Human neural stem cells induce functional myelination in mice with severe dysmyelination Pursuing the goal of a donor for everyone in need Use of reprogrammed cells to identify therapy for respiratory papillomatosis ROCK inhibitor and feeder cells induce the conditional reprogramming of epithelial cells Cardiovascular risk factors in hematopoietic cell transplantation (HCT) survivors: role in development of subsequent cardiovascular disease Human very small embryonic-like cells generate skeletal structures, in vivo Apoptotic susceptibility to DNA damage of pluripotent stem cells facilitates pharmacologic purging of teratoma risk IFNγR signaling mediates alloreactive T cell trafficking and GvHD Genetic programs constructed from layered logic gates in single cells Offspring from oocytes derived from in vitro primordial germ cell–like cells in mice Reprogramming of pericyte-derived cells of the adult human brain into induced neuronal cells DNA methylation plasticity of human adipose-derived stem cells in lineage commitment New susceptibility loci associated with kidney disease in type 1 diabetes A stable cranial neural crest cell line from mouse Longitudinal trends in resource use in an incident cohort of open-angle glaucoma patients: resource use in open-angle glaucoma Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation A combinatorial extracellular matrix platform identifies cell-extracellular matrix interactions that correlate with metastasis In vivo-validated essential genes identified in Acinetobacter baumannii by using human ascites overlap poorly with essential genes detected on laboratory media Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase Micro glass ball embedded gels to study cell mechanobiological responses to substrate curvatures Long-distance growth and connectivity of neural stem cells after severe spinal cord injury Identification of a specific reprogramming-associated epigenetic signature in human induced pluripotent stem cells Differentiation of mouse pancreatic stem cells into insulin-producing cells by recombinant sendai virus-mediated gene transfer technology Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production A strong regenerative ability of cardiac stem cells derived from neonatal hearts Adiponectin gene therapy ameliorates high-fat, high-sucrose diet-induced metabolic perturbations in mice A kinase inhibitor screen identifies small-molecule enhancers of reprogramming and iPS cell generation Dynamic and coordinated epigenetic regulation of developmental transitions in the cardiac lineage Restoration of auditory evoked responses by human ES-cell-derived otic progenitors Controlling spatial organization of multiple cell types in defined 3D geometries Cancer regression in patients after transfer of genetically engineered lymphocytes Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia T cells engineered with a T cell receptor against the prostate antigen TARP specifically kill HLA-A2+ prostate and breast cancer cells Induced pluripotency and oncogenic transformation are related processes Distinct contribution of stem and progenitor cells to epidermal maintenance Predicting the diagnosis of autism spectrum disorder using gene pathway analysis Identifying metalloproteins through X-ray fluorescence mapping and mass spectrometry Mesenchymal stem cell transplantation improves regional cardiac remodeling following ovine infarction Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer δ-Catenin is genetically and biologically associated with cortical cataract and future alzheimer-related structural and functional brain changes Diminished temporal coding with sensorineural hearing loss emerges in background noise Fasting enhances the response of glioma to chemo- and radiotherapy A dense poly(ethylene glycol) coating improves penetration of large polymeric nanoparticles within brain tissue Gene therapy for adenosine deaminase-deficient severe combined immune deficiency: clinical comparison of retroviral vectors and treatment plans Live-cell, temporal gene expression analysis of osteogenic differentiation in adipose-derived stem cells Myocardial protection, perioperative management, and vascular biology Wireless power transfer to a cardiac implant Initiation of transcription-coupled repair characterized at single-molecule resolution Identification, proliferation, and differentiation of adult leydig stem cells NR4A nuclear receptors support memory enhancement by histone deacetylase inhibitors Population-based case-control study of recreational drug use and testis cancer risk confirms an association between marijuana use and nonseminoma risk Suppression of acquired docetaxel resistance in prostate cancer through depletion of notch- and hedgehog-dependent tumor-initiating cells Cis-element mutated in GATA2-dependent immunodeficiency governs hematopoiesis and vascular integrity Flow-regulated endothelial S1P receptor-1 signaling sustains vascular development Direct reprogramming of fibroblasts into embryonic sertoli-like cells by defined factors An RNA virus hijacks an incognito function of a DNA repair enzyme LIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma The BH3-only proteins Bim and Puma cooperate to impose deletional tolerance of organ-specific antigens The sirtuin SIRT6 regulates lifespan in male mice Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence Antitumor activity of the tea polyphenol epigallocatechin-3-gallate encapsulated in targeted vesicles after intravenous administration Amputation induces stem cell mobilization to sites of injury during planarian regeneration Nanostructuring platinum nanoparticles on multilayered graphene petal nanosheets for electrochemical biosensing ALDH1A isozymes are markers of human melanoma stem cells and potential therapeutic targets Gene therapy rescues cilia defects and restores olfactory function in a mammalian ciliopathy model Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein Virus-mediated shRNA knockdown of Nav1.3 in rat dorsal root ganglion attenuates nerve injury-induced neuropathic pain Macroporous nanowire nanoelectronic scaffolds for synthetic tissues Formation and optogenetic control of engineered 3D skeletal muscle bioactuators Lymphoid priming in human bone marrow begins before expression of CD10 with upregulation of L-selectin Multifaceted roles of PTEN and TSC orchestrate growth and differentiation of Drosophila blood progenitors Effect of plasmodial RESA protein on deformability of human red blood cells harboring Plasmodium falciparum Pf155/RESA protein influences the dynamic microcirculatory behavior of ring-stage Plasmodium falciparum infected red blood cells Adipose stem cells can secrete angiogenic factors that inhibit hyaline cartilage regeneration Improving dendritic cell vaccine immunogenicity by silencing PD-1 ligands using siRNA-lipid nanoparticles combined with antigen mRNA electroporation Functionalized, biodegradable hydrogels for control over sustained and localized siRNA delivery to incorporated and surrounding cells Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia Differential trafficking of transport vesicles contributes to the localization of dendritic proteins A universal system for highly efficient cardiac differentiation of human induced pluripotent stem cells that eliminates interline variability Growth factor-activated stem cell circuits and stromal signals cooperatively accelerate non-integrated iPSC reprogramming of human myeloid progenitors Set2 methylation of histone H3 lysine 36 suppresses histone exchange on transcribed genes Partial nerve injury induces electrophysiological changes in conducting (uninjured) nociceptive and nonnociceptive DRG neurons: Possible relationships to aspects of peripheral neuropathic pain and paresthesias Deletion of claudin-10 (Cldn10) in the thick ascending limb impairs paracellular sodium permeability and leads to hypermagnesemia and nephrocalcinosis TrxG and PcG proteins but not methylated histones remain associated with DNA through replication Targeted tumor-penetrating siRNA nanocomplexes for credentialing the ovarian cancer oncogene ID4 Continuous 24-Hour monitoring of intraocular pressure patterns with a contact lens sensor Hypoxia promotes satellite cell self-renewal and enhances the efficiency of myoblast transplantation The mouse lymph node as an ectopic transplantation site for multiple tissues Intestinal inflammation targets cancer-inducing activity of the microbiota Human amniotic fluid stem cell injection therapy for urethral sphincter regeneration in an animal model Instructive nanofiber scaffolds with VEGF create a microenvironment for arteriogenesis and cardiac repair Synthetic riboswitches for external regulation of genes transferred by replication-deficient and oncolytic adenoviruses A voltage-gated sodium channel is essential for the positive selection of CD4+ T cells Phase I trial of a multi-epitope-pulsed dendritic cell vaccine for patients with newly diagnosed glioblastoma The histone acetyltransferase MOF is a key regulator of the embryonic stem cell core transcriptional network Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase Feeder cells support the culture of induced pluripotent stem cells even after chemical fixation Serum- and stromal cell-free hypoxic generation of embryonic stem cell-derived hematopoietic cells in vitro, capable of multilineage repopulation of immunocompetent mice Intra-articular delivery of purified mesenchymal stem cells from C57BL/6 or MRL/MpJ superhealer mice prevents post-traumatic arthritis First-in-human trial of a STAT3 decoy oligonucleotide in head and neck tumors: implications for cancer therapy Novel, high-yield red blood cell production methods from CD34-positive cells derived from human embryonic stem, yolk sac, fetal liver, cord blood, and peripheral blood Transforming fusions of FGFR and TACC genes in human glioblastoma Proteasome inhibition alleviates SNARE-dependent neurodegeneration Sacrificial nanofibrous composites provide instruction without impediment and enable functional tissue formation Improvements in the life expectancy of type 1 diabetes: The Pittsburgh Epidemiology of Diabetes Complications Study cohort Nicotinamide adenine dinucleotide phosphate oxidase (nox) in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent Energy-dependent modulation of glucagon-like signaling in Drosophila via the AMP-activated protein kinase FAM83A and FAM83B: candidate oncogenes and TKI resistance mediators FAM83A confers EGFR-TKI resistance in breast cancer cells and in mice FAM83B mediates EGFR- and RAS-driven oncogenic transformation Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signaling Fate-restricted neural progenitors in the mammalian cerebral cortex Mosaic hydrogels: one-step formation of multiscale soft materials Spray-applied cell therapy with human allogeneic fibroblasts and keratinocytes for the treatment of chronic venous leg ulcers: a phase 2, multicentre, double-blind, randomised, placebo-controlled trial Randomized, controlled trial of a sustained delivery formulation of 5-fluorouracil for the treatment of failing blebs Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling Novel atypical PKC inhibitors prevent vascular endothelial growth factor-induced blood–retinal barrier dysfunction The intermediate filament vimentin regulates chondrogenesis of adult human bone marrow-derived multipotent progenitor cells Direct differentiation of human pluripotent stem cells into haploid spermatogenic cells Lipidomics identifies cardiolipin oxidation as a mitochondrial target for redox therapy of brain injury Rationally designed controlled release systems for periodontal disease that promote immunological homeostasis New reservoirs of HLA alleles: pools of rare variants enhance immune defense 1α,25-dihydroxyvitamin D3 modulates the hair-inductive capacity of dermal papilla cells: therapeutic potential for hair regeneration Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts Transcription activator-like effector proteins induce the expression of the Frataxin gene Human apolipoprotein E peptides inhibit hepatitis C virus entry by blocking virus binding RhoC impacts the metastatic potential and abundance of breast cancer stem cells Direct observation of mammalian cell growth and size regulation Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision The mitochondrial targeting chaperone 14-3-3 regulates a RIG-I translocon that mediates membrane association and innate antiviral immunity The RIG-I-like receptor LGP2 controls CD8+ T cell survival and fitness Transcription activator-like effector proteins induce the expression of the Frataxin gene Stat3-mediated activation of microRNA-23a suppresses gluconeogenesis in hepatocellular carcinoma by down-regulating glucose-6-phosphatase and peroxisome proliferator-activated receptor gamma, coactivator 1 alpha Restoration of hearing in the VGLUT3 knockout mouse using virally mediated gene therapy Cord blood-derived neuronal cells by ectopic expression of Sox2 and c-Myc Microwave sintering and in vitro study of defect-free stable porous multilayered HAp–ZrO2 artificial bone scaffold Stem cell therapy for craniofacial bone regeneration: a randomized, controlled, feasibility trial A tissue-engineered jellyfish with biomimetic propulsion Subnetwork-based analysis of chronic lymphocytic leukemia identifies pathways that associate with disease progression c-kit+ precursors support postinfarction myogenesis in the neonatal, but not adult, heart Bioresorbable bone graft substitutes of different osteoconductivities: a histologic evaluation of osteointegration of poly(propylene glycol-co-fumaric acid)-based cement implants in rats Innovative collagen nano-hydroxyapatite scaffolds offer a highly efficient non-viral gene delivery platform for stem cell-mediated bone formation OX40 signaling favors the induction of TH9 cells and airway inflammation Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche The GCTM-5 epitope associated with the mucin-like glycoprotein FCGBP marks progenitor cells in tissues of endodermal origin Cholangiocarcinomas can originate from hepatocytes in mice Paracrine signalling events in embryonic stem cell renewal mediated by affinity targeted nanoparticles Robust tumor immunity to melanoma mediated by interleukin-9–producing T cells Dominance of the CD4+ T helper cell response during acute resolving hepatitis A virus infection Activation of an IL6 inflammatory loop mediates trastuzumab resistance in HER2+ breast cancer by expanding the cancer stem cell population Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson’s Disease Gain and loss of multiple functionally related, horizontally transferred genes in the reduced genomes of two microsporidian parasites Histone modifications and lamin A regulate chromatin protein dynamics in early embryonic stem cell differentiation Rational design of cationic lipids for siRNA delivery Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo Asthmatic granulomatosis: a novel disease with asthmatic and granulomatous features High-definition fiber tractography of the human brain: neuroanatomical validation and neurosurgical applications Direct central nervous system delivery provides enhanced protection following vector mediated gene replacement in a severe model of Spinal Muscular Atrophy Glycerol supplementation enhances L. reuteri’s protective effect against S. Typhimurium colonization in a 3-D model of colonic epithelium Combination delivery of TGF-β inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumour immunotherapy Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53 The LIM protein Ajuba restricts the second heart field progenitor pool by regulating Isl1 activity Anti-inflammatory mesenchymal stem cells (MSC2) attenuate symptoms of painful diabetic peripheral neuropathy Ultraviolet radiation damages self noncoding RNA and is detected by TLR3 Aneuploidy as a mechanism for stress-induced liver adaptation Novel vascular endothelial growth factor gene delivery system-manipulated mesenchymal stem cells repair infarcted myocardium Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway Sequencing chromosomal abnormalities reveals neurodevelopmental loci that confer risk across diagnostic boundaries Oligodendroglia metabolically support axons and contribute to neurodegeneration Properties of mechano-transduction via simulated microgravity and its effects on intracellular trafficking of VEGFR’s Induced pluripotent stem cells from patients with Huntington's disease show CAG-repeat-expansion-associated phenotypes Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson’s disease Histone demethylases KDM4B and KDM6B promotes osteogenic differentiation of human MSCs Derivation conditions impact X-inactivation status in female human induced pluripotent stem cells High-throughput single-microparticle imaging flow analyzer Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human Long-term remission of diabetes in NOD mice is induced by nondepleting anti-CD4 and anti-CD8 antibodies Topical delivery of siRNA-based spherical nucleic acid nanoparticle conjugates for gene regulation Valproic acid confers functional pluripotency to human amniotic fluid stem cells in a transgene-free approach Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues Targeted gene knockout by direct delivery of zinc-finger nuclease proteins Reprogramming of tRNA modifications controls the oxidative stress response by codon-biased translation of proteins Adoptive transfer of immunomodulatory M2 macrophages prevents type 1 diabetes in NOD mice Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study Adult hematopoietic progenitors are multipotent in chimeric mice Follicular dendritic cells emerge from ubiquitous perivascular precursors Soft fibrin gels promote selection and growth of tumorigenic cells Manual wheelchair skills capacity predicts quality of life and community integration in persons with spinal cord injury Neo-vascularization of the stroke cavity by implantation of human neural stem cells on VEGF-releasing PLGA microparticles Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation Increased asymmetric and multi-daughter cell division in mechanically confined microenvironments Serum apolipoproteins are associated with systemic and retinal microvascular function in people with diabetes DNA methylome signature in rheumatoid arthritis Transplantation of genetically corrected human iPSC-derived progenitors in mice with limb-girdle Muscular Dystrophy Induced pluripotent stem cells from patients with Huntington's Disease show CAG-repeat-expansion-associated phenotypes Synthetic homeostatic materials with chemo-mechano-chemical self-regulation Endoscopic therapy is effective for patients with chronic pancreatitis Maturation of human embryonic stem cell–derived pancreatic progenitors into functional islets capable of treating pre-existing diabetes in mice Production and implantation of renal extracellular matrix scaffolds from porcine kidneys as a platform for renal bioengineering investigations De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly Can magnetic targeting of magnetically labeled circulating cells optimize intramyocardial cell retention? Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death Id proteins synchronize stemness and anchorage to the niche of neural stem cells Fates of murine pluripotent stem cell-derived neural progenitors following transplantation into mouse cochleae Induced pluripotent stem cells from patients with Huntington's disease show CAG-repeat-expansion-associated phenotypes Genetic correction of Huntington's disease phenotypes in induced pluripotent stem cells Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes Induced pluripotent stem cells from a spinal muscular atrophy patient Inhibition of apoptosis blocks human motor neuron cell death in a stem cell model of spinal muscular atrophy MicroRNA profiling of carcinogen-induced rat colon tumors and the influence of dietary spinach Embryonic stem cell potency fluctuates with endogenous retrovirus activity Self-formation of optic cups and storable stratified neural retina from human ESCs Simultaneous voltage and calcium mapping of genetically purified human induced pluripotent stem cell–derived cardiac myocyte monolayers Targeted delivery of PLK1-siRNA by ScFv suppresses Her2+ breast cancer growth and metastasis ROCK inhibitor converts corneal endothelial cells into a phenotype capable of regenerating in vivo endothelial tissue Matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors Two-compartment tumor metabolism: Autophagy in the tumor microenvironment and oxidative mitochondrial metabolism (OXPHOS) in cancer cells Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells The transcriptional and epigenomic foundations of ground state pluripotency Extracellular-matrix tethering regulates stem-cell fate Evolutionary selection of enzymatically synthesized semiconductors from biomimetic mineralization vesicles Direct reprogramming of mouse and human fibroblasts into multipotent neural stem cells with a single factor Brain expression Genome-Wide Association Study (eGWAS) identifies human disease-associated variants Generation of an HIV-1-resistant immune system with CD34+ hematopoietic stem cells transduced with a triple-combination anti-HIV lentiviral vector A combined micromagnetic-microfluidic device for rapid capture and culture of rare circulating tumor cells Liver tissue engineering utilizing hepatocytes propagated in mouse livers in vivo Intracellular trafficking pathways involved in the gene transfer of nano-structured calcium phosphate-DNA particles Clonally dominant cardiomyocytes direct heart morphogenesis SIV replication in the infected rhesus macaque is limited by the size of the preexisting TH17 cell compartment Phage-based molecular probes that discriminate force-induced structural states of fibronectin in vivo Perivascular stem cells: a prospectively purified mesenchymal stem cell population for bone tissue engineering MicroRNA-mediated in vitro and in vivo direct reprogramming of cardiac fibroblasts to Cardiomyocytes Differentiation of multipotent vascular stem cells contributes to vascular diseases Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma Flow mechanotransduction regulates traction forces, intercellular forces, and adherens junctions Human epidermal Langerhans Cells maintain immune homeostasis in skin by activating skin resident regulatory T cells Recurrent variations in DNA methylation in human pluripotent stem cells and their differentiated derivatives Human embryonic stem cells have constitutively active Bax at the Golgi and are primed to undergo rapid apoptosis Adhesion failures determine the pattern of choroidal neovascularization in the eye: a computer simulation study Notch ligand endocytosis generates mechanical pulling force dependent on dynamin, epsins, and actin Optical tweezers studies on notch: single-molecule interaction strength is independent of ligand endocytosis Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development Functional neuromuscular junctions formed by embryonic stem cell-derived motor neurons NF-κB inhibition delays DNA damage–induced senescence and aging in mice Amniotic fluid inhibits Toll-like receptor 4 signaling in the fetal and neonatal intestinal epithelium Human ES- and iPS-derived myogenic progenitors restore DYSTROPHIN and improve contractility upon transplantation in dystrophic mice The PSA/lo prostate cancer cell population harbors self-renewing long-term tumor-propagating cells that resist castration Low incidence of DNA sequence variation in human induced pluripotent stem cells generated by nonintegrating plasmid expression Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation Divergent transcriptional programming of class-specific B cell memory by T-bet and RORα Genome-wide RNAi screening identifies human proteins with a regulatory function in the early secretory pathway Single cell profiling of circulating tumor cells: transcriptional heterogeneity and diversity from breast cancer cell lines A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions Caffeic acid phenethyl ester suppresses the proliferation of human prostate cancer cells through inhibition of p70S6K and Akt signaling networks Circulating tumour cells in non-metastatic breast cancer: a prospective study Histone H1 depletion impairs embryonic stem cell differentiation Regulation of TH2 development by CXCR5+ dendritic cells and lymphotoxin-expressing B cells Identification of drugs including a dopamine receptor antagonist that selectively target cancer stem cells Ganglioside GD2 identifies breast cancer stem cells and promotes tumorigenesis Sphingosine-1-phosphate enhances satellite cell activation in dystrophic muscles through a S1PR2/STAT3 signaling pathway Decade-long safety and function of retroviral-modified chimeric antigen receptor T cells Mind bomb 1 is required for pancreatic β-cell formation Role of stem cells in human uterine leiomyoma growth Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation Derivation of mesenchymal stem cells from human induced pluripotent stem cells cultured on synthetic substrates Light-triggered eradication of Acinetobacter baumannii by means of NO delivery from a porous material with an entrapped metal nitrosyl Mesenchymal-stem-cell-induced immunoregulation involves FAS-ligand-/FAS-mediated T cell apoptosis A clinical and serologic comparison of African-American and Caucasian patients with systemic sclerosis Defective B cell tolerance in adenosine deaminase deficiency is corrected by gene therapy Foxp-mediated suppression of N-cadherin regulates neuroepithelial character and progenitor maintenance in the CNS Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling Molecular analysis of FMR1 reactivation in fragile-X induced pluripotent stem cells and their neuronal derivatives Prevention of allogeneic fetal rejection by tryptophan catabolism Macrophage activation associated with chronic murine cytomegalovirus infection results in more severe experimental choroidal neovascularization Engineering DNA nanoparticles as immunomodulatory reagents that activate regulatory T cells Astrocytes secrete exosomes enriched with pro-apoptotic ceramide and prostate apoptosis response 4 (PAR-4): a potential mechanism of apoptosis induction in Alzheimer's disease (AD) Opiate antagonist prevents μ- and δ-opiate receptor dimerization to facilitate ability of agonist to control ethanol-altered natural killer cell functions and mammary tumor growth The landscape of cancer genes and mutational processes in breast cancer Oscillatory dynamics of Cdc42 GTPase in the control of polarized growth Allele-specific p53 mutant reactivation Photovoltaic retinal prosthesis with high pixel density Atoh1 directs the formation of sensory mosaics and induces cell proliferation in the postnatal mammalian cochlea in vivo Engineering bone tissue from human embryonic stem cells Cellular mechanical properties reflect the differentiation potential of adipose-derived mesenchymal stem cells Hepatocyte growth factor mediates mesenchymal stem cell–induced recovery in multiple sclerosis models KCTD13 is a major driver of mirrored neuroanatomical phenotypes of the 16p11.2 copy number variant A peptide derived from endostatin ameliorates organ fibrosis Multipotent stromal stem cells from human placenta demonstrate high therapeutic potential Derivation and cardiomyocyte differentiation of induced pluripotent stem cells from heart failure patients Gene therapy for aromatic l-amino acid decarboxylase deficiency Anticancer PAD inhibitors regulate the autophagy flux and the mammalian target of rapamycin complex 1 activity Glioma gene therapy using induced pluripotent stem cell derived neural stem cells Tumor tropism of intravenously injected human-induced pluripotent stem cell-derived neural stem cells and their gene therapy application in a metastatic breast cancer model Live-cell delamination counterbalances epithelial growth to limit tissue overcrowding Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia Risk and reward in stem cell products: a new model for stem cell product liability Regenerative medicine: DIY eye Restoration of vision after transplantation of photoreceptors Sequencing chromosomal abnormalities reveals neurodevelopmental loci that confer risk across diagnostic boundaries Enhanced homing permeability and retention of bone marrow stromal cells by noninvasive pulsed focused ultrasound In vivo suppression of HIV by antigen specific T cells derived from engineered hematopoietic stem cells Identification of common variants associated with human hippocampal and intracranial volumes Inactivation of conserved c. elegans genes engages pathogen- and xenobiotic-associated defenses Host translational inhibition by pseudomonas aeruginosa exotoxin A triggers an immune response in caenorhabditis elegans C. elegans detects pathogen-induced translational inhibition to activate immune signaling Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy The adult human brain harbors multipotent perivascular mesenchymal stem cells Fully functional hair follicle regeneration through the rearrangement of stem cells and their niches Derivation, expansion and differentiation of induced pluripotent stem cells in continuous suspension cultures Small molecules enable highly efficient neuronal conversion of human fibroblasts Antibiotic resistance is prevalent in an isolated cave microbiome Arsenic-transformed malignant prostate epithelia can convert noncontiguous normal stem cells into an oncogenic phenotype Nrf2-dependent induction of proteasome and Pa28αβ regulator are required for adaptation to oxidative stress De novo mutations revealed by whole-exome sequencing are strongly associated with autism Patterns and rates of exonic de novo mutations in autism spectrum disorders Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations Adeno associated viral vector-mediated expression of somatostatin in rat hippocampus suppresses seizure development ESCRT-III governs the Aurora B–mediated abscission checkpoint through CHMP4C Genetic and pharmacologic inhibition of β-catenin targets imatinib-resistant leukemia stem cells in CML Distinct lineage specification roles for NANOG, OCT4, and SOX2 in human embryonic stem cells NOD2 triggers an interleukin-32–dependent human dendritic cell program in leprosy Nighttime intensivist staffing and mortality among critically ill patients The Arp2/3 complex is required for lamellipodia extension and directional fibroblast cell migration Self-renewing endodermal progenitor lines generated from human pluripotent stem cells NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components MRI-guided disruption of the blood-brain barrier using transcranial focused ultrasound in a rat model Rapid and sensitive detection of an intracellular pathogen in human peripheral leukocytes with hybridizing magnetic relaxation nanosensors A genome-wide association meta-analysis identifies new childhood obesity loci Direct observation of nanoparticle–cancer cell nucleus interactions Efficient derivation of purified lung and thyroid progenitors from embryonic stem cells DNA/amphiphilic block copolymer nanospheres reduce asthmatic response in a mouse model of allergic asthma Extracellular matrix protein CCN1 limits oncolytic efficacy in glioma Ultrathin transnasal endoscopy without sedation: the straight skinny Feasibility, safety, acceptability, and yield of office-based, screening transnasal esophagoscopy (with video) A biohybrid device for the systemic control of acute inflammation Timing isn't everything: donor heart allocation in the present LVAD era Risk assessment for continuous flow left ventricular assist devices: does the destination therapy risk score work?: an analysis of over 1,000 patients Kidney attack Genome abnormalities precede prostate cancer and predict clinical relapse REST-mediated recruitment of polycomb repressor complexes in mammalian cells Blood-derived human ips cells generate optic vesicle–like structures with the capacity to form retinal laminae and develop synapses Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma Genome-wide polycomb target gene prediction in Drosophila melanogaster Multiple intravenous administrations of human umbilical cord blood cells benefit in a mouse model of ALS Role of RhoA-specific guanine exchange factors in regulation of endomitosis in megakaryocytes Exogenous leukemia inhibitory factor stimulates oligodendrocyte progenitor cell proliferation and enhances hippocampal remyelination A rat decellularized small