Authors: Fang Fang Zhang, Norimitsu Morioka, Sakura Harano, Yoki Nakamura, Keyue Liu, Masahiro Nishibori, Kazue Hisaoka-Nakashima and Yoshihiro Nakata
Summary: Increased peripheral high-mobility group box-1 (HMGB1) is involved in the modulation of nociceptive transduction following a peripheral neuropathy. Following nerve injury in mice, increased HMGB1 is detected in both infiltrating macrophages and proliferating Schwann cells in the ipsilateral nerve. Repeated perineural treatment with anti-HMGB1 antibody significantly ameliorates nerve injury-induced mechanical hypersensitivity, and suppresses expression of matrix metalloprotease-9 (MMP-9). The findings demonstrate that the maintenance of the neuropathic state following an injury nerve is dependent on the up-regulation of HMGB1 and MMP-9.
Source:
Journal of Neurochemistry; Vol. 136, Issue 4, 837-850 (02/2016)