Authors:
Zhihui Zhong, Rashid Deane, Zarina Ali, Margaret Parisi, Yuriy Shapovalov, M Kerry O'Banion, Konstantin Stojanovic, Abhay Sagare, Severine Boillee, Don W Cleveland & Berislav V Zlokovic
Summary:
We report here that amyotrophic lateral sclerosis–linked superoxide dismutase 1 (SOD1) mutants with different biochemical characteristics disrupted the blood–spinal cord barrier in mice by reducing the levels of the tight junction proteins ZO-1, occludin and claudin-5 between endothelial cells. This resulted in microhemorrhages with release of neurotoxic hemoglobin-derived products, reductions in microcirculation and hypoperfusion. SOD1 mutant–mediated endothelial damage accumulated before motor neuron degeneration and the neurovascular inflammatory response occurred, indicating that it was a central contributor to disease initiation.
Source:
Nature Neuroscience 11, 420 - 422, 2008