bowel scaffold that preserves villus-crypt architecture for intestinal regeneration Codanin-1, mutated in the anaemic disease CDAI, regulates Asf1 function in S-phase histone supply Arp2/3 is critical for lamellipodia and response to extracellular matrix cues but is dispensable for chemotaxis Genetic regulators of a pluripotent adult stem cell system in planarians identified by RNAi and clonal analysis DNA demethylation dynamics Acute exercise remodels promoter methylation in human skeletal muscle A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest Infection-responsive expansion of the hematopoietic stem and progenitor cell compartment in zebrafish is dependent upon inducible nitric oxide Inhibiting autophagy during interleukin 2 immunotherapy promotes long term tumor regression A two-compartment mathematical model of endotoxin-induced inflammatory and physiologic alterations in swine Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells AAV2 gene therapy readministration in three adults with congenital blindness Induction therapy with autologous mesenchymal stem cells in living-related kidney transplants Germline stem cells and follicular renewal in the postnatal mammalian ovary Production of offspring from a germline stem cell line derived from neonatal ovaries Oocyte formation by mitotically active germ cells purified from ovaries of reproductive-age women Targeting the epidermal growth factor receptor in non-small cell lung cancer cells: the effect of combining RNA interference with tyrosine kinase inhibitors or cetuximab Catheter-deliverable hydrogel derived from decellularized ventricular extracellular matrix increases endogenous cardiomyocytes and preserves cardiac function post-myocardial infarction A human stem cell model of early Alzheimer’s disease pathology in Down Syndrome Human embryonic stem cell-derived GABA neurons correct locomotion deficits in quinolinic acid-lesioned mice PNPASE regulates RNA import into mitochondria Correcting human mitochondrial mutations with targeted RNA import Blood-derived human ips cells generate optic vesicle–like structures with the capacity to form retinal laminae and develop synapses Direct reprogramming of fibroblasts into neural stem cells by defined factors Effect of transendocardial delivery of autologous bone marrow mononuclear cells on functional capacity, left ventricular function, and perfusion in chronic heart failure A model for personalized in vivo analysis of human immune responsiveness Role of lentivirus-mediated overexpression of programmed death-ligand 1 on corneal allograft survival Human platelet-rich plasma- and extracellular matrix-derived peptides promote impaired cutaneous wound healing in vivo Bioactive peptides derived from vascular endothelial cell extracellular matrices promote microvascular morphogenesis and wound healing in vitro Long-term gene therapy causes transgene-specific changes in the morphology of regenerating retinal ganglion cells Direct conversion of fibroblasts into stably expandable neural stem cells Wild-type microglia arrest pathology in a mouse model of Rett syndrome Self-assembled RNA interference microsponges for efficient siRNA delivery Generation of functional insulin-producing cells in the gut by Foxo1 ablation Multi-input RNAi-based logic circuit for identification of specific cancer cells Lumbar intraspinal injection of neural stem cells in patients with ALS: results of a phase I trial in 12 patients Improvement of islet function in a bioartificial pancreas by enhanced oxygen supply and growth hormone releasing hormone agonist Transferred melanoma-specific CD8+ T cells persist, mediate tumor regression, and acquire central memory phenotype Human Müller glia with stem cell characteristics differentiate into retinal ganglion cell (RGC) precursors in vitro and partially restore RGC function in vivo following transplantation Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability Gene therapy for Leber Congenital Amaurosis caused by RPE65 mutations Sox2+ adult stem and progenitor cells are important for tissue regeneration and survival of mice Complement factor H binds malondialdehyde epitopes and protects from oxidative stress BikDD eliminates breast cancer initiating cells and synergizes with lapatinib for breast cancer treatment An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming Adult spinal cord radial glia display a unique progenitor phenotype Substance use disorder and the risk of open-angle glaucoma The determination of stem cell fate by 3D scaffold structures through the control of cell shape Scanning probe-enabled nanocombinatorics define the relationship between fibronectin feature size and stem cell fate Direct signaling from astrocytes to neurons in cultures of mammalian brain cells Extracellular Ca2+ acts as a mediator of communication from neurons to glia Therapeutic angiogenesis due to balanced single-vector delivery of VEGF and PDGF-BB Hierarchical genetic organization of human cortical surface area Towards regenerative therapy for cardiac disease A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism Synergistic effects of central nervous system-directed gene therapy and bone marrow transplantation in the murine model of infantile neuronal ceroid lipofuscinosis Association of TPH1, TPH2, and 5HTTLPR with PTSD and depressive symptoms A versatile synthetic platform for a wide range of functionalized biomaterials The development and fate of follicular helper T cells defined by an IL-21 reporter mouse Mechanical unloading reverses transverse tubule remodelling and normalizes local Ca2+-induced Ca2+release in a rodent model of heart failure Inflammatory ocular adverse events with the use of oral bisphosphonates: a retrospective cohort study Estrogen negatively regulates epithelial wound healing and protective lipid mediator circuits in the cornea Synergistic, context-dependent, and hierarchical functions of epithelial components in thymic microenvironments Wnt signaling regulates acetylcholine receptor translocation and synaptic plasticity in the adult nervous system Therapeutic hemoglobin levels after gene transfer in β-thalassemia mice and in hematopoietic cells of β-thalassemia and sickle cells disease patients Nanocomposite materials with antimicrobial activity based on chitosan Cancer stem cell vaccination confers significant antitumor immunity Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer Functionalized conducting polymer nanodots for enhanced cell capturing: the synergistic effect of capture agents and nanostructures Oral mucosal progenitor cells are potently immunosuppressive in a dose-independent manner Differentiation potential of germ line stem cells derived from the postnatal mouse ovary Production of offspring from a germline stem cell line derived from neonatal ovaries Bone marrow transplantation generates immature oocytes and rescues long-term fertility in a preclinical mouse model of chemotherapy-induced premature ovarian failure Oocyte generation in adult mammalian ovaries by putative germ cells in bone marrow and peripheral blood Germline stem cells and follicular renewal in the postnatal mammalian ovary Oocyte formation by mitotically active germ cells purified from ovaries of reproductive-age women Cooperation between both Wnt/β-catenin and PTEN/PI3K/Akt signaling promotes primitive hematopoietic stem cell self-renewal and expansion Antibody-functionalized fluid-permeable surfaces for rolling cell capture at high flow rates Mechanical resuscitation of chemical oscillations in Belousov–Zhabotinsky gels Position-specific chemical modification and quantitative proteomics disclose protein orientation adsorbed on silica nanoparticles Isolation and in vitro expansion of human colonic stem cells De novo mutations in the actin genes ACTB and ACTG1 cause Baraitser-Winter syndrome SUMO1-dependent modulation of SERCA2a in heart failure Specific lectin biomarkers for isolation of human pluripotent stem cells identified through array-based glycomic analysis CT angiography for safe discharge of patients with possible acute coronary syndromes Myeloid progenitor cells in the premetastatic lung promote metastases by inducing mesenchymal to epithelial transition The competitive advantage of a dual-transporter system Intravital imaging of thymopoiesis reveals dynamic lympho-epithelial interactions Maintenance of muscle stem-cell quiescence by microRNA-489 Directional DNA methylation changes and complex intermediate states accompany lineage specificity in the adult hematopoietic compartment A metalloproteinase secreted by Streptococcus pneumoniae removes membrane mucin MUC16 from the epithelial glycocalyx barrier Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion Nanowired three-dimensional cardiac patches Development of skin-humanized mouse models of pachyonychia congenital Left-right symmetry breaking in tissue morphogenesis via cytoskeletal mechanics A systematic survey of loss-of-function variants in human protein-coding genes Truncations of titin causing dilated cardiomyopathy Myeloid dendritic cells isolated from tissues of SIV-infected Rhesus macaques promote the induction of regulatory T cells Radiation-induced reprograming of breast cancer cells SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates Derivation and characterization of embryonic stem cells lines derived from transgenic fischer 344 and dark agouti rats HLA-mismatched renal transplantation without maintenance immunosuppression Chimerism and tolerance without GVHD or engraftment syndrome in HLA-mismatched combined kidney and hematopoietic stem cell transplantation Transcriptional activation by Oct4 is sufficient for the maintenance and induction of pluripotency Combinatorial activation and repression by seven transcription factors specify drosophila odorant receptor expression Human Müller glia with stem cell characteristics differentiate into retinal ganglion cell (RGC) precursors in vitro and partially restore RGC function in vivo following transplantation Choice-specific sequences in parietal cortex during a virtual-navigation decision task Glaucoma 2.0: neuroprotection, neuroregeneration, neuroenhancement Tissue engineering a fetal membrane High levels of circulating CD34+ cells at autologous stem cell collection are associated with favourable prognosis in multiple myeloma A human memory T cell subset with stem cell–like properties PDGFRβ expression and function in fibroblasts derived from pluripotent cells is linked to DNA demethylation Genome-wide polycomb target gene prediction in Drosophila melanogaster Intraocular pressure and corneal biomechanics in an adult British population: the EPIC-Norfolk eye study Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing Direct lineage conversion of terminally differentiated hepatocytes to functional neurons Distal airway stem cells yield alveoli in vitro and during lung regeneration following H1N1 influenza infection A rare penetrant mutation in CFH confers high risk of age-related macular degeneration Effect of intracoronary delivery of autologous bone marrow mononuclear cells 2 to 3 weeks following acute myocardial infarction on left ventricular function: the LateTIME randomized trial Sox2+ adult stem and progenitor cells are important for tissue regeneration and survival of mice Sequence- and target-independent angiogenesis suppression by siRNA via TLR3 Short-interfering RNAs induce retinal degeneration via TLR3 and IRF3 Human oocytes reprogram somatic cells to a pluripotent state Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus Targeted focal adhesion kinase activation in cardiomyocytes protects the heart from ischemia/reperfusion injury Trophoblasts regulate the placental hematopoietic niche through PDGF-B signaling Adult mice generated from induced pluripotent stem cells Genome sequencing of mouse induced pluripotent stem cells reveals retroelement stability and infrequent DNA rearrangement during reprogramming Lipotoxicity causes multisystem organ failure and exacerbates acute pancreatitis in obesity Effect of donor—recipient HLA matching at HLA A, B, C, and DRB1 on outcomes after umbilical-cord blood transplantation for leukaemia and myelodysplastic syndrome: a retrospective analysis AMD1 is essential for ESC self-renewal and is translationally down-regulated on differentiation to neural precursor cells Engineered whole organs and complex tissues Inducible apoptosis as a safety switch for adoptive cell therapy Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state Interconversion between intestinal stem cell populations in distinct niches Lyn is a redox sensor that mediates leukocyte wound attraction in vivo Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion Cross-presentation of tumour antigens by human induced pluripotent stem cell-derived CD141+XCR1+ dendritic cells Restoration of normal BMP signaling levels and osteogenic differentiation in FOP mesenchymal progenitor cells by mutant allele-specific targeting Hydrogen sulfide increases hepatic differentiation in tooth-pulp stem cells Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition Single-cell dissection of transcriptional heterogeneity in human colon tumors Dedifferentiation-reprogrammed mesenchymal stem cells with improved therapeutic potential Engineered cell homing Fluid biopsy for circulating tumor cell identification in patients with early-and late-stage non-small cell lung cancer: a glimpse into lung cancer biology High-definition imaging of circulating tumor cells and associated cellular events in non-small cell lung cancer patients: a longitudinal analysis Cytometric comparisons between circulating tumor cells from prostate cancer patients and the prostate-tumor-derived LNCaP cell line Characterization of circulating tumor cell aggregates identified in patients with epithelial tumors Fluid biopsy in patients with metastatic prostate, pancreatic and breast cancers BRCA1 is an essential regulator of heart function and survival following myocardial infarction BRCA2 protein deficiency exaggerates doxorubicin-induced cardiomyocyte apoptosis and cardiac failure Mer receptor tyrosine kinase inhibition impedes glioblastoma multiforme migration and alters cellular morphology Cigarette smoke induction of osteopontin (SPP1) mediates TH17 inflammation in human and experimental emphysema Amyloid fibril formation by the glaucoma-associated olfactomedin domain of myocilin Legionella pneumophila regulates the small GTPase Rab1 activity by reversible phosphorylcholination Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development Sca-1+ cardiosphere-derived cells are enriched for Isl1-expressing cardiac precursors and improve cardiac function after myocardial injury Saccade-confounded image statistics explain visual crowding Pericyte depletion results in hypoxia-associated epithelial-to-mesenchymal transition and metastasis mediated by met signaling pathway Small molecule induction of human umbilical stem cells into myelin basic protein positive oligodendrocytes in a defined three-dimensional environment Time trends in the incidence and causes of blindness in Israel Incidence of legal blindness from age-related macular degeneration in Denmark: year 2000 to 2010 Spider silk inspired functional microthreads Bile acid and inflammation activate gastric cardia stem cells in a mouse model of Barrett-like metaplasia The resistance of breast cancer stem cells to conventional hyperthermia and their sensitivity to nanoparticle-mediated photothermal therapy Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting Exogenous leukemia inhibitory factor stimulates oligodendrocyte progenitor cell proliferation and enhances hippocampal remyelination Effective treatment of metastatic forms of Epstein-Barr virus–associated nasopharyngeal carcinoma with a novel adenovirus-based adoptive immunotherapy Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells Ret is a multifunctional coreceptor that integrates diffusible- and contact-axon guidance signals Transplantation of human embryonic stem cells onto a partially wounded human cornea in vitro Small molecule mesengenic induction of human induced pluripotent stem cells to generate mesenchymal stem/stromal cells Freeze-dried heart valve scaffolds A CD74-dependent MHC class I endolysosomal cross-presentation pathway Low-pressure foaming: a novel method for the fabrication of porous scaffolds for tissue engineering Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase Evaluation of endothelial cells differentiated from amniotic fluid-derived stem cells Directing mesenchymal stem cells to bone to augment bone formation and increase bone mass Lithocholic bile acid selectively kills neuroblastoma cells, while sparing normal neuronal cells Functional inhibition of osteoblastic cells in an in vivo mouse model of myeloid leukemia Osteoblastic cells regulate the haematopoietic stem cell niche Synthetic mast-cell granules as adjuvants to promote and polarize immunity in lymph nodes Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells Modeling hepatitis C virus infection using human induced pluripotent stem cells Generation of reactive oxygen species by grape seed extract causes irreparable DNA damage leading to G2/M arrest and apoptosis selectively in head and neck squamous cell carcinoma cells Endothelial and perivascular cells maintain haematopoietic stem cells Distinguishing DNA by analog-to-digital-like conversion by using optofluidic lasers Prostaglandin E2 promotes intestinal tumor growth via DNA methylation Rare variants in APP, PSEN1 and PSEN2 increase risk for AD in late-onset Alzheimer's Disease families Genetic instability in neural stem cells: an inconvenient truth? Novel histone demethylase LSD1 inhibitors selectively target cancer cells with pluripotent stem cell properties Recurrent genomic instability of chromosome 1q in neural derivatives of human embryonic stem cells Blocking of CDCP1 cleavage in vivo prevents Akt-dependent survival and inhibits metastatic colonization through PARP1-mediated apoptosis of cancer cells Hydrogels with time-dependent material properties enhance cardiomyocyte differentiation in vitro Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa Embryonic stem cell trials for macular degeneration: a preliminary report Betacellulin promotes cell proliferation in the neural stem cell niche and stimulates neurogenesis Incidence and clinical characteristics of thyroid cancer in prospective series of individuals with Cowden and Cowden-Like Syndrome characterized by germline PTEN, SDH, or KLLN alterations DUX4 activates germline genes, retroelements, and immune mediators: implications for facioscapulohumeral dystrophy Somatic progenitor cell vulnerability to mitochondrial DNA mutagenesis underlies progeroid phenotypes in polg mutator mice Generation of chimeric rhesus monkeys Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism RNA-guided RNA cleavage by a CRISPR RNA-Cas protein complex Essential features and rational design of CRISPR RNAs that function with the Cas RAMP module complex to cleave RNAs Adult human RPE can be activated into a multipotent stem cell that produces mesenchymal derivatives A single autoimmune T cell receptor recognizes more than a million different peptides Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis Rejuvenation of regeneration in the aging central nervous system Reversal of type 1 diabetes via islet beta cell regeneration following immune modulation by cord blood-derived multipotent stem cells Generation of human vascular smooth muscle subtypes provides insight into embryological origin–dependent disease susceptibility Dendritic cells promote pancreatic viability in mice with acute pancreatitis Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age Fetal cells traffic to injured maternal myocardium and undergo cardiac differentiation Human embryonic stem cell-derived neurons adopt and regulate the activity of an established neural network Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome p63 regulates olfactory stem cell self-renewal and differentiation Antibody-based protection against HIV infection by vectored immunoprophylaxis Efficient correction of hemoglobinopathy-causing mutations by homologous recombination in integration-free patient iPSCs Rational bioprocess design for human pluripotent stem cell expansion and endoderm differentiation based on cellular dynamics Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling Demographic and geographic features of exfoliation glaucoma in 2 United States-based prospective cohorts The nuclear receptor PPARβ/δ programs muscle glucose metabolism in cooperation with AMPK and MEF2 Adult cardiac-resident MSC-like stem cells with a proepicardial origin Charge inversion, condensation and decondensation of DNA and polystyrene sulfonate by polyethylenimine Polycomb-repressed genes have permissive enhancers that initiate reprogramming MicroRNA-520/373 family functions as a tumor suppressor in estrogen receptor negative breast cancer by targeting NF-κB and TGF-β signaling pathways Optimization of immunosuppressive therapy for spinal grafting of human spinal stem cells in a rat model of ALS Acquisition of a multifunctional IgA+ plasma cell phenotype in the gut Bone marrow contributes simultaneously to different neural types in the central nervous system through different mechanisms of plasticity The STARD9/Kif16a kinesin associates with mitotic microtubules and regulates spindle pole assembly FT1050 (16,16-dimethyl prostaglandin e2)-enhanced umbilical cord blood accelerates hematopoietic engraftment after reduced intensity conditioning and double umbilical cord blood transplantation A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis Adenovirus-associated virus vector–mediated gene transfer in hemophilia B A trial of intrapleural adenoviral-mediated interferon-α2b gene transfer for malignant pleural mesothelioma Th17 cells mediate clade-specific, serotype-independent mucosal immunity Implantation site and lesion topology determine efficacy of a human neural stem cell line in a rat model of chronic stroke ΔNp63α protein triggers epithelial-mesenchymal transition and confers stem cell properties in normal human keratinocytes Mutations in MEGF10, a regulator of satellite cell myogenesis, cause early onset myopathy, areflexia, respiratory distress and dysphagia (EMARDD) Telomere shortening alters the kinetics of the DNA damage response after ionizing radiation in human cells Tuberin and PRAS40 are anti-apoptotic gatekeepers during early human amniotic fluid stem-cell differentiation Excitation-induced ataxin-3 aggregation in neurons from patients with Machado–Joseph disease Wnt signaling and a Smad pathway blockade direct the differentiation of human pluripotent stem cells to multipotent neural crest cells Mesenchymal stem cell–based tissue regeneration is governed by recipient T lymphocytes via IFN-γ and TNF-α Neural correlates of reliability-based cue weighting during multisensory integration Combination epigenetic therapy has efficacy in patients with refractory advanced non–small cell lung cancer In vivo sustained release of siRNA from solid lipid nanoparticles Tracheobronchial transplantation with a stem-cell-seeded bioartificial nanocomposite: a proof-of-concept study UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells Interleukin-2 and regulatory T cells in graft-versus-host disease Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage Rational bioprocess design for human pluripotent stem cell expansion and endoderm differentiation based on cellular dynamics Reversible cell-cycle entry in adult kidney podocytes through regulated control of telomerase and Wnt signaling Reprogramming factor stoichiometry influences the epigenetic state and biological properties of induced pluripotent stem cells New gene functions in megakaryopoiesis and platelet formation Antitumor activity from antigen-specific CD8 T cells generated in vivo from genetically engineered human hematopoietic stem cells Long noncoding RNA-mediated anti-apoptotic activity in murine erythroid terminal differentiation Prevalence of immune disease in patients with wounds presenting to a tertiary wound healing centre Erythroid/myeloid progenitors and hematopoietic stem cells originate from distinct populations of endothelial cells Genetic and epigenetic defects in DNA repair lead to synthetic lethality of poly (ADP-ribose) polymerase (PARP) inhibitors in aggressive myeloproliferative disorders Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway Adoptive immunotherapy with autologous CD3/CD28-costimulated T-cells after fludarabine-based chemotherapy in patients with chronic lymphocytic leukemia Jamb and Jamc are essential for vertebrate myocyte fusion Biodegradable poly(amine-co-ester) terpolymers for targeted gene delivery A 2-step approach to myeloablative haploidentical stem cell transplantation: a phase 1/2 trial performed with optimized T-cell dosing Adipocyte lineage cells contribute to the skin stem cell niche to drive hair cycling Amyloid triggers extensive cerebral angiogenesis causing blood brain barrier permeability and hypervascularity in Alzheimer's Disease Optimizing the societal benefits of the annual influenza vaccine: a stochastic programming approach Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model Adeno-associated virus type 2 infection activates caspase dependent and independent apoptosis in multiple breast cancer lines but not in normal mammary epithelial cells Lentivirus-mediated expression of cDNA and shRNA slows degeneration in retinitis pigmentosa CAD/CAM-assisted breast reconstruction Defective photoreceptor phagocytosis in a mouse model of enhanced S-cone syndrome causes progressive retinal degeneration Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans lincRNAs act in the circuitry controlling pluripotency and differentiation Direct laser writing of 3D scaffolds for neural tissue engineering applications SUMO1-dependent modulation of SERCA2a in heart failure Axon regeneration pathways identified by systematic genetic screening in C. elegans The ALS-associated proteins FUS and TDP-43 function together to affect Drosophila locomotion and life span Inhibition of fatty acid metabolism ameliorates disease activity in an animal model of multiple sclerosis Pancreatic mesenchyme regulates epithelial organogenesis throughout development Isolation and in vitro expansion of human colonic stem cells ROCK and JAK1 signaling cooperate to control actomyosin contractility in tumor cells and stroma Mutational inactivation of STAG2 causes aneuploidy in human cancer Biochemical alterations associated with ALS Damage associated molecular patterns within xenogeneic biologic scaffolds and their effects on host remodeling Stem cell gene expression programs influence clinical outcome in human leukemia Spatially controlled simultaneous patterning of multiple growth factors in three-dimensional hydrogels Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells Derivation of insulin producing cells from human endometrial stromal stem cells and use in the treatment of murine diabetes Conversion of mouse and human fibroblasts into functional spinal motor neurons Transplantation of human pericyte progenitor cells improves the repair of infarcted heart through activation of an angiogenic program involving micro-RNA-132 The lamina propria of adult human oral mucosa harbors a novel stem cell population Heterogeneity in SDF-1 expression defines the vasculogenic potential of adult cardiac progenitor cells CD8α+ dendritic cells are the critical source of interleukin-12 that controls acute infection by toxoplasma gondii tachyzoites CD8α+ dendritic cells are an obligate cellular entry point for productive infection by listeria monocytogenes ATP7A gene addition to the choroid plexus results in long-term rescue of the lethal copper transport defect in a menkes disease mouse model Multi-hierarchical self-assembly of a collagen mimetic peptide from triple helix to nanofibre and hydrogel SLC6A14 (ATB0,+) protein, a highly concentrative and broad specific amino acid transporter, is a novel and effective drug target for treatment of estrogen receptor-positive breast cancer Intravenous autologous bone marrow mononuclear cells for ischemic stroke Mutations in CIC and FUBP1 contribute to human oligodendroglioma Decreased zinc and downregulation of ZIP3 zinc uptake transporter in the development of pancreatic adenocarcinoma Risk assessment model for development of advanced age-related macular degeneration GeT peptides: a single-domain approach to gene delivery Overcoming hypoxia-induced apoptotic resistance through combinatorial inhibition of GSK-3β and CDK1 Fresh surgical specimens yield breast stem/progenitor cells and reveal their oncogenic abnormalities Successful implantation of bioengineered, intrinsically innervated, human internal anal sphincter Exome sequencing and analysis of induced pluripotent stem cells identify the cilia-related gene male germ cell-associated kinase (MAK) as a cause of retinitis pigmentosa Stimulating cardiac muscle by light RALA and RALBP1 regulate mitochondrial fission at mitosis LIM kinase 1 modulates cortical actin and CXCR4 cycling and is activated by HIV-1 to initiate viral infection Activation of human T-helper/inducer cell, T-cytotoxic cell, B-cell, and natural killer (NK)-cells and induction of natural killer cell activity against k562 chronic myeloid leukemia cells with modified citrus pectin Genome-wide association studies of adolescent idiopathic scoliosis suggest candidate susceptibility genes Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder A resource of vectors and ES cells for targeted deletion of microRNAs in mice Notch post-translationally regulates β-catenin protein in stem and progenitor cells An antibody against SSEA-5 glycan on human pluripotent stem cells enables removal of teratoma-forming cells Lineage restricted progenitors for the repopulation of decellularized heart Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection An unbiased genome-wide analysis of zinc-finger nuclease specificity Combination therapy utilizing shRNA knockdown and an optimized resistant transgene for rescue of diseases caused by misfolded proteins Mechanoregulation of vascularization in aligned tissue-engineered muscle: a role for vascular endothelial growth factor Phase IB study of gene-mediated cytotoxic immunotherapy adjuvant to up-front surgery and intensive timing radiation for malignant glioma Rb and p130 control cell cycle gene silencing to maintain the postmitotic phenotype in cardiac myocytes T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia Chimeric antigen receptor–modified T cells in chronic lymphoid leukemia Defining the nature of human pluripotent stem cell progeny Understanding the metabolic basis of drug resistance: Therapeutic induction of the Warburg effect kills cancer cells HIV-1 adaptation to NK-cell-mediated immune pressure Spider silk-based gene carriers for tumor cell-specific delivery Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming Nonrandom attrition of the naive CD8+ T-cell pool with aging governed by T-cell receptor:pMHC interactions Engineered lentiviral vectors pseudotyped with a CD4 receptor and a fusogenic protein can target cells expressing HIV-1 envelope proteins Stem cell–mediated transfer of a human artificial chromosome ameliorates muscular dystrophy Visual data integration for imaging-based planning in human craniofacial transplantation Skin-resident murine dendritic cell subsets promote distinct and opposing antigen-specific T helper cell responses Efficient recombinase-mediated cassette exchange at the AAVS1 locus in human embryonic stem cells using baculoviral vectors Recurrent GNAS mutations define an unexpected pathway for pancreatic cyst development Radical acceleration of nuclear reprogramming by chromatin remodeling with the transactivation domain of MyoD Clustering and activity tuning of Kv1 channels in myelinated hippocampal Direct reprogramming of adult human fibroblasts to functional neurons under defined conditions Long-term outcome of patients with metastatic breast cancer treated with high-dose chemotherapy and transplantation of purified autologous hematopoietic stem cells Fgf differentially controls cross-antagonism between cardiac and haemangioblast regulators Impaired respiratory and body temperature control upon acute serotonergic neuron inhibition Bcl6 mediates the development of T follicular helper cells Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: an open-label, phase 2, dose-escalation study Brief report: efficient generation of hematopoietic precursors and progenitors from human pluripotent stem cell lines Genetic engineering of human pluripotent cells using TALE nucleases Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations Human neural stem cell transplantation ameliorates radiation-induced cognitive dysfunction Observations on the remarkable (and mysterious) wound-healing process of the bottlenose dolphin Proinvasion metastasis drivers in early-stage melanoma are oncogenes Progesterone inhibits the growth of human neuroblastoma: in vitro and in vivo evidence Nanoscale surfaces for the long-term maintenance of mesenchymal stem cell phenotype and multipotency High success rate of hematopoietic cell transplantation regardless of donor source in children with very high-risk leukemia Precise manipulation of chromosomes in vivo enables genome-wide codon replacement Epigenetic memory and preferential lineage-specific differentiation in induced pluripotent stem cells derived from human pancreatic islet beta cells The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function Functional regeneration of respiratory pathways after spinal cord injury MicroRNA-mediated conversion of human fibroblasts to neurons Cardiac AAV9-S100A1 gene therapy rescues post-ischemic heart failure in a preclinical large animal model Expression of apolipoprotein A-I in rabbit carotid endothelium protects against atherosclerosis Control of TH17 cells occurs in the small intestine Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial Foxp2 regulates gene networks implicated in neurite outgrowth in the developing brain Dehydro-α-lapachone, a plant product with antivascular activity Intramyocardial, autologous CD34+ cell therapy for refractory angina Chemotactic cell trapping in controlled alternating gradient fields Transcriptome transfer provides a model for understanding the phenotype of cardiomyocytes One-pot synthesis of microcapsules with nanoscale inclusions Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets A multicellular approach forms a significant amount of tissue-engineered small intestine in the mouse Purification of immature neuronal cells from neural stem cell progeny Non-viral gene delivery nanoparticles based on Poly(β-amino esters) for treatment of glioblastoma Novel stem/progenitor cell population from murine tracheal submucosal gland ducts with multipotent regenerative potential Embryonic stem cell bioprinting for uniform and controlled size embryoid body formation Temporal dissection of tumorigenesis in primary cancers Upregulation of adipogenesis and chondrogenesis in MSC serum-free culture Integrated genomic analyses of ovarian carcinoma Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin TRPV3 regulates nitric oxide synthase-independent nitric oxide synthesis in the skin Dosage thresholds for AAV2 and AAV8 photoreceptor gene therapy in monkey Functional motor recovery from brain ischemic insult by carbon nanotube-mediated siRNA silencing MiR-34a chemo-sensitizes bladder cancer cells to cisplatin treatment regardless of P53-Rb pathway status Loss of H3K4 methylation destabilizes gene expression patterns and physiological functions in adult murine Cardiomyocytes Micropatterned mammalian cells exhibit phenotype-specific left-right asymmetry DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors Altered telomeres in tumors with ATRX and DAXX mutations In vivo clonal analysis reveals self-renewing and multipotent adult neural stem cell characteristics Charcot-Marie-Tooth disease-associated mutant tRNA synthetases linked to altered dimer interface and neurite distribution defect Dispersed disease-causing neomorphic mutations on a single protein promote the same localized conformational opening On-demand controlled release of docetaxel from a battery-less MEMS drug delivery device Calcium upregulation by percutaneous administration of gene therapy in cardiac disease (CUPID) Multiple forms of activity-dependent competition refine hippocampal circuits in vivo Extracellular matrix powder protects against bleomycin-induced pulmonary fibrosis Identification and expansion of a unique stem cell population from adult mouse gallbladder Ultrasound elasticity imaging for detecting intestinal fibrosis and inflammation in rats and humans with Crohn's disease A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice Nanomaterials for X-ray imaging: gold nanoparticle enhancement of X-ray scatter imaging of hepatocellular carcinoma In vivo genome editing restores haemostasis in a mouse model of haemophilia Zfp488 promotes oligodendrocyte differentiation of neural progenitor cells in adult mice after demyelination Multimodal silica nanoparticles are effective cancer-targeted probes in a model of human melanoma Notch-dependent differentiation of adult airway basal stem cells Broad antigenic coverage induced by vaccination with virus-based cDNA libraries cures established tumors An analysis of high ferritin levels before allogeneic hematopoietic cell transplantation (AlloHCT): A retrospective study to evaluate prognostic factors in patients (pts) undergoing AlloHCT for myelodysplasia Nanoparticles that communicate in vivo to amplify tumour targeting Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform Graded Nodal/Activin signaling titrates conversion of quantitative Phospho-Smad2 levels into qualitative embryonic stem cell fate decisions Artificially induced protein–membrane anchorage with cholesterol-based recognition agents as a new therapeutic concept Radioimmunotherapy with Lu-177 labeled anti-CAIX monoclonal antibody in advanced renal cell carcinoma Hedgehog overexpression is associated with stromal interactions and predicts for poor outcome in breast cancer Direct conversion of human fibroblasts to dopaminergic neurons Optic vesicle-like structures derived from human pluripotent stem cells facilitate a customized approach to retinal disease treatment Engineering biosynthetic excitable tissues from unexcitable cells for electrophysiological and cell therapy studies Basolateral amygdala regulation of adult hippocampal neurogenesis and fear-related activation of newborn neurons Evolutionary origin of a novel gene expression pattern through co-option of the latent activities of existing regulatory sequences First experience with a paracorporeal artificial lung in a small child with pulmonary hypertension Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem cells of ALS8 patients Engineered bivalent ligands to bias ErbB receptor-mediated signaling and phenotypes Loss of the miR-21 allele elevates the expression of its target genes and reduces tumorigenesis De novo cardiomyocytes from within the activated adult heart after injury RUNX3 acts as a tumor suppressor in breast cancer by targeting estrogen receptor α Antireflux surgery preserves lung function in patients with gastroesophageal reflux disease and end-stage lung disease before and after lung transplantation The impact of conversion from prograf to generic tacrolimus in liver and kidney transplant recipients with stable graft function A biochemical–biophysical study of hemoglobins from woolly mammoth, asian elephant, and humans An isoform of decorin is a resistin receptor on the surface of adipose progenitor cells Determinants of nucleosome organization in primary human cells A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers The orphan disease networks α-catenin is a tumor suppressor that controls cell accumulation by regulating the localization and activity of the transcriptional coactivator Yap1 Kinome screening for regulators of the estrogen receptor identifies LMTK3 as a new therapeutic target in breast cancer Optic vesicle-like structures derived from human pluripotent stem cells facilitate a customized approach to retinal disease treatment E-cadherin is crucial for embryonic stem cell pluripotency and can replace OCT4 during somatic cell reprogramming Tumor-initiating stem cells of squamous cell carcinomas and their control by TGF-β and integrin/focal adhesion kinase (FAK) signaling Genomic comparison of multi-drug resistant invasive and colonizing Acinetobacter baumannii isolated from diverse human body sites reveals genomic plasticity Induction of human neuronal cells by defined transcription factors Democracy derived? New trajectories in pluripotent stem cell research Specification of transplantable astroglial subtypes from human pluripotent stem cells Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast A low-dose insulin infusion suppresses the expression of β-amyloid precursor protein Post-progression treatment with APC8015F may have prolonged survival of subjects in the control arm of sipuleucel-T phase III studies Supercoiled Minivector DNA resists shear forces associated with gene therapy delivery Virus-induced tumor inflammation facilitates effective DC cancer immunotherapy in a Treg-dependent manner in mice Off-target lapatinib activity sensitizes colon cancer cells through TRAIL death receptor up-regulation gp100 peptide vaccine and interleukin-2 in patients with advanced melanoma Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca2+ channel complex The use of mesenchymal stem cells in orthopedics: review of the literature, current research, and regulatory landscape Functional crosstalk between Bmi1 and MLL/Hoxa9 axis in establishment of normal hematopoietic and leukemic stem cells Kinase inhibitors modulate huntingtin cell localization and toxicity Polyvalent nucleic acid nanostructures Association of lipidome remodeling in the adipocyte membrane with acquired obesity in humans Attenuation of HIV-associated human B cell exhaustion by siRNA downregulation of inhibitory receptors ABCB5 identifies a therapy-refractory tumor cell population in colorectal cancer patients Vaccination with patient-specific tumor-derived antigen in first remission improves disease-free survival in follicular lymphoma The cysteine protease inhibitor, E64d, reduces brain amyloid-β and improves memory deficits in Alzheimer's Disease animal models by inhibiting cathepsin B, but not BACE1, β-secretase activity Autocrine effects of mesenchymal stem cells expressing IGF-I rescue the fracture-healing defects of Irs1 knockout mice Microstructured templates for directed growth and vascularization of soft tissue in vivo A voltage-dependent channel involved in nutrient uptake by red blood cells infected with the malaria parasite Malaria parasite clag3 genes determine channel-mediated nutrient uptake by infected red blood cells Massive ex vivo expansion of human natural regulatory T cells (Tregs) with minimal loss of in vivo functional activity The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors Sorafenib enhances the antitumor effects of chemoradiation treatment by downregulating ERCC-1 and XRCC-1 DNA repair proteins Three-dimensional polymer constructs exhibiting a tunable negative poisson's ratio Poly(lactic–co-glycolic acid): Carbon nanofiber composites for myocardial tissue engineering applications Regulation of angiogenesis by a non-canonical Wnt–Flt1 pathway in myeloid cells Functional regulatory T cells produced by inhibiting cyclic nucleotide phosphodiesterase type 3 prevent allograft rejection Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status Targeted gene correction of laminopathy-associated LMNA mutations in patient-specific iPSCs Lrp5 functions in bone to regulate bone mass Human regulatory T cells with alloantigen specificity are more potent inhibitors of alloimmune skin graft damage than polyclonal regulatory T cells Simultaneous visualization of both signaling cascade activity and end-point gene expression in single cells Loss of the miR-21 allele elevates the expression of its target genes and reduces tumorigenesis Sensitization of head and neck cancer to cisplatin through the use of a novel curcumin analog Chromatin “prepattern” and histone modifiers in a fate choice for liver and pancreas Computational design of proteins targeting the conserved stem region of influenza hemagglutinin Hydrogen peroxide promotes injury-induced peripheral sensory axon regeneration in the zebrafish skin In vivo liver regeneration potential of human induced pluripotent stem cells from diverse origins Improving cutaneous scar formation by controlling the mechanical environment: large animal and phase I studies Collective cell guidance by cooperative intercellular forces Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells Multiple recognition assay reveals prostasomes as promising plasma biomarkers for prostate cancer Complete budding and asymmetric division of primitive model cells to produce daughter vesicles with different interior and membrane compositions High-throughput analysis of single hematopoietic stem cell proliferation in microfluidic cell culture arrays BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR–ABL1 kinase inhibition New adeno-associated virus strategies to support momentum in the clinic A simple method to increase the transduction efficiency of single-stranded adeno-associated virus vectors in vitro and in vivo Systemic elimination of de novo capsid protein synthesis from replication-competent AAV contamination in the liver A versatile adeno-associated virus vector producer cell line method for scalable vector production of different serotypes Mycophenolate mofetil impairs transduction of single-stranded adeno-associated viral vectors Good manufacturing practice production of self-complementary serotype 8 adeno-associated viral vector for a hemophilia B clinical trial Cancer screening by systemic administration of a gene delivery vector encoding tumor-selective secretable biomarker expression C20-D3-vitamin A slows lipofuscin accumulation and electrophysiological retinal degeneration in a mouse model of Stargardt disease Deuterium enrichment of vitamin A at the C20 position slows the formation of detrimental vitamin A dimers in wild-type rodents Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2 Tissue-engineered vascular grafts form neovessels that arise from regeneration of the adjacent blood vessel γδ intraepithelial lymphocytes are essential mediators of host–microbial homeostasis at the intestinal mucosal surface Object detection in the ring scotoma of a monocular bioptic telescope Celecoxib inhibits STAT3 phosphorylation and suppresses cell migration and colony forming ability in rhabdomyosarcoma cells Celecoxib inhibits Interleukin-6/Interleukin-6 receptor–induced JAK2/STAT3 phosphorylation in human hepatocellular carcinoma cells The Parkinsonian mimetic, MPP+, specifically impairs mitochondrial transport in dopamine axons Hierarchical self-assembly of amelogenin and the regulation of biomineralization at the nanoscale Defective regulation of autophagy upon leucine deprivation reveals a targetable liability of human melanoma cells in vitro and in vivo Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24–mediated toxicity Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors Evidence for human lung stem cells Structurally distinct LewisX glycans distinguish subpopulations of neural stem/progenitor cells A hormone-dependent module regulating energy balance Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis Clonogenic neoblasts are pluripotent adult stem cells that underlie planarian regeneration Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine Immunogenicity of induced pluripotent stem cells Delayed intrathecal delivery of RhoA siRNA to the contused spinal cord inhibits allodynia, preserves white matter, and increases serotonergic fiber growth Transplantation of adult mouse iPS cell-derived photoreceptor precursors restores retinal structure and function in degenerative mice Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress Transmembrane semaphorin signalling controls laminar stratification in the mammalian retina A combinatorial semaphorin code instructs the initial steps of sensory circuit assembly in the Drosophila CNS Injectable fibroblast growth factor-2 coacervate for persistent angiogenesis A dynamic view of trauma/hemorrhage-induced inflammation in mice: principal drivers and networks Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum Division-coupled astrocytic differentiation and age-related depletion of neural stem cells in the adult hippocampus Human ESC-derived neural crest model reveals a key role for SOX2 in sensory neurogenesis In vivo protein trapping produces a functional expression codex of the vertebrate proteome CD4+CD25+CD127dimFoxp3+ T cells are cytotoxic for human neurons Novel CCL21-vault nanocapsule intratumoral delivery inhibits lung cancer growth Use of size and a copolymer design feature to improve the biodistribution and the enhanced permeability and retention effect of doxorubicin-loaded mesoporous silica nanoparticles in a murine xenograft tumor model Composite scaffold provides a cell delivery platform for cardiovascular repair Cdc42-interacting protein 4 is a Src substrate that regulates invadopodia and invasiveness of breast tumors by promoting MT1-MMP endocytosis Immune and genetic correlates of vaccine protection against mucosal infection by SIV in monkeys Transcription factor Foxp1 exerts essential cell-intrinsic regulation of the quiescence of naive T cells Therapeutic cell engineering with surface-conjugated synthetic nanoparticles Temperature-dependent STIM1 activation induces Ca2+ influx and modulates gene expression A rapid, extensive, and transient transcriptional response to estrogen signaling in breast cancer cells Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors Direct reprogramming of mouse fibroblasts to neural progenitors A Drosophila model of FUS-related neurodegeneration reveals genetic interaction between FUS and TDP-43 The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF Pancreatic β cell identity is maintained by DNA methylation-mediated repression of Arx Layer-by-layer nanoparticles with a pH-sheddable layer for in vivo targeting of tumor hypoxia A model of threshold behavior reveals rescue mechanisms of bystander proteins in conformational diseases Alteration of the serine protease PRSS56 causes angle-closure glaucoma in mice and posterior microphthalmia in humans and mice Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury Human xeno-autoantibodies against a non-human sialic acid serve as novel serum biomarkers and immunotherapeutics in cancer Molecular targeting of CSN5 in human hepatocellular carcinoma: a mechanism of therapeutic response Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors Polycystin-1 regulates STAT activity by a dual mechanism Drug discovery using chemical systems biology: weak inhibition of multiple kinases may contribute to the anti-cancer effect of Nelfinavir Intramyocardial, autologous CD34+ cell therapy for refractory angina Nitric oxide scavenging by red blood cell microparticles and cell-free hemoglobin as a mechanism for the red cell storage lesion Gastroesophageal reflux disease symptom severity, proton pump inhibitor use, and esophageal carcinogenesis CD28 costimulation improves expansion and persistence of chimeric antigen receptor–modified T cells in lymphoma patients Imipramine treatment improves cognitive outcome associated with enhanced hippocampal neurogenesis after traumatic brain injury in mice Combinatorial binding of transcription factors in the pluripotency control regions of the genome Engineering nanocarriers for siRNA delivery Vaults engineered for hydrophobic drug delivery Reelin, Rap1 and N-cadherin orient the migration of multipolar neurons in the developing neocortex Use of whole-genome sequencing to diagnose a cryptic fusion oncogene Identification of a novel TP53 cancer susceptibility mutation through whole-genome sequencing of a patient with therapy-related AML A non membrane-targeted human soluble CD59 attenuates choroidal neovascularization in a model of age related macular degeneration Oxidase-deficient neutrophils from X-linked chronic granulomatous disease iPS cells: functional correction by zinc finger nuclease–mediated safe harbor targeting Pharmacological characterization of chemically synthesized monomeric phi29 pRNA nanoparticles for systemic delivery Assembly of therapeutic pRNA-siRNA nanoparticles using bipartite approach The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers A high-resolution C. elegans essential gene network based on phenotypic profiling of a complex tissue A kinase shRNA screen links LATS2 and the pRB tumor suppressor DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly A new subtype of progenitor cell in the mouse embryonic neocortex PDGFRα-positive cells in bone marrow are mobilized by high mobility group box 1 (HMGB1) to regenerate injured epithelia Modelling schizophrenia using human induced pluripotent stem cells Cutting edge: humanized nano-proresolving medicines mimic inflammation-resolution and enhance wound healing Differentiation of induced pluripotent stem cells of swine into rod photoreceptors and their integration into the retina Gene therapy for pain: Results of a phase I clinical trial A rapid and scalable system for studying gene function in mice using conditional RNA interference Reversible suppression of an essential gene in adult mice using transgenic RNA interference ApoE isoform-specific regulation of regeneration in the peripheral nervous system Polycomb EZH2 controls self-renewal and safeguards the transcriptional identity of skeletal muscle stem cells Mice with behavioral evidence of tinnitus exhibit dorsal cochlear nucleus hyperactivity because of decreased GABAergic inhibition Human flap endonuclease structures, DNA double-base flipping, and a unified understanding of the FEN1 superfamily Genetic correction and analysis of induced pluripotent stem cells from a patient with gyrate atrophy Preclinical screening of anti-HER2 nanobodies for molecular imaging of breast cancer Fibroblast growth factor 9 delivery during angiogenesis produces durable, vasoresponsive microvessels wrapped by smooth muscle cells IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function Control of pancreatic β cell regeneration by glucose metabolism A universal system for highly efficient cardiac differentiation of human induced pluripotent stem cells that eliminates interline variability Microbial electricity generation via microfluidic flow control Esophageal preservation in five male patients after endoscopic inner-layer circumferential resection in the setting of superficial cancer: a regenerative medicine approach with a biologic scaffold Virally delivered channelrhodopsin-2 safely and effectively restores visual function in multiple mouse models of blindness Nanofibrous hollow microspheres self-assembled from star-shaped polymers as injectable cell carriers for knee repair Engineering a waste management enzyme to overcome cancer resistance to apoptosis: adding DNase1 to the anti-cancer toolbox Chronic ulcerative stomatitis: evidence of autoimmune pathogenesis Bone marrow-derived cell therapy stimulates endogenous cardiomyocyte progenitors and promotes cardiac repair Quantification of the forces driving self-assembly of three-dimensional microtissues Polymalic acid–based nanobiopolymer provides efficient systemic breast cancer treatment by inhibiting both HER2/neu receptor synthesis and activity Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency Modified Tat peptide with cationic lipids enhances gene transfection efficiency via temperature-dependent and caveolae-mediated endocytosis Genome-wide association study identifies a common variant associated with risk of endometrial cancer Prostaglandin E2 enhances human cord blood stem cell xenotransplants and shows long-term safety in preclinical nonhuman primate transplant models Self-organizing optic-cup morphogenesis in three-dimensional culture Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state Generation of bioengineered corneas with decellularized xenografts and human keratocytes Control of copper resistance and inorganic sulfur metabolism by paralogous regulators in Staphylococcus aureus Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation A nanomechanical interface to rapid single-molecule interactions A diverse range of gene products are effectors of the type I interferon antiviral response Human induced pluripotent stem-derived retinal pigment epithelium (RPE) cells exhibit ion transport, membrane potential, polarized vascular endothelial growth factor secretion, and gene expression pattern similar to native RPE In vivo systems analysis identifies spatial and temporal aspects of the modulation of TNF-α–induced apoptosis and proliferation by MAPKs A randomized trial of the effect of patient race on physicians' intensive care unit and life-sustaining treatment decisions for an acutely unstable elder with end-stage cancer Characterization of KRAS rearrangements in metastatic prostate cancer Mutations in the RNA granule component TDRD7 cause cataract and glaucoma Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium Multipotent progenitor cells derived from adult peripheral blood of swine have high neurogenic potential in vitro Noise contributions in an inducible genetic switch: a whole-cell simulation study Ciliary neurotrophic factor delivered by encapsulated cell intraocular implants for treatment of geographic atrophy in age-related macular degeneration Vitamin D status and early age-related macular degeneration in postmenopausal women Efficacy of periodontal stem cell transplantation in the treatment of advanced periodontitis Targeted delivery of small interfering RNA using rHDL nanoparticles SKIP counteracts p53-mediated apoptosis via selective regulation of p21Cip1 mRNA splicing Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells Circadian rhythm gene period 3 is an inhibitor of the adipocyte cell fate A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression Identification of novel and distinct binding sites within tenascin-c for soluble and fibrillar fibronectin Therapeutic targeting of SPINK1-positive prostate cancer Rapid modulation of local neural activity by controlled drug release from polymer-coated recording microelectrodes Dominant prion mutants induce curing through pathways that promote chaperone-mediated disaggregation A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells Catecholamine receptor polymorphisms affect decision-making in C. elegans Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis Efficacy and safety of sirolimus in lymphangioleiomyomatosis The complexity hypothesis revisited: connectivity rather than function constitutes a barrier to horizontal gene transfer High-resolution Fourier-transform infrared chemical imaging with multiple synchrotron beams Modulation of metabolic brain networks after subthalamic gene therapy for Parkinson's disease Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial Subthalamic GAD gene therapy in a Parkinson's disease rat model Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trial Integration-free induced pluripotent stem cells derived from schizophrenia patients with a DISC1 mutation Pancreatic cancers require autophagy for tumor growth Drosophila katanin is a microtubule depolymerase that regulates cortical-microtubule plus-end interactions and cell migration Myocardial infarction and cerebrovascular accident in patients with retinal vein occlusion Evidence for partial epithelial-to-mesenchymal transition (pEMT) and recruitment of motile blastoderm edge cells during avian epiboly Recapitulation of premature ageing with iPSCs from Hutchinson–Gilford progeria syndrome Rescue of lethal hepatic failure by hepatized lymph nodes in mice Parallel high-throughput RNA interference screens identify PINK1 as a potential therapeutic target for the treatment of DNA mismatch repair–deficient cancers Predicting cytotoxic T-cell age from multivariate analysis of static and dynamic biomarkers Immunotherapy with tolerogenic apolipoprotein B-100–loaded dendritic cells attenuates atherosclerosis in hypercholesterolemic mice Yap1 acts downstream of α-catenin to control epidermal proliferation Using self-assembled nanomaterials to inhibit the formation of metastatic cancer stem cell colonies in vitro Tissue-engineered autologous urethras for patients who need reconstruction: an observational study Short-term immunosuppression promotes engraftment of embryonic and induced pluripotent stem cells Single cell transcriptional profiling reveals heterogeneity of human induced pluripotent stem cells Uncovering the behaviors of individual cells within a multicellular microvascular community Evaluation of a multi-functional nanocarrier for targeted breast cancer iNOS gene therapy The treatment of neurodegenerative disorders using umbilical cord blood and menstrual blood-derived stem cells A high-throughput label-free nanoparticle analyser The cerebrospinal fluid provides a proliferative niche for neural progenitor cells LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress A meningococcal factor H binding protein mutant that eliminates factor H binding enhances protective antibody responses to vaccination Wnt1 is a proangiogenic molecule, enhances human endothelial progenitor function, and increases blood flow to ischemic limbs in a HGF-dependent manner The controlled generation of functional basal forebrain cholinergic neurons from human embryonic stem cells Copy number variation and selection during reprogramming to pluripotency Materials for multifunctional balloon catheters with capabilities in cardiac electrophysiological mapping and ablation therapy Rapid three-dimensional isotropic imaging of living cells using Bessel beam plane illumination Self-renewal induced efficiently, safely, and effective therapeutically with one regulatable gene in a human somatic progenitor cell Mutations in NOTCH2 cause Hajdu-Cheney syndrome, a disorder of severe and progressive bone loss Transplantation of specific human astrocytes promotes functional recovery after spinal cord injury Astrocyte-neuron lactate transport is required for long-term memory formation NKp46 identifies an NKT cell subset susceptible to leukemic transformation in mouse and human Designed reduction of Streptococcus pneumoniae pathogenicity via synthetic changes in virulence factor codon-pair bias Parkin mediates beclin-dependent autophagic clearance of defective mitochondria and ubiquitinated Aβ in AD models Progressive regional atrophy in normal adults with a maternal history of Alzheimer disease Binge alcohol drinking is associated with GABAA α2-regulated Toll-like receptor 4 (TLR4) expression in the central amygdale Coupling of V(D)J recombination to the cell cycle suppresses genomic instability and lymphoid tumorigenesis Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis MEK-ERK pathway modulation ameliorates disease phenotypes in a mouse model of Noonan syndrome associated with the Raf1L613V mutation Recombinant human CD19-ligand protein as a potent anti-leukaemic agent Microscale 3-D hydrogel scaffold for biomimetic gastrointestinal (GI) tract model Multiple self-healing squamous epithelioma is caused by a disease-specific spectrum of mutations in TGFBR1 Autografting of renal progenitor cells ameliorates kidney damage in experimental model of pyelonephritis Predicting clonal self-renewal and extinction of hematopoietic stem cells Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses Retinoid-independent motor neurogenesis from human embryonic stem cells reveals a medial columnar ground state Transient regenerative potential of the neonatal mouse heart Cancer genetics-guided discovery of serum biomarker signatures for diagnosis and prognosis of prostate cancer Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences Autologous bone marrow mononuclear cell therapy for severe traumatic brain injury in children RNA aptamer against a cancer stem cell marker epithelial cell adhesion molecule Human cord blood-derived endothelial progenitor cells and their conditioned media exhibit therapeutic equivalence for diabetic wound healing Glass-like dynamics of collective cell migration Outcomes after minimally invasive esophagectomy Small molecule inhibitors of Staphylococcus aureus RnpA alter cellular mRNA turnover, exhibit antimicrobial activity, and attenuate pathogenesis Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens Synaptic potentiation onto habenula neurons in the learned helplessness model of depression Detection of circulating tumor cells in human peripheral blood using surface-enhanced raman scattering nanoparticles IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology Induced pluripotent stem cell lines derived from equine fibroblasts DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration Tregs prevent GvHD and promote immune reconstitution in HLA-haploidentical transplantation Functional effects of adult human olfactory stem cells on early-onset sensorineural hearing loss UBE4B promotes Hdm2-mediated degradation of the tumor suppressor p53 The stilbenoid tyrosine kinase inhibitor, G6, suppresses Jak2-V617F-mediated human pathological cell growth in vitro and in vivo β-catenin enhances Oct-4 activity and reinforces pluripotency through a TCF-independent mechanism 9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome The glmS riboswitch integrates signals from activating and inhibitory metabolites in vivo ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification 5-lipoxygenase metabolite 4-HDHA is a mediator of the antiangiogenic effect of ω-3 polyunsaturated fatty acids Epicatechin blocks pro-nerve growth factor (proNGF)-mediated retinal neurodegeneration via inhibition of p75 neurotrophin receptor proNGF expression in a rat model of diabetes Diabetes-induced peroxynitrite impairs the balance of pro-nerve growth factor and nerve growth factor, and causes neurovascular injury Low prevalence of "ideal cardiovascular health" in a community-based population Mapping of the disease locus and identification of ADAMTS10 as a candidate gene in a canine model of primary open angle glaucoma Translocation of the cytoplasmic domain of ADAM13 to the nucleus is essential for Calpain8-a expression and cranial neural crest cell migration CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells EZH2 promotes expansion of breast tumor initiating cells through activation of RAF1-β-catenin signaling Golden Goal collaborates with Flamingo in conferring synaptic-layer specificity in the visual system Genomic instability in induced stem cells Access to stem cells and data: persons, property rights, and scientific progress Wounding mobilizes hair follicle stem cells to form tumors Oral delivery of RNase P ribozymes by Salmonella inhibits viral infection in mice Regulation of induced colonic inflammation by Lactobacillus acidophilus deficient in lipoteichoic acid Disruption of Src function potentiates Chk1-inhibitor–induced apoptosis in human multiple myeloma cells in vitro and in vivo Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS) Paternal MHC expression on mouse trophoblast affects uterine vascularization and fetal growth Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells Time-reversed ultrasonically encoded optical focusing into scattering media Small RNA-mediated regulation of iPS cell generation Identification of adult nephron progenitors capable of kidney regeneration in zebrafish NT5E mutations and arterial calcifications ΔNp63α is an oncogene that targets chromatin remodeler Lsh to drive skin stem cell proliferation and tumorigenesis Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures Cancer tumors as Metazoa 1.0: tapping genes of ancient ancestors Redox regulation by Keap1 and Nrf2 controls intestinal stem cell proliferation in Drosophila Efficient generation of transgene-free induced pluripotent stem cells from normal and neoplastic bone marrow and cord blood mononuclear cells A functionally characterized test set of human induced pluripotent stem cells Reference maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines Self-assembling elastin-like peptides growth factor chimeric nanoparticles for the treatment of chronic wounds Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy Creating higher titer lentivirus with caffeine Fabrication of stable and RNase-resistant RNA nanoparticles active in gearing the nanomotors for viral DNA packaging Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1 Acquisition of HIV-1 resistance in T lymphocytes using an ACA-specific E. coli mRNA interferase Erythropoietin contrastingly affects bacterial infection and experimental colitis by inhibiting nuclear Factor-κB-inducible immune pathways Hydrophilic agarose macrobead cultures select for outgrowth of carcinoma cell populations that can restrict tumor growth Three-dimensional culture of mouse renal carcinoma cells in agarose macrobeads selects for a subpopulation of cells with cancer stem cell or cancer progenitor properties DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration Cell infiltration and growth in a low density, uncompressed three-dimensional electrospun nanofibrous scaffold An optimized small molecule inhibitor cocktail supports long-term maintenance of human embryonic stem cells Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice Thermodynamic additivity of sequence variations: an algorithm for creating high affinity peptides without large libraries or structural information Exploring antibody recognition of sequence space through random-sequence peptide microarrays A human iPSC model of Hutchinson Gilford Progeria reveals vascular smooth muscle and mesenchymal stem cell defects Dentin matrix protein 1 induces membrane expression of VE-cadherin on endothelial cells and inhibits VEGF-induced angiogenesis by blocking VEGFR-2 phosphorylation Readily available tissue-engineered vascular grafts Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGFβ signalling and EMT Characterization and functionality of cardiac progenitor cells in congenital heart patients Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases Role of parallel reformable bonds in the self-healing of cross-linked nanogel particles In vivo anomalous diffusion and weak ergodicity breaking of lipid granules Breast on-a-chip: mimicry of the channeling system of the breast for development of theranostics Targeted removal of migratory tumor cells by functionalized magnetic nanoparticles impedes metastasis and tumor progression Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks The dual impact of HIV-1 infection and aging on naïve CD4+ T-cells: additive and distinct patterns of impairment Identification of adult nephron progenitors capable of kidney regeneration in zebrafish Evidence for an inherited predisposition to lumbar disc disease Maternal T cells limit engraftment after in utero hematopoietic cell transplantation in mice Nascent transcript sequencing visualizes transcription at nucleotide resolution Heat shock protein 27 differentiates tolerogenic macrophages that may support human breast cancer progression Staphylococcus aureus phenotype switching: an effective bacterial strategy to escape host immune response and establish a chronic infection Stromal endothelial cells directly influence cancer progression Multipotent adult progenitor cells prevent macrophage-mediated axonal dieback and promote regrowth after spinal cord injury Nestin negatively regulates postsynaptic differentiation of the neuromuscular synapse Cellular and extracellular programming of cell fate through engineered intracrine-, paracrine-, and endocrine-like mechanisms Mechanical properties and in vivo behavior of a biodegradable synthetic polymer microfiber-extracellular matrix hydrogel biohybrid scaffold A phase I study of concurrent chemotherapy (paclitaxel and carboplatin) and thoracic radiotherapy with swallowed manganese superoxide dismutase plasmid liposome protection in patients with locally advanced stage III non-small-cell lung cancer Generation of induced pluripotent stem cell lines from Friedreich Ataxia patients Cell therapy, a new standard in management of chronic critical limb ischemia and foot ulcer Modelling the long QT syndrome with induced pluripotent stem cells Treatment of acute otitis media in children under 2 years of age Detection of heteroplasmic mitochondrial DNA in single mitochondria Protein nanodisk assembling and intracellular trafficking powered by an arginine-rich (R9) peptide Internalization and kinetics of nuclear migration of protein-only, arginine-rich nanoparticles A transgenic mouse for in vivo detection of endogenous labeled mRNA Strain-resolved community genomic analysis of gut microbial colonization in a premature infant Increased expression and activity of 12-lipoxygenase in oxygen-induced ischemic retinopathy and proliferative diabetic retinopathy Covalently immobilized platelet-derived growth factor-BB promotes angiogenesis in biomimetic poly(ethylene glycol) hydrogels miR-29b is activated during neuronal maturation and targets BH3-only genes to restrict apoptosis Dexamethasone intravitreal implant for noninfectious intermediate or posterior uveitis Identification of molecular-mimicry-based ligands for cholera diagnostics using magnetic relaxation The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44 Using mechanobiological mimicry of red blood cells to extend circulation times of hydrogel microparticles Regulation of E2Fs and senescence by PML nuclear bodies Dynamics between stem cells, niche, and progeny in the hair follicle Transdifferentiation of glioblastoma cells into vascular endothelial cells An optimized small molecule inhibitor cocktail supports long-term maintenance of human embryonic stem cells Determination of somatic and cancer stem cell self-renewing symmetric division rate using sphere assays Stromal endothelial cells directly influence cancer progression A human iPSC model of Hutchinson Gilford Progeria reveals vascular smooth muscle and mesenchymal stem cell defects ROCK inhibition facilitates the generation of human-induced pluripotent stem cells in a defined, feeder-, and serum-free system Functional mesenchymal stem cells derived from human induced pluripotent stem cells attenuate limb ischemia in mice Maximizing the efficiency of the U.S. liver allocation system through region design Flexural characterization of cell encapsulated PEGDA hydrogels with applications for tissue engineered heart valves De novo designed proteins from a library of artificial sequences function in Escherichia coli and enable cell growth Regulator of calcineurin 1 (RCAN1) facilitates neuronal apoptosis through caspase 3 activation Prefoldin 5 is required for normal sensory and neuronal development in a murine model The Notch target Hes1 directly modulates Gli1 expression and Hedgehog signaling: a potential mechanism of therapeutic resistance Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living mice Characteristics of the earliest cross-neutralizing antibody response to HIV-1 IRF5 promotes inflammatory macrophage polarization and T(H)1-T(H)17 responses Aberrant overexpression of satellite repeats in pancreatic and other epithelial cancers Tunable signal processing in synthetic MAP kinase cascades Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture Bald scalp in men with androgenetic alopecia retains hair follicle stem cells but lacks CD200-rich and CD34-positive hair follicle progenitor cells Proliferative neural stem cells have high endogenous ROS levels that regulate self-renewal and neurogenesis in a PI3K/Akt-dependant manner Gene therapy by allele selection in a mouse model of beta-thalassemia Robo4 cooperates with Cxcr4 to specify hematopoietic stem cell localization to bone marrow niches Active scaffolds for on-demand drug and cell delivery Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection Angiotensin-(1-7) reduces fibrosis in orthotopic breast tumors Non-stem cell origin for oligodendroglioma CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells Massive genomic rearrangement acquired in a single catastrophic event during cancer development Loss-of-function mutations in the glutamate transporter SLC1A1 cause human dicarboxylic aminoaciduria Enhancing mda-7/IL-24 therapy in renal carcinoma cells by inhibiting multiple protective signaling pathways using sorafenib and by Ad.5/3 gene delivery Adipose-derived stem cells differentiate to keratocytes in vitro Transient regenerative potential of the neonatal mouse heart IOC consensus paper on the use of platelet-rich plasma in sports medicine Generation of viable male and female mice from two fathers Transcription of functionally related constitutive genes is not coordinated Retinoid X receptor gamma signaling accelerates CNS remyelination Multifunctional carbon-nanotube cellular endoscopes TRIM24 links a non-canonical histone signature to breast cancer Abl kinases are required for invadopodia formation and chemokine-induced invasion Quantifying the biophysical characteristics of Plasmodium-falciparum-parasitized red blood cells in microcirculation Podocyte-secreted angiopoietin-like-4 mediates proteinuria in glucocorticoid-sensitive nephrotic syndrome Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis Short telomeres and stem cell exhaustion model Duchenne Muscular Dystrophy in mdx/mTR mice Fetal and adult hematopoietic stem cells give rise to distinct T cell lineages in humans The dynamic distribution of CARD11 at the immunological synapse is regulated by the inhibitory kinesin GAKIN Epigenetic suppression of the TGF-beta pathway revealed by transcriptome profiling in ovarian cancer Repression of the miR-143/145 cluster by oncogenic Ras initiates a tumor-promoting feed-forward pathway Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K β-catenin mediates the establishment and drug resistance of MLL leukemic stem cells Multifunctional carbon-nanotube cellular endoscopes Degradable polyester scaffolds with controlled surface chemistry combining minimal protein adsorption with specific bioactivation Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy Ectopic expression of germline genes drives malignant brain tumor growth in Drosophila Association of a leukemic stem cell gene expression signature with clinical outcomes in acute myeloid leukemia Tumor-specific imaging through progression elevated gene-3 promoter-driven gene expression Substantial expression of mature elastin in arterial constructs Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization Astrocyte elevated gene-1 induces protective autophagy Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro MicroRNA profiling reveals two distinct p53-related human pluripotent stem cell states Reprogramming of human primary somatic cells by OCT4 and chemical compounds Regulation of hematopoietic stem cells by their mature progeny Bioactive peptides derived from vascular endothelial cell extracellular matrices promote microvascular morphogenesis and wound healing in vitro Mycobacterium tuberculosis evades host immunity by recruiting mesenchymal stem cells Sharing pathogenetic mechanisms between acute myocardial infarction and Alzheimer's disease as shown by partially overlapping of gene variant profiles Invasive three-dimensional organotypic neoplasia from multiple normal human epithelia Subdivisions of primary motor cortex based on cortico-motoneuronal cells The basal ganglia communicate with the cerebellum Maintenance treatment of depression in old age: A randomized, double-blind, placebo-controlled evaluation of the efficacy and safety of donepezil combined with antidepressant pharmacotherapy Periodic incorporation of pendant hydroxyl groups in repeating sequence PLGA copolymers Results following gamma knife radiosurgical anterior capsulotomies for obsessive compulsive disorder Repeatable photoinduced self-healing of covalently cross-linked polymers through reshuffling of trithiocarbonate units Epigenetic suppression of the TGF-beta pathway revealed by transcriptome profiling in ovarian cancer Fibrin microthreads support mesenchymal stem cell growth while maintaining differentiation potential Subtypes of medulloblastoma have distinct developmental origins MicroRNA miR-125b causes leukemia Bmi-1 Is a crucial regulator of prostate stem cell self-renewal and malignant transformation Ultraviolet B irradiation and activation of protein kinase D in primary mouse epidermal keratinocytes Brachyury establishes the embryonic mesodermal progenitor niche Mre11–Rad50–Xrs2 and Sae2 promote 5′ strand resection of DNA double-strand breaks COT drives resistance to RAF inhibition through MAP kinase pathway reactivation Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling L1 retrotransposition in neurons is modulated by MeCP2 Rewiring of genetic networks in response to DNA damage Shotgun glycomics: a microarray strategy for functional glycomics Hybrid pore formation by directed insertion of α-haemolysin into solid-state nanopores Long-distance axon regeneration in the mature optic nerve: Contributions of oncomodulin, cAMP, and pten gene deletion Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α miR-200 family and targets, ZEB1 and ZEB2, modulate uterine quiescence and contractility during pregnancy and labor Stage-specific sensitivity to p53 restoration during lung cancer progression Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice Malignant cells facilitate lung metastasis by bringing their own soil The role of interleukin-1 in wound biology. Part II: In vivo and human translational studies The role of interleukin-1 in wound biology. Part I: Murine in silico and in vitro experimental analysis A non-human primate model for urinary bladder regeneration utilizing autologous sources of bone marrow derived mesenchymal stem cells Siah regulation of Pard3A controls neuronal cell adhesion during germinal zone exit Dynamic electromechanical hydrogel matrices for stem cell culture Interplay between the transcription factor Zif and aPKC regulates neuroblast polarity and self-renewal Tension directly stabilizes reconstituted kinetochore-microtubule attachments Overexpression of Fto leads to increased food intake and results in obesity Reversing EphB2 depletion rescues cognitive functions in Alzheimer model Three-dimensional cellular ultrastructure resolved by X-ray microscopy Complement factor H and age-related macular degeneration: the role of glycosaminoglycan recognition in disease pathology Impaired binding of the age-related macular degeneration-associated complement factor H 402H allotype to Bruch's Membrane in human retina Anti-acrolein treatment improves behavioral outcome and alleviates myelin damage in experimental autoimmune encephalomyelitis mouse Conversion of vascular endothelial cells into multipotent stem-like cells Nonsense mutations in FAM161A cause RP28-associated recessive retinitis pigmentosa CRX ChIP-seq reveals the cis-regulatory architecture of mouse photoreceptors Transplantation of mouse HSCs genetically modified to express a CD4-restricted TCR results in long-term immunity that destroys tumors and initiates spontaneous autoimmunity Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance Stem-cell gene therapy for the Wiskott-Aldrich syndrome A model for neural development and treatment of Rett Syndrome using human induced pluripotent stem cells A defined glycosaminoglycan-binding substratum for human pluripotent stem cells Frequent mutation of BAP1 in metastasizing uveal melanomas A quality risk management model approach for cell therapy manufacturing Development of a Bacillus subtilis-based rotavirus vaccine Efficacy, heat stability and safety of intranasally administered Bacillus subtilis spore or vegetative cell vaccines expressing tetanus toxin fragment C Induction of human epithelial stem/progenitor expansion by FOXM1 DNMT3A mutations in acute myeloid leukemia Measurement of adherent cell mass and growth Physiological and pathological population dynamics of circulating human red blood cells The use of whole organ decellularization for the generation of a vascularized liver organoid Prevention of muscle aging by myofiber-associated satellite cell transplantation Visual activity regulates neural progenitor cells in developing Xenopus CNS through Musashi1 Neural crest origin of olfactory ensheathing glia Identifying single bases in a DNA oligomer with electron tunneling A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells Stem-cell gene therapy for the Wiskott-Aldrich syndrome Therapeutic potential of human umbilical cord mesenchymal stem cells in the treatment of rheumatoid arthritis Conditional outlier detection for clinical alerting The emerging relationship between regenerative medicine and physical therapeutics Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis Stem cell dynamics in response to nutrient availability Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy The major genetic determinants of HIV-1 control affect HLA class I peptide presentation Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3) Anaplastic lymphoma kinase inhibition in non–small-cell lung cancer Effect of a lung protective strategy for organ donors on eligibility and availability of lungs for transplantation: a randomized controlled trial Estimated supply of organ donors after circulatory determination of death: a population-based cohort study Improving the supply of donor organs: being careful with the gift of life Insulin-like growth factor receptor 1(IGFIR) is overexpressed in a subset of triple negative breast cancers Human anti–HIV-neutralizing antibodies frequently target a conserved epitope essential for viral fitness Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation Organotypic 3D cell culture models: using the rotating wall vessel to study host–pathogen interactions Phosphodiesterase 11A (PDE11A) genetic variants may increase susceptibility to prostatic cancer Clonal tracking of hESCs reveals differential contribution to functional assays Directed differentiation of human embryonic stem cells toward chondrocytes A genome-wide study reveals copy number variants exclusive to childhood obesity cases A reductionist cell-free major histocompatibility complex class II antigen processing system identifies immunodominant epitopes The structural basis for membrane binding and pore formation by lymphocyte perforin On-line, voluntary control of human temporal lobe neurons Overexpression of transcription factor sp2 inhibits epidermal differentiation and increases susceptibility to wound- and carcinogen-induced tumorigenesis Generation of transgene-free lung disease-specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette Transmembrane potential of GlyCl-expressing instructor cells induces a neoplastic-like conversion of melanocytes via a serotonergic pathway Elastomeric osteoconductive synthetic scaffolds with acquired osteoinductivity expedite the repair of critical femoral defects in rats Transfection of shRNA-encoding Minivector DNA of a few hundred base pairs to regulate gene expression in lymphoma cells Synthetic lethality screens reveal RPS6 and MST1R as modifiers of insulin-like growth factor-1 receptor inhibitor activity in childhood sarcomas Efficient CNS gene delivery by intravenous injection Loss of inositol polyphosphate 5-phosphatase is an early event in development of cutaneous squamous cell carcinoma p63 and p73 are required for p53-dependent apoptosis in response to DNA damage TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs Binding-induced folding of prokaryotic ubiquitin-like protein on the Mycobacterium proteasomal ATPase targets substrates for degradation Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2 Reversal of depressed behaviors in mice by p11 gene therapy in the nucleus accumbens Sept4/ARTS is required for stem cell apoptosis and tumor suppression Targeting mitochondrial glutaminase activity inhibits oncogenic transformation Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels SNPs associated with cerebrospinal fluid phospho-tau levels influence rate of decline in Alzheimer's disease Selective inhibition of BET bromodomains Nucleotide excision repair deficiency is intrinsic in sporadic stage I breast cancer Allelic variation at the 8q23.3 colorectal cancer risk locus functions as a cis-acting regulator of EIF3H Reconstruction of the complete human cytomegalovirus genome in a BAC reveals RL13 to be a potent inhibitor of replication Granulocyte-colony stimulating factor reactivates human cytomegalovirus in a latently infected humanized mouse model Intestinal stem cell replacement follows a pattern of neutral drift Pharmacological inhibition of EGFR signaling enhances G-CSF–induced hematopoietic stem cell mobilization A human MAP kinase interactome AID-induced genotoxic stress promotes B cell differentiation in the germinal center via ATM and LKB1 signaling Nanoscale approaches to define biologic signatures and measure proteomic response to targeted therapies in hematologic and solid tumors Nanotopographical control of stem cell differentiation Cone and rod photoreceptor transplantation in models of the childhood retinopathy Leber congenital amaurosis using flow-sorted Crx-positive donor cells Differentially expressed RNA from public microarray data identifies serum protein biomarkers for cross-organ transplant rejection and other conditions Humanized nonobese diabetic-scid IL2rγnull mice are susceptible to lethal Salmonella Typhi infection Cloud-scale RNA-sequencing differential expression analysis with Myrna ARID1A mutations in endometriosis-associated ovarian carcinomas Modulation of K-Ras-dependent lung tumorigenesis by MicroRNA-21 Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma Endogenous HMGB1 regulates autophagy Selectivity mechanism of the nuclear pore complex characterized by single cargo tracking Gilgamesh is required for rutabaga-independent olfactory learning in Drosophila Bevacizumab vs ranibizumab for age-related macular degeneration: 1-year outcomes of a prospective, double-masked randomised clinical trial In vitro maturation of oocytes via the pre-fabricated self-assembled artificial human ovary MicroRNAs and pharmacogenomics Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists Molecular pathway and cell state responsible for dissociation-induced apoptosis in human pluripotent stem cells Induction of vertebrate regeneration by a transient sodium current A tubular cell-enriched subpopulation of primary renal cells improves survival and augments kidney function in a rodent model of chronic kidney disease Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma A genome-wide association study identifies a susceptibility locus for refractive errors and myopia at 15q14 Common genetic variants near the brittle cornea syndrome locus ZNF469 influence the blinding disease risk factor central corneal thickness Genome-wide association identifies ATOH7 as a major gene determining human optic disc size The in vivo performance of plasmonic nanobubbles as cell theranostic agents in zebrafish hosting prostate cancer xenografts Synthetic lethal screen of an EGFR-centered network to improve targeted therapies Personalized epigenomic signatures that are stable over time and covary with body mass index Apatite microtopographies instruct signaling tapestries for progenitor-driven new attachment of teeth Selective cell death mediated by small conditional RNAs Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma A microfluidic bioreactor with integrated transepithelial electrical resistance (TEER) measurement electrodes for evaluation of renal epithelial cells The implantable artificial kidney A spindle-independent cleavage furrow positioning pathway Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial Epigenetic regulation of stem cell maintenance in the drosophila testis via the nucleosome-remodeling factor NURF Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system Insulin resistance is associated with the pathology of Alzheimer disease Puma is required for p53-induced depletion of adult stem cells Nonsense mutations in FAM161A cause RP28-associated recessive retinitis pigmentosa CRX ChIP-seq reveals the cis-regulatory architecture of mouse photoreceptors Protamine contents and P1/P2 ratio in human spermatozoa from smokers and non-smokers Cigarette smoking during early pregnancy reduces the number of embryonic germ and somatic cells Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1 Non-muscle myosin II regulates survival threshold of pluripotent stem cells γ-Secretase inhibitors enhance temozolomide treatment of human gliomas by inhibiting neurosphere repopulation and xenograft recurrence Combinatorial development of biomaterials for clonal growth of human pluripotent stem cells Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations A new research and development policy framework for the biomedical research enterprise Female human iPSCs retain an inactive X chromosome Complement factor H polymorphism and age-related macular degeneration E2-2 protein and Fuchs's corneal dystrophy The lingering consequences of sepsis: a hidden public health disaster? Long-term cognitive impairment and functional disability among survivors of severe sepsis Pericyte-based human tissue engineered vascular grafts Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1 The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche Inhibition of mutated, activated BRAF in metastatic melanoma The molecular interaction of CAR and JAML recruits the central cell signal transducer PI3K The junctional adhesion molecule JAML is a costimulatory receptor for epithelial γδT cell activation A biosynthetic alternative to human donor tissue for inducing corneal regeneration: 24-month follow-up of a phase 1 clinical study BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells Mitotic recombination in patients with ichthyosis causes reversion of dominant mutations in KRT10 Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma Functional diversity of ESC-derived motor neuron subtypes revealed through intraspinal transplantation Crystal structure of human adenovirus at 3.5 Å resolution Identity-by-descent filtering of exome sequence data identifies PIGV mutations in hyperphosphatasia mental retardation syndrome Adeno-associated viral vector-induced overexpression of neuropeptide Y Y2 receptors in the hippocampus suppresses seizures Heterochromatin silencing of p53 target genes by a small viral protein A unifying genetic model for facioscapulohumeral muscular dystrophy Human neural stem cells differentiate and promote locomotor recovery in an early chronic spinal cord injury NOD-scid mouse model A regulatory toolbox of MiniPromoters to drive selective expression in the brain Myc represses primitive endoderm differentiation in pluripotent stem cells Atomic structure of human adenovirus by cryo-EM reveals interactions among protein networks Optimal matrix rigidity for stress-fibre polarization in stem cells GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects Association between reduced copy-number at T-cell receptor gamma (TCRgamma) and childhood allergic asthma: A possible role for somatic mosaicism PDE11A associations with asthma: Results of a genome-wide association scan CD31+ cells represent highly angiogenic and vasculogenic cells in bone marrow Human peripheral blood-derived CD31+ cells have robust angiogenic and vasculogenic properties and are effective for treating ischemic vascular disease Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells A kinetochore-independent mechanism drives anaphase chromosome separation during acentrosomal meiosis Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2 Ascorbate promotes epigenetic activation of CD30 in human embryonic stem cells Vitamin C promotes widespread yet specific DNA demethylation of the epigenome in human embryonic stem cells Mammalian microRNAs predominantly act to decrease target mRNA levels SIK2 is a centrosome kinase required for bipolar mitotic spindle formation that provides a potential target for therapy in ovarian cancer Mediator and cohesin connect gene expression and chromatin architecture Microenvironmental reprogramming of thymic epithelial cells to skin multipotent stem cells Combinatorial development of biomaterials for clonal growth of human pluripotent stem cells Evolution of an adenocarcinoma in response to selection by targeted kinase inhibitors Proangiogenic scaffolds as functional templates for cardiac tissue engineering Crohn's disease activity index does not correlate with endoscopic recurrence one year after ileocolonic resection Bone marrow transplantation for recessive dystrophic epidermolysis bullosa MicroRNA miR-125a controls hematopoietic stem cell number Exome sequencing identifies MLL2 mutations as a cause of Kabuki syndrome Production of p53 gene knockout rats by homologous recombination in embryonic stem cells Optical pacing of the embryonic heart Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver Vitamin D3 attenuates Th2 responses to Aspergillus fumigatus mounted by CD4+ T cells from cystic fibrosis patients with allergic bronchopulmonary aspergillosis Genome-wide association study identifies variants in the CFH region associated with host susceptibility to meningococcal disease An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis Presence of a putative tumor-initiating progenitor cell population predicts poor prognosis in smokers with non–small cell lung cancer Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma MicroRNA-29a regulates intestinal membrane permeability in patients with irritable bowel syndrome MicroRNA-132–mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis Susceptibility to chronic pain following nerve injury is genetically affected by CACNG2 New class of gene-termini-associated human RNAs suggests a novel RNA copying mechanism Molecular targeting of intracellular compartments specifically in cancer cells From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus Biological, clinical and population relevance of 95 loci for blood lipids Phase I/II study of oncolytic HSVGM-CSF in combination with radiotherapy and cisplatin in untreated stage III/IV squamous cell cancer of the head and neck Bevacizumab vs ranibizumab for age-related macular degeneration: 1-year outcomes of a prospective, double-masked randomised clinical trial POD nanoparticles expressing GDNF provide structural and functional rescue of light-induced retinal degeneration in an adult mouse Pivotal advance: the pattern recognition receptor ligands lipopolysaccharide and polyinosine-polycytidylic acid stimulate factor B synthesis by the macrophage through distinct but overlapping mechanisms Anthropometric measures and their relation to incident primary open-angle glaucoma Deletion of the potassium channel Kv12.2 causes hippocampal hyperexcitability and epilepsy Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression Force-controlled spatial manipulation of viable mammalian cells and micro-organisms by means of FluidFM technology Mesenchymal and haematopoietic stem cells form a unique bone marrow niche Defective erythroid differentiation in miR-451 mutant mice mediated by 14-3-3ζ Transient inactivation of Rb and ARF yields regenerative cells from postmitotic mammalian muscle Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors PNPASE regulates RNA import into mitochondria High-throughput tracking of pluripotent human embryonic stem cells with dual fluorescence resonance energy transfer molecular beacons An alphavirus vector overcomes the presence of neutralizing antibodies and elevated numbers of Tregs to induce immune responses in humans with advanced cancer Polycomb target genes are silenced in multiple myeloma Scalable synthetic oligodeoxynucleotide purification with use of a catching by polymerization, washing, and releasing approach Induction of human β-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6 FAN1 acts with FANCI-FANCD2 to promote DNA interstrand cross-link repair Regulation of the autophagy protein LC3 by phosphorylation Optical coherence tomography detection of subclinical traumatic cartilage injury Regenerative therapy and cancer: in vitro and in vivo studies of the interaction between adipose-derived stem cells and breast cancer cells from clinical isolates Direct evidence of lymphatic function improvement after advanced pneumatic compression device treatment of lymphedema Mechanical regulation of cell function with geometrically modulated elastomeric substrates Bone marrow mesenchymal stem cells stimulate cardiac stem cell proliferation and differentiation Identification of a cell of origin for human prostate cancer Regeneration of the articular surface of the rabbit synovial joint by cell homing: a proof of concept study The efficient generation of induced pluripotent stem (iPS) cells from adult mouse adipose tissue-derived and neural stem cells Innate immune suppression enables frequent transfection with RNA encoding reprogramming proteins Ectopic human mesenchymal stem cell-coated scaffolds in NOD/SCID Mice: an in vivo model of the leukemia niche miR-451 protects against erythroid oxidant stress by repressing 14-3-3ζ Comprehensive, quantitative mapping of T cell epitopes in gluten in celiac disease Cushing's syndrome and fetal features resurgence in adrenal cortex–specific Prkar1a knockout mice NT-020, a natural therapeutic approach to optimize spatial memory performance and increase neural progenitor cell proliferation and decrease inflammation in the aged rat Allogeneic T-cell therapy for Epstein-Barr virus-positive posttransplant lymphoproliferative disease: long-term follow-up Discovery of a proneurogenic, neuroprotective chemical A gene on the HER2 amplicon, C35, is an oncogene in breast cancer whose actions are prevented by inhibition of Syk Genetic reactivation of cone photoreceptors restores visual responses in retinitis pigmentosa MicroRNA miR-125a controls hematopoietic stem cell number Transient inactivation of Rb and ARF yields regenerative cells from postmitotic mammalian muscle Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification Molecular steps of G-overhang generation at human telomeres and its function in chromosome end protection Regulation of myeloid leukaemia by the cell-fate determinant Musashi Substrate elasticity regulates skeletal muscle stem cell self-renewal in culture Origins and diversification of a complex signal transduction system in prokaryotes Kinetic phases of distribution and tumor targeting by T cell receptor engineered lymphocytes inducing robust antitumor responses PTEN inhibition to facilitate intrinsic regenerative outgrowth of adult peripheral axons TGF-β2 alters the characteristics of the neuromuscular junction by regulating presynaptic quantal size Rituximab versus cyclophosphamide for ANCA-associated vasculitis Collective chemotaxis requires contact-dependent cell polarity Cross-species genomics matches driver mutations and cell compartments to model ependymoma A new DAF-16 isoform regulates longevity Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming Dynamic single-cell imaging of direct reprogramming reveals an early specifying event Regulation of mouse spermatogonial stem cell differentiation by STAT3 signaling Reprogramming of human peripheral blood cells to induced pluripotent stem cells Genetically abnormal circulating cells in lung cancer patients: an antigen-independent fluorescence in situ hybridization–based case-control study A KRAS-variant in ovarian cancer acts as a genetic marker of cancer risk Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation SIRT1 suppresses β-amyloid production by activating the α-secretase gene ADAM10 Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells Innate immune suppression enables frequent transfection with RNA encoding reprogramming proteins Irradiation of the potential cancer stem cell niches in the adult brain improves progression-free survival of patients with malignant glioma Mapping the first stages of mesoderm commitment during differentiation of human embryonic stem cells Topological optimization for designing patient-specific large craniofacial segmental bone replacements Reprogramming of T cells from human peripheral blood Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271 Increased mutagenesis and unique mutation signature associated with mitotic gene conversion Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia Pax6 is a human neuroectoderm cell fate determinant Serotonergic neurons mediate dyskinesia side effects in Parkinson’s patients with neural transplants Primary tumor genotype is an important determinant in identification of lung cancer propagating cells Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1 Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01 Allogeneic stem cell transplantation provides durable disease control in poor-risk chronic lymphocytic leukemia:long-term clinical and MRD results of the GCLLSG CLL3X trial Cancerous stem cells: deviant stem cells with cancer-causing misbehavior Ronin/Hcf-1 binds to a hyperconserved enhancer element and regulates genes involved in the growth of embryonic stem cells Genetic variation and neuroimaging measures in Alzheimer disease Self-assembly of three-dimensional prestressed tensegrity structures from DNA A novel mechanism of indole-3-carbinol effects on breast carcinogenesis involves induction of Cdc25A degradation An early T cell lineage commitment checkpoint dependent on the transcription factor Bcl11b Lipid-coated nano-calcium-phosphate (LNCP) for gene delivery Vortex-assisted DNA delivery Phosphorylation stabilizes Nanog by promoting its interaction with Pin1 A recessive screen for genes regulating hematopoietic stem cells Increased osteoarthritis in moose from Isle Royale Ecology of arthritis A thin film detection/response system for pathogenic bacteria Structural changes in a marine podovirus associated with release of its genome into Prochlorococcus Reconstituting organ-level lung functions on a chip Melanocytes are deficient in repair of oxidative DNA damage and UV-induced photoproducts The interaction between Myc and Miz1 is required to antagonize TGFβ-dependent autocrine signaling during lymphoma formation and maintenance Intergroup randomized phase III study of androgen deprivation therapy (ADT) plus radiation therapy (RT) in locally advanced prostate cancer (CaP) (NCIC-CTG, SWOG, MRC-UK, INT: T94-0110; NCT00002633). Genetic reactivation of cone photoreceptors restores visual responses in retinitis pigmentosa A distinctive role for focal adhesion proteins in three-dimensional cell motility Mesenchymal stem cells reduce inflammation while enhancing bacterial clearance and improving survival in sepsis Ablation of the kinase NDR1 predisposes mice to the development of T cell lymphoma Interference with Sin3 function induces epigenetic reprogramming and differentiation in breast cancer cells Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis Molecular characterization of mucosal adherent bacteria and associations with colorectal adenomas Antimethicillin-resistant Staphylococcus aureus (MRSA) activity of 'pacific propolis' and isolated prenylflavanones Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists Diabetes depresses synaptic transmission in sympathetic ganglia by inactivating nAChRs through a conserved intracellular cysteine residue A coding-independent function of gene and pseudogene mRNAs regulates tumour biology Single-cell NF-κB dynamics reveal digital activation and analogue information processing Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine Harnessing structure-activity relationship to engineer a cisplatin nanoparticle for enhanced antitumor efficacy Serotonin regulates pancreatic beta cell mass during pregnancy Engineered allosteric activation of kinases in living cells Human amnion epithelial cell transplantation abrogates lung fibrosis and augments repair Tissue-engineered lungs for in vivo implantation Human polynucleotide phosphorylase selectively and preferentially degrades microRNA-221 in human melanoma cells Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition Umpolung reactivity in amide and peptide synthesis Multiple epigenetic modifiers induce aggressive viral extinction in extraembryonic endoderm stem cells Gene therapy for type 1 diabetes: a combinatorial approach using neurogenin-3-interleukin-10 hepatic gene transfer reverses diabetes in overtly diabetic NOD mice Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer Tissue-engineered lungs for in vivo implantation Regeneration and orthotopic transplantation of a bioartificial lung Reconstructing the lung Nucleotide-binding oligomerization domain-2 inhibits toll-like receptor-4 signaling in the intestinal epithelium Tracking differentiating neural progenitors in pluripotent cultures using microRNA-regulated lentiviral vectors Functionally defective germline variants of sialic acid acetylesterase in autoimmunity Influenza A virus-generated small RNAs regulate the switch from transcription to replication Functional impact of global rare copy number variation in autism spectrum disorders Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations Reprogramming of T cells to natural killer–like cells upon Bcl11b deletion Dental pulp cells for induced pluripotent stem cell banking RNA-based gene therapy for HIV with lentiviral vector–modified CD34+ cells in patients undergoing transplantation for AIDS-related lymphoma The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing Short RNAs are transcribed from repressed polycomb target genes and interact with polycomb repressive complex-2 Transposable elements have rewired the core regulatory network of human embryonic stem cells Tumour angiogenesis is reduced in the Tc1 mouse model of Down’s syndrome Designing communicating colonies of biomimetic microcapsules Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome In vivo targeting of B-cell lymphoma with glycan ligands of CD22 Phase II trial of daily, oral green tea extract in patients with asymptomatic, Rai stage 0-II chronic lymphocytic leukemia (CLL) Mutations in TMEM216 perturb ciliogenesis and cause Joubert, Meckel and related syndromes Quiescent haematopoietic stem cells are activated by IFN-γ in response to chronic infection A murine ESC-like state facilitates transgenesis and homologous recombination in human pluripotent stem cells A phase III random assignment trial comparing percutaneous hepatic perfusion with melphalan (PHP-mel) to standard of care for patients with hepatic metastases from metastatic ocular or cutaneous melanoma Permanently blocked stem cells derived from breast cancer cell lines Structural basis for 5′-nucleotide base-specific recognition of guide RNA by human AGO2 Gene delivery to mitotic and postmitotic photoreceptors via compacted DNA nanoparticles results in improved phenotype in a mouse model of retinitis pigmentosa A role for the Werner syndrome protein in epigenetic inactivation of the pluripotency factor Oct4 A novel phosphatase cascade regulates differentiation in Trypanosoma brucei via a glycosomal signaling pathway Systemic delivery of scAAV9 expressing SMN prolongs survival in a model of spinal muscular atrophy Functional impact of global rare copy number variation in autism spectrum disorders Regulation of microRNA expression and abundance during lymphopoiesis Effect of zoledronic acid on disseminated tumour cells in women with locally advanced breast cancer: an open label, randomised, phase 2 trial Effective, broad spectrum control of virulent bacterial infections using cationic DNA liposome complexes combined with bacterial antigens Long-lasting reduction in hippocampal neurogenesis by alcohol consumption in adolescent nonhuman primates Migration of engrafted neural stem cells is mediated by CXCL12 signaling through CXCR4 in a viral model of multiple sclerosis Selective changes in thin spine density and morphology in monkey prefrontal cortex correlate with aging-related cognitive impairment A genome-wide RNA interference screen reveals an essential CREB3L2-ATF5-MCL1 survival pathway in malignant glioma with therapeutic implications Identification of a B cell signature associated with renal transplant tolerance in humans Detection of femtomole quantities of mature cathepsin K with zymography Relationship between nucleosome positioning and DNA methylation Gold nanorod delivery of an ssRNA immune activator inhibits pandemic H1N1 influenza viral replication B-lymphoid cells with attributes of dendritic cells regulate T cells via indoleamine 2,3-dioxygenase Three-dimensional early retinal progenitor 3D tissue constructs derived from human embryonic stem cells Pathologic caveolin-1 regulation of PTEN in idiopathic pulmonary fibrosis GJC2 missense mutations cause human lymphedema Is the incidence of rheumatoid arthritis rising?: results from Olmsted County, Minnesota, 1955-2007 Tissue-engineered lungs for in vivo implantation An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression CD95 promotes tumour growth Phase I study of anti-CD25 mab daclizumab to deplete regulatory T cells prior to telomerase/survivin peptide vaccination in patients (pts) with metastatic breast cancer (MBC) A phase I study of CD40 agonist monoclonal antibody (CP-870,893) with gemcitabine in pancreatic cancer A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci Gazing into a crystal ball to predict kidney transplant outcome Identification of a B cell signature associated with renal transplant tolerance in humans Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans A molecular classifier for predicting future graft loss in late kidney transplant biopsies Directing astroglia from the cerebral cortex into subtype specific functional neurons Endothelial nitric oxide synthase deficiency causes collateral vessel rarefaction and impairs activation of a cell cycle gene network during arteriogenesis Micro-masonry: construction of 3D structures by microscale self-assembly Nanofiber assembly by rotary jet-spinning Segment-specific neuronal subtype specification by the integration of anteroposterior and temporal cues Common variation in ISL1 confers genetic susceptibility for human congenital heart disease PediaFlow maglev ventricular assist device: a prescriptive design approach Infection rate and acute organ dysfunction risk as explanations for racial differences in severe sepsis Gait biomechanics, spatial and temporal characteristics, and the energy cost of walking in older adults with impaired mobility A prospective U.S. ovarian cancer screening study using the risk of ovarian cancer algorithm (ROCA) A randomized phase II trial comparing exemestane, letrozole, and anastrozole in postmenopausal women with clinical stage II/III estrogen receptor-positive breast cancer Mechanosensitive hair cell-like cells from embryonic and induced pluripotent stem cells Loss of type III transforming growth factor-β receptor expression is due to methylation silencing of the transcription factor GATA3 in renal cell carcinoma Functional heterogeneity of embryonic stem cells revealed through translational amplification of an early endodermal transcript Prothymosin-α inhibits HIV-1 via Toll-like receptor 4-mediated type I interferon induction Complete chemical synthesis, assembly, and cloning of a Mycoplasma genitalium genome Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs Derivation of pre-x inactivation human embryonic stem cells under physiological oxygen concentrations Creation of a bacterial cell controlled by a chemically synthesized genome Autophagy as a therapeutic target in cancer treatment Indoor tanning and risk of melanoma: a case-control study in a highly exposed population Human cardiac tissue induces transdifferentiation of adult stem cells towards cardiomyocytes An autophagy-enhancing drug promotes degradation of mutant α1-antitrypsin z and reduces hepatic fibrosis Porcine induced pluripotent stem cells produce chimeric offspring Differential modeling of Fragile X Syndrome by human embryonic stem cells and induced pluripotent stem cells Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs A microarray analysis of sexual dimorphism of adipose tissues in high-fat-diet-induced obese mice Retinal glial cells enhance human vision acuity A family history of type 2 diabetes increases risk factors associated with overfeeding A pathobiont of the microbiota balances host colonization and intestinal inflammation Bim-Bcl-2 homology 3 mimetic therapy is effective at suppressing inflammatory arthritis through the activation of myeloid cell apoptosis Permanently blocked stem cells derived from breast cancer cell lines rAAV2/5 gene-targeting to rods:dose-dependent efficiency and complications associated with different promoters Human CD34+ cells in experimental myocardial infarction. long-term survival, sustained functional improvement, and mechanism of action Segment-specific neuronal subtype specification by the integration of anteroposterior and temporal cues A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth Stem cell transplantation in multiple sclerosis: current status and future prospects Designed biomaterials to mimic the mechanical properties of muscles Endometrial stem cell transplantation restores dopamine production in a parkinson's disease model Circadian-independent cell mitosis in immortalized fibroblasts Generation of pluripotent stem cells from eggs of aging mice CNS transplantation of purified human neural stem cells in neuronal ceroid lipofuscinoses: phase I trial IGF-1R regulation of colon cancer stem cells Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst Effects of aerobic exercise training on cognitive function and cortical vascularity in monkeys Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma Alternate protein kinase A activity identifies a unique population of stromal cells in adult bone Retargeted adenoviral cancer gene therapy for tumour cells overexpressing epidermal growth factor receptor or urokinase-type plasminogen activator receptor Cyclooxygenase-2 generates anti-inflammatory mediators from omega-3 fatty acids c-Myc regulates transcriptional pause release Maternal circulating CD34+VEGFR-2+ and CD133+VEGFR-2+ progenitor cells increase during normal pregnancy but are reduced in women with preeclampsia Identification of select glucocorticoids as Smoothened agonists: Potential utility for regenerative medicine Mesenchymal stem cells protect breast cancer cells through regulatory T cells: role of mesenchymal stem cell-derived TGF-β XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification Metabolic oxidation regulates embryonic stem cell differentiation Sequence variants at CHRNB3–CHRNA6 and CYP2A6 affect smoking behavior Genome-wide meta-analyses identify multiple loci associated with smoking behavior Meta-analysis and imputation refines the association of 15q25 with smoking quantity Synovial fluid proteins differentiate between the subtypes of juvenile idiopathic arthritis Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infection Progesterone induces adult mammary stem cell expansion Safety and feasibility of autologous bone marrow cellular therapy in relapsing-progressive Multiple Sclerosis Physiological levels of reactive oxygen species are required to maintain genomic stability in stem cells The effect of prenatal smoking exposure on adolescents' use of psychiatric drugs New loci associated with kidney function and chronic kidney disease Targeted gene deletions in C. elegans using transposon excision Activation of the imprinted Dlk1-Dio3 region correlates with pluripotency levels of mouse stem cells HAMLET interacts with lipid membranes and perturbs their structure and integrity Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease Genomic profiling of sentinel lymph node breast cancer metastasis Increased monocyte turnover from bone marrow correlates with severity of SIV encephalitis and CD163 levels in plasma Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells Compact, light-weight and cost-effective microscope based on lensless incoherent holography for telemedicine applications Induction of cancer cell death by self-assembling nanostructures incorporating a cytotoxic peptide Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth A small-molecule inhibitor of BCL6 kills DLBCL cells in vitro and in vivo Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules Genetic variants near TIMP3 and high-density lipoprotein–associated loci influence susceptibility to age-related macular degeneration Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer Tumor necrosis factor-like weak inducer of apoptosis is a mitogen for liver progenitor cells Isothiocyanate exposure, glutathione S-transferase polymorphisms, and colorectal cancer risk Substitutions in woolly mammoth hemoglobin confer biochemical properties adaptive for cold tolerance p53-mediated hematopoietic stem and progenitor cell competition T helper type 1 and 17 cells determine efficacy of interferon-β in multiple sclerosis and experimental encephalomyelitis Sex differences of chondrogenic progenitor cells in late stages of osteoarthritis In vivo evaluation of a tissue-engineered stem cell vascular graft Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss Magnetic targeting enhances engraftment and functional benefit of iron-labeled cardiosphere-derived cells in myocardial infarction Derivation, propagation and controlled differentiation of human embryonic stem cells in suspension Epigenetic stability increases extensively during Drosophila follicle stem cell differentiation Control of mammary stem cell function by steroid hormone signaling Nerve growth factor promotes cardiac repair following myocardial infarction Gene delivery to mitotic and postmitotic photoreceptors via compacted DNA nanoparticles results in improved phenotype in a mouse model of retinitis pigmentosa Plant thymidine kinase 1: a novel efficient suicide gene for malignant glioma therapy Labeling human embryonic stem cell-derived cardiomyocytes with indocyanine green for noninvasive tracking with optical imaging: an FDA-compatible alternative to firefly luciferase A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations Gold nanocages as photothermal transducers for cancer treatment Carbon nanotubes degraded by neutrophil myeloperoxidase induce less pulmonary inflammation Coronary arteries form by developmental reprogramming of venous cells MiDReG: A method of mining developmentally regulated genes using Boolean implications Primary contribution to zebrafish heart regeneration by gata4+ cardiomyocytes Retinoic acid regulates differentiation of the secondary heart field and TGFβ-mediated outflow tract septation Geometric cues for directing the differentiation of mesenchymal stem cells Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells Corticosteroid suppression of VEGF-A in infantile hemangioma-derived stem cells Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects Using nanoparticle-filled microcapsules for site-specific healing of damaged substrates--creating a "repair-and-go" system Inactivation of both foxo and reaper promotes long-term adult neurogenesis in Drosophila Hypoxia inducible microRNA 210 attenuates keratinocyte proliferation and impairs closure in a murine model of ischemic wounds Genetic analysis of variation in transcription factor binding in yeast Variation in transcription factor binding among humans RBPjκ-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development Safety and efficacy of subretinal readministration of a viral vector in large animals to treat congenital blindness The basal ganglia communicate with the cerebellum A human gut microbial gene catalogue established by metagenomic sequencing Protein folding stability and dynamics imaged in a living cell Scaling laws of marine predator search behavior Human mammary epithelial cells exhibit a bimodal correlated random walk pattern Programmed death-1–induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele Lack of p21 expression links cell cycle control and appendage regeneration in mice Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles Computational prediction of neural progenitor cell fates Transplantation of reprogrammed embryonic stem cells improves visual function in a mouse model for retinitis pigmentosa Tumor cell-specific bioluminescence platform to identify stroma-induced changes to anticancer drug activity Generation of functional multipotent adult stem cells from GPR125+ germline progenitors Expansion and maintenance of human embryonic stem cell-derived endothelial cells by TGFbeta inhibition is Id1 dependent Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factors Generation of a functional and durable vascular niche by the adenoviral E4ORF1 gene Endothelial cells are essential for the self-renewal and repopulation of notch-dependent hematopoietic stem cells Kinetics of antimicrobial peptide activity measured on individual bacterial cells using high-speed atomic force microscopy Leptin therapy in insulin-deficient type I diabetes miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia Hydrated xenogeneic decellularized tracheal matrix as a scaffold for tracheal reconstruction Innate immune lectins kill bacteria expressing blood group antigen Common genetic variants associated with breast cancer and mammographic density measures that predict disease Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development Haematopoietic stem cells derive directly from aortic endothelium during development Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency Daclizumab in active relapsing multiple sclerosis (CHOICE study): a phase 2, randomised, double-blind, placebo-controlled, add-on trial with interferon beta Caspase 3/caspase-activated DNase promote cell differentiation by inducing DNA strand breaks Risk of recurrent stroke, myocardial infarction, or death in hospitalized stroke patients Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis Computational prediction of neural progenitor cell fates TGF-β-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI Gallstones play a significant role in Salmonella spp. gallbladder colonization and carriage Nuclear targeting of gold nanoparticles in cancer cells induces DNA damage, causing cytokinesis arrest and apoptosis Effects of carboxylic acids on nC60 aggregate formation Characterization of airborne particles during production of carbonaceous nanomaterials U87MG decoded: the genomic sequence of a cytogenetically aberrant human cancer cell line Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis Quorum-sensing-regulated virulence factors in Pseudomonas aeruginosa are toxic to Lucilia sericata maggots Molecular basis of the death-associated protein kinase–calcium/calmodulin regulator complex Communication via gap junctions underlies early functional and beneficial interactions between grafted neural stem cells and the host Cancer stem cells from colorectal cancer-derived cell lines Coexistence of quiescent and active adult stem cells in mammals A nonviral minicircle vector for deriving human iPS cells Acute kidney injury in non-severe pneumonia is associated with an increased immune response and lower survival Cell fusion of bone marrow cells and somatic cell reprogramming by embryonic stem cells Amplification of LAPTM4B and YWHAZ contributes to chemotherapy resistance and recurrence of breast cancer Chronic morphine administration delays wound healing by inhibiting immune cell recruitment to the wound site Tinkering inside the organelle Dynamic changes in the human methylome during differentiation DNA heats up: energetics of genome ejection from phage revealed by isothermal titration calorimetry Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction Aberrant alternative splicing and extracellular matrix gene expression in mouse models of myotonic dystrophy Direct conversion of fibroblasts to functional neurons by defined factors Pluripotency factors Lin28 and Oct4 identify a sub-population of stem cell-like cells in ovarian cancer CRFR1 is expressed on pancreatic β cells, promotes β cell proliferation, and potentiates insulin secretion in a glucose-dependent manner Anucleate platelets generate progeny The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism Brainstem serotonergic deficiency in sudden infant death syndrome Regulation of alternative splicing by histone modifications G protein subunit Gα13 binds to integrin αIIbβ3 and mediates integrin "outside-in" signaling Cyclin D1 kinase activity is required for the self-renewal of mammary stem and progenitor cells that are targets of MMTV-ErbB2 tumorigenesis Modulation of heat shock transcription factor 1 as a therapeutic target for small molecule intervention in neurodegenerative disease Interaction between RasV12 and scribbled clones induces tumor growth and invasion Dual roles for perivascular macrophages in immune-to-brain signaling Altered gene expression and DNA damage in peripheral blood cells from Friedreich's Ataxia patients: cellular model of pathology Identification of a class of HCV inhibitors directed against the nonstructural protein NS4B AHI1 is required for photoreceptor outer segment development and is a modifier for retinal degeneration in nephronophthisis The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1α Transforming growth factor β-activated kinase 1 (TAK1) kinase adaptor, TAK1-binding protein 2, plays dual roles in TAK1 signaling by recruiting both an activator and an inhibitor of TAK1 kinase in tumor Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk Glioblastoma cancer-initiating cells inhibit T-cell proliferation and effector responses by the signal transducers and activators of transcription 3 pathway Glioma-associated cancer-initiating cells induce immunosuppression Thymic development beyond β-selection requires phosphatidylinositol 3-kinase activation by CXCR4 Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution Human stem cell delivery for treatment of large segmental bone defects COUP-TFII regulates tumor growth and metastasis by modulating tumor angiogenesis Amelioration of emphysema in mice through lentiviral transduction of long-lived pulmonary alveolar macrophages Extending the transposable payload limit of Sleeping Beauty (SB) using the Herpes Simplex Virus (HSV)/SB amplicon-vector platform Calculating the potential for within-flight transmission of influenza A (H1N1) APOBEC3 proteins mediate the clearance of foreign DNA from human cells Analysis of dystrophin deletion mutations predicts age of cardiomyopathy onset in Becker Muscular Dystrophy Modeling disease in human ESCs using an efficient BAC-based homologous recombination system Multicenter, phase II study of decitabine for the first-line treatment of older patients with acute myeloid leukemia A biohybrid artificial lung prototype with active mixing of endothelialized microporous hollow fibers Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis A new target for amyloid beta toxicity validated by standard and high-throughput electrophysiology A phase II trial of talampanel in subjects with amyotrophic lateral sclerosis A reconfigured pattern of MLL occupancy within mitotic chromatin promotes rapid transcriptional reactivation following mitotic exit Beyond the scalpel: targeting hedgehog in skin cancer prevention Hippocampal mean diffusivity and memory in healthy elderly individuals Production of cell-cell signalling molecules by bacteria isolated from human chronic wounds Restricted ethnic diversity in human embryonic stem cell lines Activation of the abundant nuclear factor poly(ADP-ribose) polymerase-1 by Helicobacter pylori Alzheimer’s-related endosome dysfunction in Down syndrome is Aβ-independent but requires APP and is reversed by BACE-1 inhibition Isolation of cancer-specific chimeric transcripts induced by hypomethylation of the LINE-1 antisense promoter High-performance genetically targetable optical neural silencing by light-driven proton pumps Monocyte/macrophage androgen receptor suppresses cutaneous wound healing in mice by enhancing local TNF-α expression A pharmacogenetic study of docetaxel and thalidomide in patients with castration-resistant prostate cancer using the DMET genotyping platform Smoking, smoking cessation, and risk for type 2 diabetes mellitus: a cohort study CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts A role for the elongator complex in zygotic paternal genome demethylation Is survival better at hospitals with higher "end-of-life" treatment intensity? Nitric oxide releasing nanoparticles are therapeutic for Staphylococcus aureus abscesses in a murine model of infection The transcriptional network for mesenchymal transformation of brain tumours Dramatic increase in cortical thickness induced by femoral marrow ablation followed by a three-month treatment with PTH in rats Sex-dependent association of common variants of microcephaly genes with brain structure In vivo fluorescent detection of Fe-S clusters coordinated by human GRX2 Electrostatic focusing of unlabelled DNA into nanoscale pores using a salt gradient Real-time imaging reveals the single steps of brain metastasis formation Forever young: how to control the elongation, differentiation, and proliferation of cells using nanotechnology Blanes cells mediate persistent feedforward inhibition onto granule cells in the olfactory bulb Semilunar granule cells: glutamatergic neurons in the rat dentate gyrus with axon collaterals in the inner molecular layer Nonrandom local circuits in the dentate gyrus Representing information in cell assemblies: persistent activity mediated by semilunar granule cells Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells Amelioration of emphysema in mice through lentiviral transduction of long-lived pulmonary alveolar macrophages Receptor channel TRPC6 is a key mediator of notch-driven glioblastoma growth and invasiveness The histone variant macroH2A1 marks repressed autosomal chromatin, but protects a subset of its target genes from silencing Tumor self-seeding by circulating cancer cells Lipid-like materials for low-dose, in vivo gene silencing Bioartificial matrices for therapeutic vascularization Impaired hepatocyte regeneration in acute severe hepatic injury enhances effective repopulation by transplanted hepatocytes Long-term effects of bupivacaine on cartilage in a rabbit shoulder model The in vitro effects of bupivacaine on articular chondrocytes Patient-specific, time-varying predictors of post-ICU informal caregiver burden: the caregiver outcomes after ICU discharge project Adipose tissue regeneration Deciding fate in adverse times: sporulation and competence in Bacillus subtilis A selective eradication of human nonhereditary breast cancer cells by phenanthridine-derived polyADP-ribose polymerase inhibitors Identification of mutations in TRAPPC9, which encodes the NIK- and IKK-beta-binding protein, in nonsyndromic autosomal-recessive mental retardation A physical and regulatory map of host-influenza interactions reveals pathways in H1N1 infection The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus Genomewide association study of leprosy An adequately robust early TNF-α response is a hallmark of survival following trauma/hemorrhage A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (Prochymal) after acute myocardial infarction JAK-STAT signal inhibition regulates competition in the Drosophila testis stem cell niche Cell therapy of corneal diseases with umbilical mesenchymal stem cells Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis Transcriptional competence and the active marking of tissue-specific enhancers by defined transcription factors in embryonic and induced pluripotent stem cells A novel inhibitor of DNA polymerase β enhances the ability of temozolomide to impair the growth of colon cancer cells A synergistic small-molecule combination directly eradicates diverse prion strain structures Donor statin treatment protects against severe acute graft-versus-host disease after related allogeneic hematopoietic cell transplantation Adenoviral transfer of HIF-1α enhances vascular responses to critical limb ischemia in diabetic mice Nanoscale cues regulate the structure and function of macroscopic cardiac tissue constructs Targeting breast stem cells with the cancer preventive compounds curcumin and piperine GABAergic interneuron dysfunction impairs hippocampal neurogenesis in adult apolipoprotein E4 knockin mice Imbalance between GABAergic and glutamatergic transmission impairs adult neurogenesis in an animal model of Alzheimer's Disease Engineered “smart” materials for improved cardiomyocyte differentiation Atypical Progeroid Syndrome due to heterozygous missense LMNA mutations Genetic variation in CYP27B1 is associated with congestive heart failure in patients with hypertension RanBPM has proapoptotic activities that regulate cell death pathways in response to DNA damage Induction of death receptor ligand-mediated apoptosis in epithelial ovarian carcinoma: The search for sensitizing agents Isolation of antagonists of antigen-specific autoimmune T cell proliferation Notch promotes radioresistance of glioma stem cells PCNA is required for initiation of recombination-associated DNA synthesis by DNA polymerase δ Surgical stress-induced immune cell redistribution profiles predict short-term and long-term postsurgical recovery Haploid genetic screens in human cells identify host factors used by pathogens Ligand-mediated dimerization of the Met receptor tyrosine kinase by the bacterial invasion protein InlB A selective glial barrier at motor axon exit points prevents oligodendrocyte migration from the spinal cord Protective effects of human iPS-derived retinal pigment epithelium cell transplantation in the retinal dystrophic rat Derivation of functional retinal pigmented epithelium from induced pluripotent stem cells Asymmetric deactivation of HIV-1 gp41 following fusion inhibitor binding In situ regulation of dc subsets and T cells mediates tumor regression in mice A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction MEMS-based 3D optical microendoscopy Innate immune and chemically triggered oxidative stress modifies translational fidelity Embryoid body formation of human amniotic fluid stem cells depends on mTOR Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis Defining the role of syndecan-4 in mechanotransduction using surface-modification approaches Progressive chondrocyte death after impact injury indicates a need for chondroprotective therapy High harvest yield, high expansion, and phenotype stability of CD146 mesenchymal stromal cells from whole primitive human umbilical cord tissue Wheelchair repairs, breakdown, and adverse consequences for people with traumatic spinal cord injury A mixed integer linear optimization framework for the identification and quantification of targeted post-translational modifications of highly modified proteins using multiplexed electron transfer dissociation tandem mass spectrometry High throughput characterization of combinatorial histone codes Role of NMDA receptor–dependent activation of SREBP1 in excitotoxic and ischemic neuronal injuries Superselective intraarterial cerebral infusion of bevacizumab: a revival of interventional neuro-oncology for malignant glioma In vivo magnetic enrichment and multiplex photoacoustic detection of circulating tumour cells In vivo, noninvasive, label-free detection and eradication of circulating metastatic melanoma cells using two-color photoacoustic flow cytometry with a diode laser Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling Human embryonic stem-cell derivatives for full reconstruction of the pluristratified epidermis: a preclinical study Three-dimensional nanostructured substrates toward efficient capture of circulating tumor cells FoxJ1-dependent gene expression is required for differentiation of radial glia into ependymal cells and a subset of astrocytes in the postnatal brain A diet enriched in polyphenols and polyunsaturated fatty acids, LMN diet, induces neurogenesis in the subventricular zone and hippocampus of adult mouse brain Donor-recipient mismatch for common gene deletion polymorphisms in graft-versus-host disease MOR23 promotes muscle regeneration and regulates cell adhesion and migration Autologous CD34+ cell therapy for refractory angina: 12 month results of the phase II ACT34-CMI study Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells Adaptive force transmission in amoeboid cell migration Eosinophil-selective binding and proapoptotic effect in vitro of a synthetic Siglec-8 ligand, polymeric 6′-sulfated sialyl Lewis X Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth Human umbilical cord blood-derived mesenchymal stem cells attenuate hyperoxia-induced lung injury in neonatal rats Autologous umbilical cord blood mononuclear cell transplantation preserves right ventricular function in a novel model of chronic right ventricular volume overload Self-assembling chimeric polypeptide–doxorubicin conjugate nanoparticles that abolish tumours after a single injection Epidemiological pathology of dementia: attributable-risks at death in the medical research council cognitive function and ageing study The heritability and genetics of frontotemporal lobar degeneration A selective eradication of human nonhereditary breast cancer cells by phenanthridine-derived polyADP-ribose polymerase inhibitors Common variants at five new loci associated with early-onset inflammatory bowel disease Rescue of radiation-induced cognitive impairment through cranial transplantation of human embryonic stem cells FoxO3 regulates neural stem cell homeostasis Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice Dissociation of EphB2 signaling pathways mediating progenitor cell proliferation and tumor suppression Injectable, rapid gelling and highly flexible hydrogel composites as growth factor and cell carriers Long-term controlled normoglycemia in diabetic non-human primates after transplantation with hCD46 transgenic porcine islets Novel synthetic porous and biodegradable bone cement for orthopaedic and craniofacial regeneration Cell stimulation with optically manipulated microsources Effective repair of traumatically injured spinal cord by nanoscale block copolymer micelles Reprogramming erythroid cells for lysosomal enzyme production leads to visceral and CNS cross-correction in mice with Hurler syndrome TAp63 induces senescence and suppresses tumorigenesis in vivo Translating metabolic exchange with imaging mass spectrometry SPINK1 N34S is strongly associated with recurrent acute pancreatitis but is not a risk factor for the first or sentinel acute pancreatitis event Chemical control over immune recognition: a class of antibody-recruiting small molecules that target prostate cancer An antibody-recruiting small molecule that targets HIV gp120 Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants improve recovery after cervical spinal cord injury Requirement of alpha(4)beta(1) and alpha(5)beta(1) integrin expression in bone-marrow derived progenitor cells in preventing endotoxin-induced lung vascular injury and edema in mice Alcohol stimulates activation of Snail, epidermal growth factor receptor signaling, and biomarkers of epithelial–mesenchymal transition in colon and breast cancer cells The postsynaptic function of type II cochlear afferents Massive gliosis induced by interleukin-6 suppresses Ab deposition in vivo: evidence against inflammation as a driving force for amyloid deposition Lung cancer diagnostic and treatment intervals in the United States: a health care disparity? Mst3b, an Ste20-like kinase, regulates axon regeneration in mature CNS and PNS pathways T helper 17 cells promote cytotoxic T cell activation in tumor immunity Pten in stromal fibroblasts suppresses mammary epithelial tumors Functional repair of human donor lungs by IL-10 gene therapy Activating mutations in FGFR3 and HRAS reveal a shared genetic origin for congenital disorders and testicular tumors DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212 Age-dependent effects of RPE65 gene therapy for Leber's congenital amaurosis: a phase 1 dose-escalation trial Lung myeloid dendritic cells coordinately induce TH1 and TH17 responses in human emphysema Basal cancer cell survival involves JNK2 suppression of a novel JNK1/c-Jun/Bcl-3 apoptotic network Loss of Lkb1 in adult β cells increases β cell mass and enhances glucose tolerance in mice Liver X receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells Directed single molecule diffusion triggered by surface energy gradients A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium Enhanced leukemia cell detection using a novel magnetic needle and nanoparticles Racial differences in the association between SNPs on 15q25.1, smoking behavior, and risk of non-small cell lung cancer Molecular aging and rejuvenation of human muscle stem cells Radioprotection in normal tissue and delayed tumor growth by blockade of CD47 signaling The Argus™ II retinal prosthesis improves the ability of subjects to perform a spatial task Development of a model system for retinogenesis from a highly enriched population of human embryonic stem cell-derived retinal progenitors Retinal transplantation improves vision in macular degeneration and retinitis pigmentosa patients LigluR-mediated visual cortical responses in the rd1 mouse model of retinitis pigmentosa Genetic diagnosis by whole exome capture and massively parallel DNA sequencing Nanoparticle-based bio-barcode assay redefines "undetectable" PSA and biochemical recurrence after radical prostatectomy Generation of induced pluripotent stem cells using recombinant proteins A chemical platform for improved induction of human iPSCs Material properties of the cell dictate stress-induced spreading and differentiation in embryonic stem cells Generation of functional ventricular heart muscle from mouse ventricular progenitor cells Stem cell therapies benefit Alport syndrome Marked induction of the helix-loop-helix protein Id3 promotes the γδ T cell fate and renders their functional maturation notch independent Saturation density of skin fibroblasts as a quantitative screen for human cancer susceptibility Functional interaction of plasmacytoid dendritic cells with multiple myeloma cells: a therapeutic target Activating receptors promote NK cell expansion for maintenance, IL-10 production, and CD8 T cell regulation during viral infection Investigating the role of the extracellular environment in modulating hepatic stellate cell biology with arrayed combinatorial microenvironments GSK-3 is a master regulator of neural progenitor homeostasis Human DNA methylomes at base resolution show widespread epigenomic differences Lhx2 specifies regional fate in Emx1 lineage of telencephalic progenitors generating cerebral cortex Aldehyde dehydrogenase–expressing colon stem cells contribute to tumorigenesis in the transition from colitis to cancer Physiological function and transplantation of scaffold-free and vascularized human cardiac muscle tissue Directed differentiation of human embryonic stem cells into functional retinal pigment epithelium cells Thymic involution in amyotrophic lateral sclerosis Expansion of allospecific regulatory T cells after anergized, mismatched bone marrow transplantation CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury Kcne2 deletion uncovers its crucial role in thyroid hormone biosynthesis Genetic population structure analysis in New Hampshire reveals eastern European ancestry Epistasis and its implications for personal genetics Adenosine and osteopontin contribute to the development of chronic obstructive pulmonary disease Expansion of CD133-expressing liver cancer stem cells in liver-specific phosphatase and tensin homolog deleted on chromosome 10-deleted mice A mathematical model of ischemic cutaneous wounds Differentiation of human embryonic stem cells to a parathyroid-like phenotype Programming the detection limits of biosensors through controlled nanostructuring Lung cancer in never smokers: molecular profiles and therapeutic implications Lung cancer in never smokers: clinical epidemiology and environmental risk factors Lung cancer in never smokers: a call to action LysRS serves as a key signaling molecule in the immune response by regulating gene expression Transcriptional signature and memory retention of human-induced pluripotent stem cells Towards a definition of inorganic nanoparticles from an environmental, health and safety perspective HLA-DR alleles in amyloid β-peptide autoimmunity: a highly immunogenic role for the DRB1*1501 allele Transoral endoscopic inner layer esophagectomy: management of high-grade dysplasia and superficial cancer with organ preservation Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer Gene expression profiling reveals new protective roles for vitamin C in human skin cells Regulation of vertebrate nervous system alternative splicing and development by an sr-related protein Genome-wide association reveals three SNPs associated with sporadic amyotrophic lateral sclerosis through a two-locus analysis Mutations in LOXHD1, an evolutionarily conserved stereociliary protein, disrupt hair cell function in mice and cause progressive hearing loss in humans FOXO3a promotes tumor cell invasion through the induction of matrix metalloproteinases Injectable hydrogels for brain tissue regeneration after traumatic brain injury (TBI) C/EBP-alpha and beta couple interfollicular keratinocyte proliferation arrest to commitment and terminal differentiation Telomere extension occurs at most chromosome ends and is uncoupled from fill-in in human cancer cells Five hundred intestinal and multivisceral transplantations at a single center: major advances with new challenges Polymer-functionalized nanodiamond platforms as vehicles for gene delivery 14-3-3z cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition A luminal epithelial stem cell that is a cell of origin for prostate cancer Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia Epigenetic silencing of death receptor 4 mediates tumor necrosis factor–related apoptosis-inducing ligand resistance in gliomas On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex The basic leucine zipper transcription factor E4BP4 is essential for natural killer cell development Structural and biological mimicry of protein surface recognition by α/β-peptide foldamers Epigenetic changes during disease progression in a murine model of human chronic lymphocytic leukemia Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer Widespread shortening of 3′UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells Oxidized lipids enhance RANKL production by T lymphocytes: Implications for lipid-induced bone loss Dual and opposing roles of primary cilia in medulloblastoma development Loss of Parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation Biologic activity of irradiated, autologous, GM-CSF-secreting leukemia cell vaccines early after allogeneic stem cell transplantation Nanog is the gateway to the pluripotent ground state Modeling early retinal development with human embryonic and induced pluripotent stem cells Tight long-term dynamic doxycycline responsive nigrostriatal GDNF using a single rAAV vector Migration of neurotrophic factors-secreting mesenchymal stem cells toward a quinolinic acid lesion as viewed by magnetic resonance imaging Genetically encoded FRET sensors to monitor intracellular Zn2+ homeostasis Emergent or just complex? Concise review: isolation and characterization of cells from human term placenta: outcome of the first international Workshop on Placenta Derived Stem Cells Production of hepatocyte-like cells from human amnion Naive rat amnion-derived cell transplantation improved left ventricular function and reduced myocardial scar of postinfarcted heart Magnetic tagging increases delivery of circulating progenitors in vascular injury A common MECP2 haplotype associates with reduced cortical surface area in humans in two independent populations DNA focusing using microfabricated electrode arrays Waterborne synthetic adhesives modeled after the Sandcastle glue of P. californica A water-borne adhesive modeled after the sandcastle glue of P. californica Targeted capture and massively parallel sequencing of 12 human exomes A role of histone H3 lysine 4 methyltransferase components in endosomal trafficking Targeted activation of innate immunity for therapeutic induction of autophagy and apoptosis in melanoma cells Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy A role for the transcriptional repressor blimp-1 in CD8+ T cell exhaustion during chronic viral infection Targeted activation of innate immunity for therapeutic induction of autophagy and apoptosis in melanoma cells Human RPE65 gene therapy for leber congenital amaurosis: persistence of early visual improvements and safety at 1 year Regulation of the fibrosis and angiogenesis promoter SPARC/osteonectin in human adipose tissue by weight change, leptin, insulin, and glucose The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain A granulocyte-macrophage colony–stimulating factor and interleukin-15 fusokine induces a regulatory B cell population with immune suppressive properties Optical torques guide cell motility Cerebellothalamocortical connectivity regulates penetrance in dystonia Generation of mature human myelomonocytic cells through expansion and differentiation of pluripotent stem cell–derived lin–CD34+CD43+CD45+ progenitors A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth Tumor emergence is sensed by self-specific CD44hi memory Tregs that create a dominant tolerogenic environment for tumors in mice Differentiation of a highly tumorigenic basal cell compartment in urothelial carcinoma STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells Tumor suppression by phospholipase C-β3 via SHP-1-mediated dephosphorylation of Stat5 Cell–cell interaction networks regulate blood stem and progenitor cell fate Phosphoproteomic analysis of human embryonic stem cells Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells Nanoparticle-delivered suicide gene therapy effectively reduces ovarian tumor burden in mice Programming cells by multiplex genome engineering and accelerated evolution Sociodemographic differences in early access to liver transplantation services Phase II trial of dendritic cells loaded with antigens from self-renewing, proliferating autologous tumor cells as patient-specific antitumor vaccines in patients with metastatic melanoma: final report Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers MEK4 function, genistein treatment, and invasion of human prostate cancer cells Intrinsic light response of retinal horizontal cells of teleosts MafB restricts M-CSF-dependent myeloid commitment divisions of hematopoietic stem cells Nanodiamond-insulin complexes as pH-dependent protein delivery vehicles MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synuclein Critical role for caspase-8 in epidermal growth factor signaling Induction of stem cell gene expression in adult human fibroblasts without transgenes Identification of splenic reservoir monocytes and their deployment to inflammatory sites Mobile genetic element-encoded cytolysin connects virulence to methicillin resistance in MRSA The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues EphA2 immunoconjugate as molecularly targeted chemotherapy for ovarian carcinoma Regulation of adult hematopoietic stem cells fate for enhanced tissue-specific repair The intrinsic dynamics of enzymes plays a dominant role in determining the structural changes induced upon inhibitor binding An exploratory pathways analysis of temporal changes induced by spinal cord injury in the rat bladder wall: insights on remodeling and inflammation Amnion: a potent graft source for cell therapy in stroke Direct transdifferentiation of stem/progenitor spermatogonia into reproductive and nonreproductive tissues of all germ layers Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease XIAP discriminates between type I and type II FAS-induced apoptosis Srs2 disassembles Rad51 filaments by a protein-protein interaction triggering ATP turnover and dissociation of Rad51 from DNA Bcl6 mediates the development of T follicular helper cells Enhanced monocyte response and decreased central memory T cells in children with invasive Staphylococcus aureus infections Psychoneuroimmunology--psychology’s gateway to the biomedical future N-myc downstream regulated gene 1 (NDRG1) is fused to ERG in prostate cancer CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis Regulated fluctuations in Nanog expression mediate cell fate decisions in embryonic stem cells Identification of genes conferring resistance to 5-fluorouracil Circulating osteogenic precursor cells in heterotopic bone formation Hearing improvement after Bevacizumab in patients with Neurofibromatosis Type 2 Nanoscale cellular changes in field carcinogenesis detected by partial wave spectroscopy Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion A network model of a cooperative genetic landscape in brain tumors Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome Hematopoietic cytokines can instruct lineage choice Effect of ingested interferon-α on β-cell function in children with new-onset type 1 diabetes Plk1-mediated phosphorylation of topors regulates p53 stability Dependence of mouse embryonic stem cells on threonine catabolism A functional role for adult hippocampal neurogenesis in spatial pattern separation Immune blood biomarkers of Alzheimer disease patients High levels of circulating VEGFR2+ bone marrow–derived progenitor cells correlate with metastatic disease in patients with pediatric solid malignancies Release of HMGB1 in response to proapoptotic glioma killing strategies: efficacy and neurotoxicity Transplantation of cardiac progenitor cells ameliorates cardiac dysfunction after myocardial infarction in mice Chd1 regulates open chromatin and pluripotency of embryonic stem cells HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation BRIT1/MCPH1 links chromatin remodelling to DNA damage response Gene targeting of a disease-related gene in human induced pluripotent stem and embryonic stem cells The Arp2/3 complex and WASp are required for apical trafficking of Delta into microvilli during cell fate specification of sensory organ precursors Prosaposin inhibits tumor metastasis via paracrine and endocrine stimulation of stromal p53 and Tsp-1 CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia The malignant pleural effusion as a model to investigate intratumoral heterogeneity in lung cancer HUMMR, a hypoxia- and HIF-1a–inducible protein, alters mitochondrial distribution and transport Understanding biophysicochemical interactions at the nano–bio interface Cancer mortality in patients with schizophrenia: an 11-year prospective cohort study Cell derived hierarchical assembly of a novel phosphophoryn-based biomaterial Gene expression profiles of acute exacerbations of idiopathic pulmonary fibrosis. Resistance to age-dependent thymic atrophy in long-lived mice that are deficient in pregnancy-associated plasma protein A. Regulatory T cell differentiation of thymocytes does not require a dedicated antigen-presenting cell but is under T cell-intrinsic developmental control Directing cell motions on micropatterned ratchets The DNA replication FoSTeS/MMBIR mechanism can generate genomic, genic and exonic complex rearrangements in humans A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis Formation of conjugated polymer brushes by surface-initiated catalyst-transfer polycondensation Controlling transgene expression in subcutaneous implants using a skin lotion containing the apple metabolite phloretin The vascular basement membrane as “soil” in brain metastasis Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response H3K4me3 stimulates the V(D)J RAG complex for both nicking and hairpinning in trans in addition to tethering in cis: implications for translocations Allogeneic stem cell transplantation for acute myeloid leukemia in first complete remission Live-imaging of single stem cells within their niche reveals that a U3snoRNP component segregates asymmetrically and is required for self-renewal in Drosophila Nanocapsule-delivered Sleeping Beauty mediates therapeutic Factor VIII expression in liver sinusoidal endothelial cells of hemophilia A mice Essential role for eIF4GI overexpression in the pathogenesis of inflammatory breast cancer Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia A mechanism linking extra centrosomes to chromosomal instability CCR3 is a target for age-related macular degeneration diagnosis and therapy Wnt7a activates the planar cell polarity pathway to drive the symmetric expansion of satellite stem cells Activation of tumor cell integrin αvβ3 controls angiogenesis and metastatic growth in the brain REL, encoding a member of the NF-kB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model PAMAM nanoparticles promote acute lung injury by inducing autophagic cell death through the Akt-TSC2-mTOR signaling pathway Distinctive chromatin in human sperm packages genes for embryo development Global gene expression analysis of reactive stroma in prostate cancer Targeting tumor endothelial marker 8 in the tumor vasculature of colorectal carcinomas in mice Repeated aerosol delivery of carboxyl-terminal modulator protein suppresses tumor in the lungs of K-rasLA1 mice Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages The role of Scgb1a1+ clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium Life and death by death receptors Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment Functional substitution by TAT-utrophin in dystrophin-deficient mice Prediction of response to alkylator-based chemotherapy in metastatic melanoma (MM) using gene expression and promoter methylation signatures Biomechanical regulation of blood vessel growth during tissue vascularization Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells Generation of pig-induced pluripotent stem cells with a drug-inducible system The aIRE1-XBP1 pathway of the unfolded protein response is required for adipogenesis Development of microfluidics as endothelial progenitor cell capture technology for cardiovascular tissue engineering and diagnostic medicine Gene expression profiling of preplate neurons destined for the subplate: genes involved in transcription, axon extension, neurotransmitter regulation, steroid hormone signaling, and neuronal survival Reciprocal responsiveness to interleukin-12 and interferon-a specifies human CD8+ effector versus central memory T-cell fates Delivery of adipose-derived precursor cells for peripheral nerve repair Phase III randomized trial of the chimeric anti-GD2 antibody ch14.18 with GM-CSF and IL2 as immunotherapy following dose intensive chemotherapy for high-risk neuroblastoma: Children’s Oncology Group (COG) study ANBL0032 Efficient siRNA delivery into primary cells by a peptide transduction domain–dsRNA binding domain fusion protein Simulation and prediction of the adaptive immune response to influenza A virus infection Implantable diagnostic device for cancer monitoring Capsid antigen presentation flags human hepatocytes for destruction after transduction by adeno-associated viral vectors Biomechanical forces promote embryonic haematopoiesis Hematopoietic stem cell development is dependent on blood flow Nest making and oxytocin comparably promote wound healing in isolation reared rats A new role for FGF2 as an endogenous inhibitor of anxiety Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II–induced aortic aneurysms Ube3a is required for experience-dependent maturation of the neocortex Non-expanded adipose stromal vascular fraction cell therapy for multiple sclerosis Directed transdifferentiation of mouse mesoderm to heart tissue by defined factors Surface antigen phenotypes of hematopoietic stem cells from embryos and murine embryonic stem cells Methods for human demographic inference using haplotype patterns from genomewide single-nucleotide polymorphism data Cotransplantation of mouse embryonic stem cells and bone marrow stromal cells following spinal cord injury suppresses tumor development Genes that mediate breast cancer metastasis to the brain Engineering three-dimensional cartilage- and bone-like tissues using human dermal fibroblasts and macroporous gelatine microcarriers Base excision by thymine DNA glycosylase mediates DNA-directed cytotoxicity of 5-fluorouracil Stem cell therapy restores transparency to defective murine corneas Self-regulation of inflammatory cell trafficking in mice by the leukocyte surface apyrase CD39 Dendrimers as synthetic gene vectors: Cell membrane attachment Lymphocyte crawling and transendothelial migration require chemokine triggering of high-affinity LFA-1 integrin Serial time-encoded amplified imaging for real-time observation of fast dynamic phenomena All-in-one target-cell-specific magnetic nanoparticles for simultaneous molecular imaging and siRNA delivery CD4+ CD25+ T cells control autoimmunity in the absence of B cells miR-375 maintains normal pancreatic α- and β-cell mass Cell–cell contact globally activates microRNA biogenesis Intravaginal gene silencing using biodegradable polymer nanoparticles densely loaded with small-interfering RNA Transcription factor ELF4 controls the proliferation and homing of CD8+ T cells via the Krüppel-like factors KLF4 and KLF2 Repair of the tympanic membrane with urinary bladder matrix Atomic force microscopy detects differences in the surface brush of normal and cancerous cells Regulator of calcineurin (RCAN1-1L) is deficient in Huntington disease and protective against mutant huntingtin toxicity in vitro LGMD 2D gene therapy restores alpha-sarcoglycan and associated proteins Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (sc) and tracks sc overpopulation during colon tumorigenesis Human CD133+ progenitor cells promote the healing of diabetic ischemic ulcers by paracrine stimulation of angiogenesis and activation of Wnt signaling Parvalbumin neurons and gamma rhythms enhance cortical circuit performance Phasic firing in dopaminergic neurons is sufficient for behavioral conditioning A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation A computational model of the role of presenilin-1 and glycogen synthase kinase-3 in familial Alzheimer’s disease Single molecule–sensitive probes for imaging RNA in live cells Nanofluidic proteomic assay for serial analysis of oncoprotein activation in clinical specimens Bmi1 lineage tracing identifies a self-renewing pancreatic acinar cell subpopulation capable of maintaining pancreatic organ homeostasis Revascularization of ischemic limbs after transplantation of human bone marrow cells with high aldehyde dehydrogenase activity NCRs and DNAM-1 mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo JunB protects against myeloid malignancies by limiting hematopoietic stem cell proliferation and differentiation without affecting self-renewal Molecular stages of rapid and uniform neuralization of human embryonic stem cells Thymosin beta4 mediated PKC activation is essential to initiate the embryonic coronary developmental program and epicardial progenitor cell activation in adult mice in vivo Adenovirus encoding human platelet-derived growth factor-b delivered to alveolar bone defects exhibits safety and biodistribution profiles favorable for clinical use Protein-directed synthesis of highly fluorescent gold nanoclusters Oncolytic reovirus effectively targets breast cancer stem cells A functional screen to identify novel effectors of hematopoietic stem cell activity Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells Histone modifications at human enhancers reflect global cell-type-specific gene expression Neurogenin3 is sufficient for transdetermination of hepatic progenitor cells into neo-islets in vivo but not transdifferentiation of hepatocytes Programmed subcellular release for studying the dynamics of cell detachment MERIT40 controls BRCA1–Rap80 complex integrity and recruitment to DNA double-strand breaks Molecular therapy of obesity and diabetes by a physiological autoregulatory approach Frankincense oil derived from Boswellia carteri induces tumor cell specific cytotoxicity The influence of macrophage migration inhibitory factor gene polymorphisms on outcome from community-acquired pneumonia Differences in immune response may explain lower survival among older men with pneumonia Cancer-specific transgene expression mediated by systemic injection of nanoparticles Long-term survival and integration of transplanted engineered nervous tissue constructs promotes peripheral nerve regeneration MicroRNA-125b is a novel negative regulator of p53 The support of neural stem cells transplanted into stroke-induced brain cavities by PLGA particles A functional genomic screen identifies cellular cofactors of hepatitis C virus replication Common variants at ten loci modulate the QT interval duration in the QTSCD Study β1 integrin cytoplasmic domain residues selectively modulate fibronectin matrix assembly and cell spreading through talin and Akt-1 Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity Dendritic cell targeting of Bacillus anthracis protective antigen expressed by Lactobacillus acidophilus protects mice from lethal challenge Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease CD98hc facilitates B cell proliferation and adaptive humoral immunity Structural insights into the molecular organization of the S-layer from Clostridium difficile Identification of progenitor cells that contribute to heterotopic skeletogenesis Disruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid beta Can phase III trial results of antidepressant medications be generalized to clinical practice? A STAR*D report A unified mathematical model for the prediction of controlled release from surface and bulk eroding polymer matrices ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing Gold nanorod/Fe3O4 nanoparticle "nano-pearl-necklaces" for simultaneous targeting, dual-mode imaging, and photothermal ablation of cancer cells Imaging intracellular viscosity of a single cell during photoinduced cell death New insights into the genetics of addiction BrafV600E cooperates with Pten loss to induce metastatic melanoma The neural origins of shell structure and pattern in aquatic mollusks Instant immunity through chemically programmable vaccination and covalent self-assembly Transcription factor Achaete Scute-Like 2 controls intestinal stem cell fate piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells Supervised risk predictor of breast cancer based on intrinsic subtypes Oncogenic function of ATDC in pancreatic cancer through Wnt pathway activation and B-catenin stabilization Telomerase insufficiency in rheumatoid arthritis An embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency Programmed assembly of 3-dimensional microtissues with defined cellular connectivity A fluidic device to study directional angiogenesis in complex tissue and organ culture models Toll-like receptor 2-dependent induction of vitamin A-metabolizing enzymes in dendritic cells promotes T regulatory responses and inhibits autoimmunity A rosette-type, self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integration Partial-wave microscopic spectroscopy detects subwavelength refractive index fluctuations: an application to cancer diagnosis The reciprocal coordination and mechanics of molecular motors in living cells Endocrine-immune-paracrine interactions in prostate cells as targeted by phytomedicines From donuts to drugs: nano-biotechnology evolution or revolution? A two-step mechanism for stem cell activation during hair regeneration Cardiac fibroblasts regulate myocardial proliferation through B1 integrin signaling Identification of antigen-presenting dendritic cells in mouse aorta and cardiac valves Directed evolution of adeno-associated virus to an infectious respiratory virus Glycogen synthase kinase 3β missplicing contributes to leukemia stem cell generation A multi-center, randomized, clinical study to compare the effect and safety of autologous cultured osteoblast(Ossron™) injection to treat fractures Lumican inhibits collagen deposition in tissue engineered cartilage Atomic structure reveals the unique capsid organization of a dsRNA virus Superoxide dismutase 3, extracellular (SOD3) variants and lung function Endotoxin uptake in mouse liver is blocked by endotoxin pretreatment through a suppressor of cytokine signaling-1-dependent mechanism Three-dimensional ultrahigh resolution optical coherence tomography imaging of age-related macular degeneration Interferometric fluorescent super-resolution microscopy resolves 3D cellular ultrastructure Difference between the abilities of human Fc Y receptor-expressing CV-1 cells to neutralize American and Asian genotypes of Dengue Virus 2 Oct4-induced pluripotency in adult neural stem cells Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle Screening and characterization of surface-tethered cationic peptides for antimicrobial activity CXCL10 impairs B cell function and viability in diabetes through TLR4 signaling Epigenetic regulation of microRNAs in acute lymphoblastic leukemia Association of reactive oxygen species levels and radioresistance in cancer stem cells Controlling cell position in complex heterotypic 3D microtissues by tissue fusion Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice A genome-wide survey of the prevalence and evolutionary forces acting on human nonsense SNPs Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains Nkx2–5 transactivates the Ets-related protein 71 gene and specifies an endothelial/endocardial fate in the developing embryo An acellular matrix-bound ligand enhances the mobilization, recruitment and therapeutic effects of circulating progenitor cells in a hindlimb ischemia model Luminal flow patterns dictate arterial drug deposition in stent-based delivery Autologous non-myeloablative haemopoietic stem cell transplantation in relapsing-remitting multiple sclerosis: a phase I/II study Biohybrid devices and encapsulation technologies for engineering a bioartificial pancreas The choice of anatomical site for islet transplantation Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia Regulation of the IL-23 and IL-12 balance by Stat3 signaling in the tumor microenvironment Infection-mimicking materials to program dendritic cells in situ Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals Metabolic dysregulation and adipose tissue fibrosis: the role of collagen VI Comparison of autologous full-thickness gingiva and skin substitutes for wound healing The role of tumor cell–derived connective tissue growth factor (CTGF/CCN2) in pancreatic tumor growth Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity Model of genetic variation in human social networks Transient elastic support for vein grafts using a constricting microfibrillar polymer wrap Human embryonic stem cell differentiation toward regional specific neural precursors Dysregulation of CalDAG-GEFI and CalDAG-GEFII predicts the severity of motor side-effects induced by anti-parkinsonian therapy Dynamic proteomics of individual cancer cells in response to a drug On the role of cell signaling models in cancer research Survival from hypoxia in C. elegans by inactivation of aminoacyl-tRNA synthetases Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells Neuroblastoma cell lines contain pluripotent tumor initiating cells that are susceptible to a targeted oncolytic virus Axon regeneration requires a conserved MAP kinase pathway miRNA in situ hybridization in formaldehyde and EDC–fixed tissues Different T cell receptor signals determine CD8+ memory versus effector development Intravital imaging of metastatic behavior through a mammary imaging window Nanoscale imaging of molecular positions and anisotropies Photoactivatable mCherry for high-resolution two-color fluorescence microscopy T-cell activation leads to reduced collagen maturation in atherosclerotic plaques of Apoe–/– mice Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation Dopamine modulates an mGluR5-mediated depolarization underlying prefrontal persistent activity Hyperactivity and hyperconnectivity of the default network in schizophrenia and in first-degree relatives of persons with schizophrenia Programmed assembly of DNA-coated nanowire devices The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores HMGB1 mediates endogenous TLR2 activation and brain tumor regression Reduced COX-2 expression in aged mice is associated with impaired fracture healing A subpopulation of mouse esophageal basal cells has properties of stem cells with the capacity for self-renewal and lineage specification Near-infrared gold nanocages as a new class of tracers for photoacoustic sentinel lymph node mapping on a rat model Pick-and-place using chemically actuated microgrippers Tetherless thermobiochemically actuated microgrippers DNA repair gene polymorphisms and risk of pancreatic cancer Positive regulation of plasmacytoid dendritic cell function via Ly49Q recognition of class I MHC Prolonged continuous in vitro human platelet production using three-dimensional scaffolds Nuclear import is required for the pro-apoptotic function of the Golgi protein p115 Induced pluripotent stem cells from a spinal muscular atrophy patient Survey of the human pancreatic beta cell G1/S proteome reveals a potential therapeutic role for Cdk-6 and cyclin D1 in enhancing human beta cell replication and function in vivo Tissue-engineered skin containing mesenchymal stem cells improves burn wounds Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease SIRT6 links histone H3 lysine 9 deacetylation to NF-kB-dependent gene expression and organismal life span An adenoviral vector-based mucosal vaccine is effective in protection against botulism Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter Human calmodulin-like protein (CLP) expression in oral squamous mucosa and in malignant transformation Transcriptome sequencing to detect gene fusions in cancer AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency COX2 in CNS neural cells mediates mechanical inflammatory pain hypersensitivity in mice Dissociation of seizure traits in inbred strains of mice using the flurothyl kindling model of epileptogenesis In vitro senescence of rat mesenchymal stem cells is accompanied by downregulation of stemness-related and DNA damage repair genes Drosophila stem cells share a common requirement for the histone H2B ubiquitin protease scrawny iPS cell generation using a single lentiviral stem cell cassette Neuronal activity–induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis Isolation and characterization of pluripotent human spermatogonial stem cell-derived cells Advancing systems biology for medical applications The role of the biochemical and biophysical environment in chondrogenic stem cell differentiation assays and cartilage tissue engineering Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche Development of a novel mouse glioma model using lentiviral vectors Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer Myocardial adeno-associated virus serotype 6–βARKct gene therapy improves cardiac function and normalizes the neurohormonal axis in chronic heart failure Microfluidic control of cell pairing and fusion Effects of cardiorespiratory fitness and cerebral blood flow on cognitive outcomes in older women Differential mobilization of subsets of progenitor cells from the bone marrow Ulcerative colitis–risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth Reversal of heroin neurobehavioral teratogenicity by grafting of neural progenitors Transplantation of neural progenitors enhances production of endogenous cells in the impaired brain The brain in the age of old: The hippocampal formation is targeted differentially by diseases of late life Comparative genome sequence analysis of multidrug-resistant Acinetobacter baumannii Development of a portable therapeutic and high intensity ultrasound system for military, medical, and research use Fate tracing reveals the endothelial origin of hematopoietic stem cells Label-free biomedical imaging with high sensitivity by stimulated Raman scattering microscopy Tissue-specific genetic control of splicing: implications for the study of complex traits Tumor vasculature-targeted delivery of tumor necrosis factor-a Clinical responses to gene therapy in joints of two subjects with rheumatoid arthritis Starving neurons show sex difference in autophagy Multiplex protein assays based on real-time magnetic nanotag sensing A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart Nodal signalling is involved in left–right asymmetry in snails Murine bone marrow-derived mesenchymal stem cells as vehicles for interleukin-12 gene delivery into Ewing sarcoma tumors Leukemic cells create bone marrow niches that disrupt the behavior of normal hematopoietic progenitor cells β-Catenin downregulation attenuates ischemic cardiac remodeling through enhanced resident precursor cell differentiation Genetic defects in surfactant protein a2 are associated with pulmonary fibrosis and lung cancer Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes In vitro analog of human bone marrow from 3D scaffolds with biomimetic inverted colloidal crystal geometry Cultural cognition of the risks and benefits of nanotechnology Shared and distinct genetic variants in type 1 diabetes and celiac disease Non-myeloablative hematopoietic stem cell transplantation in older patients with AML and MDS: Results from the Center for International Blood and Marrow Transplant Research (CIBMTR) Common variants at 30 loci contribute to polygenic dyslipidemia Subdivisions of primary motor cortex based on cortico-motoneuronal cells Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation An obesity-associated FTO gene variant and increased energy intake in children Deregulation of HDAC1 by p25/Cdk5 in neurotoxicity Calcium phosphate nanocomposite particles for in vitro imaging and encapsulated chemotherapeutic drug delivery to cancer cells Multimodal optical sensing and analyte specificity using single-walled carbon nanotubes Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair Synergistic actions of hematopoietic and mesenchymal stem/progenitor cells in vascularizing bioengineered tissues Dynamic correlation between intrahost HIV-1 quasispecies evolution and disease progression Reprogramming of murine and human somatic cells using a single polycistronic vector AAV2/1-TNFR:Fc gene delivery prevents periodontal disease progression Optical methodology for detecting histologically unapparent nanoscale consequences of genetic alterations in biological cells Delivery of apoptotic signal to rolling cancer cells: A novel biomimetic technique using immobilized TRAIL and E-selectin Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia Endochondral ossification is required for haematopoietic stem-cell niche formation Self-renewal and expansion of single transplanted muscle stem cells Chromosome 15q25.1 genetic markers associated with level of response to alcohol in humans Evaluating the safety and efficacy of anti-HIV transgenic cells in a humanized mouse model (NOD/SCIDγc–/–) for HIV stem cell gene therapy Selective molecular imaging of viable cancer cells with pH-activatable fluorescence probes Membrane shape as a reporter for applied forces Detection of functional haematopoietic stem cell niche using real-time imaging Amelioration of epidermolysis bullosa by transfer of wild-type bone marrow cells Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells Non-cell-autonomous effect of human SOD1G37R astrocytes on motor neurons derived from human embryonic stem cells Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair Sequential development of synapses in dendritic domains during adult neurogenesis Genomic analysis of the clonal origins of relapsed acute lymphoblastic leukemia Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune control Fanconi anemia deficiency stimulates HPV-associated hyperplastic growth in organotypic epithelial raft culture Cutting edge: a T-bet-independent role for IFN-/β in regulating IL-2 secretion in human CD4+ central memory T cells Membrane potential controls adipogenic and osteogenic differentiation of mesenchymal stem cells Single-RNA counting reveals alternative modes of gene expression in yeast Blazing the trail from stem cell research to regenerative medicine Ascites specific inhibition of CD1d-mediated activation of natural killer T cells Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma Notch pathway modulation on bone marrow-derived vascular precursor cells regulates their angiogenic and wound healing potential Efficient tumour formation by single human melanoma cells Identification of a receptor required for the anti-inflammatory activity of IVIG A dynamic zone defines interneuron remodeling in the adult neocortex α-Catenin mediates initial E-cadherin-dependent cell–cell recognition and subsequent bond strengthening A novel flex-stretch-flow bioreactor for the study of engineered heart valve tissue mechanobiology Mistranslation of membrane proteins and two-component system activation trigger antibiotic-mediated cell death Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia Exercise enhances the proliferation of neural stem cells and neurite growth and survival of neuronal progenitor cells in dentate gyrus of middle-aged mice Stimulation of neural regeneration in the mouse retina A novel method for enrichment and selection of dopamine progenitor cells from human ES cells New ISSCR guidelines underscore major principles for responsible translational stem cell research Derivation of functional insulin-producing cell lines from primary mouse embryo culture Generating mESC-derived insulin-producing cell lines through an intermediate lineage-restricted progenitor line Association of genes involved in lipid metabolismperoxidation and risk of renal cancer in the Central European Renal Cancer Case-Control Study Convergent functional genomics of genome-wide association data for bipolar disorder: Comprehensive identification of candidate genes, pathways and mechanisms Transplanted mouse embryonic stem-cell-derived motoneurons form functional motor units and reduce muscle atrophy Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice Generation of retinal stem cells and functional eyes from pluripotent cells Clinical transplantation of a tissue-engineered airway Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers Endogenous VEGF is required for visual function: evidence for a survival role on Müller cells and photoreceptors Stable long-term donor engraftment following reduced-intensity hematopoietic cell transplantation for sickle cell disease The forkhead protein Foxj1 specifies node-like cilia in Xenopus and zebrafish embryos Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity PEA-15 induces autophagy in human ovarian cancer cells and is associated with prolonged overall survival Striatal dysregulation of Cdk5 alters locomotor responses to cocaine, motor learning, and dendritic morphology Cdk5 is essential for adult hippocampal neurogenesis The histone H3 lysine 27-specific demethylase Jmjd3 is required for neural commitment A missense variant (P10L) of the melanopsin (OPN4) gene in seasonal affective disorder Putative dental pulp-derived stem/stromal cells promote proliferation and differentiation of endogenous neural cells in the hippocampus of mice The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid B-protein level in vivo Intravital imaging of metastatic behavior through a mammary imaging window H3K79 methylation profiles define murine and human MLL-AF4 leukemias A role for VEGF as a negative regulator of pericyte function and vessel maturation Electromagnetic interference (EMI) of implanted cardiac devices by MP3 player headphones Early treatment of high-risk chronic lymphocytic leukemia with alemtuzumab and rituximab Targeting ErbB2 and ErbB3 with a bispecific single-chain Fv enhances targeting selectivity and induces a therapeutic effect in vitro Myogenic endothelial cells purified from human skeletal muscle improve cardiac function after transplantation into infarcted myocardium Illumination controls differentiation of dopamine neurons regulating behavior Effects of direct transplantation of multipotent mesenchymal stromal/stem cells into the demyelinated spinal cord Foxl1 is a marker of bipotential hepatic progenitor cells in mice Mechanical and biological properties of nanoporous carbon membranes Harvesting the energy of cardiac motion to power a pacemaker Cleavage of the Wnt receptor Ryk regulates neuronal differentiation during cortical neurogenesis Human tissue-engineered heart valves based on umbilical cord blood derived progenitor cells as single cell source A role for VEGF as a negative regulator of pericyte function and vessel maturation Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds CaMKII-mediated phosphorylation of the myosin motor Myo1c is required for insulin-stimulated GLUT4 translocation in adipocytes Structure of Seneca Valley Virus-001: an oncolytic picornavirus representing a new genus Wnt signaling mediates self-organization and axis formation in embryoid bodies A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity Immune control of an SIV challenge by a T-cell-based vaccine in rhesus monkeys H2AZ is enriched at polycomb complex target genes in ES cells and is necessary for lineage commitment Cathepsin L proteolytically processes histone H3 during mouse embryonic stem cell differentiation 5|[prime]|-triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma Alternative isoform regulation in human tissue transcriptomes HITS-CLIP yields genome-wide insights into brain alternative RNA processing Androgen receptor functional analyses by high throughput imaging: determination of ligand, cell cycle, and mutation-specific effects Toll-like receptor–induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens Accordion-like honeycombs for tissue engineering of cardiac anisotropy The in vitro effects of bupivacaine on articular chondrocytes Arsenic-stimulated liver sinusoidal capillarization in mice requires NADPH oxidase–generated superoxide Sfrp5 coordinates foregut specification and morphogenesis by antagonizing both canonical and noncanonical Wnt11 signaling Chemical engineering of mesenchymal stem cells to induce a cell rolling response Nf1-dependent tumors require a microenvironment containing Nf1+/−- and c-kit-dependent bone marrow Hedgehog signaling regulates brain tumor initiating cell proliferation and portends shorter survival for patients with PTEN-coexpressing glioblastomas Genome-wide association analysis reveals putative Alzheimer's Disease susceptibility loci in addition to APOE Engineering microRNA responsiveness to decrease virus pathogenicity Diverse RNA-binding proteins interact with functionally related sets of RNAs, suggesting an extensive regulatory system A conserved arginine containing motif crucial for the assembly and enzymatic activity of the Mixed Lineage Leukemia protein-1 core complex A single intravenous injection of adeno-associated virus serotype-9 leads to whole body skeletal muscle transduction in dogs Role of kinin B2 receptor signaling in the recruitment of circulating progenitor cells with neovascularization potential Serum inter-a-trypsin inhibitor and matrix hyaluronan promote angiogenesis in fibrotic lung injury Glia are essential for sensory organ function in C. elegans Fault diagnosis engineering of digital circuits can identify vulnerable molecules in complex cellular pathways Gene expression profiles during in vivo human rhinovirus infection A fast, robust and tunable synthetic gene oscillator Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf expression Compensatory growth of healthy cardiac cells in the presence of diseased cells restores tissue homeostasis during heart development Notch signaling regulates mammary stem cell function and luminal cell-fate commitment Generation of a prostate from a single adult stem cell Network model of survival signaling in large granular lymphocyte leukemia DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes Cross-talk between GlcNAcylation and phosphorylation: Site-specific phosphorylation dynamics in response to globally elevated O-GlcNAc Evolution of MDA-5/RIG-I-dependent innate immunity: Independent evolution by domain grafting Global reorganization of replication domains during embryonic stem cell differentiation Modulation of potassium channel function confers a hyperproliferative invasive phenotype on embryonic stem cells Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes Restoration of visual function in retinal degeneration mice by ectopic expression of melanopsin Centrosome misorientation reduces stem cell division during ageing Lgr5 marks cycling, yet long-lived, hair follicle stem cells Hematopoietic stem cell transplantation in patients with sporadic amyotrophic lateral sclerosis Mitochondrial metabolism modulates differentiation and teratoma formation capacity in mouse embryonic stem cells Mobilized hematopoietic stem cell yield depends on species-specific circadian timing HSP90β regulates rapsyn turnover and subsequent AChR cluster formation and maintenance Ikaros confers early temporal competence to mouse retinal progenitor cells Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family ACF7 regulates cytoskeletal-focal adhesion dynamics and migration and has ATPase activity Nanoparticulate delivery of diphtheria toxin DNA effectively kills mesothelin expressing pancreatic cancer cells A role for macroautophagy in protection against 4-hydroxytamoxifen–induced cell death and the development of antiestrogen resistance Focal transplantation–based astrocyte replacement is neuroprotective in a model of motor neuron disease Higher-order cellular information processing with synthetic RNA devices In vivo cloning of artificial DNA nanostructures Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy Spinal cord injury reveals multilineage differentiation of ependymal cells Distinct tumor suppressor mechanisms evolve in rodent species that differ in size and lifespan Planarian PTEN homologs regulate stem cells and regeneration through TOR signaling In vivo modeling and detection of the ovarian cancer vascular marker TEM1 Identification of white adipocyte progenitor cells in vivo Generation of pluripotent stem cells from adult human testis Repigmentation of vitiligo by transplantation of autologous melanocyte cells cultured on amniotic membrane TSG-6 regulates bone remodeling through inhibition of osteoblastogenesis and osteoclast activation Oligopotent stem cells are distributed throughout the mammalian ocular surface Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy Generation of insulin-secreting islet-like clusters from human skin fibroblasts Tissue- and age-specific changes in gene expression during disease induction and progression in NOD mice Evidence that an early pregnancy causes a persistent decrease in the number of functional mammary epithelial stem cells—implications for pregnancy-induced protection against breast cancer Effective rescue of dystrophin improves cardiac function in dystrophin-deficient mice by a modified morpholino oligomer Targeted development of registries of biological parts Volumetric and ionic regulation during the in vitro development of a corneal endothelial barrier Ependymal stem cells divide asymmetrically and transfer progeny into the subventricular zone when activated by injury Quantitation of aurora kinase A gene copy number in urine sediments and bladder cancer detection Human gene therapy for RPE65 isomerase deficiency activates the retinoid cycle of vision but with slow rod kinetics Induced pluripotent stem cells generated without viral integration Small-molecule inhibitors of microRNA miR-21 function Preventing growth of brain tumors by creating a zone of resistance Noncytotoxic lytic granule–mediated CD8+ T cell inhibition of HSV-1 reactivation from neuronal latency. Calcification of multipotent prostate tumor endothelium Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum Regulatory networks define phenotypic classes of human stem cell lines ES-cell derived hematopoietic cells induce transplantation tolerance Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium Embryonic stem cell therapy of heart failure in genetic cardiomyopathy Isolation of a slowly adhering cell fraction containing stem cells from murine skeletal muscle by the preplate technique. Phase I trial of leber congenital amaurosis due to RPE65 mutations by ocular subretinal injection of adeno-associated virus gene vector: short-term results Regulatory networks define phenotypic classes of human stem cell lines In vivo gene delivery to proliferating cells in the striatum generated in response to a 6-hydroxydopamine lesion of the nigro-striatal dopamine pathway DYRK1A-dosage imbalance perturbs NRSF/REST Levels, Deregulating Pluripotency and Embryonic Stem Cell Fate in Down Syndrome The type I TGF-b receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner Genes mirror geography within Europe Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis In vivo reprogramming of adult pancreatic exocrine cells to B-cells HES-1 is involved in adaptation of adult human β-cells to proliferation in vitro Synthesis and evaluation of synthetic retinoid derivatives as inducers of stem cell differentiation Integrins control the positioning and proliferation of follicle stem cells in the Drosophila ovary Senescence of activated stellate cells limits liver fibrosis Allogeneic endometrial regenerative cells: an "off the shelf solution" for critical limb ischemia? Immunosuppressive therapy mitigates immunological rejection of human embryonic stem cell xenografts Making insulin-deficient type 1 diabetic rodents thrive without insulin Biological properties and enucleation of red blood cells from human embryonic stem cells The rho-rock-myosin signaling axis determines cell-cell integrity of self-renewing pluripotent stem cells Interferon-α initiates type 1 diabetes in nonobese diabetic mice Posttraumatic stress and complicated grief in family members of patients in the intensive care unit. TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice A perivascular origin for mesenchymal stem cells in multiple human organs Transoral endoscopic fundoplication in the treatment of gastroesophageal reflux disease: the anatomic and physiologic basis for reconstruction of the esophagogastric junction using a novel device Functional auditory hair cells produced in the mammalian cochlea by in utero gene transfer Drug delivery with carbon nanotubes for in vivo cancer treatment Toll-like receptor 3 and geographic atrophy in age-related macular degeneration Carcinogen-altered genes in rat esophagus positively modulated to normal levels of expression by both black raspberries and phenylethyl isothiocyanate Increase in endoplasmic reticulum stress–related proteins and genes in adipose tissue of obese, insulin-resistant individuals Neuropilin-1 in regulation of VEGF-induced activation of p38MAPK and endothelial cell organization Expression of ACE (CD143) identifies and regulates primitive hemangioblasts derived from human pluripotent stem cells Systems biology of the clock in Neurospora crassa Racial differences in the frequencies of HLA-specific B cells The age lipid A2E and mitochondrial dysfunction synergistically impair phagocytosis by retinal pigment epithelial cells Mouse development with a single E2F activator A pilot study of consolidative immunotherapy in patients with high-risk pediatric sarcomas Ectodermal Smad4 and p38 MAPK are functionally redundant in mediating TGF-β/BMP signaling during tooth and palate development Gastrin-releasing peptide receptor silencing suppresses the tumorigenesis and metastatic potential of neuroblastoma Tumor regression in cancer patients by very low doses of a T cell–engaging antibody Pre-clinical evaluation of a novel nanoemulsion-based hepatitis B mucosal vaccine Inhibition of human glutaminyl cyclase: A potential new treatment for AD PRDM16 controls a brown fat/skeletal muscle switch Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form shh-induced medulloblastoma GATA transcription factors directly regulate the Parkinson's disease-linked gene α-synuclein Bone marrow-derived mesenchymal stem cells ameliorate autoimmune enteropathy independently of regulatory T cells Association of a polymorphism near CREB1 with differential aversion processing in the insula of healthy participants Detecting skin cancer using volatile biomarkers Analyses of volatile organic compounds from human skin Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling A human embryonic stem cell line derived from a single blastomere of a 4-cell stage embryo Immobilized metal-affinity protein delivery via polyketal microparticles A new reactive oxygen species sensitive drug delivery vehicle for targeting oxidative stress Establishment of endoderm progenitors by SOX transcription factor expression in human embryonic stem cells Current and future considerations in the use of mechanical circulatory support devices Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells Dual origin of tissue-specific progenitor cells in Drosophila tracheal remodeling Senescence of activated stellate cells limits liver fibrosis Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder Synthesis and antiproliferative activity of curcumin analogs Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function Phosphorylation of SNAP-23 by IκB kinase 2 regulates mast cell degranulation Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects Genome-scale DNA methylation maps of pluripotent and differentiated cells Dissecting direct reprogramming through integrative genomic analysis Cellular origins of adult human islet in vitro dedifferentiation Engineering robust and functional vascular networks in vivo with human adult and cord blood–derived progenitor cells T cell-independent and toll-like receptor-dependent antigen-driven activation of autoreactive B cells T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice Experience-dependent transfer of Otx2 homeoprotein into the visual cortex activates postnatal plasticity Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1 Germline mutations and variants in the succinate dehydrogenase genes in cowden and cowden-like syndromes Disease-specific induced pluripotent stem cells The effect of particle design on cellular internalization pathways A preliminary gene expression profile of acute graft-versus-host disease Induction of plasma (TRAIL), TNFR-2, Fas ligand, and plasma microparticles after human immunodeficiency virus type 1 (HIV-1) transmission: implications for HIV-1 vaccine design Gene expression patterns in visual cortex during the critical period: Synaptic stabilization and reversal by visual deprivation Role of Sox-9, ER81 and VE-Cadherin in retinoic acid-mediated trans-differentiation of breast cancer cells Adaptive Foxp3+ regulatory t cell-dependent and -independent control of allergic inflammation A precisely regulated gene expression cassette potently modulates metastasis and survival in multiple solid cancers Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein Bioresorbable hyaluronic acid hydrogels for tissue engineering applications Catalytic antibodies to HIV: Physiological role and potential clinical utility Calcium control of endocytic capacity at a CNS synapse Duffy antigen receptor for chemokines mediates trans-infection of HIV-1 from red blood cells to target cells and affects HIV-AIDS susceptibility Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosis Highly efficient, functional engraftment of skeletal muscle stem cells in dystrophic muscles Miniaturized probe for femtosecond laser microsurgery and two-photon imaging An RNAi screen of chromatin proteins identifies Tip60-p400 as a regulator of embryonic stem cell identity Young age at diagnosis correlates with worse prognosis and defines a subset of breast cancers with shared patterns of gene expression Antisense transcripts are targets for activating small RNAs Statin treatment of adult human glial progenitors induces PPARΎ-mediated oligodendrocytic differentiation Multiphoton fabrication of chemically responsive protein hydrogels for microactuation Large-scale analysis of gene clustering in bacteria Mesp1 coordinately regulates cardiovascular fate restriction and epithelial-mesenchymal transition in differentiating escs A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types Genomic and proteomic analysis reveals a threshold level of MYC required for tumor maintenance Olfactory mucosa is a potential source for autologous stem cell therapy for Parkinson's Disease PANIC–ATTAC, a mouse model for inducible and reversible β cell ablation Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1 Targeting mutant p53 protein and tumor vasculature: An effective combination therapy for advanced breast tumors A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration GHRH improves survival and quality of life of companion dogs with cancer Protein−protein interaction detection in vitro and in cells by proximity biotinylation DNA packaging via combinative self-assembly Myocyte enhancer factor 2C as a neurogenic and antiapoptotic transcription factor in murine embryonic stem cells The B cell antigen receptor and overexpression of MYC can cooperate in the genesis of B cell lymphomas Intra-abdominal vagal blocking (VBLOC therapy): Clinical results with a new implantable medical device Dunking doughnuts into cells—selective cellular translocation and in vivo analysis of polymeric micro-doughnuts IRF4 addiction in multiple myeloma Polygenes, risk prediction, and targeted prevention of breast cancer Neonatal chimerization with human glial progenitor cells can both remyelinate and rescue the otherwise lethally hypomyelinated shiverer mouse IL1RL1-IL18R1-IL18RAP-SLC9A4 and CARD9 loci are susceptibility factors for both Crohn’s disease and ulcerative colitis Synergistic and additive effects of hydrostatic pressure and growth factors on tissue formation Enhanced chondrocyte densities on carbon nanotube composites: The combined role of nanosurface roughness and electrical stimulation Evaluating suppression of nonsense mutations by aminoglycoside antibiotics as an intervention for vision loss in type I Usher syndrome Treatment of Late Infantile Neuronal Ceroid Lipofuscinosis by CNS administration of a serotype 2 adeno-associated virus expressing CLN2 cDNA Blocking TGF-–Smad2/3 innate immune signaling mitigates Alzheimer-like pathology Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells In vivo biocompatibility of ultra-short single-walled carbon nanotube/biodegradable polymer nanocomposites for bone tissue engineering Fatty acid synthase is upregulated during HCV infection and regulates HCV entry and production Ephrins as negative regulators of adult neurogenesis in diverse regions of the central nervous system Bmi1 is expressed in vivo in intestinal stem cells Shear stress improves adult stem cell attachment to vascular basement membrane components via upregulation of α5ß1integrin expression Inhalable siRNA: potential as a therapeutic agent in the lungs Cooperation of two MRNA-binding proteins drives metabolic adaptation to iron deficiency Cortical control of a prosthetic arm for self-feeding The ground state of embryonic stem cell self-renewal Gene expression profiling of human prostate cancer stem cells reveals a pro-inflammatory phenotype and the importance of extracellular matrix interactions Toward a cure for type 1 diabetes mellitus: diabetes-suppressive dendritic cells and beyond Small-molecule activation of neuronal cell fate Neurons born in the adult dentate gyrus form functional synapses with target cells Defining the incidence of cardiorespiratory instability in patients in step-down units using an electronic integrated monitoring system Regional anatomic and age effects on cell function of human adipose-derived stem cells Increased plasma interleukin-6 in donors is associated with lower recipient hospital-free survival after cadaveric organ transplantation Improved efficiency and pace of generating induced pluripotent stem cells from human adult and fetal fibroblasts CD133 expression is not restricted to stem cells, and both CD133+ and CD133– metastatic colon cancer cells initiate tumors Pilot study of granulocyte colony stimulating factor (G-CSF)-mobilized peripheral blood stem cells in amyotrophic lateral sclerosis (ALS) cAMP/PKA pathway activation in human mesenchymal stem cells in vitro results in robust bone formation in vivo Establishment of mouse embryonic stem cell-derived erythroid progenitor cell lines able to produce functional red blood cells Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation Osteolineage niche cells initiate hematopoietic stem cell mobilization Absorbent microbicidal wound dressing material with protease inhibition properties Functional genomic screen reveals genes involved in lipid-droplet formation and utilization Microparticle-mediated delivery of morphogenic factors within embryoid bodies Lysine-derived urethane surgical adhesive prevents seroma formation in a canine abdominoplasty model Repair of iatrogenic sphincter damage and urinary incontinence by autologous skeletal muscle derived cells (mdc) Transurethral ultrasound guided injection of autologus myo- and fibroblasts in incontinent men: 2 year data Bergmann glia and the recognition molecule CHL1 organize GABAergic axons and direct innervation of Purkinje cell dendrites Next generation of adeno-associated virus 2 vectors: point mutations in tyrosines lead to high-efficiency transduction at lower doses Oral IL-10 gene delivery in a microsphere-based formulation for local transfection and therapeutic efficacy in inflammatory bowel disease Ex vivo expansion of cord blood nk cells with in vivo efficacy against acute myeloblastic and lymphoblastic leukemias The epithelial-mesenchymal transition generates cells with properties of stem cells Label-retaining cells of the bladder: candidate urothelial stem cells Latent stem and progenitor cells in the hippocampus are activated by neural excitation Endochondral bone tissue engineering using embryonic stem cells Expression of an estrogen receptor agonist in differentiating osteoblast cultures Dendritic cells in islets of Langerhans constitutively present β cell-derived peptides bound to their class II MHC molecules Genetic approaches identify adult pituitary stem cells Safety and efficacy of gene transfer for Leber's Congenital Amaurosis Multiple genetic loci for bone mineral density and fractures Extensive fusion of haematopoietic cells with Purkinje neurons in response to chronic inflammation Fibronectin bridges monocytes and reticulocytes via integrin α4β1 Efficacy and safety of renal tubule cell therapy for acute renal failure Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells A novel magnetic approach to enhance the efficacy of cell-based gene therapies Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency Identification and characterization of cancer stem cells in ovarian cancer In vivo immunogold labeling confirms large-scale chromatin folding motifs Akt requires glucose-mediated regulation of bcl-2 family members to inhibit cell death Local delivery of gene vectors from bare-metal stents by use of a biodegradable synthetic complex inhibits in-stent restenosis in rat carotid arteries Serotype-dependent packaging of large genes in adeno-associated viral vectors results in effective gene delivery in mice A microsphere-based vaccine prevents and reverses new-onset autoimmune diabetes Translational systems biology of inflammation A novel flex-stretch-flow bioreactor for the study of engineered heart valve tissue mechanobiology HDAC4 and PCAF bind to cardiac carcomeres and play a role in regulating myofilament contractile activity Minute dosages of aVB3-targeted fumagillin nanoparticles impair Vx-2 tumor angiogenesis and development in rabbits Musashi1 regulates mammary progenitor cell expansion through activation of the Wnt and Notch pathway Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons Cardiogenic small molecules that enhance myocardial repair by stem cells Lifetime probabilities of hematopoietic stem cell transplantation in the U.S. Nucleofection mediates high-efficiency stable gene knockdown and transgene expression in human embryonic stem cells Noninvasive delivery of gene targeting probes to live brains for transcription MRI Memory enhancement induced by hypothalamic/fornix deep brain stimulation Light-activated channels targeted to ON bipolar cells restore visual function in retinal degeneration A combinatorial library of lipid-like materials for delivery of RNAi therapeutics Arthroscopic replacement of massive, irreparable rotator cuff tears using a graftjacket allograft: technique and preliminary results Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases Nanofibrous scaffolds incorporating PDGF-BB microspheres induce chemokine expression and tissue neogenesis in vivo Origin and progeny of reactive gliosis: a source of multipotent cells in the injured brain Harvested human neurons engineered as live nervous tissue constructs: implications for transplantation AAV vector-mediated reversal of hypoglycemia in canine and murine glycogen storage disease type Ia The emergence of hematopoietic stem cells is initiated in the placental vasculature in the absence of circulation Contractile smooth muscle cells derived from hair-follicle stem cells PAX4 enhances beta-cell differentiation of human embryonic stem cells Cavity-enhanced optical frequency comb spectroscopy: application to human breath analysis Delayed rectifier and A-type potassium channels associated with Kv 2.1 and Kv 4.3 expression in embryonic rat neural progenitor cells Sequence- and target-independent angiogenesis suppression by siRNA via TLR3 Long-term enhancement of skeletal muscle mass and strength by single gene administration of myostatin inhibitors Neuroepithelial stem cell proliferation requires LIS1 for precise spindle orientation and symmetric division Peripheral injection of human umbilical cord blood stimulates neurogenesis in the aged rat brain An extended transcriptional network for pluripotency of embryonic stem cells Stem cells from human fat as cellular delivery vehicles in an athymic rat posterolateral spine fusion model In vivo correction of a Menkes disease model using antisense oligonucleotides Peripherally administered human umbilical cord blood cells reduce parenchymal and vascular B-amyloid deposit in Alzheimer mice Flt3L in combination with HSV1-TK-mediated gene therapy reverses brain tumor-induced behavioral deficits A comprehensive platform for ex vivo t-cell expansion based on biodegradable polymeric artificial antigen-presenting cells Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a Systemic vesicular stomatitis virus selectively destroys multifocal glioma and metastatic carcinoma in brain Evidence for the involvement of miRNA in redox regulated angiogenic response of human microvascular endothelial cells Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing The molecular etiology of breast cancer: evidence from biomarkers of risk A new arena virus in a cluster of fatal transplant-associated diseases Nonmuscle myosin heavy chain IIA mediates integrin LFA-1 de-adhesion during T lymphocyte migration Rapid appearance and local toxicity of amyloid-B plaques in a mouse model of Alzheimer's disease Loss of singleminded-2s in the mouse mammary gland induces an epithelial-mesenchymal transition associated with up-regulation of slug and matrix metalloprotease 2 Transparent adult zebrafish as a tool for in vivo transplantation analysis Lentiviral delivered VRX496 long antisense sequences exerts molecular pressure on HIV-1 in human subjects Clinical applications of blood-derived and marrow-derived stem cells for nonmalignant diseases Hematopoiesis and immunity of HOXB4-transduced embryonic stem cell–derived hematopoietic progenitor cells Self-assembly of large and small molecules into hierarchically ordered sacs and membranes Independent evolution of an antiviral TRIMCyp in rhesus macaques Stimuli-responsive polymer nanocomposites inspired by the sea cucumber dermis Adherent self-renewable human embryonic stem cell-derived neural stem cell line: functional engraftment in experimental stroke model Transplanted endothelial cells repopulate the liver endothelium and correct the phenotype of hemophilia A mice The transition from stiff to compliant materials in squid beaks ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration Autologous transplantation of endothelial progenitor cells attenuates acute lung injury in rabbits Intrauterine transplantation of human fetal mesenchymal stem cells from first-trimester blood repairs bone and reduces fractures in osteogenesis imperfecta mice Sensory neuron targeting by self-complementary AAV8 via lumbar puncture for chronic pain Conserved GU-rich elements mediate mRNA decay by binding to CUG-binding protein 1 Gene expression changes in children with autism Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model Submicroscopic duplications of the hydroxysteroid dehydrogenase HSD17B10 and the E3 ubiquitin ligase HUWE1 are associated with mental retardation DNA double helices recognize mutual sequence homology in a protein free environment NFATc1 balances quiescence and proliferation of skin stem cells P-selectin–coated microtube for enrichment of CD34+ hematopoietic stem and progenitor cells from human bone marrow Investigating the feasibility of stem cell enrichment mediated by immobilized selectins Capture and enrichment of CD34-positive haematopoietic stem and progenitor cells from blood circulation using P-selectin in an implantable device Human embryonic stem cell derivation from poor-quality embryos Generation of biologically contained Ebola viruses Characterization of transplanted green fluorescent protein+ bone marrow cells into adipose tissue Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukemia Identification of cells initiating human melanomas Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci Molecular mechanisms linking wound inflammation and fibrosis: knockdown of osteopontin leads to rapid repair and reduced scarring Functional skeletal muscle regeneration from differentiating embryonic stem cells Nanomagnetic actuation of receptor-mediated signal transduction Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome Positive end-expiratory pressure setting in adults with acute lung injury and acute respiratory distress syndrome Testing protocols in the intensive care unit--complex trials of complex interventions for complex patients Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone A comparison of bare-metal and drug-eluting stents for off-label indications Cancer stem cells with genetic instability: the best vehicle with the best engine for cancer Genome-wide transcriptional analysis of the human cell cycle identifies genes differentially regulated in normal and cancer cells Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells High field gradient targeting of magnetic nanoparticle-loaded endothelial cells to the surfaces of steel stents Interleukin-6 is an essential regulator of satellite cell-mediated skeletal muscle hypertrophy Freeze-dried tendon allografts as tissue-engineering scaffolds for Gdf5 gene delivery Recurrent 16p11.2 microdeletions in autism Expression of indoleamine 2,3-dioxygenase in metastatic pancreatic ductal adenocarcinoma recruits regulatory t cells to avoid immune detection Review of U.S. medical device regulation The use of keratin biomaterials derived from human hair for the promotion of rapid regeneration of peripheral nerves Human embryonic stem cell lines generated without embryo destruction Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart Early intramedullary femoral fixation versus external fixation in polytrauma patients at risk for systemic complications: a prospective randomized controlled multicenter study Rescue of pituitary function in a mouse model of isolated growth hormone deficiency type II by RNAi Recovery of supraspinal control of stepping via indirect propriospinal relay connections after spinal cord injury The potential of umbilical cord blood multipotent stem cells for nonhematopoietic tissue and cell regeneration Gene therapy reduces ethanol intake in an animal model of alcohol dependence Acute exposure to a moderate strength magnetic field reduces edema formation in rats Correction of Fragile X syndrome in mice Evaluation of promoter hypermethylation detection in body fluids as a screening/diagnosis tool for head and neck squamous cell carcinoma Effect of chemistry on thermo-mechanical shape-memory properties of acrylate networks Designing shape memory polymers networks for biomedical applications Atomistic characterization of the elastic bending behavior of metallic nanowires Modulating neuronal responses by controlled integration of acetylcholine-like functionalities in biomimetic polymers Reprogramming of human somatic cells to pluripotency with defined factors Imaging of mesenchymal stem cell transplant by bioluminescence and PET Three-dimensional cellular microarray for high-throughput toxicology assays HLA homozygous stem cell lines derived from human parthenogenetic blastocysts Unique dielectric properties distinguish stem cells and their differentiated progeny Improved cell survival in infarcted myocardium using a novel combination transmyocardial laser and cell delivery system Development of a tissue-engineered vascular graft combining a biodegradable scaffold, muscle-derived stem cells and a rotational vacuum seeding technique Isolation of rare circulating tumour cells in cancer patients by microchip technology Stem cell augmented reconstruction: a new hope for reconstruction after breast conservation therapy Identification of small molecules from human embryonic stem cells using metabolomics Comparable outcomes after nonmyeloablative hematopoietic cell transplantation with unrelated and related donors Safety of MGMT gene transfer into hematopoietic progenitors: a phase I clinical trial using retroviral gene transfer of G156A MGMT to protect hematopoiesis during BG plus alkylating agent treatment of advanced malignancies Restoration of human dystrophin following transplantation of exon-skipping-engineered DMD patient stem cells into dystrophic mice Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin Scaffolds based on degradable alginate hydrogels and poly(lactide-co-glycolide) microspheres for stem cell culture Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues Mutation in glycerol-3-phosphate dehydrogenase 1–like gene (gpd1-l) decreases cardiac NA+ current and causes inherited arrhythmias Choosing among living-donor and cadaveric livers Endometrial regenerative cells: a novel stem cell population Evidence for skeletal progenitor cells in the degenerate human intervertebral disc Neural stem cells improve memory in an inducible mouse model of neuronal loss Rotary suspension culture enhances the efficiency, yield, and homogeneity of embryoid body differentiation Skin-derived precursors generate myelinating schwann cells that promote remyelination and functional recovery after contusion spinal cord injury Agent-based model of inflammation and wound healing: insights into diabetic foot ulcer pathology and the role of transforming growth factor-b1 Prospective identification of myogenic endothelial cells in human skeletal muscle A novel multiparametric flow cytometry-based cytotoxicity assay simultaneously immunophenotypes effector cells: Comparisons to a 4 h (51)Cr-release assay Long-term propagation of distinct hematopoietic differentiation programs in vivo Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS–ADRDA criteria Examination of the therapeutic potential of Delta-24-RGD in brain tumor stem cells: role of autophagic cell death Carbon nanotube sensors for exhaled breath components Transformation of different human breast epithelial cell types leads to distinct tumor phenotypes Understanding the inflammatory cytokine response in pneumonia and sepsis Common molecular signature in SOD1 for both sporadic and familial amyotrophic lateral sclerosis An elastic, biodegradable cardiac patch induces contractile smooth muscle and improves cardiac remodeling and function in subacute myocardial infarction Directed engineering of umbilical cord blood stem cells to produce C-peptide and insulin Amelioration of pain and histopathologic joint abnormalities in the Col1-IL-1βXAT mouse model of arthritis by intraarticular induction of μ-opioid receptor into the temporomandibular joint The healing effects of autologous platelet gel on acute human skin wounds Recovery from major depression in older adults receiving augmentation of antidepressant pharmacotherapy Developmental reprogramming after chromosome transfer into mitotic mouse zygotes Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution Platelet-derived growth factor receptor-α: a novel therapeutic target in human hepatocellular cancer From Baghdad to Germany: use of a new pumpless extracorporeal lung assist system in two severely injured us soldiers Cyanidin-3-rutinoside, a natural polyphenol antioxidant, selectively kills leukemic cells by induction of oxidative stress A role for cell sex in stem cell–mediated skeletal muscle regeneration: female cells have higher muscle regeneration efficiency Environmentally sensitive gels assembled through protein-polysaccharide interactions Carbon monoxide protects against hyperoxia-induced endothelial cell apoptosis by inhibiting reactive oxygen species formation Stem and progenitor cells in skeletal muscle development, maintenance, and therapy Fiber kinematics of small intestinal submucosa under biaxial and uniaxial stretch Strategies for reducing the door-to-balloon time in acute myocardial infarction Design and analysis of tissue engineering scaffolds that mimic soft tissue mechanical anisotropy Craniofacial tissue engineering by stem cells Cartilage repair using bone morphogenetic protein 4 and muscle-derived stem cells Microintegrating smooth muscle cells into a biodegradable, elastomeric fiber matrix Differentiated cells are more efficient than adult stem cells for cloning by somatic cell nuclear transfer In situ labeling of immune cells with iron oxide particles: An approach to detect organ rejection by cellular MRI Proteomic profiling of cerebrospinal fluid identifies biomarkers for amyotrophic lateral sclerosis Differential myocardial infarct repair with muscle stem cells compared to myoblasts Surgical treatment for congestive heart failure with autologous adult stem cell transplantation: A prospective randomized study Mouse fetal liver cells in artificial capillary beds in three-dimensional four-compartment bioreactors Tissue-engineered myocardial patch derived from extracellular matrix provides regional mechanical function The vascular wall as a source of stem cells Outcomes 18 months after the first human partial face transplantation Autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus Towards improved artificial lungs through biocatalysis Integrating bench to operating room: journey of a clinician-scientist Wnt5a-treated midbrain neural stem cells improve dopamine cell replacement therapy in Parkinsonian mice Tissue-engineered autologous bladders for patients needing cystoplasty Nerve regeneration promoted in a tube with vascularity containing bone marrow-derived cells